New models show gut–brain transmission of Parkinson disease pathology Heather Wood p491 | doi:10.1038/s41582-019-0241-x PDF
Predicting progression to AD using a deep-learning model  Rebecca Kelsey p492 | doi:10.1038/s41582-019-0236-7 PDF
Different clinical profiles in Huntington disease show distinct patterns of brain alterations  Rebecca Kelsey p492 | doi:10.1038/s41582-019-0237-6 PDF
Antibiotic use might increase risk of ALS  Rebecca Kelsey p492 | doi:10.1038/s41582-019-0238-5 PDF
Drug reduces excess iron in ultra-rare neurodegenerative disease  Sarah Lemprière pp492 - 493 | doi:10.1038/s41582-019-0235-8 PDF
Predicting treatment response in post-TBI cognitive impairment  Ian Fyfe pp492 - 493 | doi:10.1038/s41582-019-0234-9 PDF
Inflammatory pathways relate to early Alzheimer disease pathology  Ian Fyfe p493 | doi:10.1038/s41582-019-0242-9 PDF
AD biomarkers at AAIC 2019  Heather Wood p494 | doi:10.1038/s41582-019-0247-4 PDF
AAIC 2019 highlights sex differences in AD  Heather Wood p494 | doi:10.1038/s41582-019-0248-3 PDF
Sensory links to dementia from AAIC 2019  Heather Wood p494 | doi:10.1038/s41582-019-0249-2 PDF
NEWS & VIEWS
Follow-up of active Aβ immunization in Alzheimer disease  Thomas Wisniewski pp495 - 496 | doi:10.1038/s41582-019-0239-4 PDF
Can imaging extend the thrombolytic time window after stroke?  Min Lou pp496 - 498 | doi:10.1038/s41582-019-0232-y PDF
Primary fatty amides are potential plasma biomarkers for AD  Niklas Mattsson & Oskar Hansson pp498 - 499 | doi:10.1038/s41582-019-0229-6 PDF
REVIEWS
Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies     Yu Yamazaki, Na Zhao, Thomas R. Caulfield, Chia-Chen Liu & Guojun Bu pp501 - 518 | doi:10.1038/s41582-019-0228-7 Polymorphism in the apolipoprotein E (APOE) gene influences the risk of Alzheimer disease (AD). The authors describe recent research into the role of APOE in AD pathogenesis and discuss how new AD therapies could be tailored toAPOE genotype.  Full Text | PDF
Narcolepsy — clinical spectrum, aetiopathophysiology, diagnosis and treatment     Claudio L. A. Bassetti, Antoine Adamantidis, Denis Burdakov, Fang Han, Steffen Gay et al. pp519 - 539 | doi:10.1038/s41582-019-0226-9 In the past 20 years, understanding of the clinical manifestations, aetiopathophysiology, diagnosis and treatment of narcolepsy has greatly advanced. In this Review, Bassetti et al. present these advances, discuss unmet needs and offer future perspectives for the field of narcolepsy.  Full Text | PDF
Neuroinflammation in frontotemporal dementia     Fiona Bright, Eryn L. Werry, Carol Dobson-Stone, Olivier Piguet, Lars M. Ittner et al. pp540 - 555 | doi:10.1038/s41582-019-0231-z An altered microglial landscape and ageing-related inflammatory changes contribute to the neurodegeneration associated with frontotemporal dementia (FTD). Here, Bright and colleagues discuss the evidence for a pathogenetic role of neuroinflammatory mechanisms in FTD, including links with autoimmunity and gene mutations associated with neuroinflammation.  Full Text | PDF