Purpose of review The larynx is a complex organ that houses some of the most intricate structures of the human body. Owing to its delicate nature, the larynx is affected by different medications to varying degrees. Many of these effects manifest in subjective complaints in one's voice or swallow. This review article invokes the present available literature to describe the effects different medical agents have on the functionality of the laryngeal structures. Recent findings Multiple available...
4h
Purpose of review The purpose of this review is to assess recent literature on the clinical relevance of the gastric inlet patch with particular focus on endoscopic diagnosis and treatment, the relationship of the inlet patch to laryngopharyngeal reflux disease and the association of proximal esophageal adenocarcinoma with inlet patch. Recent findings Recent studies suggest endoscopic diagnosis of inlet patch increases with endoscopist awareness (up to 10-fold) and when using enhanced imaging...
4h
Purpose of review A wide range of diagnostic and therapeutic laryngology procedures are currently performed in an office setting. In-office laryngology procedures (IOLP) are increasingly seen as standard-of-care, and while generally considered safe, high-quality evidence supporting the latter statement is lacking. This review aims to summarize recent literature regarding the safety of IOLP. Recent findings There is a paucity of guidelines and standardized protocols for IOLP. To date, there...
4h
4h
4h
6h
6h
6h
Rejuvenation Research, Ahead of Print.
4h
Rejuvenation Research, Ahead of Print.
4h
Rejuvenation Research, Ahead of Print.
4h
Mutations in genes encoding isocitrate dehydrogenases (IDHs) 1 and 2 are common cancer-related genetic abnormalities. Malignancies with mutated IDHs exhibit similar pathogenesis, metabolic pattern, and resistance signature. However, an effective therapy against IDH1-mutated solid tumor remains unavailable. In the present study, we showed that acquisition of IDH1 mutation results in the disruption of NADP+/NADPH balance and an increased demand for glutathione metabolism. Moreover, the nuclear factor...
4h
The second-generation anti-androgen, enzalutamide (ENZ), is approved for castrate-resistant (CR) PC and targets androgen receptor (AR) activity in CRPC. Despite initial clinical activity, acquired resistance to ENZ arises rapidly and most patients develop terminal disease. Previous work has established Stat5 as a potent inducer of PC growth. Here, we investigated the significance of Jak2-Stat5 signaling in resistance of PC to ENZ. The levels of Jak2 and Stat5 mRNA, proteins and activation were evaluated...
4h
Autotaxin catalyzes the formation of lysophosphatidic acid, which stimulates tumor growth and metastasis and decreases the effectiveness of cancer therapies. In breast cancer, autotaxin is secreted mainly by breast adipocytes, especially when stimulated by inflammatory cytokines produced by tumors. In this work, we studied the effects of an ATX inhibitor, GLPG1690, which is in Phase 3 clinical trials for idiopathic pulmonary fibrosis, on responses to radiotherapy and chemotherapy in a syngeneic...
4h
Summary Advances in interventional radiology have seen the adaptation of urological endoscopic laser techniques to treat biliary tract calculi. Percutaneous transhepatic biliary laser lithotripsy provides an effective alternative procedure for the management of intrahepatic or conventionally refractory choledocholithiasis which would otherwise require invasive and high‐risk surgical intervention. Several small studies have validated the procedure for management in this subset of patients, with most...
4h
Agency releases draft guidance outlining strategies to improve drug development for uncommon disease.
4h
MONDAY, Sept. 23, 2019 -- Most protected health information (PHI) breaches compromise sensitive demographic and/or financial information, according to a research letter published online Sept. 23 in the Annals of Internal Medicine. John (Xuefeng)...
4h
MONDAY, Sept. 23, 2019 -- Female physicians remain underrepresented in adult cardiology, according to a study published online Sept. 11 in JAMA Cardiology. Laxmi S. Mehta, M.D., from The Ohio State University in Columbus, and colleagues used data...
4h
MONDAY, Sept. 23, 2019 -- For patients with colorectal adenomas, high-intensity surveillance could provide modest benefits over low-intensity surveillance, at an acceptable cost, according to a study published online Sept. 24 in the Annals of...
4h
MONDAY, Sept. 23, 2019 -- In a synopsis of the 2018 Kidney Disease: Improving Global Outcomes (KDIGO) clinical practice guideline, published online Sept. 24 in the Annals of Internal Medicine, updated recommendations are presented for the...
4h
MONDAY, Sept. 23, 2019 -- A Connecticut resident has died from eastern equine encephalitis (EEE), the first such death in the state since 2013, health officials report. In addition, another person in the state has contracted the infection, as an...
4h
MONDAY, Sept. 23, 2019 -- Polysomnographic resolution of obstructive sleep apnea (OSA) and changes in polysomnographic severity of OSA in children account for a small but significant proportion of changes in symptoms and disease-specific quality of...
