- Impact of CT-based brachytherapy in elderly patients with cervical cancerPublication date: Available online 7 September 2019Source: BrachytherapyAuthor(s): Daijiro Kobayashi, Noriyuki Okonogi, Masaru Wakatsuki, Yuhei Miyasaka, Hiroki Kiyohara, Tatsuya Ohno, Shingo Kato, Takashi Nakano, Tadashi KamadaAbstractPurposeThree-dimensional image-guided brachytherapy (3D-IGBT) has become the standard therapy for patients with cervical cancer. However, in this population, the impact of 3D-IGBT in elderly individuals remains un
- Assessment of the Physical Compatibility of Eravacycline and Common Parenteral Drugs During Simulated Y-site AdministrationPublication date: Available online 7 September 2019Source: Clinical TherapeuticsAuthor(s): Lindsay M. Avery, Iris H. Chen, Sergio Reyes, David P. Nicolau, Joseph L. KutiAbstractPurposeEravacycline is a broad-spectrum, intravenous fluorocycline antibiotic approved for the treatment of complicated intra-abdominal infections in adults. A 60-minute infusion is recommended for each infused dose. Compatibility data that may allow convenient Y-site adm
- YiQiFuMai powder injection ameliorates chronic heart failure through cross-talk between adipose tissue and cardiomyocytes via up-regulation of circulating adipokine omentinPublication date: November 2019Source: Biomedicine & Pharmacotherapy, Volume 119Author(s): Fang Li, Li-Zhi Pang, Ling Zhang, Yu Zhang, Yuan-Yuan Zhang, Bo-Yang Yu, Jun-Ping KouAbstractYiQiFuMai Powder Injection (YQFM) is widely used in clinical practice for the treatment of heart failure (HF). However, its functional molecular mechanism remains to be fully uncovered. Our present study aimed to elucidate the impact of YQFM and underlying mech
- Long non-coding RNAs and endometrial cancerPublication date: November 2019Source: Biomedicine & Pharmacotherapy, Volume 119Author(s): Hongyang Liu, Junhu Wan, Jie ChuAbstractEndometrial cancer (EC) is one of the most common gynecologic malignancies. In spite of the advance in chemotherapy, radiotherapy or surgical techniques for EC in recent years, the survival rate of advanced stage EC patients remains unsatisfactory. Long non-coding RNAs (lncRNAs) are known as transcripts longer tha
- Response of FDG avid pelvic bone marrow to concurrent chemoradiation for anal cancerPublication date: Available online 7 September 2019Source: Radiotherapy and OncologyAuthor(s): Maxwell Robinson, Rebecca Muirhead, Clare Jacobs, Rosie Cooke, Kwun-Ye Chu, Frank Van den Heuvel, Stasya Ng, Pradeep Virdee, Victoria Strauss, Maria HawkinsAbstractBackground and purposeTo determine if suppression of active bone marrow, as defined on FDG PETCT, is seen in on-treatment imaging of anal cancer patients receiving concurrent chemoradiation.
