Abstract To prospectively study a series of scleroma patients with a focus on socioeconomic status, clinical presentation, pathology, microbiology, and treatment. A total of 52 patients diagnosed with scleroma were included in the study. Demographic data of the patients were collected and clinical, radiographic, and histopathologic findings were analyzed. Biopsies from atypical patients were sent for electron microscopic examination. Patients were treated both medically and surgically...
Mon Sep 16, 2019 03:00
Elevated pre‐diagnostic serum levels of the immune activation markers sCD27 and sCD30 have been associated with non‐Hodgkin lymphoma (NHL). However, the use of a single sample per participant in these studies has limited etiologic inferences. We report findings, overall and by NHL subtype, from a case‐control analysis (422 cases, 434 controls) within the Janus Serum Bank with two samples per subject collected on average five years apart. Chronic lymphocytic leukemia / small lymphocytic lymphoma (CLL/SLL)...
Sun Sep 15, 2019 20:23
Endometrial carcinoma is traditionally diagnosed by histopathological assessment of an endometrial biopsy, leaving up to 30% of patients undiagnosed due to technical failure or an inadequate amount of tissue. The aim of the current study is to assess whether mutational analysis of cervical cytology or pipelle endometrial biopsies improves the diagnostic accuracy of traditional histopathological diagnosis of endometrial carcinoma. This prospective multicentre cohort study included patients surgically...
Sun Sep 15, 2019 20:23
Modern cancer therapy has led to a growing number of pediatric and young adult cancer survivors, who are prone to increased morbidities caused by the late‐effects of therapy. The aim of this study was to investigate pediatric and young adult cancer survivors' morbidity due to renal and bone metabolism diseases and especially to study bone metabolism in cancer survivors with renal disease. Patients were identified from the Finnish Cancer Registry, and the cohort consisted of 13,860, 5‐year survivors...
Sun Sep 15, 2019 20:24
Handling mistakes is the key skill we need to develop as a Doctor, here is a video by Dr Sumer Sethi explaining how to go about it.Famous Radiology Blog http://www.sumerdoc.blogspot.com TeleRad Providers at www.teleradproviders.com Mail us at sales@teleradproviders.com
Mon Sep 16, 2019 10:38
Abstract Adenoid cystic carcinoma (ACC) is one of the most common salivary gland malignant tumors. Its treatment failure is partly due to the limitations of chemotherapeutic agents and their adverse effects. The objective of this study was to determine the potential additive anti-cancer effect of a novel CDK inhibitor dinaciclib with first-line chemotherapy drugs in ACC. Protein expression of phosphorylated CDK2 (p-CDK2) in paraffin-embedded tissue specimens of ACC from 17 patients...
Mon Sep 16, 2019 03:00
Abstract Non‐SMC condensing I complex subunit H (NCAPH) is a member of the Barr protein family and part of the condensin I complex. The upregulation of NCAPH is associated with poor prognosis in patients with colon cancer. However, the relationship between NCAPH and hepatocellular carcinoma (HCC) remains unclear. This study aimed to explore NCAPH expression in HCC tissues and to investigate NCAPH functions in HCC cells. In this study, we found that high expression of NCAPH in HCC indicated worse...
Sun Sep 15, 2019 19:28
Background and Objectives There is a clinical need to assess the resection margins of tongue cancer specimens, intraoperatively. In the current ex vivo study, we evaluated the feasibility of hyperspectral diffuse reflectance imaging (HSI) for distinguishing tumor from the healthy tongue tissue. Study Design/Materials and Methods Fresh surgical specimens (n = 14) of squamous cell carcinoma of the tongue were scanned with two hyperspectral cameras that cover the visible and near‐infrared spectrum...
Sun Sep 15, 2019 18:53
Abstract This review article aims to address the kinetic of TDEs in cancer cells pre- and post-radiotherapy. Radiotherapy is traditionally used for the treatment of multiple cancer types; however, there is growing evidence to show that radiotherapy exerts NTEs on cells near to the irradiated cells. In tumor mass, irradiated cells can affect non-irradiated cells in different ways. Of note, exosomes are nano-scaled cell particles releasing from tumor cells and play key roles in survival,...
Mon Sep 16, 2019 03:00
The organic carbon mineralization process reflects the release intensity of soil CO2. Therefore, the study of organic carbon mineralization and particle composition analysis of soft rock and sand compound soil can provide technical support and a theoretical basis for soil organic reconstruction (soil structure, materials and biological nutrition). Based on previous research, four treatments were selected: CK (soft rock:sand=0:1), C1 (soft rock:sand=1:5), C2 (soft rock:sand=1:2) and C3 (soft rock:sand=1:1),...