12h
MONDAY, Sept. 23, 2019 -- Male breast cancer patients have higher mortality after cancer diagnosis than female patients, according to a study published online Sept. 19 in JAMA Oncology. Fei Wang, M.D., Ph.D., from the Vanderbilt University Medical...
12h
MONDAY, Sept. 23, 2019 -- In patients with type 2 diabetes, higher fat mass is associated with a higher risk for major adverse cardiovascular events, according to a study published in the Sept. 23 issue of CMAJ, the journal of the Canadian Medical...
12h
MONDAY, Sept. 23, 2019 -- For patients with heart failure and reduced ejection fraction, dapagliflozin is associated with a lower risk for worsening heart failure or death from cardiovascular causes, regardless of the presence of type 2 diabetes,...
12h
MONDAY, Sept. 23, 2019 -- HIV testing in South African emergency departments shows a high prevalence and incidence of HIV, as well as significant attrition along the HIV care cascade for HIV-positive individuals, according to a study published...
12h
MONDAY, Sept. 23, 2019 -- For patients with advanced lung cancer, palliative care is associated with increased survival when it is received 31 to 365 days after cancer diagnosis, according to a study published online Sept. 19 in JAMA...
12h
MONDAY, Sept. 23, 2019 -- Nonsteroidal anti-inflammatory drugs (NSAIDs) are correlated with better overall survival in patients with head and neck squamous cell carcinoma (HNSCC), and there is a nonsignificant benefit for aspirin use in non-small...
12h
MONDAY, Sept. 23, 2019 -- Exercising may delay brain deterioration in people at high risk for Alzheimer disease, according to a proof-of-concept study published Sept. 17 in the Journal of Alzheimer's Disease. Takashi Tarumi, Ph.D., from Texas Health...
12h
MONDAY, Sept. 23, 2019 -- Vaping is increasing among adolescents, with significant increases seen from 2018 to 2019, according to a research letter published online Sept. 18 in the New England Journal of Medicine. Richard Miech, Ph.D., from the...
12h
MONDAY, Sept. 23, 2019 -- Even with care in specialty clinics, low-density lipoprotein cholesterol (LDL-C) persists above target levels in more than half of patients with familial hypercholesterolemia (FH), according to a study published in the...
12h
Colicin U is a protein produced by the bacterium Shigella boydii (serovars 1 and 8). It exerts antibacterial activity against strains of the enterobacterial genera Shigella and Escherichia. Here we report that colicin U forms voltage-dependent pores in planar lipid membranes; its single-pore conductance was found to be about 22 pS in 1M KCl, at pH 6 under 80 mV in asolectin bilayers. In agreement with the high degree of homology between their C-terminal domains, colicin U shares some pore characteristics...
4h
Chromosome dimers occur in bacterial cells as a result of the recombinational repair of DNA. In most bacteria, chromosome dimers are resolved by XerCD site specific recombination at the dif (deletion induced filamentation) site located in the terminus region of the chromosome. Caulobacter crescentus, a gram-negative oligotrophic bacterium, also possesses Xer recombinases called CcXerC and CcXerD, which have been shown to interact with the Escherichia coli dif site in vitro. Previous studies on Caulobacter...
4h
Bacteria have remarkable mechanisms to survive severe external stresses and one of the most enigmatic is the non-replicative persistent (NRP) state. Practically, NRP bacteria are difficult to treat, so inhibiting proteins underlying this survival state may render such bacteria more susceptible to external stresses including antibiotics. Unfortunately, we know little about the proteins and mechanisms conferring survival through NRP. Here, we report a universal stress protein (Usps) is a primary regulator...
4h
Chronic infections are frequently caused by polymicrobial biofilms. Importantly, these infections are often difficult to treat effectively in part due to the recalcitrance of biofilms to antimicrobial therapy. Emerging evidence suggests that polymicrobial interactions can lead to dramatic and unexpected changes in the ability of antibiotics to eradicate biofilms, and often result in decreased antimicrobial efficacy in vitro. In this review, we discuss the influence of polymicrobial interactions on...
4h
All organisms regulate cell cycle progression by coordinating cell division with DNA replication status. In eukaryotes, DNA damage or problems with replication fork progression induce the DNA damage response (DDR) causing cyclin-dependent kinases to remain active preventing further cell cycle progression until replication and repair are complete. In bacteria, cell division is coordinated with chromosome segregation preventing cell division ring formation over the nucleoid in a process termed nucleoid...
4h
Cancer Gene Therapy, Published online: 24 September 2019; doi:10.1038/s41417-019-0137-3Specific driving of the suicide E gene by the CEA promoter enhances the effects of paclitaxel in lung cancer
4h
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου