Related ArticlesAndrogen receptor activation reduces the endothelial cell proliferation through activating the cSrc/AKT/p38/ERK/NFκB-mediated pathway. J Steroid Biochem Mol Biol. 2019 Aug 27;:105459 Authors: Huo YN, Yeh SD, Lee WS Abstract The effect of androgen on angiogenesis has been documented. However, its underlying molecular mechanisms have not been well illustrated. Here, we show that treatment with an androgen receptor (AR) agonist, metribolone...
Sat Aug 31, 2019 14:32
Related ArticlesSelective inhibition of spindle microtubules by a tubulin-binding quinazoline derivative. Mol Pharmacol. 2019 Aug 30;: Authors: Sawada JI, Ishii H, Matsuno K, Sato M, Suzuki Y, Asai A Abstract In the research field of tubulin-binding agents for the development of anticancer agents, hidden targets are emerging as a problem in understanding the exact mechanisms of actions. The quinazoline derivative PVHD121 has anti-cell proliferative activity...
Sun Sep 01, 2019 13:12
Related ArticlesEBV encoded miRNA BART8-3p promotes radioresistance in nasopharyngeal carcinoma by regulating ATM/ATR signaling pathway. Biosci Rep. 2019 Aug 30;: Authors: Zhou X, Zheng J, Tang Y, Lin Y, Wang L, Li Y, Liu C, Wu D, Cai L Abstract Resistance to radiotherapy is one of the main causes of treatment failure in patients with nasopharyngeal carcinoma (NPC). Epstein-Barr virus (EBV) infection is an important factor in the pathogenesis of NPC,...
Sun Sep 01, 2019 13:12
Related ArticlesFacile fabrication of Cu9-S5 loaded core-shell nanoparticles for near infrared radiation mediated tumor therapeutic strategy in human esophageal squamous carcinoma cells nursing care of esophageal cancer patients. J Photochem Photobiol B. 2019 Aug 02;199:111583 Authors: Wang S, Liu J, Qiu S, Yu J Abstract Copper chalcogenides have been exhibited to be an encouraging photothermal operator because of their great photothermal transformation...
Sun Sep 01, 2019 15:10
Related ArticlesMolecular Subtype-Specific Immunocompetent Models of High-Grade Urothelial Carcinoma Reveal Differential Neoantigen Expression and Response to Immunotherapy. Cancer Res. 2018 07 15;78(14):3954-3968 Authors: Saito R, Smith CC, Utsumi T, Bixby LM, Kardos J, Wobker SE, Stewart KG, Chai S, Manocha U, Byrd KM, Damrauer JS, Williams SE, Vincent BG, Kim WY Abstract High-grade urothelial cancer contains intrinsic molecular subtypes that exhibit...
Fri Aug 30, 2019 13:19
Addressing Challenges in Converting Grant-Funded Infrastructures to Broadly Used Research Resources.
Related ArticlesAddressing Challenges in Converting Grant-Funded Infrastructures to Broadly Used Research Resources. Cancer Epidemiol Biomarkers Prev. 2019 Aug 28;: Authors: Rolland B, Geiger AM Abstract The NCI invests heavily in research resources to serve the research community, including datasets, biospecimen banks, and networks of institutions in which clinical trials and other human subjects research are conducted. These resources often begin as...
Fri Aug 30, 2019 13:19
Related ArticlesThe development, usability, and reliability of the Electronic Patient Visit Assessment (ePVA) for head and neck cancer. Mhealth. 2019;5:21 Authors: Van Cleave JH, Fu MR, Bennett AV, Persky MS, Li Z, Jacobson A, Hu KS, Most A, Concert C, Kamberi M, Mojica J, Peyser A, Riccobene A, Tran A, Persky MJ, Savitski J, Liang E, Egleston BL Abstract Background: Annually, over 65,000 persons are diagnosed with head and neck cancer in the United...
