Antibiotics, Vol. 8, Pages 238: Increases in Hydrophilicity and Charge on the Polar Face of Alyteserin 1c Helix Change its Selectivity towards Gram-Positive Bacteria Antibiotics doi: 10.3390/antibiotics8040238 Authors: Liscano Salamanca Vargas Cantor Laverde-Rojas Oñate-Garzón Recently, resistance of pathogens towards conventional antibiotics has increased, representing a threat to public health globally. As part of the fight against this, studies on alternative...
Wed Nov 27, 2019 02:00
Antibiotics, Vol. 8, Pages 237: Antimicrobial Resistance: We Must Pursue a Collaborative, Global Approach and Use a “One Health” Approach Antibiotics doi: 10.3390/antibiotics8040237 Authors: Lonsdale Lipman Treating infection is a key part of the work of most clinicians. Whilst new drug technologies like biologics have begun a revolution in the treatment of cancer and autoimmune disease, there has been a conspicuous absence of new classes of antibiotic over the last 30 years. [...]
Wed Nov 27, 2019 02:00
Antibiotics, Vol. 8, Pages 236: Exploitation of Potentially New Antibiotics from Mangrove Actinobacteria in Maowei Sea by Combination of Multiple Discovery Strategies Antibiotics doi: 10.3390/antibiotics8040236 Authors: Qin-Pei Lu Jing-Jing Ye Yong-Mei Huang Di Liu Li-Fang Liu Kun Dong Elizaveta A. Razumova Ilya A. Osterman Petr V. Sergiev Olga A. Dontsova Shu-Han Jia Da-Lin Huang Cheng-Hang Sun Rediscovery of known antibiotics from actinobacteria,...
Wed Nov 27, 2019 02:00
Antioxidants, Vol. 8, Pages 592: Purification and Identification of Antioxidant Alcalase-Derived Peptides from Sheep Plasma Proteins Antioxidants doi: 10.3390/antiox8120592 Authors: Chengli Hou Liguo Wu Zhenyu Wang Elena Saguer Dequan Zhang In this study, sheep plasma was submitted to Alcalase-hydrolysis and peptides with better antioxidant properties measured through both the ferric-reducing antioxidant power (FRAP) and the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging...
Wed Nov 27, 2019 02:00
Antioxidants, Vol. 8, Pages 591: Polyphenolic Composition and Hypotensive Effects of Parastrephia quadrangularis (Meyen) Cabrera in Rat Antioxidants doi: 10.3390/antiox8120591 Authors: Fredi Cifuentes Javier Palacios Chukwuemeka R. Nwokocha Jorge Bórquez Mario J. Simirgiotis Ignacio Norambuena Mario Chiong Adrián Paredes Parastrephia quadrangularis (Pq), commonly called “Tola”, is widely used in folk medicine in the Andes, including for altitude...
Wed Nov 27, 2019 02:00
Atmosphere, Vol. 10, Pages 748: Temporal Changes in China’s Air Temperature Distribution and Its Impact on Hot Extreme Occurrence Atmosphere doi: 10.3390/atmos10120748 Authors: Wei Dong Chen Shao The likelihood of experiencing hot extremes has drastically increased due to global warming. Using 554 ground-based air temperature stations, changes in the number of hot days (NHD) in the Chinese mainland during 1960 to 2011 was investigated. We found that the NHD of the current...
Wed Nov 27, 2019 02:00
Atmosphere, Vol. 10, Pages 747: The Mars Regional Atmospheric Modeling System (MRAMS): Current Status and Future Directions Atmosphere doi: 10.3390/atmos10120747 Authors: Scot Rafkin Timothy Michaels The Mars Regional Atmospheric Modeling System (MRAMS) is closing in on two decades of use as a tool to investigate mesoscale and microscale circulations and dynamics in the atmosphere of Mars. Over this period of time, there have been numerous improvements and additions to the model dynamical...
Wed Nov 27, 2019 02:00
Behavioral Sciences, Vol. 9, Pages 129: Socio-Moral Development of Preschool Children: Aspects of Theory and Practice Behavioral Sciences doi: 10.3390/bs9120129 Authors: Korotaeva Chugaeva This article deals with issues relating to the social and moral education and development of preschool children. The theoretical understanding of the current state of this field is reflected in the modern normative documents “On education in the Russian Federation”, the state...
