Related ArticlesTargeting DNA methylation for treating triple-negative breast cancer. Pharmacogenomics. 2019 Nov;20(16):1151-1157 Authors: Yu J, Zayas J, Qin B, Wang L Abstract Triple-negative breast cancer (TNBC) accounts for 15-20% of all invasive breast cancers and tends to have aggressive histological features and poor clinical outcomes. Unlike, estrogen receptor- or HER2-positive diseases, TNBC patients currently lack the US FDA-approved targeted...
Sat Nov 23, 2019 14:46
Related ArticlesMultimodal image-guided surgery of HER2-positive breast cancer using [111In]In-DTPA-trastuzumab-IRDye800CW in an orthotopic breast tumor model. EJNMMI Res. 2019 Nov 21;9(1):98 Authors: Deken MM, Bos DL, Tummers WSFJ, March TL, van de Velde CJH, Rijpkema M, Vahrmeijer AL Abstract BACKGROUND: Combining modalities using dual-labeled antibodies may allow preoperative and intraoperative tumor localization and could be used in image-guided...
Sat Nov 23, 2019 14:46
Related ArticlesBaseline Lymphopenia: A Predictor Of Poor Outcomes In HER2 positive Metastatic Breast Cancer Treated With Trastuzumab. Drug Des Devel Ther. 2019;13:3727-3734 Authors: Che YQ, Zhang Y, Wang D, Liu HY, Shen D, Luo Y Abstract Purpose: Despite selection based on human epidermal growth factor receptor 2 (HER2) overexpression, not all HER2-positive patients benefit from trastuzumab therapy. Recent reports indicate that trastuzumab treatment...
Sat Nov 23, 2019 14:46
Related ArticlesCost-utility analysis of adjuvant trastuzumab therapy for HER2-positive early-stage breast cancer in the Philippines. BMC Health Serv Res. 2019 Nov 21;19(1):874 Authors: Genuino AJ, Chaikledkaew U, Guerrero AM, Reungwetwattana T, Thakkinstian A Abstract BACKGROUND: Breast cancer is the leading malignancy among Filipino women, with about 23.50% of cases characterized by human epidermal growth factor receptor-2 (HER2) overexpression. Trastuzumab,...
Sat Nov 23, 2019 14:46
Publication date: Available online 23 November 2019Source: BrachytherapyAuthor(s): Jean-Michel Hannoun-Lévi, Daniel Lam Cham Kee, Jocelyn Gal, Renaud Schiappa, Arthur Hannoun, Yves Fouche, Mathieu Gautier, Rabia Boulahssass, Marie-Eve ChandAbstractPurposeTo evaluate the clinical outcomes of a very-accelerated partial breast irradiation (vAPBI) in the elderly based on a single fraction of multicatheter interstitial high-dose rate brachytherapy (MIB). Mature results with a median follow-up of 5 years.Methods...
Sat Nov 23, 2019 14:42
98 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human physiology These pubmed results were generated on 2019/11/23PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sat Nov 23, 2019 14:41
Related Articles[Pretesting of the German Vocal Fatigue Index (VFI-D)-transcultural translation and cross validation]. HNO. 2019 Nov 21;: Authors: Stappenbeck LE, Bohlender JE, Brockmann-Bauser M Abstract BACKGROUND: In clinical routine, vocal fatigue is a common symptom in patients with dysphonia. OBJECTIVE: The aim of this study was to conduct a transcultural translation of the Vocal Fatigue Index (VFI), a standardized subjective questionnaire....
Sat Nov 23, 2019 14:40
Related ArticlesLong non-coding RNA H19 and cancer: A competing endogenous RNA. Bull Cancer. 2019 Nov 18;: Authors: Ye Y, Shen A, Liu A Abstract Long non-coding RNA (lncRNA) is a class of non-coding RNA with a length of more than 200 nucleotides, which has become a hotspot in the research of tumorigenesis and development in recent years. Accumulating studies have indicated that H19 is abnormally expressed in human malignant tumors, and regulates cell...
Sat Nov 23, 2019 14:39
21 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human homeostasis These pubmed results were generated on 2019/11/23PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sat Nov 23, 2019 14:35
We produced a guideline for management of functional constipation that provides evidence‐based practical algorithms for diagnosis and stepwise treatment of constipation in adults. Implementation of the guideline should improve and harmonize management of constipation across different countries. Abstract Introduction Chronic constipation is a common disorder with a reported prevalence ranging from 3% to 27% in the general population. Several management strategies, including diagnostic tests,...
