Opinion statement There has been rapid progress in the use of targeted therapies for ALK-positive which has led to improve dramatically PFS and OS in the metastatic ALK-rearranged NSCLC patients. There are several molecules now available (crizotinib, ceritinib, brigatinib, alectinib, and lorlatinib) and others in development. Such an improvement in treatment efficacy has even more highlighted the importance of an adequate identification of ALK alterations. Efficient and easily...
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PURPOSE: External-beam radiation is the single most effective therapy for localized lymphoma. However, toxicity limits its use for multifocal disease. We evaluated CD45 as a therapeutic target for an antibody-radionuclide conjugate (ARC) for the treatment of lymphoma based on its ubiquitous expression, infrequent antigen loss or blockade, and the ability to target minimal disease based on panhematopoietic expression. EXPERIMENTAL DESIGN: We performed a phase I trial of escalating doses of single-agent...
Tue Sep 03, 2019 17:04
Purpose: Over-activation of TGF-b signaling is observed in myelodysplastic syndromes and is associated with dysplastic hematopoietic differentiation. Galunisertib, a first-in-class oral inhibitor of the TGF-b receptor type 1 kinase (ALK5) has shown effectiveness in preclinical models of myelodysplastic syndromes (MDS) and acceptable toxicity in phase 1 studies of solid malignancies. Experimental Design: A Phase 2 multicenter study of galunisertib was conducted in patients with very low-, low-, or...
Tue Sep 03, 2019 17:04
Purpose: Diffuse Intrinsic Pontine Gliomas (DIPGs) are the most severe pediatric brain tumors. While accepted as the standard therapeutic, radiotherapy is only efficient transiently and not even in every patient. The goal of the study was to identify the underlying molecular determinants of response to radiotherapy in DIPG. Experimental Design: We assessed in vitro response to ionizing radiations in 13 different DIPG cellular models derived from treatment-naïve stereotactic biopsies reflecting the...
Tue Sep 03, 2019 17:04
Purpose: Androgen receptor (AR)-targeting prostate cancer drugs, which are predominantly competitive ligand binding domain (LBD)-binding antagonists, are inactivated by common resistance -mechanisms. It is important to develop next-generation mechanistically-distinct drugs to treat castration- and drug- resistant prostate cancers. Experimental Design: Second-generation AR pan antagonist UT-34 was selected from a library of compounds and tested in competitive AR binding and transactivation assays....
Tue Sep 03, 2019 17:04
Purpose: Imaging techniques for highly specific detection of cancer cells in-vivo can have applications ranging from preclinical drug discovery studies to clinical cancer diagnosis and surgical therapy. While fluorescence imaging using cancer targeted antibodies has shown promise, non-specific probe accumulation in tissue results in significant background fluorescence, reducing detection sensitivity using traditional intensity-based continuous wave (CW) fluorescence imaging. Here we demonstrate that...
Tue Sep 03, 2019 17:04
Purpose: Multiple myeloma (MM) patients with t(11;14) have been considered to have standard-risk disease. However, several recent reports have shown contradictory results. We identified 95 MM patients with t(11;14) on Fluorescence In Situ Hybridization (FISH) studies, who underwent upfront autologous hematopoietic stem cell transplant (auto-HCT) at our center. We compared their outcome with a group of standard-risk MM patients who had diploid cytogenetics by both conventional cytogenetics (CC) and...
Tue Sep 03, 2019 17:04
Purpose: Identification of clinically actionable molecular subtypes of pancreatic ductal adenocarcinoma (PDAC) is key to improving patient outcome. Inter-tumoral metabolic heterogeneity contributes to cancer survival and the balance between distinct metabolic pathways may influence PDAC outcome. We hypothesized that PDAC can be stratified into prognostic metabolic subgroups based on alterations in the expression of genes involved in glycolysis and cholesterol synthesis. Experimental Design: We performed...
Tue Sep 03, 2019 17:04
Purpose: Based on the potential for Ipilimumab (I) to augment T cell activation, we hypothesize that ipilimumab would augment the efficacy of rituximab (R) in patients with relapsed/refractory (R/R) CD20+ NHL. This phase 1 study aimed to identify a recommended phase 2 dose (RP2D), document toxicities, and preliminarily assess efficacy and potential predictive biomarkers. Patients and methods: Thirty-three patients with R/R CD20+ B-cell lymphoma received R at 375mg/m2 weekly for 4 weeks and I at 3mg/kg...
