Related ArticlesSuper-resolution Diffusion Tensor Imaging for Delineating the Facial Nerve in Patients with Vestibular Schwannoma. J Neurol Surg B Skull Base. 2019 Dec;80(6):648-654 Authors: Epprecht L, Kozin ED, Piccirelli M, Kanumuri VV, Tarabichi O, Remenschneider A, Barker FG, McKenna MJ, Huber AM, Cunnane ME, Reinshagen KL, Lee DJ Abstract Objectives Predicting the course of cranial nerves (CNs) VII and VIII in the cerebellopontine angle on preoperative...
Sat Nov 23, 2019 13:58
Related ArticlesImproved Surgical Safety via Intraoperative Navigation for Transnasal Transsphenoidal Resection of Pituitary Adenomas. J Neurol Surg B Skull Base. 2019 Dec;80(6):626-631 Authors: Achey RL, Karsy M, Azab MA, Scoville J, Kundu B, Bowers CA, Couldwell WT Abstract Objectives Intraoperative navigation during neurosurgery can aid in the detection of critical structures and target lesions. The safety and efficacy of intraoperative, stereotactic...
Sat Nov 23, 2019 13:58
Related ArticlesAudit of Complications in an Otolaryngology Led Skull-Base Surgical Practice. J Neurol Surg B Skull Base. 2019 Dec;80(6):586-592 Authors: Patnaik U, Panda S, Thakar A Abstract Objective This study was aimed to classify and study complications of surgery of the cranial base, primarily from an otorhinolaryngology perspective. Design This study was designed with consecutive cohort of skull base surgical cases. Setting Tertiary referral...
Sat Nov 23, 2019 13:58
Related ArticlesGeographical Differences in Intracranial Meningioma Management: Examining 65,973 Patients across the United States. J Neurol Surg B Skull Base. 2019 Dec;80(6):547-554 Authors: Anzalone CL, Glasgow A, Habermann E, Grossard BR, Van Gompel JJ, Carlson ML Abstract Background Age, tumor size and location, overall health, and patient preference are primary considerations driving treatment decision-making for intracranial meningiomas. However,...
Sat Nov 23, 2019 13:58
Related ArticlesThe preliminary results of proton and carbon ion therapy for chordoma and chondrosarcoma of the skull base and cervical spine. Radiat Oncol. 2019 Nov 21;14(1):206 Authors: Guan X, Gao J, Hu J, Hu W, Yang J, Qiu X, Hu C, Kong L, Lu JJ Abstract PURPOSE: To evaluate the short-term outcomes in terms of tumor control and toxicity of patients with skull base or cervical spine chordoma and chondrosarcoma treated with intensity-modulated proton...
Sat Nov 23, 2019 13:58
Related Articles[Pituitary gland tumors]. Radiologe. 2019 Nov;59(11):982-991 Authors: Karimian-Jazi K Abstract BACKGROUND: In this article, the most common pituitary gland tumors and the various differential diagnoses with focus on (neuro-)radiological diagnostic criteria are presented. MATERIALS AND METHODS: An intensive, selective search of the literature in PubMed was carried out. RESULTS: Pituitary adenomas account for approximately...
Sat Nov 23, 2019 13:58
Related ArticlesDefining the Zygomaticosphenoidal Angle as a Guide to Anatomic Zygomaticomaxillary Complex Fracture Reduction. J Craniofac Surg. 2019 Oct;30(7):2030-2033 Authors: De Ruiter BJ, Levin A, Nash D, Kamel G, Mostafa E, Baghdasarian D, Davidson EH Abstract BACKGROUND: Alignment of the zygomaticosphenoid suture is fundamental to reduction of zygomaticomaxillary complex fractures. To prevent a rotational deformity, the correct angle of the zygoma...
Sat Nov 23, 2019 13:58
Related ArticlesThe Cooperative Effect between Polybasic Region (PBR) and Polysialyltransferase Domain (PSTD) within Tumor-Target Polysialyltranseferase ST8Sia II. Curr Top Med Chem. 2019 Nov 21;: Authors: Zhou GP, Liao SM, Chen D, Huang RB Abstract ST8Sia II (STX) is a highly homologous mammalian polysialyltransferases (polyST), which is validated tumor-target in the treatment of cancer metastasis reliant on tumor cell polysialylation. PolyST catalyze...
Sat Nov 23, 2019 15:52
Related ArticlesSalivary mir-27b expression in oral lichen planus patients: a series of cases and a narrative review of litterature. Curr Top Med Chem. 2019 Nov 21;: Authors: Stasio DD, Mosca L, Lucchese A, Cave DD, Kawasaki H, Lombardi A, Porcelli M, Caraglia M Abstract BACKGROUND: microRNAs play a critical role in auto-immunity, cell proliferation, differentiation and cell death. miRNAs are present in all biological fluids, and their expression is...
Sat Nov 23, 2019 15:52
Related ArticlesAtomic Force Microscopy: The Characterisation of Amyloid Protein Structure in Pathology. Curr Top Med Chem. 2019 Nov 21;: Authors: Visser MJ, Pretorius E Abstract Proteins are versatile macromolecules that perform a variety of functions and participate in virtually all cellular processes. The functionality of a protein greatly depends on its structure and alterations may result in the development of disease states. Most well-known of...
Sat Nov 23, 2019 15:52
Related ArticlesAntibacterial Activity of Cissus incisa Extracts against Multidrug-Resistant Bacteria. Curr Top Med Chem. 2019 Nov 21;: Authors: Nocedo-Mena D, Garza-González E, González-Ferrara M, Camacho-Corona MDR Abstract AIMS: The need to find new antimicrobial agents to cope with this phenomenon increases. BACKGROUND: Infection diseases are illness caused by different microorganisms, such as bacteria, among those caused by resistant bacteria...
Sat Nov 23, 2019 15:52
Related Articles[Application of surface electromyography in children with dysphagia]. Zhongguo Dang Dai Er Ke Za Zhi. 2019 Nov;21(11):1089-1093 Authors: He JH, Zhang J, Yuan LP, Qin R, Liu H, Duan YQ, Zhou HT, Xiong YJ Abstract OBJECTIVE: To study the application value of surface electromyography in children with dysphagia. METHODS: A total of 20 children with dysphagia were enrolled as the observation group, and 20 healthy children, matched...
Sat Nov 23, 2019 13:56
Related ArticlesStarvation Ketoacidosis due to the Ketogenic Diet and Prolonged Fasting - A Possibly Dangerous Diet Trend. Am J Case Rep. 2019 Nov 22;20:1728-1731 Authors: Blanco JC, Khatri A, Kifayat A, Cho R, Aronow WS Abstract BACKGROUND The low-carbohydrate, high-fat ketogenic diet has been popularized in the press recently, touting multiple health benefits such as weight loss and increased energy. In this diet, participants intentionally push themselves...
Sat Nov 23, 2019 15:51
Related ArticlesSuccessful Treatment of Hypokalemic Rhabdomyolysis Caused by a Pancreatic VIPoma: A Case Report. Am J Case Rep. 2019 Nov 22;20:1723-1727 Authors: Ramirez S, Lytle M, Togores E, Parellada J, Carlan SJ, Madruga M, Murillo-Alvarez RM Abstract BACKGROUND VIPomas are rare neuroendocrine tumors typically located in the pancreas. The majority of cases autonomously secret vasoactive intestinal polypeptide (VIP), which can result in profuse, refractory,...
Sat Nov 23, 2019 13:53
Related ArticlesStructural analysis and potential anti-tumor activity of Sporisorium reilianum (Fries) polysaccharide. Int J Biol Macromol. 2019 Nov 19;: Authors: Kan L, Chai Y, Li X, Zhao M Abstract A neutral polysaccharide WM-NP-60 was successfully isolated and purified from a phytopathogenic fungus Sporisorium reilianum (Fries). The characteristics and potential antitumor activities of WM-NP-60 were studied. WM-NP-60 was a water-soluble polysaccharide....
Sat Nov 23, 2019 14:45
Related ArticlesTriptolide inhibits PDGF-induced proliferation of ASMCs through G0/G1 cell cycle arrest and suppression of the AKT/NF-κB/cyclinD1 signaling pathway. Eur J Pharmacol. 2019 Nov 19;:172811 Authors: He S, Chen M, Lin X, Lv Z, Liang R, Huang L Abstract Abnormal proliferation of airway smooth muscle cells (ASMCs) is a hallmark of airway remodeling. Platelet-derived growth factor (PDGF) is known to be a major stimulus inducing the proliferation...
Sat Nov 23, 2019 14:45
Related ArticlesClioquinol induces S-phase cell cycle arrest through the elevation of the calcium level in human neurotypic SH-SY5Y cells. Metallomics. 2019 Nov 22;: Authors: Lv X, Zheng Q, Li M, Huang Z, Peng M, Sun J, Shi P Abstract Clioquinol is recently considered to be the most promising drug for treating cancer and neurodegenerative diseases. However, its mode of action varies from different disease models. In this study, we found that clioquinol...
Sat Nov 23, 2019 14:45
Related ArticlesDeglucohellebrin. A Potent Agent for Glioblastoma Treatment. Anticancer Agents Med Chem. 2019 Nov 20;: Authors: Vartholomatos E, Alexiou GA, Markopoulos GS, Lazari D, Tsiftsoglou O, Chousidis I, Leonardos I, Kyritsis AP Abstract BACKGROUND: Glioblastoma is the most common primary brain tumor in adults with dismal prognosis. To date several anticancer agents have been isolated from plants. Helleborus odorus subsp. Cyclophyllus is an endemic...
Sat Nov 23, 2019 14:45
Related ArticlesTherapeutic potential of quercetin on human breast cancer in different dimensions. Inflammopharmacology. 2019 Nov 21;: Authors: Kasiri N, Rahmati M, Ahmadi L, Eskandari N, Motedayyen H Abstract BACKGROUND: There has been an extensive range of incidence and mortality of breast cancer (BC), and the comprehensively available treatments for BC have not been completely successful in achieving satisfactory outcomes up to date. HYPOTHESIS:...
Sat Nov 23, 2019 13:47
Related ArticlesCACYBP Enhances Cytoplasmic Retention of P27Kip1 to Promote Hepatocellular Carcinoma Progression in the Absence of RNF41 Mediated Degradation. Theranostics. 2019;9(26):8392-8408 Authors: Lian YF, Huang YL, Zhang YJ, Chen DM, Wang JL, Wei H, Bi YH, Jiang ZW, Li P, Chen MS, Huang YH Abstract Calcyclin-binding protein (CACYBP) is a multi-ligand protein implicated in the progression of various human cancers. However, its function in hepatocellular...
Sat Nov 23, 2019 13:47
Related ArticlesTumor suppressive BTB/POZ zinc-finger protein ZBTB28 inhibits oncogenic BCL6/ZBTB27 signaling to maintain p53 transcription in multiple carcinogenesis. Theranostics. 2019;9(26):8182-8195 Authors: Xiang T, Tang J, Li L, Peng W, Du Z, Wang X, Li Q, Xu H, Xiong L, Xu C, Le X, Wei X, Yu F, Li S, Xiao Q, Luo B, Xiang X, Huang A, Lin Y, Ren G, Tao Q Abstract Zinc-finger and BTB/POZ domain-containing family proteins (ZBTB) are important transcription...
Sat Nov 23, 2019 13:47
Related ArticlesMicheliolide Inhibits Liver Cancer Cell Growth Via Inducing Apoptosis And Perturbing Actin Cytoskeleton. Cancer Manag Res. 2019;11:9203-9212 Authors: Yu L, Chen W, Tang Q, Ji KY Abstract Purpose: Micheliolide (MCL) is an effector compound of the flower which has been traditionally used to treat inflammation and cancer patients in oriental medicine. MCL has killing effects on several cancer and immune cells by modulating apoptosis, cell...
Sat Nov 23, 2019 13:47
Related ArticlesDesign, synthesis and biological evaluation of novel indole-based oxalamide and aminoacetamide derivatives as tubulin polymerization inhibitors. Bioorg Med Chem Lett. 2019 Nov 11;:126816 Authors: Diao PC, Jian XE, Chen P, Huang C, Yin J, Huang JC, Li JS, Zhao PL Abstract A series of novel indole-based oxalamide and aminoacetamide derivatives were designed, synthesized, and evaluated for antiproliferative activities. Preliminary results...