Wed Nov 27, 2019 02:00
Behavioral Sciences, Vol. 9, Pages 130: Features of Media Multitasking in School-Age Children Behavioral Sciences doi: 10.3390/bs9120130 Authors: Galina Soldatova Svetlana Chigarkova Anna Dreneva The paper addresses the phenomenon of media multitasking that is being widely spread among children and adolescents in the context of digital socialization. The previous research has revealed its strong connection with cognitive control, executive functions, and academic performance, yet...
Wed Nov 27, 2019 02:00
Behavioral Sciences, Vol. 9, Pages 131: Visual Perception of Facial Emotional Expressions during Saccades Behavioral Sciences doi: 10.3390/bs9120131 Authors: Vladimir A. Barabanschikov Ivan Y. Zherdev The regularities of visual perception of both complex and ecologically valid objects during extremely short photo expositions are studied. Images of a person experiencing basic emotions were displayed for as low as 14 ms amidst a saccade spanning 10 degrees of visual angle. The observers...
Wed Nov 27, 2019 02:00
Biomedicines, Vol. 7, Pages 92: On the Critical Issues in Temozolomide Research in Glioblastoma: Clinically Relevant Concentrations and MGMT-independent Resistance Biomedicines doi: 10.3390/biomedicines7040092 Authors: Stepanenko Chekhonin The current standard first-line treatment for adult patients with newly diagnosed glioblastoma includes concurrent radiotherapy and daily oral temozolomide (TMZ), followed by adjuvant TMZ. As a prodrug, TMZ undergoes spontaneous hydrolysis generating...
Wed Nov 27, 2019 02:00
Biomimetics, Vol. 4, Pages 75: Biomimetic Groundwork for Thermal Exchange Structures Inspired by Plant Leaf Design Biomimetics doi: 10.3390/biomimetics4040075 Authors: Rupp Gruber Geometry is a determining factor for thermal performance in both biological and technical systems. While biology has inspired thermal design before, biomimetic translation of leaf morphology into structural aspects of heat exchangers remains largely unaddressed. One determinant of plant thermal endurance...
Wed Nov 27, 2019 02:00
Biomolecules, Vol. 9, Pages 794: Structural Lesions of Proteins Connected to Lipid Membrane Damages Caused by Radical Stress: Assessment by Biomimetic Systems and Raman Spectroscopy Biomolecules doi: 10.3390/biom9120794 Authors: Torreggiani Tinti Jurasekova Capdevila Saracino Foggia Model systems constituted by proteins and unsaturated lipid vesicles were used to gain more insight into the effects of the propagation of an initial radical damage on protein to the...
Wed Nov 27, 2019 02:00
Biomolecules, Vol. 9, Pages 793: Disease Resistant Bouquet Vine Varieties: Assessment of the Phenolic, Aromatic, and Sensory Potential of Their Wines Biomolecules doi: 10.3390/biom9120793 Authors: González-Centeno Chira Miramont Escudier Samson Salmon Ojeda Teissedre The search for grape varieties resistant to diseases and to climatic changes notably concerns the wine industry. Nine monovarietal wines from new red grape varieties resistant to cryptogamic...
Wed Nov 27, 2019 02:00
Biomolecules, Vol. 9, Pages 792: Lanatoside C Induces G2/M Cell Cycle Arrest and Suppresses Cancer Cell Growth by Attenuating MAPK, Wnt, JAK-STAT, and PI3K/AKT/mTOR Signaling Pathways Biomolecules doi: 10.3390/biom9120792 Authors: Dhanasekhar Reddy Ranjith Kumavath Preetam Ghosh Debmalya Barh Cardiac glycosides (CGs) are a diverse family of naturally derived compounds having a steroid and glycone moiety in their structures. CG molecules inhibit the α-subunit of ubiquitous...
Wed Nov 27, 2019 02:00
Biomolecules, Vol. 9, Pages 791: Trafficking of Stretch-Regulated TRPV2 and TRPV4 Channels Inferred Through Interactomics Biomolecules doi: 10.3390/biom9120791 Authors: Pau Doñate-Macián Jennifer Enrich-Bengoa Irene R. Dégano David G. Quintana Alex Perálvarez-Marín Transient receptor potential cation channels are emerging as important physiological and therapeutic targets. Within the vanilloid subfamily, transient receptor potential vanilloid 2 (TRPV2) and 4 (TRPV4) are osmo-...