Fri Aug 30, 2019 13:19
Related ArticlesMultiplex isolation and profiling of extracellular vesicles using a microfluidic DICE device. Analyst. 2019 Aug 29;: Authors: Kang YT, Purcell E, Hadlock T, Lo TW, Mutukuri A, Jolly S, Nagrath S Abstract Profiling of extracellular vesicles (EVs) is an emerging area in the field of liquid biopsies because of their innate significance in diseases and abundant information reflecting disease status. However, unbiased enrichment of EVs and...
Fri Aug 30, 2019 13:19
Related ArticlesPatient-Reported Outcomes in Surgical Oncology: An Overview of Instruments and Scores. Ann Surg Oncol. 2019 Aug 28;: Authors: Phillips JD, Wong SL Abstract Traditional measures of quality and effectiveness in surgical oncology have focused on morbidity, mortality, and when available, recurrence rates. Measuring patient-reported outcomes (PROs) has become more widely accepted during the last decade. This article reviews instruments commonly...
Fri Aug 30, 2019 13:19
Related ArticlesParticipation of the hospitals in the Republic of Ireland in international research over more than a decade: a bibliometric analysis. Ir J Med Sci. 2019 Aug 28;: Authors: Abdelaal Ahmed Mahmoud A, Younis MI, Holmes C, Sallam A, Kamel MG, Dempsey E, Mulhern O Abstract BACKGROUND: This study provides an accurate awareness of the present situation of health research in Irish hospitals both public and private. We aimed to analyze factors...
Fri Aug 30, 2019 13:19
Related ArticlesPrognostic role of body composition parameters in gastric/gastroesophageal junction cancer patients from the EXPAND trial. J Cachexia Sarcopenia Muscle. 2019 Aug 28;: Authors: Hacker UT, Hasenclever D, Linder N, Stocker G, Chung HC, Kang YK, Moehler M, Busse H, Lordick F Abstract BACKGROUND: Body fat and/or muscle composition influences prognosis in several cancer types. For advanced gastric and gastroesophageal junction cancer, we investigated...
Fri Aug 30, 2019 13:19
Related ArticlesAbemaciclib, a potent cyclin-dependent kinase 4 and 6 inhibitor, for treatment of ER-positive metastatic breast cancer. Future Oncol. 2019 Aug 29;: Authors: Lee KA, Shepherd ST, Johnston SR Abstract CDK 4/6 inhibitors have given patients with estrogen receptor (ER)-positive/HER2-negative (ER+/HER2ࢤ) advanced metastatic breast cancer important new therapeutic options. Abemaciclib is different to the other two licensed and approved CDK...
Fri Aug 30, 2019 15:13
Related ArticlesCancer cell reprogramming: a promising therapy converting malignancy to benignity. Cancer Commun (Lond). 2019 Aug 29;39(1):48 Authors: Gong L, Yan Q, Zhang Y, Fang X, Liu B, Guan X Abstract In the past decade, remarkable progress has been made in reprogramming terminally differentiated somatic cells and cancer cells into induced pluripotent cells and cancer cells with benign phenotypes. Recent studies have explored various approaches...
Fri Aug 30, 2019 15:13
Related ArticlesHead-to-Head Comparison of the Performance of 17 Risk Models for Predicting Presence of Advanced Neoplasms in Colorectal Cancer Screening. Am J Gastroenterol. 2019 Aug 20;: Authors: Peng L, Balavarca Y, Weigl K, Hoffmeister M, Brenner H Abstract OBJECTIVES: Many risk scores have been proposed to predict presence of advanced colorectal neoplasms, but a comprehensive comparison conducted in the same population is sparse. The aim of this...
Fri Aug 30, 2019 15:13
Related ArticlesWindow of Opportunity trials for biomarker discovery in breast cancer. Curr Opin Oncol. 2019 Aug 23;: Authors: Arnedos M, Roulleaux Degage M, Perez-Garcia J, Cortes J Abstract PURPOSE OF REVIEW: Window of Opportunity (WOO) studies have gain their place in current clinical and translational research in breast cancer patients. This review provides current information and future applications of this specific type of research. RECENT...