Fri Nov 22, 2019 13:44
Abstract Although sleep hygiene is often used for broad sleep health promotion efforts, sleep hygiene education programmes are largely ineffective. These programmes are limited by their lack of a theoretical foundation. Health behaviour theory (HBT) has been used for decades to successfully predict and modify many health behaviours, but its use in the study of sleep health is rare. The purpose of this review is threefold. First, four dominant HBTs will be introduced. Second, the brief literature...
Fri Nov 22, 2019 18:43
Related ArticlesIn-Vitro Study of Urokinase Thrombolysis Following Stereotactic Aspiration of Intracerebral Hematoma. J Korean Neurosurg Soc. 2019 Nov 22;: Authors: Son W, Park J, Kang DH, Han YM, Choi YJ, Ohk B Abstract Objective: A consensus regarding the ideal regimen for urokinase (UK) thrombolysis subsequent to stereotactic spontaneous intracerebral hemorrhage aspiration has yet to be established. The purpose of this study is to evaluate the efficacy...
Sat Nov 23, 2019 14:32
Related ArticlesMethodological aspects of testing vestibular evoked myogenic potentials in infants at universal hearing screening program. Sci Rep. 2019 Nov 21;9(1):17225 Authors: Verrecchia L, Karpeta N, Westin M, Johansson A, Aldenklint S, Brantberg K, Duan M Abstract Motor development in infants is dependent upon the function of the inner ear balance organ (vestibular organ). Vestibular failure causes motor delays in early infancy and suboptimal motor...
Sat Nov 23, 2019 14:28
2745 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: medical science These pubmed results were generated on 2019/11/23PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sat Nov 23, 2019 14:27
22 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Future Oncology These pubmed results were generated on 2019/11/23PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sat Nov 23, 2019 14:24
22 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Future Oncology These pubmed results were generated on 2019/11/23PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sat Nov 23, 2019 13:24
Related ArticlesIntrigue: Phase III study of ripretinib versus sunitinib in advanced gastrointestinal stromal tumor after imatinib. Future Oncol. 2019 Nov 22;: Authors: Nemunaitis J, Bauer S, Blay JY, Choucair K, Gelderblom H, George S, Schöffski P, Mehren MV, Zalcberg J, Achour H, Ruiz-Soto R, Heinrich MC Abstract Ripretinib (DCC-2618) is a novel, type II tyrosine switch control inhibitor designed to broadly inhibit activating and drug-resistant mutations...
Sat Nov 23, 2019 14:20
Related ArticlesTongue involvement in embouchure dystonia: new piloting results using real-time MRI of trumpet players. J Clin Mov Disord. 2019;6:5 Authors: Hellwig SJ, Iltis PW, Joseph AA, Voit D, Frahm J, Schoonderwaldt E, Altenmüller E Abstract Background: The embouchure of trumpet players is of utmost importance for tone production and quality of playing. It requires skilled coordination of lips, facial muscles, tongue, oral cavity, larynx and breathing...
Sat Nov 23, 2019 14:19
Related ArticlesRecurrence in patients with benign paroxysmal positional vertigo of the lateral semicircular canal. Auris Nasus Larynx. 2019 Nov 19;: Authors: Ichijo H Abstract OBJECTIVES: There are 3 subtypes of lateral canal benign paroxysmal positional vertigo. Persistent geotropic positional nystagmus is due to a light cupula, heavy cupula produces apogeotropic positional nystagmus, and canalolithiasis accounts for transient geotropic positional...
Sat Nov 23, 2019 14:19
Related ArticlesPediatric thyroglossal duct cysts: Post-operative complications. Int J Pediatr Otorhinolaryngol. 2019 Sep;124:14-17 Authors: Lekkerkerker I, van Heurn EL, van der Steeg AF, Derikx JP Abstract INTRODUCTION: Thyroglossal duct cysts (TGDCs) result from incomplete involution of the thyroglossal duct and are resected with a Sistrunk-procedure. We studied and graded severity of postoperative complications in children who underwent this procedure,...
Sat Nov 23, 2019 14:19
Related ArticlesStatistical analysis of variability in TnSeq data across conditions using zero-inflated negative binomial regression. BMC Bioinformatics. 2019 Nov 21;20(1):603 Authors: Subramaniyam S, DeJesus MA, Zaveri A, Smith CM, Baker RE, Ehrt S, Schnappinger D, Sassetti CM, Ioerger TR Abstract BACKGROUND: Deep sequencing of transposon mutant libraries (or TnSeq) is a powerful method for probing essentiality of genomic loci under different environmental...
Sat Nov 23, 2019 14:14
Related ArticlesSIMLIN: a bioinformatics tool for prediction of S-sulphenylation in the human proteome based on multi-stage ensemble-learning models. BMC Bioinformatics. 2019 Nov 21;20(1):602 Authors: Wang X, Li C, Li F, Sharma VS, Song J, Webb GI Abstract BACKGROUND: S-sulphenylation is a ubiquitous protein post-translational modification (PTM) where an S-hydroxyl (-SOH) bond is formed via the reversible oxidation on the Sulfhydryl group of cysteine...
Sat Nov 23, 2019 14:14
Related ArticlesIdentification of native protein structures captured by principal interactions. BMC Bioinformatics. 2019 Nov 21;20(1):604 Authors: Mirzaie M Abstract BACKGROUND: Evaluation of protein structure is based on trustworthy potential function. The total potential of a protein structure is approximated as the summation of all pair-wise interaction potentials. Knowledge-based potentials (KBP) are one type of potential functions derived by known...
Sat Nov 23, 2019 14:14
Related ArticlesMultiplatform biomarker identification using a data-driven approach enables single-sample classification. BMC Bioinformatics. 2019 Nov 21;20(1):601 Authors: Zhang L, Thapa I, Haas C, Bastola D Abstract BACKGROUND: High-throughput gene expression profiles have allowed discovery of potential biomarkers enabling early diagnosis, prognosis and developing individualized treatment. However, it remains a challenge to identify a set of reliable...
Sat Nov 23, 2019 14:14
Publication date: Available online 22 November 2019Source: International ImmunopharmacologyAuthor(s): Somaye Sadeghi, Nariman Mosaffa, Seyed Mahmoud Hashemi, Mohammad Mehdi Naghizadeh, Tooba GhazanfariAbstractIntroductionSulfur Mustard (SM) is one of the most lethal chemicals with major complications manifested in the lungs. Although the pathogenesis behind SM-induced lung injury still remains poorly understood, prolonged activation and the imbalance of two major macrophage populations (M1 and M2)...
Sat Nov 23, 2019 14:09
Publication date: Available online 22 November 2019Source: International ImmunopharmacologyAuthor(s): Dianwen Xu, Juxiong Liu, He Ma, Wenjin Guo, Jiaxin Wang, Xingchi Kan, Yanwei Li, Qian Gong, Yu Cao, Ji Cheng, Shoupeng FuAbstractSchisandrin A (Sch A), a dibenzocyclooctadiene lignan extracted from Schisandra chinensis (Turcz.) Baill., has anti-oxidant and anti-inflammatory effects, but the effect on masitits has not been studied. Therefore, we investigated the effect of Sch A in cell and mouse models...
Sat Nov 23, 2019 14:09
Publication date: Available online 22 November 2019Source: International ImmunopharmacologyAuthor(s): Murat Çakır, Suat Tekin, Aslı Okan, Pınar Çakan, Züleyha DoğanyiğitAbstractUncontrolled infection and increased inflammatory mediators might cause systemic inflammatory response. It is already known that Cannabinoid Type 2 (CB2) receptors, which are commonly expressed in immune cells and in many other tissues, have an effect on the regulation of immune response. In the present study of ours, the...
Sat Nov 23, 2019 14:09
Related ArticlesExposure of Mactra corallina to acute doses of lead: effects on redox status, fatty acid composition and histomorphological aspect. Drug Chem Toxicol. 2019 Nov 22;:1-13 Authors: Chetoui I, Bejaoui S, Trabelsi W, Rabeh I, Nechi S, Chelbi E, Ghalghaf M, El Cafsi M, Soudani N Abstract The aim of this study is to elucidate the toxicity induced by PbCl2, administered in graded doses (1; 2.5; 5 mg/L), in the redox state, in the fatty acid composition...
Sat Nov 23, 2019 14:05
Publication date: Available online 23 November 2019Source: Allergology InternationalAuthor(s): Youin Bae, Sung Hun Kang, Ju Ok Park, Gyeong-Hun Park, Jeong-Hee Choi
Sat Nov 23, 2019 14:02
Publication date: Available online 22 November 2019Source: Allergology InternationalAuthor(s): Keisuke Sakai, Satoshi Fukushima, Satoru Mizuhashi, Masatoshi Jinnin, Takamitsu Makino, Yuji Inoue, Hironobu IhnAbstractBackgroundThe Japanese guidelines for the treatment of alopecia areata list topical immunotherapies as a drug therapy for this condition. However, there is insufficient evidence of its efficacy to support this recommendation. Thus, we sought to clarify the effect of topical immunotherapy...