Tue Sep 03, 2019 17:04
Purpose: We aimed to develop a diagnostic platform to capture the transcriptomic resemblance of individual adult diffuse gliomas of WHO grades II-IV to neural development and the genomic signature associated with glioma progression. Experimental Design: Based on the EM/PM classification scheme, we designed a RT-PCR-based TaqMan Low-density array (TLDA) containing 44 classifier and 4 reference genes. Samples of a training data set (GSE48865), characterized by RNA-sequencing, were utilized to optimize...
Tue Sep 03, 2019 17:04
Purpose: This study was aimed at investigating whether the PPARg agonist pioglitazone - given in combination with trabectedin - is able to reactivate adipocytic differentiation in myxoid liposarcoma (MLS) patient-derived xenografts overcoming resistance to trabectedin. Experimental Design: The antitumor and biological effects of trabectedin, pioglitazone and the combination of the two drugs were investigated in nude mice bearing well-characterized MLS xenografts representative of innate or acquired...
Tue Sep 03, 2019 17:04
British Journal of Cancer, Published online: 04 September 2019; doi:10.1038/s41416-019-0565-8Combined poly-ADP ribose polymerase and ataxia-telangiectasia mutated/Rad3-related inhibition targets ataxia-telangiectasia mutated-deficient lung cancer cells
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British Journal of Cancer, Published online: 04 September 2019; doi:10.1038/s41416-019-0556-9Eribulin rapidly inhibits TGF-β-induced Snail expression and can induce Slug expression in a Smad4-dependent manner
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British Journal of Cancer, Published online: 04 September 2019; doi:10.1038/s41416-019-0566-7MicroRNA-222 reprogrammed cancer-associated fibroblasts enhance growth and metastasis of breast cancer
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British Journal of Cancer, Published online: 04 September 2019; doi:10.1038/s41416-019-0564-9Comparing uptake across breast, cervical and bowel screening at an individual level: a retrospective cohort study
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Abstract Background and purpose microRNAs are small noncoding RNAs that play important roles in cancer regulation. In this study, we investigated the expression, functional effects and mechanisms of action of microRNA-29a (miR-29a) in glioblastoma (GBM). Methods miR-29a expression levels in GBM cells, stem cells (GSCs) and human tumors as well as normal astrocytes...
Tue Sep 03, 2019 03:00
The use of margins in photon radiotherapy is a long established and universally adopted method to provide adequate target coverage under the presence of uncertainties. The CTV-PTV margin provides a geometrical buffer zone around the target within which the desired dose is achieved for the majority of treatments; criteria of 95% of the prescription dose in 90% of the patient population has found general appeal [1,2]. The suitability of a geometrically-expanded buffer zone arises from the (relative)...
Tue Sep 03, 2019 03:00
Radiotherapy is frequently used in the therapy of lymphoma. Since lymphoma, for example Hodgkin’s disease, frequently affect rather young patients, the induction of secondary cancer or other long-term adverse ...
Mon Sep 02, 2019 03:00
This study aimed to evaluate the impact of previous local treatment on lymphatic drainage patterns in ipsilateral breast tumor recurrence (IBTR) based on our data on re-operative sentinel lymph node biopsy (re...
Mon Sep 02, 2019 03:00
Meningiomas are the most common primary tumors of the central nervous system. In patients with WHO grade I meningiomas no adjuvant therapy is recommended after resection. In case of anaplastic meningiomas (WHO...
Mon Sep 02, 2019 03:00
To report results from our phase I dose-escalation study of stereotactic body radiotherapy (SBRT) using 4 fractions for patients with localized prostate cancer.
Mon Sep 02, 2019 03:00
Adjuvant radiotherapy is the standard treatment after breast-conserving surgery. According to meta-analyses, adjuvant 3d-conventional irradiation reduces the risk of local recurrence and thereby improves long-...
Mon Sep 02, 2019 03:00
Abstract Total mesorectal excision quality (TMEq) is a prognostic factor associated with local recurrence in rectal adenocarcinoma. Neoadjuvant chemoradiotherapy (NCRT) reduces the risk of tumor recurrence, but may compromise TMEq. The time between NCRT and surgery (TTS) and how it influences TMEq and tumor control were evaluated. In prospective registry, 236 patients after NCRT and TME were analyzed. NCRT involved radiotherapy with 45 Gy to the pelvis, plus tumor boost dose 5.4 Gy...
Tue Sep 03, 2019 03:00
Cancers, Vol. 11, Pages 1299: AT2 Receptor Mediated Activation of the Tyrosine Phosphatase PTP1B Blocks Caveolin-1 Enhanced Migration, Invasion and Metastasis of Cancer Cells Cancers doi: 10.3390/cancers11091299 Authors: Martínez-Meza Díaz Sandoval-Bórquez Valenzuela-Valderrama Díaz-Valdivia Rojas-Celis Contreras Huilcaman Ocaranza Chiong Leyton Lavandero Quest : The renin–angiotensin receptor AT2R controls systemic blood pressure...
