Related ArticlesPrevalence, morphology, and morphometry of the pterygospinous bar: a meta-analysis. Surg Radiol Anat. 2019 Aug 28;: Authors: Henry BM, Pękala PA, Frączek PA, Pękala JR, Natsis K, Piagkou M, Tomaszewski KA, Tomaszewska IM Abstract PURPOSE: The purpose of the study was to analyze the total prevalence, morphologic, and morphometric characteristics of the pterygospinous (PS) bar and its gender and ethnic differences among populations. PS...
Fri Aug 30, 2019 13:04
Related ArticlesMorphometric evaluation of the pterygoid hamulus and upper airway in patients with obstructive sleep apnea syndrome. Surg Radiol Anat. 2019 Aug 30;: Authors: Kuzucu I, Parlak IS, Baklaci D, Guler I, Kum RO, Ozcan M Abstract PURPOSE: Many anatomical factors are known to cause obstructive sleep apnea syndrome (OSAS), but only few studies have examined the relationship between the morphology of pterygoid hamulus (PH), upper airway, and OSAS...
Sun Sep 01, 2019 13:02
Related ArticlesIliocapsularis muscle in human fetuses. Surg Radiol Anat. 2019 Aug 30;: Authors: Elvan Ö, Aktekin M, Şengezer E, Olgunus ZK, Bayramoğlu A Abstract PURPOSE: To determine the incidence of the iliocapsularis muscle in fetal period and its relationship with the hip joint capsule. METHODS: Twenty-one formalin-fixed fetuses (12 female and 9 male) with a mean gestational age of 29 ± 3.89 weeks (range 25-36) were dissected to reveal...
Sun Sep 01, 2019 13:02
Related ArticlesTherapeutic nihilism of neurological diseases: A comparative qualitative study. J Clin Neurosci. 2019 Aug 26;: Authors: Sedney C, Kurowski-Burt A, Smith M, Dekeseredy P, Grey C, Boo S Abstract OBJECTIVE: The notion of therapeutic nihilism may lead to early removal of care based upon perceived poor prognosis. The goal of this study was to examine if differences for nihilism perspectives exist between professions and within professions...
Sat Aug 31, 2019 14:50
Related ArticlesContinuous intrathecal injection therapy of methotrexate is a therapeutic option in primary CNS lymphoma. J Clin Neurosci. 2019 Aug 26;: Authors: Otani R, Yamada R, Kushihara Y, Inazuka M, Shinoura N Abstract Primary central nervous system lymphoma (PCNSL) is a rare subtype of non-Hodgkin's lymphoma, and its prognosis is still very poor despite the conventional therapy of high-dose methotrexate (HD-MTX) followed by whole-brain radiation...
Sat Aug 31, 2019 14:50
Related ArticlesThe efficacy and safety of lamotrigine for absence seizures in children and adolescents: A systematic review and meta-analysis. J Clin Neurosci. 2019 Aug 26;: Authors: Cao J, Lin XX, Ma XM, Liu H Abstract AIMS: This systematic review and meta-analysis of randomized controlled trials (RCTs) systematically explored the effectiveness and safety of lamotrigine for absence seizures in children and adolescents. METHODS: Keywords searches...
Sat Aug 31, 2019 14:50
Related ArticlesCognitive decline is not influenced by the marital status or living arrangements in community-dwelling adults living in a rural setting. A population-based prospective cohort study. J Clin Neurosci. 2019 Aug 26;: Authors: Del Brutto OH, Mera RM, Zambrano M Abstract Little is known on factors influencing cognitive decline in rural communities. Using the Atahualpa Project cohort, we aimed to assess whether the marital status or living arrangements...
Sat Aug 31, 2019 14:50
Related ArticlesPredictive measures and outcomes of extent of resection in juvenile pilocytic astrocytoma. J Clin Neurosci. 2019 Aug 26;: Authors: Maharaj A, Manoranjan B, Verhey LH, Fleming AJ, Farrokhyar F, Almenawer S, Singh SK, Yarascavitch B Abstract PURPOSE: The present study aims to determine the tumor-related, clinical, and demographic factors associated with extent of resection (EOR) and post-operative outcomes in JPA patients. METHODS:...