Sat Nov 23, 2019 14:02
Related ArticlesDevelopment of the U.S. Army's Suicide Prevention Leadership Tool: The Behavioral Health Readiness and Suicide Risk Reduction Review (R4). Mil Med. 2019 Nov 22;: Authors: Curley JM, Penix EA, Srinivasan J, Sarmiento DM, McFarling LH, Newman JB, Wheeler LA Abstract INTRODUCTION: Although numerous efforts have aimed to reduce suicides in the U.S. Army, completion rates have remained elevated. Army leaders play an important role in supporting...
Sat Nov 23, 2019 16:07
Related ArticlesHistology of the vertebral artery-dural junction: relevance to posterolateral approaches to the skull base. J Neurosurg. 2019 Nov 22;:1-6 Authors: Rennert RC, Powers MP, Steinberg JA, Fukushima T, Day JD, Khalessi AA, Levy ML Abstract OBJECTIVE: The far-lateral and extreme-lateral infrajugular transcondylar-transtubercular exposure (ELITE) and extreme-lateral transcondylar transodontoid (ELTO) approaches provide access to lesions of the...
Sat Nov 23, 2019 15:59
Related ArticlesCombined Pterional Transsylvian and Bifrontal Interhemispheric Approach to a Ruptured Subcallosal and Pericallosal Brain Arteriovenous Malformation with Skeletonization of the Entire A2 ACA Segment. World Neurosurg. 2019 Nov 19;: Authors: Rubio RR, Dubnicoff T, Rutledge WC, Abla AA Abstract A 39-year-old man presented with a large left paramedian frontal lobe intracerebral hemorrhage (ICH). CT angiography and MR imaging revealed a tangle...
Sat Nov 23, 2019 15:59
Related ArticlesComparing endoscopic resection and open resection for management of sinonasal mucosal melanoma. Int Forum Allergy Rhinol. 2019 Nov 22;: Authors: Farber NI, Bavier RD, Crippen MM, Vatsa N, Hsueh WD, Eloy JA Abstract BACKGROUND: Sinonasal mucosal melanoma (SMM) is a rare, aggressive cancer, optimally managed with complete surgical resection. This study aimed to assess the impact of surgical approach on outcomes by comparison of cases managed...
Sat Nov 23, 2019 15:59
Related ArticlesLack of additive benefit of oral steroids on short-term postoperative outcomes in nasal polyposis. Laryngoscope. 2019 Nov 22;: Authors: Arancibia C, Langdon C, Mullol J, Alobid I Abstract OBJECTIVES: There is a lack of evidence concerning the efficacy of oral corticosteroids (OCS) as a postoperative treatment for patients with chronic rhinosinusitis with nasal polyps (CRSwNP). The objective of our study was to determine the short-term...
Sat Nov 23, 2019 15:59
Related ArticlesSuper-resolution Diffusion Tensor Imaging for Delineating the Facial Nerve in Patients with Vestibular Schwannoma. J Neurol Surg B Skull Base. 2019 Dec;80(6):648-654 Authors: Epprecht L, Kozin ED, Piccirelli M, Kanumuri VV, Tarabichi O, Remenschneider A, Barker FG, McKenna MJ, Huber AM, Cunnane ME, Reinshagen KL, Lee DJ Abstract Objectives Predicting the course of cranial nerves (CNs) VII and VIII in the cerebellopontine angle on preoperative...
Sat Nov 23, 2019 13:58
Related ArticlesImproved Surgical Safety via Intraoperative Navigation for Transnasal Transsphenoidal Resection of Pituitary Adenomas. J Neurol Surg B Skull Base. 2019 Dec;80(6):626-631 Authors: Achey RL, Karsy M, Azab MA, Scoville J, Kundu B, Bowers CA, Couldwell WT Abstract Objectives Intraoperative navigation during neurosurgery can aid in the detection of critical structures and target lesions. The safety and efficacy of intraoperative, stereotactic...
Sat Nov 23, 2019 13:58
Related ArticlesAudit of Complications in an Otolaryngology Led Skull-Base Surgical Practice. J Neurol Surg B Skull Base. 2019 Dec;80(6):586-592 Authors: Patnaik U, Panda S, Thakar A Abstract Objective This study was aimed to classify and study complications of surgery of the cranial base, primarily from an otorhinolaryngology perspective. Design This study was designed with consecutive cohort of skull base surgical cases. Setting Tertiary referral...
Sat Nov 23, 2019 13:58
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