Hematologic malignancies of the larynx: A single institution review☆☆☆☆☆☆
Author links open overlay panelKarunaDewanRossCampbellEdward J.Damrose
Division of Laryngology, Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, United States of America
Received 3 June 2019, Available online 4 September 2019.
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https://doi.org/10.1016/j.amjoto.2019.102285Get rights and content
Abstract
Background
Primary hematologic malignancies of the larynx are rare diagnoses, accounting for less than 1% of all laryngeal tumors. They most commonly present as submucosal masses of the supraglottis, with symptoms including hoarseness, dysphagia, dyspnea and rarely cervical lymphadenopathy.
Purpose
1.
To present a case series of primary hematologic malignancies of the larynx in patients treated in a tertiary care laryngology practice.
2.
To review the literature on primary hematologic malignancy of the larynx.
Methods
Retrospective case series of patients in a tertiary academic laryngeal practice with hematologic malignancy of the larynx presenting over a 10 year period; charts were reviewed for diagnosis, symptoms, treatment, and outcomes.
Results
12 patients were found to have primary presentation of a hematologic malignancy within the larynx between 2009 and 2019. A submucosal mass was the most common finding, and hoarseness was the most common symptom. Local control of disease was high. Airway obstruction was managed with tracheostomy. Several patients required tube feeding prior to disease control. Most patients underwent radiation therapy and chemotherapy, although surgery alone was effective in patients with isolated disease.
Conclusions
Hematologic malignancies of the larynx are rare but treatable. Biopsy is the mainstay of diagnosis, and imaging may be helpful to exclude diseases with a similar physical presentation (i.e., laryngocele). Prognosis depends on diagnosis but is generally favorable.
Keywords
Hematologic malignancySubmucosal massSupraglottic mass
☆
This work was not supported by any funding.
☆☆
The authors do not have any conflicts of interest to report.
☆☆☆
Presented at the 140th annual meeting of the American Laryngologic Association, May 1-3 in Austin, TX.
View full text
© 2019 Elsevier Inc. All rights reserved.
Author links open overlay panelKarunaDewanRossCampbellEdward J.Damrose
Division of Laryngology, Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, United States of America
Received 3 June 2019, Available online 4 September 2019.
Show less
https://doi.org/10.1016/j.amjoto.2019.102285Get rights and content
Abstract
Background
Primary hematologic malignancies of the larynx are rare diagnoses, accounting for less than 1% of all laryngeal tumors. They most commonly present as submucosal masses of the supraglottis, with symptoms including hoarseness, dysphagia, dyspnea and rarely cervical lymphadenopathy.
Purpose
1.
To present a case series of primary hematologic malignancies of the larynx in patients treated in a tertiary care laryngology practice.
2.
To review the literature on primary hematologic malignancy of the larynx.
Methods
Retrospective case series of patients in a tertiary academic laryngeal practice with hematologic malignancy of the larynx presenting over a 10 year period; charts were reviewed for diagnosis, symptoms, treatment, and outcomes.
Results
12 patients were found to have primary presentation of a hematologic malignancy within the larynx between 2009 and 2019. A submucosal mass was the most common finding, and hoarseness was the most common symptom. Local control of disease was high. Airway obstruction was managed with tracheostomy. Several patients required tube feeding prior to disease control. Most patients underwent radiation therapy and chemotherapy, although surgery alone was effective in patients with isolated disease.
Conclusions
Hematologic malignancies of the larynx are rare but treatable. Biopsy is the mainstay of diagnosis, and imaging may be helpful to exclude diseases with a similar physical presentation (i.e., laryngocele). Prognosis depends on diagnosis but is generally favorable.
Keywords
Hematologic malignancySubmucosal massSupraglottic mass
☆
This work was not supported by any funding.
☆☆
The authors do not have any conflicts of interest to report.
☆☆☆
Presented at the 140th annual meeting of the American Laryngologic Association, May 1-3 in Austin, TX.
View full text
© 2019 Elsevier Inc. All rights reserved.
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