Sat Aug 31, 2019 14:50
Related ArticlesA preliminary data: Evaluation of serum Galectin-3 levels in patients with Idiopathic Parkinson's Disease. J Clin Neurosci. 2019 Aug 27;: Authors: Yazar HO, Yazar T, Cihan M Abstract AIM: In our study, we aimed to collect data for the hypothesis that Galectin-3 might be used as a new prognostic and therapeutic biomarker in Idiopathic Parkinson's Disease (IPD). METHOD: In this prospective and cross-sectional study, the Unified...
Sun Sep 01, 2019 13:07
Related ArticlesClinical outcomes of moderate to severe acute ischemic stroke in a telemedicine network. J Clin Neurosci. 2019 Aug 27;: Authors: Sinha K, Bettermann K Abstract Acute ischemic strokes (AIS) with severe neurologic deficits are associated with poor short- and long-term prognosis. Thrombectomy alone or in combination with thrombolysis is used for reperfusion in patients with moderate-to-severe AIS. However, the best therapeutic approach within...
Sun Sep 01, 2019 13:07
Related ArticlesClinical characteristics and treatment outcomes among stroke patients hospitalized to Nekemte referral hospital, western Ethiopia. J Clin Neurosci. 2019 Aug 27;: Authors: Fekadu G, Adola B, Mosisa G, Shibiru T, Chelkeba L Abstract OBJECTIVES: Stroke is the brain equivalent of a heart attack. It is one of the most common causes of morbidity and mortality worldwide and is a prominent cause of death, disability and dementia in sub-Saharan...
Sun Sep 01, 2019 13:07
Related ArticlesCancer immunotherapy may have a dark side. Science. 2019 03 29;363(6434):1377 Authors: Kaiser J PMID: 30923204 [PubMed - indexed for MEDLINE]
Fri Aug 30, 2019 13:36
Related ArticlesAvicularin ameliorates human hepatocellular carcinoma via the regulation of NF‑κB/COX‑2/PPAR‑γ activities. Mol Med Rep. 2019 Jun;19(6):5417-5423 Authors: Wang Z, Li F, Quan Y, Shen J Abstract Hepatocellular carcinoma (HCC) has become a global public health problem. Therefore, the development of novel and effective therapeutic agents for the treatment of HCC is considered an emergency. Avicularin, a bio‑active flavonoid from plants, has...
Fri Aug 30, 2019 13:36
Related ArticlesCo-SLD suppressed the growth of oral squamous cell carcinoma via disrupting mitochondrial function. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):1746-1757 Authors: Li S, Li G, Zhang T, Li J, Zhao Q, Zhang B, Wang R, Zhou R, Si J, Gan L, Liu Y, Zhang H, Liu B Abstract To evaluate the safety and efficacy of novel cobalt complex with sulindac (Co-SLD), the zebrafish and oral squamous cell carcinoma CAL27 were investigated in the present...
Fri Aug 30, 2019 13:36
Related ArticlesDesign, synthesis, antitumor activities and biological studies of novel diaryl substituted fused heterocycles as dual ligands targeting tubulin and katanin. Eur J Med Chem. 2019 Sep 15;178:177-194 Authors: Gao F, Liang Y, Zhou P, Cheng J, Ding K, Wang Y Abstract Microtubule is one of the important targets for cancer treatment. A novel class of diaryl substituted imidazo[4,5-c]pyridin-2-ones and imidazo[4,5-c]pyridines were designed based...
Fri Aug 30, 2019 13:36
Related ArticlesNew e:b-Friedo-Hopane Type Triterpenoids from Euphorbia peplus with Simiarendiol Possessing Significant Cytostatic Activity against HeLa Cells by Induction of Apoptosis and S/G2 Cell Cycle Arrest. Molecules. 2019 Aug 27;24(17): Authors: Yu JH, Wu DX, Yu ZP, Li YP, Wang YY, Yu SJ, Zhang H Abstract Seven rare e:b-friedo-hopane-type triterpenoids including four new (1-4) and three known (5-7) ones with 5 being first reported as a natural...
Fri Aug 30, 2019 13:36
Related ArticlesOrientin Induces G0/G1 Cell Cycle Arrest and Mitochondria Mediated Intrinsic Apoptosis in Human Colorectal Carcinoma HT29 Cells. Biomolecules. 2019 Aug 27;9(9): Authors: Thangaraj K, Balasubramanian B, Park S, Natesan K, Liu W, Manju V Abstract Colorectal carcinoma is one of the utmost diagnosed cancer with a steep increase in mortality rate. The incidence has been increasing in developing countries like India due to a westernization...
Fri Aug 30, 2019 13:36
Related ArticlesBerberine and palmatine inhibit the growth of human rhabdomyosarcoma cells. Biosci Biotechnol Biochem. 2019 Aug 29;:1-13 Authors: Shinji S, Nakamura S, Nihashi Y, Umezawa K, Takaya T Abstract A natural isoquinoline alkaloid, berberine, has been known to exhibit anti-tumor activity in various cancer cells via inducing cell cycle arrest. However, it has not been investigated whether berberine and its analogs inhibit the growth of rhabdomyosarcoma...
Fri Aug 30, 2019 13:36
Related ArticlesNPM1 as a potential therapeutic target for atypical teratoid/rhabdoid tumors. BMC Cancer. 2019 Aug 28;19(1):848 Authors: Phi JH, Sun CH, Lee SH, Lee S, Park I, Choi SA, Park SH, Lee JY, Wang KC, Kim SK, Yun H, Park CK Abstract BACKGROUND: Atypical teratoid/rhabdoid tumors (AT/RTs) are highly malignant brain tumors with inactivation of the SMARCB1 gene, which play a critical role in genomic transcriptional control. In this study, we analyzed...
Fri Aug 30, 2019 13:36
Related ArticlesDiscovery and antiproliferative evaluation of new quinoxalines as potential DNA intercalators and topoisomerase II inhibitors. Arch Pharm (Weinheim). 2019 Aug 29;:e1900123 Authors: Eissa IH, Metwaly AM, Belal A, Mehany ABM, Ayyad RR, El-Adl K, Mahdy HA, Taghour MS, El-Gamal KMA, El-Sawah ME, Elmetwally SA, Elhendawy MA, Radwan MM, ElSohly MA Abstract In continuation of our previous work on the design and synthesis of topoisomerase II...
Fri Aug 30, 2019 13:36
Related ArticlesSNAIL1 employs β-Catenin-LEF1 complexes to control colorectal cancer cell invasion and proliferation. Int J Cancer. 2019 Aug 28;: Authors: Freihen V, Rönsch K, Mastroianni J, Frey P, Rose K, Boerries M, Zeiser R, Busch H, Hecht A Abstract The transcription factor SNAIL1 is a master regulator of epithelial-to-mesenchymal transition, a process entailing massive gene expression changes. To better understand SNAIL1-induced transcriptional...
Fri Aug 30, 2019 13:36
Related ArticlesResveratrol induces apoptosis of benign prostatic hyperplasia epithelial cell line (BPH-1) through p38 MAPK-FOXO3a pathway. BMC Complement Altern Med. 2019 Aug 29;19(1):233 Authors: Li C, Hu WL, Lu MX, Xiao GF Abstract BACKGROUND: Resveratrol is reported to inhibit the growth of prostate, which is characteristic of benign prostatic hyperplasia (BPH) condition. However, the mechanism remains unclear. This study aimed to identify the effects...
Fri Aug 30, 2019 14:36
Related ArticlesLycorine Induces Apoptosis and G1 Phase Arrest Through ROS/p38 MAPK Signaling Pathway in Human Osteosarcoma cells in vitro and in vivo. Spine (Phila Pa 1976). 2019 Aug 27;: Authors: Ning L, Wan S, Jie Z, Xie Z, Li X, Pan X, Wan X, Chen W, Huang H, Wang J, Qin A, Fan S, Zhao X Abstract STUDY DESIGN: Xenograft osteosarcoma mouse model. OBJECTIVE: We determined the effect of lycorine on osteosarcoma. SUMMARY OF BACKGROUND...
Fri Aug 30, 2019 14:36
Related ArticlesBiological evaluation of optically pure chiral binuclear copper(ii) complexes based on a rosin derivative as highly potential anticancer agents. Dalton Trans. 2019 Aug 29;: Authors: Fei BL, Tu S, Wei Z, Wang P, Long JY, Qiao C, Chen ZF Abstract Two optically pure chiral binuclear copper(ii) complexes [Cu2(μ-Cl)2L2]·CH2Cl2 (1) and Cu2L4 (2) based on the natural product rosin derivative N-(5-dehydroabietyl-1,3,4-thiadiazole)-2-substituted...
Fri Aug 30, 2019 14:36
Related ArticlesMolecular Mechanisms Underlying Cancer Preventive and Therapeutic Potential of Algal Polysaccharides. Curr Pharm Des. 2019;25(11):1210-1235 Authors: Sajadimajd S, Momtaz S, Haratipour P, El-Senduny FF, Panah AI, Navabi J, Soheilikhah Z, Farzaei MH, Rahimi R Abstract BACKGROUND: Algal polysaccharide and oligosaccharide derivatives have been shown to possess a variety of therapeutic potentials and drug delivery applications. Algal polysaccharides...
Fri Aug 30, 2019 14:36
Alphavbeta3 integrin blocking inhibits apoptosis and induces autophagy in murine breast tumor cells.
Related ArticlesAlphavbeta3 integrin blocking inhibits apoptosis and induces autophagy in murine breast tumor cells. Biochim Biophys Acta Mol Cell Res. 2019 Aug 26;:118536 Authors: Lino RLB, Dos Santos PK, Pisani GFD, Altei WF, Cominetti MR, Selistre-de-Araújo HS Abstract Integrins are cell receptors that mediate adhesion to the extracellular matrix (ECM) and regulate cell migration, a crucial process in tumor invasion. The αvβ3 integrin recognizes the...
Fri Aug 30, 2019 14:36
Related ArticlesDesign, synthesis, anti-inflammatory, cytotoxic and cell based studies of some novel side chain analogues of myrrhanones A & B isolated from the gum resin of Commiphora mukul. Bioorg Chem. 2019 02;82:306-323 Authors: Mallavadhani UV, Chandrashekhar M, Shailaja K, Ramakrishna S Abstract Myrrhanones A (1) and B (2), isolated from the gum resin of Commiphora mukul, were reported to exhibit anticancer and anti-inflammatory activities....
Sat Aug 31, 2019 13:32
Related ArticlesAnti-Tumor Activity of Cembranoid-Type Diterpenes Isolated from Nicotiana tabacum L. Biomolecules. 2019 01 28;9(2): Authors: Yuan XL, Mao XX, Du YM, Yan PZ, Hou XD, Zhang ZF Abstract Recently, the incidence of hepatocellular carcinoma has increased worldwide. Cembranoid-type diterpenes (CBDs) from tobacco exhibit good antimicrobial, antitumor, and neuroprotective activities. Therefore, in this study, we isolated CBDs from Nicotiana tabacum...
Sat Aug 31, 2019 13:32
Related ArticlesCRISPR/Cas9 Editing of the Polyomavirus Tumor Antigens Inhibits Merkel Cell Carcinoma Growth In Vitro. Cancers (Basel). 2019 Aug 28;11(9): Authors: Temblador A, Topalis D, Andrei G, Snoeck R Abstract Merkel cell carcinoma (MCC) is an aggressive type of skin cancer whose main causative agent is Merkel cell polyomavirus (MCPyV). MCPyV is integrated into the genome of the tumor cells in most MCCs. Virus-positive tumor cells constitutively...
Sat Aug 31, 2019 13:32
Related ArticlesDesign, Synthesis, and Anticancer Effect Studies of Iridium(III) Polypyridyl Complexes against SGC-7901 Cells. Molecules. 2019 Aug 28;24(17): Authors: Zhang LX, Gu YY, Wang YJ, Bai L, Du F, Zhang WY, He M, Liu YJ, Chen YZ Abstract Three iridium(III) complexes ([Ir(Hppy)2(L)](PF6) (Hppy = 2-phenylpyridine, L = 5-nitrophenanthroline, NP), 1; 5-nitro-6-amino-phenanthroline (NAP), 2; and 5,6-diamino-phenanthroline (DAP) 3 were synthesized...
Sat Aug 31, 2019 13:32
Related ArticlesToxoplasma gondii-induced host cellular cell cycle dysregulation is linked to chromosome missegregation and cytokinesis failure in primary endothelial host cells. Sci Rep. 2019 Aug 29;9(1):12496 Authors: Velásquez ZD, Conejeros I, Larrazabal C, Kerner K, Hermosilla C, Taubert A Abstract Toxoplasma gondii is a zoonotic and intracellular parasite with fast proliferating properties leading to rapid host cell lysis. T. gondii modulates its...
Sat Aug 31, 2019 13:32
Related ArticlesThe Increased lncRNA MIR503HG in Preeclampsia Modulated Trophoblast Cell Proliferation, Invasion, and Migration via Regulating Matrix Metalloproteinases and NF-κB Signaling. Dis Markers. 2019;2019:4976845 Authors: Cheng D, Jiang S, Chen J, Li J, Ao L, Zhang Y Abstract Background: Preeclampsia (PE) is a pregnancy-related syndrome characterized by hypertension and proteinuria after the 20th week of gestation. The long noncoding RNAs (lncRNAs)...
Sat Aug 31, 2019 13:32
Related ArticlesAutophagy: A Player in response to Oxidative Stress and DNA Damage. Oxid Med Cell Longev. 2019;2019:5692958 Authors: Galati S, Boni C, Gerra MC, Lazzaretti M, Buschini A Abstract Autophagy is a catabolic pathway activated in response to different cellular stressors, such as damaged organelles, accumulation of misfolded or unfolded proteins, ER stress, accumulation of reactive oxygen species, and DNA damage. Some DNA damage sensors like...
Sat Aug 31, 2019 13:32
Related ArticlesCompeting Endogenous RNA and Coexpression Network Analysis for Identification of Potential Biomarkers and Therapeutics in association with Metastasis Risk and Progression of Prostate Cancer. Oxid Med Cell Longev. 2019;2019:8265958 Authors: Pang X, Zhao Y, Wang J, Li W, Xiang Q, Zhang Z, Wu S, Liu A, Du G, Cui Y Abstract Prostate cancer (PCa) is the most frequently diagnosed malignant neoplasm in men. Despite the high incidence, the underlying...
Sat Aug 31, 2019 13:32
Related ArticlesInduction of intrinsic apoptotic signaling pathway in A549 lung cancer cells using silver nanoparticles from Gossypium hirsutum and evaluation of in vivo toxicity. Biotechnol Rep (Amst). 2019 Sep;23:e00339 Authors: Kanipandian N, Li D, Kannan S Abstract In the past decade, the research communities raised wide concerns on using medicinal plants for synthesis of nanomaterials due to its effective biological activity, lower side effects...
Sat Aug 31, 2019 13:32
Related ArticlesTargeting Taurine Transporter (TauT) for Cancer Immunotherapy of p53 Mutation Mediated Cancers - Molecular Basis and Preclinical Implication. Adv Exp Med Biol. 2019;1155:543-553 Authors: Han X Abstract Taurine transporter (TauT) has been identified as a target gene of p53 tumor suppressor. TauT is also found to be overexpressed in variety type of human cancers, such as leukemia. This study showed that expression of TauT was upregulated...
Sat Aug 31, 2019 13:32
Related Articles3'-Desmethylarctigenin induces G2/M cell cycle arrest and apoptosis through reactive oxygen species generation in hepatocarcinoma cells. Phytother Res. 2019 Aug 30;: Authors: Zhang E, Wang X, Liu X, Liang M, Hu H, Yin S Abstract Previous studies have shown that arctigenin is a promising chemopreventive or therapeutic agent against various cancers. However, less is known about anticancer activity of 3'-desmethylarctigenin (3'-DMAG), which...
Sat Aug 31, 2019 13:32
Related ArticlesLatent Membrane Protein 2A inhibits Expression Level of Smad2 through regulating miR-155-5p in EBV-associated gastric cancer cell lines. J Med Virol. 2019 Aug 30;: Authors: Shi Q, Zhang Y, Liu W, Xiao H, Qi Y, Li J, Luo B Abstract Epstein-Barr virus (EBV) infection is one of the causes of gastric cancer (GC). Besides, previous studies have demonstrated that EBV-encoded latent membrane protein 2A (LMP2A) influences the pathogenesis of...
Sat Aug 31, 2019 14:32
Related ArticlesCortical neurons develop a senescence-like phenotype promoted by dysfunctional autophagy. Aging (Albany NY). 2019 Aug 30;: Authors: Moreno-Blas D, Gorostieta-Salas E, Pommer-Alba A, Muciño-Hernández G, Gerónimo-Olvera C, Maciel-Barón LA, Konigsberg M, Massieu L, Castro-Obregón S Abstract Senescent cells accumulate in various tissues and organs with aging altering surrounding tissue due to an active secretome, and at least in mice their...
Sat Aug 31, 2019 14:32
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