- Combined transarterial chemoembolization and radiotherapy as a first-line treatment for hepatocellular carcinoma with macroscopic vascular invasion: Necessity to subclassify Barcelona Clinic Liver Cancer stage CPublication date: Available online 7 September 2019Source: Radiotherapy and OncologyAuthor(s): Yeon Joo Kim, Jinhong Jung, Ji Hyeon Joo, So Yeon Kim, Jin Hyoung Kim, Young-Suk Lim, Han Chu Lee, Jong Hoon Kim, Sang Min YoonAbstractBackground and purposeSystemic therapy such as sorafenib is the standard for Barcelona Clinic Liver Cancer (BCLC) stage C hepatocellular carcinoma (HCC); however, the survival benefits are modest especially for HCC with
- Photodynamic treatment for multidrug-resistant Gram-negative bacteria: perspectives for the treatment of <em>Klebsiella pneumoniae</em> infectionsPublication date: Available online 7 September 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Manuel Valenzuela-Valderrama, Iván Alonzo González, Christian Erick PalavecinoAbstractThe emergence of multi-drug resistance for pathogenic bacteria is one of the most pressing global threats to human health in the 21st century. Hence, the availability of new treatment becomes indispensable to prevent morbidity and mortality
- BIOTENSEGRITY: WHAT IS THE BIG DEAL?Publication date: Available online 7 September 2019Source: Journal of Bodywork and Movement TherapiesAuthor(s): Graham Scarr
- The effect of 8 weeks proprioception training without visual input on single-limb standing balance time in deaf students: A Randomized Controlled TrialPublication date: Available online 7 September 2019Source: Journal of Bodywork and Movement TherapiesAuthor(s): Hamed Zarei, Ali Asghar NorastehAbstractIntroductionThe aim of this study was to determine the effects of 8 weeks proprioception training without visual input on the proprioception of knee and ankle and single standing balance time in deaf students.MethodsTwenty male deaf students participated in this study and were randomly assigned in
- Influence of the order of aerobic and resistance exercise on hemodynamic responses and arterial stiffness in young normotensive individualsPublication date: Available online 7 September 2019Source: Journal of Bodywork and Movement TherapiesAuthor(s): Wagner Jorge Ribeiro Domingues, Antonio Henrique Germano Soares, Bruno Remígio Cavalcante, Rinaldo Ramos Matias da Silva, Pollyana Mayara Nunhes, Gustavo Marçal Gonçalves da Silva, Ewertton Bezerra, Nórton Luís Oliveira, José OliveiraAbstractAimsTo investigate the effects of a combination of aerobic and resistance exercises and the inve
- PREVIOUS 7 DAYS
- Febuxostat attenuates ulcerative colitis by the inhibition of NF-κB, proinflammatory cytokines, and oxidative stress in micePublication date: November 2019Source: International Immunopharmacology, Volume 76Author(s): Keyvan AmirshahrokhiAbstractUlcerative colitis is a chronic inflammatory disorder characterized by oxidative stress and upregulation of proinflammatory mediators in colonic tissue. Febuxostat, a xanthine oxidase inhibitor has been shown to exert anti-inflammatory and antioxidant effects. The aim of this study was to investigate the protective effect of fe
- Production, purification, and <em>in vivo</em> evaluation of a novel multiepitope peptide vaccine consisted of immunodominant epitopes of SYCP1 and ACRBP antigens as a prophylactic melanoma vaccinePublication date: November 2019Source: International Immunopharmacology, Volume 76Author(s): Ashkan Safavi, Amirhosein Kefayat, Fattah Sotoodehnejadnematalahi, Mansoor Salehi, Mohammad Hossein ModarressiAbstractMelanoma cells are significantly resistance to the current treatments. Therefore, the best option for high-risk populations is prevention. Recently, many preventive cancer vaccines have been developed. In our previous study, several bioinf
- Photodynamic antimicrobial chemotherapy with the photosensitizer TONS504 eradicates <em>Acanthamoeba</em>Publication date: Available online 6 September 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Dwia Pertiwi Yunialthy, Chikama Taiichiro, Sueoka Kentaro, Ko Ji-Ae, Kiuchi Yoshiaki, Onodera Makoto, Sakaguchi TakemasaAbstractBackgroundMicrobial keratitis is a potential cause of corneal blindness. We investigated the amoebicidal efficacy of photodynamic antimicrobial chemotherapy with a light-emitting diode as the light source and the
