Two-Stage Procedure to Correct Scalp and Facial Scars—Autologous Fat Grafting Before Hair Grafting No abstract available

Silicone Oil—Systemic Safety Data Still Pending No abstract available

Update in Soft-Tissue Filler–Associated Blindness BACKGROUND Soft-tissue filler administration is an increasingly popular minimally invasive cosmetic procedure. Simultaneously, there have been a greater number of adverse events reported, including the devastating complication of blindness. OBJECTIVE To report cases of filler-related blindness published since 2015. MATERIALS AND METHODS The Ovid MEDLINE database was searched from January 1, 2015, to August 1, 2018, using a previously described Boolean string. RESULTS Sixty new cases of filler blindness were identified. The most common type of filler reported was hyaluronic acid (HA) (N = 42, 70.0%), followed by autologous fat (N = 7, 11.7%), and calcium hydroxyapatite (CaHA) (N = 7, 11.7%). The most common injection locations were the nose (N = 33, 55.0%), glabella (N = 21, 35.0%), and forehead (N = 11, 18.3%). Ten cases reported vision restoration (16.7%). Four of the successful cases involved hyaluronidase administration, including 1 retrobulbar hyaluronidase injection. CONCLUSION Since 2015, there have been 60 newly reported cases of soft-tissue filler blindness. Most recent cases have occurred with HA, which is a shift from previous reports. In HA cases, hyaluronidase injection may be successful in restoring vision if administered promptly. It is imperative for providers to be familiar with strategies for managing soft-tissue filler blindness. Address correspondence and reprint requests to: Martha Laurin Council, MD, Division of Dermatology, Washington University in St. Louis, 969 Mason Road, Suite 200, St. Louis, MO 63141, or e-mail: mcouncil@wustl.edu The authors have indicated no significant interest with commercial supporters. © 2019 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved.

Hyperbaric Oxygen Therapy in Hyaluronic Acid Filler–Induced Dermal Ischemia No abstract available

Factors Influencing the Treatment Effect of Superelastic Wire Orthonyxia for Nail Plate Deformity BACKGROUND Orthonyxia is an effective, noninvasive treatment for transverse nail curvature deformity. OBJECTIVE To discover the factors influencing treatment results of superelastic wire orthonyxia (SEWO). MATERIAL AND METHODS A retrospective study was conducted using clinical records of patients treated with SEWO. A multiple linear regression model was used to explain the correlation between correction pace (% per week) and the other collected variables (patient age, sex, position of treated toe, wire diameter [WD, mm], wire residence time [WRT, weeks], nail plate thickness [PT, mm], baseline nail curvature index [NCI], number of previous treatments, and the correction pace of previous treatments [CPT, % per week]). A logistic regression model was used to identify risk factors for adverse effects. RESULTS A total of 475 cases were collected from 197 patients. The correction pace was positively related to baseline NCI, WD, and correction pace in previous treatment. Also, it was negatively related to WRT and nail PT. No clinical factor was correlated with the occurrence of side effects. CONCLUSION The correction pace of SEWO is affected by the baseline NCI, the diameter of the wire, nail PT, the CPT, and the WRT. Address correspondence and reprint requests to: Sook Jung Yun, MD, PhD, Department of Dermatology, Chonnam National University Medical School, 42, Jaebong-ro, Dong-gu, Gwangju, Korea, or e-mail: sjyun@chonnam.ac.kr The authors have indicated no significant interest with commercial supporters. © 2019 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved.

Intralesional Triamcinolone May Not Be Beneficial for Treating Acute Hidradenitis Suppurativa Lesions: A Double-Blind, Randomized, Placebo-Controlled Trial BACKGROUND Hidradenitis suppurativa (HS) is a chronic, inflammatory condition characterized by recurrent nodules, sinus tracts, comedones, and scarring. Hidradenitis suppurativa is often associated with pain and decreased quality of life. Limited clinical trial data exist regarding the management of acute HS lesions, but clinical experience and a prospective case series suggest that intralesional triamcinolone may be useful. OBJECTIVE To compare the efficacy of intralesional triamcinolone to placebo for the treatment of HS inflammatory lesions. MATERIALS AND METHODS This is a double-blind, randomized, placebo-controlled trial comparing intralesional triamcinolone 10 mg/mL, triamcinolone 40 mg/mL, and normal saline (NS). Thirty-two subjects at University of North Carolina Dermatology and Skin Cancer Centers were enrolled for a total of 67 lesions. Subjects reported pain scores, days to resolution, and satisfaction on a standardized survey over a 14-day period. RESULTS When intralesional injections of triamcinolone 10 mg/mL, triamcinolone 40 mg/mL, and NS were compared, no significant difference was found for days to HS inflammatory lesion clearance, pain reduction at Day 5, or patient satisfaction. CONCLUSION No statistically significant difference was found between varying concentrations of triamcinolone and NS for the treatment of HS lesions. Steroid injections may be less effective for the management of acute HS than typically presumed. Address correspondence and reprint requests to: Christopher Sayed, MD, Department of Dermatology, University of North Carolina School of Medicine, 410 Market Street, #400, Chapel Hill, NC 27516, or e-mail: Christopher_sayed@med.unc.edu The authors have indicated no significant interest with commercial supporters. Institutional review board approval: reviewed and approved by UNC IRB; approval #16-0773. Clinicaltrials.gov listing: NCT02781818. © 2019 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved.

Sequential Scalp Assessment in Hair Regeneration Therapy Using an Adipose-Derived Stem Cell–Conditioned Medium BACKGROUND An adipose-derived stem cell–conditioned medium (ADSC-CM) reportedly exerts skin-rejuvenating and hair growth-promoting effects. In the therapeutic application of ADSC-CM for alopecia, changes to the interfollicular scalp remain unclear although some evidence has indicated hair growth-promoting effects. OBJECTIVE To evaluate the effects of ADSC-CM not only on hair follicles, but also on the interfollicular scalp. METHODS Forty patients (21 men, 19 women; age range, 23–74 years) with alopecia were treated by intradermal injection of ADSC-CM every month for 6 months. Eighty fixed sites on patients were investigated by trichograms, physiological examinations, and ultrasonographic examinations at 4 time points (before treatment and 2, 4, and 6 months after the initial treatment). RESULTS Hair density and anagen hair rate increased significantly. As physiological parameters, transepidermal water loss value gradually increased, with significant differences at 4 and 6 months after the initial treatment, but hydration state of the stratum corneum and skin surface lipid level showed no obvious changes. As ultrasonographic parameters, dermal thickness and dermal echogenicity were increased significantly. CONCLUSION Intradermal administration of ADSC-CM on the scalp has strong potential to provide regenerative effects for hair follicles and the interfollicular scalp. An adipose-derived stem cell–conditioned medium offers a promising prospect as an alternative treatment for alopecia. Address correspondence and reprint requests to: Hirotaro Fukuoka, MD, PhD, Cherry-Blossom Plastic and Regenerative Surgery, Nishishinjuku 1-4-10, Shinjuku-ku, Tokyo 160-0023, Japan, or e-mail: taro@minato-cl.co.jp The authors have indicated no significant interest with commercial supporters. © 2019 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved.

Recurrence Rates of Nonmelanoma Skin Cancer After Malignant Destruction: A Single-Center Retrospective Analysis of 984 Tumors No abstract available

Retrospective Review of Atypical Squamous Proliferations No abstract available

Quantitative Evaluation of the Effects of Botulinum Toxin Injection Into the Temporalis Muscles and Parotid Glands No abstract available