Fri Aug 30, 2019 15:13
Related ArticlesTagraxofusp, the first CD123-targeted therapy and first targeted treatment for blastic plasmacytoid dendritic cell neoplasm. Expert Rev Clin Pharmacol. 2019 Aug 29;: Authors: Economides MP, McCue D, Lane AA, Pemmaraju N Abstract INTRODUCTION: CD123 or interleukin 3 receptor alpha is overexpressed in multiple hematologic malignancies. Tagraxofusp is an intravenously administered CD123-directed cytotoxin consisting of the fusion of interleukin-3...
Fri Aug 30, 2019 15:13
Related ArticlesDynamic factors affecting HPV-attributable fraction for head and neck cancers. Curr Opin Virol. 2019 Aug 26;39:33-40 Authors: Shewale JB, Gillison ML Abstract Head and neck squamous cell carcinoma (HNSCC) is attributable to carcinogen and oncogenic virus exposure and rates are driven by the prevalence, intensity, and duration of exposures. Recent dramatic shifts in human behavior have resulted in substantial heterogeneity in HNSCC incidence...
Fri Aug 30, 2019 15:13
Related ArticlesKaposi Sarcoma Updates. Dermatol Clin. 2019 Oct;37(4):505-517 Authors: Etemad SA, Dewan AK Abstract Kaposi sarcoma (KS) is an angioproliferative mesenchymal neoplasm caused by Kaposi sarcoma-related herpesvirus. This review outlines our current understanding of the epidemiology, pathogenesis, clinical presentation, and staging for this disease. Recent research has informed a more comprehensive understanding of the epidemiology of KS in...
Sat Aug 31, 2019 13:42
Related ArticlesThe Uppsala-Stockholm Assisted Reproductive Techniques (UppStART) study. BMJ Open. 2019 Aug 28;9(8):e028866 Authors: Iliadou AN, Öberg AS, Pege J, Rodriguez-Wallberg KA, Olofsson JI, Holte J, Wramsby H, Wramsby M, Cnattingius S, Cesta CE Abstract PURPOSE: The Uppsala-Stockholm Assisted Reproductive Techniques (UppStART) study is a prospectively recruited sample of couples undergoing assisted reproduction in Stockholm and Uppsala county...
Sat Aug 31, 2019 13:42
Related ArticlesCryo-EM Reveals Architectural Diversity in Active Rotavirus Particles. Comput Struct Biotechnol J. 2019;17:1178-1183 Authors: Hauser M, Dearnaley WJ, Varano AC, Casasanta M, McDonald SM, Kelly DF Abstract Rotavirus is a well-studied RNA virus that causes severe gastroenteritis in children. During viral entry, the outer layer of the virion is shed, creating a double-layered particle (DLP) that is competent to perform viral transcription...
Sat Aug 31, 2019 13:42
Related ArticlesPediatric cancer, posttraumatic stress and fear-related neural circuitry. Int J Hematol Oncol. 2019 Jul 11;8(2):IJH17 Authors: Marusak HA, Harper FW, Taub JW, Rabinak CA Abstract This review examines the neurobiological effects of pediatric cancer-related posttraumatic stress symptoms (PTSS). We first consider studies on prevalence and predictors of childhood cancer-related PTSS and compare these studies to those in typically developing...
Sat Aug 31, 2019 13:42
Related ArticlesMortality trends of colorectal cancer among overweight patients at the global and national levels. Int J Colorectal Dis. 2019 Aug 30;: Authors: Cao F, Li F, Shi L, Zhang L, Ma T, Zhang G Abstract PURPOSE: Colorectal cancer (CRC) is a commonly diagnosed malignancy with highly heterogeneous incidence and mortality rates worldwide. High body mass index (BMI) is a well-defined risk factor for CRC. The mortality trends of CRC among patients...
Sat Aug 31, 2019 13:42
Related ArticlesPeptide Receptor Radiotherapy: Current Approaches and Future Directions. Curr Treat Options Oncol. 2019 Aug 29;20(10):77 Authors: Kong G, Hicks RJ Abstract OPINION STATEMENT: Neuroendocrine neoplasia (NEN) represents a heterogenous group of tumours. Guidelines regarding treatment choice and sequencing remain complex given varied primary sites, hormone-secretory status, tumour grade, disease heterogeneity, and paucity of rigorous comparative...
Sat Aug 31, 2019 13:42
Related ArticlesTreatment sequencing in oncology: balancing clinical trial and real-world evidence. Future Oncol. 2019 Sep;15(25):2887-2889 Authors: Caffo O PMID: 31469005 [PubMed - in process]
Sat Aug 31, 2019 14:39
Related ArticlesExpression and CpG island methylation pattern of MMP-2 and MMP-9 genes in patients with congenital factor XIII deficiency and intracranial hemorrhage. Hematology. 2019 Dec;24(1):601-605 Authors: Noroozi-Aghideh A, Kashani Khatib Z, Naderi M, Dorgalaleh A, Yaghmaie M, Paryan M, Alizadeh S Abstract OBJECTIVES: Congenital factor XIII (FXIII) deficiency is a rare severe bleeding disorder. Intracranial hemorrhage (ICH) is the leading cause...
Sat Aug 31, 2019 14:39
Related ArticlesPatient-Initiated Pain Expressions: Interactional Asymmetries and Consequences for Cancer Care. Health Commun. 2019 Aug 30;:1-13 Authors: Chapman CR, Beach WA Abstract Only minimal attention has been given to analyzing interactional moments when patients and providers talk about "pain" in general consultations and primary care, and no attention has focused on how pain gets managed during oncology interviews. Conversation analysis (CA)...
Sat Aug 31, 2019 14:39
Related ArticlesTargeting the Sanctuary Site: Options when Breast Cancer Metastasizes to the Brain. Oncology (Williston Park). 2019 Aug 23;33(8): Authors: Krishnan M, Krishnamurthy J, Shonka N Abstract Brain metastasis is a poor prognostic factor in breast cancer progression, and traditional treatment options have shown minimal response with overall low median survival rates. The incidence of brain metastasis has been increasing despite and, in part,...
Sat Aug 31, 2019 14:39
Related ArticlesManagement of locally recurrent nasopharyngeal carcinoma. Cancer Treat Rev. 2019 Aug 21;79:101890 Authors: Lee AWM, Ng WT, Chan JYW, Corry J, Mäkitie A, Mendenhall WM, Rinaldo A, Rodrigo JP, Saba NF, Strojan P, Suárez C, Vermorken JB, Yom SS, Ferlito A Abstract As a consequence of the current excellent loco-regional control rates attained using the generally accepted treatment paradigms involving intensity-modulated radiotherapy for nasopharyngeal...
Sat Aug 31, 2019 14:39
Related ArticlesOncodermatology of the Head and Neck. Facial Plast Surg. 2019 Aug;35(4):368-376 Authors: Klop WMC, Elshot YS, Beck ACC, Brandsen RE, Lohuis PJFM Abstract The European Academy of Facial Plastic Surgery celebrates its 40th anniversary. We aimed to describe innovations in the diagnostics and treatment in head and neck skin cancer over the past 40 years as well as future perspectives. Landmark events, developments, and highlights over the...
Sat Aug 31, 2019 14:39
Challenges and Prospects of Chimeric Antigen Receptor T-cell Therapy for Metastatic Prostate Cancer.
Related ArticlesChallenges and Prospects of Chimeric Antigen Receptor T-cell Therapy for Metastatic Prostate Cancer. Eur Urol. 2019 Aug 27;: Authors: Gorchakov AA, Kulemzin SV, Kochneva GV, Taranin AV Abstract CONTEXT: Progress achieved in the treatment of prostate cancer (PCa) with surgical, radiation, and hormonal therapies has drastically reduced mortality from this disease. Yet, patients with advanced PCa have few, if any, curative options. Recent...