Sat Nov 23, 2019 13:47
Related ArticlesSynthesis and characterization of thiosemicarbazone-functionalized organoruthenium (II)-arene complexes: Investigation of antitumor characteristics in colorectal cancer cell lines. Mater Sci Eng C Mater Biol Appl. 2020 Jan;106:110152 Authors: Subasi E, Atalay EB, Erdogan D, Sen B, Pakyapan B, Kayali HA Abstract In the current study, organoruthenium(II)-arene complexes (I-IV) have been prepared by the reaction of [{(η6-p-cym)RuCl}2(μ-Cl)2]...
Sat Nov 23, 2019 13:47
Related ArticlesCurcumin Nicotinate Selectively Induces Cancer Cell Apoptosis and Cycle Arrest through a P53-Mediated Mechanism. Molecules. 2019 Nov 18;24(22): Authors: He YC, He L, Khoshaba R, Lu FG, Cai C, Zhou FL, Liao DF, Cao D Abstract Curcumin is an anticancer agent, but adverse effects and low bioavailability are its main drawbacks, which drives efforts in chemical modifications of curcumin. This study evaluated antiproliferative activity and...
Sat Nov 23, 2019 13:47
Related ArticlesApoptotic potential and chemical composition of Jordanian propolis extract against different cancer cell lines. J Microbiol Biotechnol. 2019 Nov 22;: Authors: Abutaha N Abstract Propolis is a resinous substance that is collected by Apis mellifera from plant sources and is used in traditional medicine. To study the phytochemical constituents and apoptotic potential of Jordanian propolis extract against different cancer cell lines. Propolis...
Sat Nov 23, 2019 13:47
Related ArticlesPolη, a Y-family translesion synthesis polymerase, promotes cellular tolerance of Myc-induced replication stress. J Cell Sci. 2018 06 25;131(12): Authors: Kurashima K, Sekimoto T, Oda T, Kawabata T, Hanaoka F, Yamashita T Abstract Growth of precancerous and cancer cells relies on their tolerance of oncogene-induced replication stress (RS). Translesion synthesis (TLS) plays an essential role in the cellular tolerance of various types...
Sat Nov 23, 2019 13:47
Related ArticlesThe Water Footprint of Diets: A Global Systematic Review and Meta-analysis. Adv Nutr. 2019 Sep 06;: Authors: Harris F, Moss C, Joy EJM, Quinn R, Scheelbeek PFD, Dangour AD, Green R Abstract Agricultural water requirements differ between foods. Population-level dietary preferences are therefore a major determinant of agricultural water use. The "water footprint" (WF) represents the volume of water consumed in the production of food items,...
Sat Nov 23, 2019 15:38
Related ArticlesPerspective: The Role of Beverages as a Source of Nutrients and Phytonutrients. Adv Nutr. 2019 Nov 22;: Authors: Ferruzzi MG, Tanprasertsuk J, Kris-Etherton P, Weaver CM, Johnson EJ Abstract The Dietary Guidelines for Americans (DGA) provide nutrition advice for Americans >2 y of age. The 2020-2025 DGA proposes a life stage approach, focusing on birth through older adulthood. Limited recommendations for beverages exist except for milk,...
Sat Nov 23, 2019 15:38
Related ArticlesThe Differential Diagnosis of Reparative Changes and Malignancy: Performance in the College of American Pathologists Pap Education and Proficiency Testing Programs. Arch Pathol Lab Med. 2019 Nov 22;: Authors: Staats PN, Souers RJ, Nunez AL, Li Z, Kurtycz DFI, Goodrich K, Witt BL, Davey DD, Booth CN Abstract CONTEXT.—: Repair is a challenging diagnosis and a significant source of false-positive (FP) interpretations in cervical cytology....
Sat Nov 23, 2019 15:48
Related ArticlesEvaluating Novel Markers for Specimen Validity Testing. Arch Pathol Lab Med. 2019 Nov 22;: Authors: Kyle PB, Kaur J Abstract CONTEXT.—: Synthetic urine products are commercially marketed for the purpose of specimen substitution for urine drug screens. These products are widely popular because they yield negative drug screen results, meet criteria for specimen validity testing, and are easily accessible and affordable. Current specimen...
Sat Nov 23, 2019 15:48
Related ArticlesClinicopathologic and Prognostic Significance of Gallbladder and Cystic Duct Invasion in Distal Bile Duct Carcinoma. Arch Pathol Lab Med. 2019 Nov 22;: Authors: Jun SY, An S, Sung YN, Park Y, Lee JH, Hwang DW, Hong SM Abstract CONTEXT.—: The roles of the gallbladder and cystic duct (CD) invasions in distal bile duct carcinoma (DBDC) have not been well elucidated. OBJECTIVE.—: To define the characteristics and prognostic significance...
Sat Nov 23, 2019 15:48
Related ArticlesImproving Patient Experience of Wait Times and Courtesy Through Electronic Sign-in and Notification in the Phlebotomy Clinic. Arch Pathol Lab Med. 2019 Nov 22;: Authors: Le V, Wagar EA, Phipps RA, Del Guidice RE, Le H, Middleton LP Abstract CONTEXT.—: The phlebotomy clinic, which sees on average 900 patients a day, was faced with issues of congestion and noise due to inefficient workflow and processes. The staff called out each patient...
Sat Nov 23, 2019 15:48
Abstract Ubrogepant (MK‐1602) is a novel, oral, calcitonin gene‐related peptide receptor antagonist in clinical development with positive Phase III outcomes for acute treatment of migraine. This paper describes the population exposure‐response (E‐R) modeling and simulations which were used to inform the Phase III dose‐selection rationale, based on approximately 800 participants pooled across two Phase IIb randomized dose‐finding clinical trials. The E‐R model describes the placebo and ubrogepant...
Sat Nov 23, 2019 11:46
Abstract We aimed to estimate the utility of panel‐based pharmacogenetic testing of patients undergoing percutaneous coronary intervention (PCI). Utilization of Clinical Pharmacogenetic Implementation Consortium (CPIC) level A/B drugs after PCI was estimated in a national sample of IBM MarketScan beneficiaries. Genotype data from University of Florida (UF) PCI patients (n=211) were used to project genotype‐guided opportunities among MarketScan beneficiaries with at least one‐ (N=105,547) and five‐(N=12,462)...
Sat Nov 23, 2019 11:45
Abstract A novel Pseudoalteromonas atlantica phage C7 was isolated from the coastal surface water in the Yellow Sea of China using the agar overlay method. Transmission electron microscopy analysis reveals that it belongs to Siphoviridae with a head of 56 nm in diameter and a tail of 102 nm in length. Microbiological characterization suggests that the phage is stable at a range of temperatures (from − 20 to 65 °C) and the optimal pH range is 6–12. One-step growth curve shows a...
Sat Nov 23, 2019 02:00
Abstract Introduction In the 4DCT era, the definition of lung organ‐at‐risk (OAR) volumes for dose–volume histogram (DVH) calculation is unclear, introducing potential for variability in practice. We aimed to identify definitions used clinically and evaluate the magnitude of DVH differences between these. Methods We surveyed Australian & New Zealand departments about lung radiotherapy protocols including lung OAR volume definition. We used these definitions to calculate lung DVHs on...
Fri Nov 22, 2019 14:03
Related ArticlesOur experience of a paediatrician-led clinic for the medical management of children with obstructive sleep disordered breathing. Clin Otolaryngol. 2019 Nov 22;: Authors: Kubba H, Rowe K, Pinczower G, Sloan R, Waterham M, Weiss E, Harwood R Abstract BACKGROUND: Obstructive sleep disordered breathing (OSDB) is very common in children. Adenotonsillectomy is usually curative, but there is emerging evidence that topical nasal steroids can...
Sat Nov 23, 2019 15:06
Related ArticlesTapentadol prolonged release for pain control in a frail obese patient: a case report. Eur Rev Med Pharmacol Sci. 2019 Nov;23(4 Suppl):51-54 Authors: Iapichino MC Abstract We present the case of a 59-year-old woman with third-grade obesity and severe comorbidities including osteoporosis, dyslipidemia, diabetes mellitus, hypertension, night eating following bariatric biliary-intestinal bypass surgery, severe fibromyalgia, poly-arthrosis,...
Sat Nov 23, 2019 13:38
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