Wed Nov 27, 2019 02:00
Biomolecules, Vol. 9, Pages 790: Dendrimer-Based Drug Delivery Systems for Brain Targeting Biomolecules doi: 10.3390/biom9120790 Authors: Yuefei Zhu Chunying Liu Zhiqing Pang Human neuroscience has made remarkable progress in understanding basic aspects of functional organization; it is a renowned fact that the blood–brain barrier (BBB) impedes the permeation and access of most drugs to central nervous system (CNS) and that many neurological diseases remain undertreated....
Wed Nov 27, 2019 02:00
Biomolecules, Vol. 9, Pages 789: Paclitaxel’s Mechanistic and Clinical Effects on Breast Cancer Biomolecules doi: 10.3390/biom9120789 Authors: Tala M. Abu Samaan Marek Samec Alena Liskova Peter Kubatka Dietrich Büsselberg Paclitaxel (PTX), the most widely used anticancer drug, is applied for the treatment of various types of malignant diseases. Mechanisms of PTX action represent several ways in which PTX affects cellular processes resulting in programmed cell death. PTX is...
Wed Nov 27, 2019 02:00
Brain Sciences, Vol. 9, Pages 344: How Attention to Faces and Objects Changes Over Time in Toddlers with Autism Spectrum Disorders: Preliminary Evidence from An Eye Tracking Study Brain Sciences doi: 10.3390/brainsci9120344 Authors: Filippo Muratori Lucia Billeci Sara Calderoni Maria Boncoddo Caterina Lattarulo Valeria Costanzo Marco Turi Costanza Colombi Antonio Narzisi Further understanding of the longitudinal changes in visual pattern of toddlers with autism...
Wed Nov 27, 2019 02:00
Cancers, Vol. 11, Pages 1892: Recurrent or Refractory High-Grade Gliomas Treated by Convection-Enhanced Delivery of a TGFβ2-Targeting RNA Therapeutic: A Post-Hoc Analysis with Long-Term Follow-Up Cancers doi: 10.3390/cancers11121892 Authors: Fatih M. Uckun Sanjive Qazi Larn Hwang Vuong N. Trieu Background. OT101 is a first-in-class RNA therapeutic designed to abrogate the immunosuppressive actions of transforming growth factor beta 2 (TGFβ2). Here, we report our post-hoc...
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Cancers, Vol. 11, Pages 1891: MicroRNA-9-5p-CDX2 Axis: A Useful Prognostic Biomarker for Patients with Stage II/III Colorectal Cancer Cancers doi: 10.3390/cancers11121891 Authors: Nishiuchi Hisamori Sakaguchi Fukuyama Hoshino Itatani Honma Maekawa Nishigori Tsunoda Obama Miyoshi Shimono Taketo Sakai A lack of caudal-type homeobox transcription factor 2 (CDX2) protein expression has been proposed as a prognostic biomarker for colorectal...
Wed Nov 27, 2019 02:00
Cancers, Vol. 11, Pages 1889: Bioprofiling TS/A Murine Mammary Cancer for a Functional Precision Experimental Model Cancers doi: 10.3390/cancers11121889 Authors: De Giovanni Nicoletti Landuzzi Palladini Lollini Nanni The TS/A cell line was established in 1983 from a spontaneous mammary tumor arisen in an inbred BALB/c female mouse. Its features (heterogeneity, low immunogenicity and metastatic ability) rendered the TS/A cell line suitable as a preclinical model...
Wed Nov 27, 2019 02:00
Cancers, Vol. 11, Pages 1888: Enhanced Hsa-miR-181d/p-STAT3 and Hsa-miR-181d/p-STAT5A Ratios Mediate the Anticancer Effect of Garcinol in STAT3/5A-Addicted Glioblastoma Cancers doi: 10.3390/cancers11121888 Authors: Heng-Wei Liu Peter Mingjui Lee Oluwaseun Adebayo Bamodu Yu-Kai Su Iat-Hang Fong Chi-Tai Yeh Ming-Hsien Chien I-Hung Kan Chien-Min Lin Background: Glioblastoma (GBM), a malignant grade IV tumor, is the most malignant brain tumor due to its hyper-proliferative...
Wed Nov 27, 2019 02:00
Cancers, Vol. 11, Pages 1890: Role of Postoperative Complications in Overall Survival after Radical Resection for Gastric Cancer: A Retrospective Single-Center Analysis of 1107 Patients Cancers doi: 10.3390/cancers11121890 Authors: Galata Blank Weiss Ronellenfitsch Reissfelder Hardt Background: The aim of this study was to investigate the impact of postoperative complications on overall survival (OS) after radical resection for gastric cancer. Methods: A retrospective...
Wed Nov 27, 2019 02:00
Cancers, Vol. 11, Pages 1886: Cancer Is Associated with Alterations in the Three-Dimensional Organization of the Genome Cancers doi: 10.3390/cancers11121886 Authors: Li Barth Pilarsky Taher The human genome is organized into topologically associating domains (TADs), which represent contiguous regions with a higher frequency of intra-interactions as opposed to inter-interactions. TADs contribute to gene expression regulation by restricting the interactions between their regulatory...
Wed Nov 27, 2019 02:00
Cancers, Vol. 11, Pages 1887: Photoimmunotherapy of Ovarian Cancer: A Unique Niche in the Management of Advanced Disease Cancers doi: 10.3390/cancers11121887 Authors: Nath Saad Pigula Swain Hasan Ovarian cancer (OvCa) is the leading cause of gynecological cancer-related deaths in the United States, with five-year survival rates of 15–20% for stage III cancers and 5% for stage IV cancers. The standard of care for advanced OvCa involves surgical debulking of...
Wed Nov 27, 2019 02:00
Cancers, Vol. 11, Pages 1879: IL-24 Inhibits Lung Cancer Growth by Suppressing GLI1 and Inducing DNA Damage Cancers doi: 10.3390/cancers11121879 Authors: Janani Panneerselvam Akhil Srivastava Meghna Mehta Allshine Chen Yan D. Zhao Anupama Munshi Rajagopal Ramesh Aberrant expression of GLI1 is responsible for aggressive tumor behavior and survival due to its effects on the DNA damage response (DDR). We investigated whether interleukin (IL)-24, a tumor suppressor, inhibits...
Wed Nov 27, 2019 02:00
Cancers, Vol. 11, Pages 1882: Occupational Chemical Exposure and Breast Cancer Risk According to Hormone Receptor Status: A Systematic Review Cancers doi: 10.3390/cancers11121882 Authors: Veruscka Leso Maria Luigia Ercolano Dante Luigi Cioffi Ivo Iavicoli Breast cancers include a heterogeneous group of diseases with clinical behaviors that may vary according to the hormonal receptor status. However, limited knowledge is available on the role of breast cancer environmental and...
Wed Nov 27, 2019 02:00
Cancers, Vol. 11, Pages 1881: ROCK2 Confers Acquired Gemcitabine Resistance in Pancreatic Cancer Cells by Upregulating Transcription Factor ZEB1 Cancers doi: 10.3390/cancers11121881 Authors: Yang Zhou Yunjiang Zhou Keke Wang Tao Li Minda Zhang Yunjia Yang Rui Wang Rong Hu Resistance to chemotherapy is a major clinical challenge in the treatment of pancreatic ductal adenocarcinoma (PDAC). Here, we provide evidence that Rho associated coiled-coil containing protein...
Wed Nov 27, 2019 02:00
Cancers, Vol. 11, Pages 1884: Patient-Reported Outcome (PRO) as an Addition to Long-Term Results after High-Precision Stereotactic Radiotherapy in Patients with Secreting and Non-Secreting Pituitary Adenomas: A Retrospective Cohort Study up to 17-Years Follow-Up Cancers doi: 10.3390/cancers11121884 Authors: Kerstin A. Kessel Christian D. Diehl Markus Oechsner Bernhard Meyer Jens Gempt Claus Zimmer Friederike Schmidt-Graf Stephanie E. Combs High-precision radiotherapy...
Wed Nov 27, 2019 02:00
Cancers, Vol. 11, Pages 1883: Targeting FAT1 Inhibits Carcinogenesis, Induces Oxidative Stress and Enhances Cisplatin Sensitivity through Deregulation of LRP5/WNT2/GSS Signaling Axis in Oral Squamous Cell Carcinoma Cancers doi: 10.3390/cancers11121883 Authors: Tung-Nien Hsu Chih-Ming Huang Chin-Sheng Huang Mao-Suan Huang Chi-Tai Yeh Tsu-Yi Chao Oluwaseun Adebayo Bamodu FAT atypical cadherin 1 (FAT1) regulates cell-cell adhesion and extracellular matrix architecture,...
Wed Nov 27, 2019 02:00
Cancers, Vol. 11, Pages 1880: Delineation of Tumor Migration Paths by Using a Bayesian Biogeographic Approach Cancers doi: 10.3390/cancers11121880 Authors: Antonia Chroni Tracy Vu Sayaka Miura Sudhir Kumar Understanding tumor progression and metastatic potential are important in cancer biology. Metastasis is the migration and colonization of clones in secondary tissues. Here, we posit that clone migration events between tumors resemble the dispersal of individuals between distinct...
Wed Nov 27, 2019 02:00
Cancers, Vol. 11, Pages 1885: Imaging of Preclinical Endometrial Cancer Models for Monitoring Tumor Progression and Response to Targeted Therapy Cancers doi: 10.3390/cancers11121885 Authors: Heidi Espedal Tina Fonnes Kristine E. Fasmer Camilla Krakstad Ingfrid S. Haldorsen Endometrial cancer is the most common gynecologic malignancy in industrialized countries. Most patients are cured by surgery; however, about 15% of the patients develop recurrence with limited treatment...
Wed Nov 27, 2019 02:00
Cancers, Vol. 11, Pages 1878: Colorectal Cancer Growth Retardation through Induction of Apoptosis, Using an Optimized Synergistic Cocktail of Axitinib, Erlotinib, and Dasatinib Cancers doi: 10.3390/cancers11121878 Authors: Robert H. Berndsen Nathalie Swier Judy R. van Beijnum Patrycja Nowak-Sliwinska Patients with advanced colorectal cancer (CRC) still depend on chemotherapy regimens that are associated with significant limitations, including resistance and toxicity. The contribution...
Wed Nov 27, 2019 02:00
Cells, Vol. 8, Pages 1531: An Autophagy Modifier Screen Identifies Small Molecules Capable of Reducing Autophagosome Accumulation in a Model of CLN3-Mediated Neurodegeneration Cells doi: 10.3390/cells8121531 Authors: Petcherski Chandrachud Butz Klein Zhao Reis Haggarty Ruonala Cotman Alterations in the autophagosomal–lysosomal pathway are a major pathophysiological feature of CLN3 disease, which is the most common form of childhood-onset neurodegeneration....
Wed Nov 27, 2019 02:00
Cells, Vol. 8, Pages 1529: Sex Differences in Liver, Adipose Tissue, and Muscle Transcriptional Response to Fasting and Refeeding in Mice Cells doi: 10.3390/cells8121529 Authors: Bazhan Jakovleva Feofanova Denisova Dubinina Sitnikova Makarova Fasting is often used for obesity correction but the “refeeding syndrome” limits its efficiency, and molecular mechanisms underlying metabolic response to different food availability are under investigation....
Wed Nov 27, 2019 02:00
Cells, Vol. 8, Pages 1530: Stem Cells in Cardiovascular Medicine: Historical Overview and Future Prospects Cells doi: 10.3390/cells8121530 Authors: Samak Hinkel Cardiovascular diseases remain the leading cause of death in the developed world, accounting for more than 30% of all deaths. In a large proportion of these patients, acute myocardial infarction is usually the first manifestation, which might further progress to heart failure. In addition, the human heart displays a low...
Wed Nov 27, 2019 02:00
Cells, Vol. 8, Pages 1527: CD38, a Receptor with Multifunctional Activities: From Modulatory Functions on Regulatory Cell Subsets and Extracellular Vesicles, to a Target for Therapeutic Strategies Cells doi: 10.3390/cells8121527 Authors: Fabio Morandi Irma Airoldi Danilo Marimpietri Cristiano Bracci Angelo Corso Faini Roberto Gramignoli CD38 is a multifunctional cell surface protein endowed with receptor/enzymatic functions. The protein is generally expressed at low/intermediate...
Wed Nov 27, 2019 02:00
Cells, Vol. 8, Pages 1528: Neutrophil Extracellular Traps in the Pathogenesis of Equine Recurrent Uveitis (ERU) Cells doi: 10.3390/cells8121528 Authors: Fingerhut Ohnesorge von Borstel Schumski Strutzberg-Minder Mörgelin Deeg Haagsman Beineke von Köckritz-Blickwede de Buhr Equine recurrent uveitis (ERU) is considered one of the most important eye diseases in horses and typically appears with relapsing inflammatory episodes without systemic effects....
Wed Nov 27, 2019 02:00
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