Sun Sep 01, 2019 13:17
Related ArticlesPericardial Synovial Sarcoma: Case Report, Literature Review and Pooled Analysis. In Vivo. 2019 Sep-Oct;33(5):1531-1538 Authors: Duran-Moreno J, Kampoli K, Kapetanakis EI, Mademli M, Koufopoulos N, Foukas PG, Kostopanagiotou K, Tomos P, Koumarianou A Abstract BACKGROUND: Pericardial synovial sarcomas (PSS) are very rare tumors, with dismal prognosis and limited data. We describe the clinical features and identify prognostic factors of...
Sun Sep 01, 2019 13:17
Related ArticlesSebaceous carcinoma: controversies and their evidence for clinical practice. Arch Dermatol Res. 2019 Aug 30;: Authors: Kibbi N, Worley B, Owen JL, Kelm RC, Bichakjian CK, Chandra S, Demirci H, Kim J, Nehal KS, Thomas JR, Poon E, Alam M Abstract Sebaceous carcinoma (SC) is a potentially aggressive malignancy of periocular or extraocular skin. It arises sporadically or is associated with Muir-Torre syndrome (MTS). Here, we review three...
Sun Sep 01, 2019 13:17
Related ArticlesASO Author Reflections: Margin Analysis in Head and Neck Cancer-State of the Art and Future Directions. Ann Surg Oncol. 2019 Aug 30;: Authors: Silverman DA, Li MM, Puram SV, Kang SY PMID: 31471843 [PubMed - as supplied by publisher]
Sun Sep 01, 2019 13:17
Related ArticlesSuccessful long-term outcome after combined hematopoietic stem cell transplantation and small bowel transplantation: A case report and review of the literature. Pediatr Transplant. 2019 Aug 31;:e13563 Authors: Na S, Saldana BD, Peredo-Pinto H, Gonzalez CE, Kroemer AH, Hawksworth J, Matsumoto CS, Yazigi N, Kaufman S, Fishbein TM, Khan K Abstract Combining HSCT with SOT is an unusual and challenging undertaking given the complexities of...
Sun Sep 01, 2019 13:17
Related ArticlesSkin Cancer Classification Using Convolutional Neural Networks: Systematic Review. J Med Internet Res. 2018 10 17;20(10):e11936 Authors: Brinker TJ, Hekler A, Utikal JS, Grabe N, Schadendorf D, Klode J, Berking C, Steeb T, Enk AH, von Kalle C Abstract BACKGROUND: State-of-the-art classifiers based on convolutional neural networks (CNNs) were shown to classify images of skin cancer on par with dermatologists and could enable lifesaving...
Fri Aug 30, 2019 13:29
Related ArticlesFast calculation of nanodosimetric quantities in treatment planning of proton and ion therapy. Phys Med Biol. 2018 Nov 28;63(23):235015 Authors: Ramos-Méndez J, Burigo LN, Schulte R, Chuang C, Faddegon B Abstract Details of the pattern of ionization formed by particle tracks extends knowledge of dose effects on the nanometer scale. Ionization detail (ID), frequently characterized by ionization cluster size distributions (ICSD), is obtained...
Fri Aug 30, 2019 13:29
Related Articles[Genetic Approach of Breast Cancer]. Gan To Kagaku Ryoho. 2019 May;46(5):831-837 Authors: Takei J, Yamauchi H Abstract In July 2018, olaparib, an oral poly adenosine diphosphate-ribose polymerase(PARP)inhibitor, was approved for the first time in Japan as a companion diagnostic drug for the treatment of recurrent breast cancer in BRCA-positive patients. Genetic testing had been offered only to clients who met the eligibility criteria...
Fri Aug 30, 2019 13:29
Related ArticlesA phase I trial to determine safety and pharmacokinetics of ASLAN002, an oral MET superfamily kinase inhibitor, in patients with advanced or metastatic solid cancers. Invest New Drugs. 2018 10;36(5):886-894 Authors: Roohullah A, Cooper A, Lomax AJ, Aung J, Barge A, Chow L, McHale M, Desai J, Whittle JR, Tran B, de Souza P, Horvath LG Abstract Background The MET tyrosine kinase and its ligand, hepatocyte growth factor (HGF) also known...
Sat Aug 31, 2019 13:56
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