- miR-410-3p regulates proliferation and apoptosis of fibroblast-like synoviocytes by targeting YY1 in rheumatoid arthritisPublication date: November 2019Source: Biomedicine & Pharmacotherapy, Volume 119Author(s): YueJiao Wang, Ting Jiao, WenYi Fu, Shuai Zhao, LiLi Yang, NeiLi Xu, Ning ZhangAbstractIn our previous study, miR-410-3p had been confirmed to regulate inflammatory cytokine release in rheumatoid arthritis fibroblast-like synoviocytes (RA FLSs). However, other biological functions of miR-410-3p in RA FLSs still remain unexplored. In the present study, we
- Fangxiao Formula alleviates airway inflammation and remodeling in rats with asthma via suppression of transforming growth factor-β/Smad3 signaling pathwayPublication date: November 2019Source: Biomedicine & Pharmacotherapy, Volume 119Author(s): Yuqing Ge, Rubin Cheng, Siya Sun, Saijun Zhang, Lan Li, Jianping Jiang, Chenxi Yang, Xiaobo Xuan, Jian ChenAbstractAsthma is a common obstructive airway disease characterized by inflammation and remodeling with a progressive decline in lung function. Fangxiao Formula (FXF) is an herbal medicine that has achieved significant clinical benefits toward asth
- Efficacy and Safety of Different Antiplatelet Strategies in Survivors of Myocardial Infarction With Acute Coronary SyndromePublication date: Available online 7 September 2019Source: Clinical TherapeuticsAuthor(s): Yan-guo Xin, Jun-li Li, Xiaofan Cao, Xiao-jing LiuAbstractPurposeMany patients with acute coronary syndrome may experience recurrent myocardial infarction although they are receiving optional therapy, but they are still associated with poor clincial outcomes. The goal of this study was to assess different antiplatelet strategies in these patients.MethodsTh
- Randomized Crossover Trial of Phosphate-binding Medication on Serum Phosphate Levels in Patients With Aortic StenosisPublication date: Available online 7 September 2019Source: Clinical TherapeuticsAuthor(s): David S. Wald, John Chambers, Jonathan P. Bestwick, Nicholas J. WaldAbstractPurposeAortic stenosis is a common cause of valvular heart disease with no means of prevention. The recognized association between aortic stenosis and serum phosphate raises the possibility of preventing progression of the disorder by using phosphate-binding drugs, but there is unc
- Recommended ESTRO Core Curriculum for Radiation Oncology/Radiotherapy 4th editionPublication date: Available online 5 September 2019Source: Radiotherapy and OncologyAuthor(s): Kim Benstead, Pedro C. Lara, Demetrius Andreopoulos, Jean-Emmanuel Bibault, Anthony Dix, Yannick G. Eller, Pierfrancesco Franco, Meredith Guiliani, Jana Jaal, Antonio Juretic, Elvisa Kozma, Graeme Lumsden, Marta Maddalo, Stefano Magrini, Ingvil Mjaaland, Raphael Pfeffer, Olga M.T. de Sousa de Sa Pinto, Mateusz Spalek, Marie-Catherine Vozenin, Christine
- Estimation of inter-fractional variations in interstitial multi-catheter breast brachytherapy using a hybrid treatment delivery systemPublication date: Available online 5 September 2019Source: Radiotherapy and OncologyAuthor(s): Karoline Kallis, Nadin Abu-Hossin, Stephan Kreppner, Michael Lotter, Vratislav Strnad, Rainer Fietkau, Christoph BertAbstractPurposeIrradiation of the tumor bed using interstitial multi-catheter brachytherapy is one of the treatment options for breast cancer patients. In order to ensure the planned dose delivery an advanced quality intervention method
- Quantitative imaging: Erring patterns in manual delineation of PET-imaged lung lesionsPublication date: Available online 5 September 2019Source: Radiotherapy and OncologyAuthor(s): Fei Yang, Lori Young, Yidong YangAbstractBackground and purposeUncertainty and variability in manual contouring of PET-imaged tumor targets are well recognized; however, the error patterns associated with it were little known and rarely investigated. The present study is aimed to quantitatively assess the erring patterns inherent to manual delineation
- Vienna-II ring applicator for distal parametrial/pelvic wall disease in cervical cancer brachytherapy: An experience from two institutions: Clinical feasibility and outcomePublication date: Available online 5 September 2019Source: Radiotherapy and OncologyAuthor(s): Umesh Mahantshetty, Alina Sturdza, Pushpa Naga CH, Daniel Berger, Israel Fortin, Laura Motisi, Maximilian P. Schmid, Dheera Aravindakshan, Yogesh Ghadi, Jamema V. Swamidas, Supriya Chopra, Lavanya Gurram, Nicole Nesvacil, Christian Kirisits, Richard PötterAbstractPurposeRecent evidence from EMBRACE shows that around 16% patients with locally advan
- Chicoric acid (CA) induces autophagy in gastric cancer through promoting endoplasmic reticulum (ER) stress regulated by AMPKPublication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Xiaoli Sun, Xinwu Zhang, Hongjun Zhai, Di Zhang, Shuangyu MaAbstractGastric cancer is one of the most common cancers leading to tumor-related deaths worldwide. Chicoric acid (CA) exhibits a variety of protective effects in different diseases. However, its role in regulating tumor progression has not been reported. Autophagy, as a conserved catabolic proc
- Linalool attenuates oxidative stress and mitochondrial dysfunction mediated by glutamate and NMDA toxicityPublication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Angélica María Sabogal-Guáqueta, Fabian Hobbie, Akshaya Keerthi, Asmaa Oun, Arjan Kortholt, Erik Boddeke, Amalia DolgaAbstractMitochondrial dysfunction and inflammation contribute to the initiation and development of several brain pathological conditions, including Alzheimer’s disease and cerebral ischemia. Linalool is an arom
- JBMT: Who reads it? Who writes it?Publication date: Available online 5 September 2019Source: Journal of Bodywork and Movement TherapiesAuthor(s):
- Effects of adiponectin on random pattern skin flap survival in ratsPublication date: November 2019Source: International Immunopharmacology, Volume 76Author(s): Qiming Tu, Shaodong Liu, Tingxiang Chen, Zhijie Li, Dingsheng LinAbstractBackgroundRandom flaps are commonly used to repair wounds and improve the clinical appearance. However, flap necrosis is frequently encountered in the clinical setting. Adiponectin is a biologically active endogenous polypeptide secreted by adipocytes that can reduce oxidative stress
- The immune-adjuvant activity and the mechanism of resveratrol on pseudorabies virus vaccine in a mouse modelPublication date: November 2019Source: International Immunopharmacology, Volume 76Author(s): Meng Chen, Xiangxiu Chen, Xu Song, Abaidullah Muhammad, Renyong Jia, Yuanfeng Zou, Lizi Yin, Lixia Li, Changliang He, Gang Ye, Cheng Lv, Wei Zhang, Zhongqiong YinAbstractResveratrol had shown various properties before, like immunomodulatory, anti-inflammatory and antiviral activities. Based on these properties, the present study was designed to evaluate t
- IL1A & IL1B genetic polymorphisms are risk factors for thyroid cancer in a Chinese Han populationPublication date: November 2019Source: International Immunopharmacology, Volume 76Author(s): Huajing Li, Na Duan, Qing Zhang, Yuan ShaoAbstractIntroductionThyroid carcinoma accounts for a large proportion of endocrine neoplasia, and the relationship between inflammation and thyroid cancer has been previously validated. IL-1α (Interleukin 1 alpha) and IL-1β (Interleukin 1 beta), encoded by IL1A and IL1B, respectively, are implicated in numerous in
- The small molecule macrophage migration inhibitory factor antagonist MIF098, inhibits pulmonary hypertension associated with murine SLEPublication date: November 2019Source: International Immunopharmacology, Volume 76Author(s): Huijing Huang, Dandan Chen, Jun Pu, Ancai Yuan, Qiong Fu, Jia Li, Lin Leng, Richard Bucala, Shuang Ye, Liangjing LuAbstractPulmonary arterial hypertension (PAH) is a severe complication of systemic lupus erythematosus (SLE), with unclear etiopathogenesis. We evaluated the role of macrophage migration inhibitory factor (MIF), which has been implicated in i
- Impact of suboptimal tandem implantation on local control and complications in intracavitary brachytherapy for cervix cancerPublication date: Available online 5 September 2019Source: BrachytherapyAuthor(s): Manon Kissel, Marlon Silva, Justine Lequesne, Jean-Michel Grellard, Cédric Loiseau, Victor Barraux, Delphine Lerouge, Marie Lecornu, François Lesaunier, Christine Haie-Meder, Cyrus Chargari, Juliette ThariatAbstractPURPOSECorrect tandem implantation for cervix cancer intracavitary brachytherapy may be challenging. We investigated whether suboptimal i
- A new series of acetohydroxamates shows in vitro and in vivo anticancer activity against melanomaSummary Cancer treatment is challenging, mainly due to high levels of drug toxicity and the resistance of tumours to chemotherapy. Hydroxamic acid derivatives have recently aroused attention due to their potential to treat malignancies. In the present study, we sought to investigate the anticancer effects of a new series of synthetic acetohydroxamates. The in vitro cytotoxic and antiproliferative effects of 11 synthetic acetohy
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου