Related ArticlesPredicting Persistent Opioid Use, Abuse and Toxicity Among Cancer Survivors. J Natl Cancer Inst. 2019 Nov 22;: Authors: Vitzthum LK, Riviere P, Sheridan P, Nalawade V, Deka R, Furnish T, Mell LK, Rose B, Wallace M, Murphy JD Abstract BACKGROUND: While opioids play a critical role in the management of cancer pain, the ongoing opioid epidemic has raised concerns regarding their persistent use and abuse. We lack data-driven tools in oncology...
Sat Nov 23, 2019 13:04
Related ArticlesA systematic review of health economic evaluations of proton beam therapy for adult cancer: Appraising methodology and quality. Clin Transl Radiat Oncol. 2020 Jan;20:19-26 Authors: Jones DA, Smith J, Mei XW, Hawkins MA, Maughan T, van den Heuvel F, Mee T, Kirkby K, Kirkby N, Gray A Abstract Background and purpose: With high treatment costs and limited capacity, decisions on which adult patients to treat with proton beam therapy (PBT)...
Sat Nov 23, 2019 13:04
Related ArticlesNanotopography-based lymphatic delivery for improved anti-tumor responses to checkpoint blockade immunotherapy. Theranostics. 2019;9(26):8332-8343 Authors: Kwon S, Velasquez FC, Rasmussen JC, Greives MR, Turner KD, Morrow JR, Hwu WJ, Ross RF, Zhang S, Sevick-Muraca EM Abstract Rationale: Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) is a co-inhibitory checkpoint receptor that is expressed by naïve T-cells in lymph nodes (LNs) to...
Sat Nov 23, 2019 13:04
Related ArticlesOsimertinib and pterostilbene in EGFR-mutation-positive non-small cell lung cancer (NSCLC). Int J Biol Sci. 2019;15(12):2607-2614 Authors: Bracht JWP, Karachaliou N, Berenguer J, Pedraz-Valdunciel C, Filipska M, Codony-Servat C, Codony-Servat J, Rosell R Abstract Monotherapy with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) still leads to incomplete responses in most EGFR-mutation positive non-small cell lung...
Sat Nov 23, 2019 13:04
Related ArticlesCohort profile: the MCC-Spain follow-up on colorectal, breast and prostate cancers: study design and initial results. BMJ Open. 2019 Nov 21;9(11):e031904 Authors: Alonso-Molero J, Molina AJ, Jiménez-Moleón JJ, Pérez-Gómez B, Martin V, Moreno V, Amiano P, Ardanaz E, de Sanjose S, Salcedo I, Fernandez-Tardon G, Alguacil J, Salas D, Marcos-Gragera R, Chirlaque MD, Aragonés N, Castaño-Vinyals G, Pollán M, Kogevinas M, Llorca J Abstract PURPOSE:...
Sat Nov 23, 2019 13:04
Related ArticlesMinimally Invasive Surgery for Colorectal Cancer: Hospital Type Drives Utilization and Outcomes. J Surg Res. 2019 Nov 18;: Authors: Villano AM, Zeymo A, Houlihan BK, Bayasi M, Al-Refaie WB, Chan KS Abstract INTRODUCTION: Minimally invasive surgery (MIS) for colorectal cancer (CRC) is increasingly common; however, uptake has differed by hospital type. It is unknown how these trends have evolved for laparoscopic or robotic approaches in...
Sat Nov 23, 2019 13:04
Related ArticlesCurrent Clinical Trials in the Treatment of Advanced Melanomas. Surg Clin North Am. 2020 Feb;100(1):201-208 Authors: Sarkisian S, Nair S, Sharma R Abstract The treatment of metastatic melanomas revolutionized during the past decade because of a better understanding of various pathways and mutations that play different roles in the pathogenesis of this disease. The incorporation of immunotherapy was the first in these efforts, followed...
Sat Nov 23, 2019 13:04
Related ArticlesImmune induction strategies to enhance responses to PD-1 blockade: lessons from the TONIC trial. J Immunother Cancer. 2019 Nov 21;7(1):318 Authors: Demaria S, Romano E, Brackstone M, Formenti SC Abstract Programmed cell death protein 1 (PD-1) blockade is only effective in a minority of patients, prompting the search for combinatorial therapies that increase responses. Identifying effective combinations requires lengthy testing and so...
Sat Nov 23, 2019 13:04
Related ArticlesChimeric antigen receptor T cell therapies for multiple myeloma. J Hematol Oncol. 2019 Nov 21;12(1):120 Authors: Wu C, Zhang L, Brockman QR, Zhan F, Chen L Abstract Multiple myeloma (MM) is the second most common hematologic malignancy and remains incurable despite the advent of numerous new drugs such as proteasome inhibitors (PIs), immunomodulatory agents (IMiDs), and monoclonal antibodies. There is an unmet need to develop novel therapies...
Sat Nov 23, 2019 13:04
Related ArticlesThe Potential of PI3K/AKT/mTOR Signaling as a Druggable Target for Endometrial and Ovarian Carcinomas. Curr Drug Targets. 2019 Nov 20;: Authors: Lengyel CG, Altuna SC, Habeeb BS, Trapani D, Khan SZ Abstract AIMS: In this narrative review, we summarize the role and significance of PI3K-AKT-mTOR (PAM) pathway in ovarian and endometrial cancers, providing the most recent and relevant literature on the topic and addressing options for targeting...
Sat Nov 23, 2019 13:04
Related ArticlesBulk and Single-Cell Next-Generation Sequencing: Individualizing Treatment for Colorectal Cancer. Cancers (Basel). 2019 Nov 18;11(11): Authors: Kyrochristos ID, Ziogas DE, Goussia A, Glantzounis GK, Roukos DH Abstract The increasing incidence combined with constant rates of early diagnosis and mortality of colorectal cancer (CRC) over the past decade worldwide, as well as minor overall survival improvements in the industrialized world,...
Sat Nov 23, 2019 13:04
Related ArticlesTP53, EGFR and PIK3CA gene variations observed as prominent biomarkers in breast and lung cancer by plasma cell-free DNA genomic testing. J Biotechnol. 2019 Jul 20;300:87-93 Authors: Savli H, Sertdemir N, Aydin D, Dursun B, Kurtas O, Reka S, Sunnetci-Akkoyunlu D, Eren-Keskin S, Uygun K, Ozden E, Isik U, Cabuk D, Demir G, Guzdolu E, Gokbayrak M, Aksu MG, Canturk NZ, Cine N Abstract Use of plasma cell-free DNA genomic testing, also know...
Sat Nov 23, 2019 13:04
Related ArticlesHomologous recombination enhances radioresistance in hypopharyngeal cancer cell line by targeting DNA damage response. Oral Oncol. 2019 Nov 19;100:104469 Authors: Liu C, Liao K, Gross N, Wang Z, Li G, Zuo W, Zhong S, Zhang Z, Zhang H, Yang J, Hu G Abstract BACKGROUND: Radiotherapy is a central treatment option for hypopharyngeal squamous cell carcinoma, but the prognoses of patients treated with radiotherapy only are not satisfactory...
Sat Nov 23, 2019 14:32
Related ArticlesMeta-analysis of tumor control rates in patients undergoing stereotactic radiosurgery for cystic vestibular schwannomas. Clin Neurol Neurosurg. 2019 Oct 31;188:105571 Authors: Ding K, Ng E, Romiyo P, Dejam D, Udawatta M, Sun MZ, Gopen Q, Yang I Abstract OBJECTIVE: The use of SRS for treatment of cystic vestibular schwannoma is a topic of mild controversy. This review serves to introduce a renewed understanding of the efficacy of SRS as...
Sat Nov 23, 2019 14:32
Related ArticlesSilica nanoparticles induce caspase-dependent apoptosis through reactive oxygen species-activated endoplasmic reticulum stress pathway in neuronal cells. Toxicol In Vitro. 2019 Nov 19;:104739 Authors: Lee KI, Lin JW, Su CC, Fang KM, Yang CY, Kuo CY, Wu CC, Wu CT, Chen YW Abstract Human exposure to silica nanoparticles (SiNPs) has been widely applied as vehicles for drug delivery and cellular manipulations in nanoneuromedicine. SiNPs may...
Sat Nov 23, 2019 14:32
Related ArticlesCross-modal plasticity in adult single-sided deafness revealed by alpha band resting-state functional connectivity. Neuroimage. 2019 Nov 19;:116376 Authors: Shang Y, Hinkley LB, Cai C, Mizuiri D, Cheung SW, Nagarajan SS Abstract Single-sided deafness (SSD) or profound unilateral hearing loss is the condition where the transfer of acoustic information to the brain is restricted to one ear. SSD impairment is most evident under adverse acoustic...
Sat Nov 23, 2019 14:32
Related ArticlesCombined Pterional Transsylvian and Bifrontal Interhemispheric Approach to a Ruptured Subcallosal and Pericallosal Brain Arteriovenous Malformation with Skeletonization of the Entire A2 ACA Segment. World Neurosurg. 2019 Nov 19;: Authors: Rubio RR, Dubnicoff T, Rutledge WC, Abla AA Abstract A 39-year-old man presented with a large left paramedian frontal lobe intracerebral hemorrhage (ICH). CT angiography and MR imaging revealed a tangle...
Sat Nov 23, 2019 14:32
Related ArticleseIF4E and 4EBP1 are prognostic markers of head and neck squamous cell carcinoma recurrence after definitive surgery and adjuvant radiotherapy. PLoS One. 2019;14(11):e0225537 Authors: Huang CI, Wang CC, Tai TS, Hwang TZ, Yang CC, Hsu CM, Su YC Abstract There is high risk of metastasis and recurrence in head and neck squamous cell carcinoma (HNSCC) patients, especially for patient who received definitive surgery and adjuvant radiotherapy....
Sat Nov 23, 2019 14:32
Related ArticlesDevelopment and Usage of eContour, a Novel, Three-Dimensional, Image-Based Web Site to Facilitate Access to Contouring Guidelines at the Point of Care. JCO Clin Cancer Inform. 2019 Oct;3:1-9 Authors: Sherer MV, Lin D, Puri K, Panjwani N, Zhang Z, Murphy JD, Gillespie EF Abstract PURPOSE: Variation in contouring quality by radiation oncologists is common and can have significant clinical consequences. Image-based guidelines can improve...
Sat Nov 23, 2019 14:32
Related ArticlesManagement of orbital invasion in sinonasal squamous cell carcinoma: 15 years' experience. Int Forum Allergy Rhinol. 2019 Nov 22;: Authors: Li R, Tian S, Zhu Y, Zhu W, Wang S Abstract BACKGROUND: This study was intended to review our management strategy for sinonasal squamous cell carcinomas (SNSCCs) with orbital invasion and to explore the role of radiotherapy in orbital preservation. METHODS: We retrospectively analyzed 93...
Sat Nov 23, 2019 14:32
Related ArticlesComparing endoscopic resection and open resection for management of sinonasal mucosal melanoma. Int Forum Allergy Rhinol. 2019 Nov 22;: Authors: Farber NI, Bavier RD, Crippen MM, Vatsa N, Hsueh WD, Eloy JA Abstract BACKGROUND: Sinonasal mucosal melanoma (SMM) is a rare, aggressive cancer, optimally managed with complete surgical resection. This study aimed to assess the impact of surgical approach on outcomes by comparison of cases managed...
Sat Nov 23, 2019 14:32
Related ArticlesAssociation of insurance type with time course of care in head and neck cancer management. Laryngoscope. 2019 Nov 22;: Authors: Itamura K, Kokot N, Sinha U, Swanson M Abstract OBJECTIVES/HYPOTHESIS: To determine differences in time course of care based on major insurance types for patients with head and neck squamous cell carcinoma (HNSCC). STUDY DESIGN: Retrospective cohort study. METHODS: Retrospective study of Health...
Sat Nov 23, 2019 14:32
Related ArticlesReducing Surgical Site Infections During Otolaryngology Surgical Missions. Laryngoscope. 2019 Nov 22;: Authors: Isaacson G, Doyle W, Summer D Abstract OBJECTIVES: To determine what measures an otolaryngology-head and neck surgery team might adopt to decrease the incidence of surgical site infection (SSI) on a short-term surgical mission. Despite concerns about safety and efficacy, short-term surgical missions remain the predominant structure...
Sat Nov 23, 2019 14:32
Related ArticlesEfficacy and safety of steroid-impregnated implants following sinus surgery: A meta-analysis. Laryngoscope. 2019 Nov 22;: Authors: Li W, Lu H, Wang H, Sun X, Wang D Abstract OBJECTIVES: The purpose of this meta-analysis was to discuss the efficacy and safety of bioabsorbable steroid-impregnated implants following endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS) patients. METHODS: PubMed, Cochrane, EMBASE, Web of...
Sat Nov 23, 2019 14:32
Related ArticlesDeveloping an intervention to implement an ICF-based e-intake tool in clinical otology and audiology practice. Int J Audiol. 2019 Nov 22;:1-19 Authors: van Leeuwen LM, Pronk M, Merkus P, Goverts ST, Anema JR, Kramer SE Abstract Objective: To develop an intervention for the implementation of an ICF-based e-intake tool in clinical oto-audiology practice.Design: Intervention design study using the eight-stepped Behaviour Change Wheel. Hearing...
Sat Nov 23, 2019 14:32
Related ArticlesThe Outcome and Decision-making of Extracapsular Dissection for Benign Superficial Lobe Parotid Tumors: Our Experience in 144 Patients. Clin Otolaryngol. 2019 Nov 22;: Authors: Cheng PC, Lo WC, Chang CM, Huang TW, Cheng PW, Liao LJ Abstract •The outcomes and decision-making between extracapsular dissection (ECD) and superficial parotidectomy (SP) for benign superficial lobe parotid tumors were compared. •The ECD group had less transient...
Sat Nov 23, 2019 14:32
Related ArticlesClinical utility of 177 Lu-DOTATATE PRRT in somatostatin receptor-positive metastatic medullary carcinoma of thyroid patients with assessment of efficacy, survival analysis, prognostic variables, and toxicity. Head Neck. 2019 Nov 22;: Authors: Parghane RV, Naik C, Talole S, Desmukh A, Chaukar D, Banerjee S, Basu S Abstract BACKGROUND: The primary aim of this study was to evaluate the therapeutic efficacy and outcome of 177 Lu-DOTATATE...
Sat Nov 23, 2019 14:32
Related ArticlesThe effect of jaw exercises on anxiety and depression in patients with head and neck cancer receiving radiotherapy: Prospective 2-year follow-up study. Head Neck. 2019 Nov 22;: Authors: Aghajanzadeh S, Karlsson T, Tuomi L, Finizia C Abstract BACKGROUND: This nonrandomized matched study investigates jaw exercise effect on anxiety/depressive symptoms in head and neck cancer patients with trismus during 2 years postradiotherapy. ...
Sat Nov 23, 2019 14:32
Related ArticlesCombination of antioxidants and NFAT (nuclear factor of activated T cells) inhibitor protects auditory hair cells from ototoxic insult. J Neurochem. 2019 Nov 22;: Authors: Sekulic-Jablanovic M, Voronkova K, Bodmer D, Petkovic V Abstract Hair cell (HC) degeneration causes hearing loss in millions of people worldwide. Aminoglycoside exposure is one major cause of sensory HC damage. Aminoglycosides generate free radicals within the inner...
Sat Nov 23, 2019 14:32
Related ArticlesAssociation of metabolic and genetic heterogeneity in head and neck squamous cell carcinoma with prognostic implications: integration of FDG PET and genomic analysis. EJNMMI Res. 2019 Nov 21;9(1):97 Authors: Choi J, Gim JA, Oh C, Ha S, Lee H, Choi H, Im HJ Abstract PURPOSE: The linkage between the genetic and phenotypic heterogeneity of the tumor has not been thoroughly evaluated. Herein, we investigated how the genetic and metabolic...
Sat Nov 23, 2019 13:03
Related ArticlesMyofascial pain, widespread pressure hypersensitivity, and hyperalgesia in the face, neck, and shoulder regions, in survivors of head and neck cancer. Support Care Cancer. 2019 Nov 21;: Authors: Ortiz-Comino L, Fernández-Lao C, Castro-Martín E, Lozano-Lozano M, Cantarero-Villanueva I, Arroyo-Morales M, Martín-Martín L Abstract PURPOSE: Medical treatment for head and neck cancer may induce the presence of inflammation, pain, and dysfunction....
Sat Nov 23, 2019 13:03
Related ArticlesFusion of Preoperative MRI and Postoperative FD-CT for Direct Evaluation of Cochlear Implants : An Analysis at 1.5 T and 3 T. Clin Neuroradiol. 2019 Nov 21;: Authors: Eisenhut F, Taha L, Kleibe I, Hornung J, Iro H, Doerfler A, Lang S Abstract AIM: This study was carried out to evaluate the diagnostic value of merging preoperative magnetic resonance imaging (MRI) with postoperative flat-panel computed tomography (FD-CT) and compare it...
Sat Nov 23, 2019 13:03
Related Articles[Pravastatin is capable to reduce radiation induced fibrosis after head-and-neck treatment]. Strahlenther Onkol. 2019 Nov 21;: Authors: Brunner TB PMID: 31754735 [PubMed - as supplied by publisher]
Sat Nov 23, 2019 13:03
Related ArticlesSuper-resolution Diffusion Tensor Imaging for Delineating the Facial Nerve in Patients with Vestibular Schwannoma. J Neurol Surg B Skull Base. 2019 Dec;80(6):648-654 Authors: Epprecht L, Kozin ED, Piccirelli M, Kanumuri VV, Tarabichi O, Remenschneider A, Barker FG, McKenna MJ, Huber AM, Cunnane ME, Reinshagen KL, Lee DJ Abstract Objectives Predicting the course of cranial nerves (CNs) VII and VIII in the cerebellopontine angle on preoperative...
Sat Nov 23, 2019 13:03
Related ArticlesAudit of Complications in an Otolaryngology Led Skull-Base Surgical Practice. J Neurol Surg B Skull Base. 2019 Dec;80(6):586-592 Authors: Patnaik U, Panda S, Thakar A Abstract Objective This study was aimed to classify and study complications of surgery of the cranial base, primarily from an otorhinolaryngology perspective. Design This study was designed with consecutive cohort of skull base surgical cases. Setting Tertiary referral...
Sat Nov 23, 2019 13:03
Related ArticlesGeographical Differences in Intracranial Meningioma Management: Examining 65,973 Patients across the United States. J Neurol Surg B Skull Base. 2019 Dec;80(6):547-554 Authors: Anzalone CL, Glasgow A, Habermann E, Grossard BR, Van Gompel JJ, Carlson ML Abstract Background Age, tumor size and location, overall health, and patient preference are primary considerations driving treatment decision-making for intracranial meningiomas. However,...
Sat Nov 23, 2019 13:03
Related ArticlesThe Impact of Drug-induced Sleep Endoscopy on Therapeutic Decisions in Obstructive Sleep Apnea: A Systematic Review and Meta-analysis. Cureus. 2019 Oct 30;11(10):e6041 Authors: Albdah AA, Alkusayer MM, Al-Kadi M, Almofada H, Alnofal EA, Almutairi S Abstract Objective The aim of this study was to assess the ability of drug-induced sleep endoscopy (DISE) to change therapeutic decisions through the identification of obstruction sites in...
Sat Nov 23, 2019 13:03
Related ArticlesSinonasal Chondromyxoid Fibroma: Case Report and Literature Review. Cureus. 2019 Oct 05;11(10):e5841 Authors: El-Kouri N, Elghouche A, Chen S, Shipchandler T, Ting J Abstract Chondromyxoid fibroma (CMF) is a rare, benign neoplasm of the chondroid, myxoid, and fibrous tissue. It characteristically affects the lower extremity long bones, although it may rarely arise within the craniofacial skeleton. We report the diagnosis and management...
Sat Nov 23, 2019 13:03
Related ArticlesChemical compound cinobufotalin potently induces FOXO1-stimulated cisplatin sensitivity by antagonizing its binding partner MYH9. Signal Transduct Target Ther. 2019;4:48 Authors: Li Y, Liu X, Lin X, Zhao M, Xiao Y, Liu C, Liang Z, Lin Z, Yi R, Tang Z, Liu J, Li X, Jiang Q, Li L, Xie Y, Liu Z, Fang W Abstract In this study, we present novel molecular mechanisms by which FOXO1 functions as a tumor suppressor to prevent the pathogenesis...
Sat Nov 23, 2019 13:03
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