Tue Sep 03, 2019 03:00
Abstract Engineered cytokine products represent promising agents for the treatment of immunogenic tumors, such as malignant melanoma, in addition to immune checkpoint inhibitors. Here we describe the results of a controlled, randomized phase II clinical trial, aimed at assessing the therapeutic potential of L19IL2, a fully human fusion protein consisting of the L19 antibody specific to the alternatively spliced extra-domain B of fibronectin, fused to human interleukin-2 in advanced...
Tue Sep 03, 2019 03:00
Abstract Purpose To evaluate the clinical–pathological and prognostic significance of the circulating PD-L1 level in patients with surgically treated NSCLC, by combining data for PD-L1 expression with other immune-related markers and tumor metabolism. Methods Overall, 40 patients with resected NSCLC (stage Ia–IIIa) who had preoperative blood storage and underwent...
Tue Sep 03, 2019 03:00
Abstract Objective Dosimetric comparison of HIPO (hybrid inverse planning optimisation) and IPSA (inverse planning simulated annealing) inverse and forward optimisation (FO) methods in brachytherapy (BT) of breast, cervical and prostate cancer. Methods At our institute 38 breast, 47 cervical and 50 prostate cancer patients treated with image-guided interstitial...
Tue Sep 03, 2019 03:00
Cancers, Vol. 11, Pages 1297: Tumor-Targeted Drug Conjugates as an Emerging Novel Therapeutic Approach in Small Cell Lung Cancer (SCLC) Cancers doi: 10.3390/cancers11091297 Authors: Alexander Y. Deneka Yanis Boumber Tim Beck Erica A. Golemis There are few effective therapies for small cell lung cancer (SCLC), a highly aggressive disease representing 15% of total lung cancers. With median survival <2 years, SCLC is one of the most lethal cancers. At present, chemotherapies...
Tue Sep 03, 2019 03:00
Cancers, Vol. 11, Pages 1298: Papillary Renal Cell Carcinomas Rewire Glutathione Metabolism and Are Deficient in Both Anabolic Glucose Synthesis and Oxidative Phosphorylation Cancers doi: 10.3390/cancers11091298 Authors: Al Ahmad Paffrath Clima Busch Rabien Kilic Villegas Timmermann Attimonelli Jung Meierhofer Papillary renal cell carcinoma (pRCC) is a malignant kidney cancer with a prevalence of 7–20% of all renal tumors. Proteome and...
Tue Sep 03, 2019 03:00
Abstract Retinoblastoma (RB) is a malignant intraocular tumor that frequently occurs in infants and toddlers. Although the most of RB patients in the developed countries could survival from this cancer, the patients in undeveloped areas are still suffering. The human retinal pigment epithelial cell line ARPE-19 and human retinoblastoma (RB) cell lines HXO-RB44, Y79, and WERI-Rb1 were cultured. The mRNA levels of BANCR and miR-204-3p in these cell lines were measured by qRT-PCR....
Tue Sep 03, 2019 03:00
Abstract Clear cell odontogenic carcinoma (CCOC) is a rare odontogenic tumor associated with aggressive clinical behavior, metastasis and low survival. To date, only 67 cases have been described in the English language literature, and an understanding of the behavior of CCOC has been based on limited case reports. The aim of the research was to further reveal the features of CCOC. We report 5 new cases of CCOC, with a mean age of 52.4 years. The clinical and histopathologic data...
Tue Sep 03, 2019 03:00
Abstract Objective Self‐management has been proposed as a strategy to help cancer patients optimize their health and wellbeing during survivorship. Previous reviews have shown variable effects of self‐management on outcomes. The theoretical basis and psycho‐educational components of these interventions has not been evaluated in detail. We aimed to evaluate the evidence for self‐management and provide a description of the components of these interventions. Methods We conducted a systematic...
Mon Sep 02, 2019 13:26
Mon Sep 02, 2019 12:53
Abstract Protein arginine methyltransferase 1 (PRMT1) is identified as an oncogene implicated in various types of human cancers, while Yes‐associated protein (YAP) as a key transcriptional coactivator of the Hippo signaling plays a vital role in tissue homeostasis and tumorigenesis. To date, the underlying biological functions, prognostic values, and potential mechanisms of PRMT1 and YAP in chondrosarcoma development have not been clearly elucidated. Here, we show that upregulation of PRMT1 and...
Mon Sep 02, 2019 18:44
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