Mon Sep 16, 2019 03:00
Background Aurora kinase B (AURKB) is an important carcinogenic factor in various tumors, while its role in clear cell renal cell carcinoma (ccRCC) still remains unclear. This study aimed to investigate its prognostic value and mechanism of action in ccRCC. Methods Gene expression profiles and clinical data of ccRCC patients were downloaded from The Cancer Genome Atlas database. R software was utilized to analyze the...
Mon Sep 16, 2019 03:00
Background Much of the shape variation found in animals is based on allometry and heterochrony. Horses represent an excellent model to investigate patterns of size-shape variation among breeds that were intentionally bred for extreme small and large sizes. Methods We tested whether ponies (wither height 148 cm, here-after called horses) during ontogenetic growth. We used a dataset of 194 specimens from 25 horse and...
Mon Sep 16, 2019 03:00
Background Lecanicillium lecanii is an entomopathogenic fungi, which was isolated from insects suffering from disease. Now, it is an effective bio-control resource that can control agricultural pests such as whitefly and aphids. There are many studies on the control of various agricultural pests by L. lecanii, but no report on its control of Bemisia tabaci biotype-Q exists. In this work, we studied the susceptibility of B. tabaci Q-biotype (from Ningxia, China) to L. lecanii JMC-01 in terms of...
Mon Sep 16, 2019 03:00
Developing effective methods to coordinate the trade-offs among ecosystem services (ES) is important for achieving inclusive growth and sustainable development, and has been the focus of scholars and ecosystem managers globally. Using remote sensing and geographic information system (GIS) data, our study examined Wafangdian County of Liaoning Province as a case study to reveal the spatiotemporal evolution of four ES (food supply [FS], net primary productivity [NPP], water yield [WY], and soil conservation...
Mon Sep 16, 2019 03:00
The clinicopathological features of inflammatory breast carcinoma (IBC), the effect of therapeutic options on survival outcome and the identification of prognostic factors were investigated in this study. Information on IBC patients were extracted from the Surveillance, Epidemiology, and End Results (SEER) database between 2010 and 2015. Cox proportional hazard regression was used to determine potential significant prognostic factors of IBC. A nomogram was then constructed to evaluate patient survival...
Mon Sep 16, 2019 03:00
Background Acute respiratory distress syndrome (ARDS) is associated with significantly increased risk of death, and early risk stratification may help to choose the appropriate treatment. The study aimed to develop a neural network model by using a genetic algorithm (GA) for the prediction of mortality in patients with ARDS. Methods This was a secondary analysis of two multicenter randomized controlled trials conducted...
Mon Sep 16, 2019 03:00
Background Sub-lakes are important for the maintenance of the ecosystem integrity of Lake Poyang, and zooplankton play an important role in its substance and energy flow. Methods A seasonal investigation of zooplankton was conducted in spring (April), summer (July), autumn (October) and winter (January of the following year) from 2012 to 2016 in a sub-lake of Lake Poyang. The aim of the present study was to understand...
Mon Sep 16, 2019 03:00
Background Engrailed 1 (EN1), as a member of homeobox-containing transcription factors, participates in the development of the brain. High expressions of EN1 exist in various tumors. However, the role of EN1 in lower grade glioma (LGG) is still unknown. Methods Coefficients of Cox regression were examined by data mining among 13 cancer types using OncoLnc to validate EN1 expressions in LGG patients from The Cancer Genome...
Mon Sep 16, 2019 03:00
Related ArticlesRisk factors for recurrence after drug withdrawal in childhood epilepsy. Brain Dev. 2019 Sep 11;: Authors: Karalok ZS, Guven A, Öztürk Z, Gurkas E Abstract BACKGROUND: Several studies have been conducted to determine the risk of recurrence after withdrawal of antiepileptic drugs (AEDs) in recent years. There is no consensus concerning the circumstances affecting discontinuation of AEDs. This study was designed to determine the recurrence...
Mon Sep 16, 2019 14:19
Related ArticlesHemispherotomy can cause post-operative strabismus. Brain Dev. 2019 Sep 11;: Authors: Fujimoto A, Okanishi T, Sato K, Itamura S, Baba S, Ichikawa N, Nishimura M, Sakakura K, Masuda Y, Enoki H Abstract BACKGROUND: Hemispherotomy, which involves disconnecting hemispherical fibers, is a treatment option for medically intractable epilepsy. As various neurological disorders can cause strabismus, we hypothesized that hemispherotomy can cause...
Mon Sep 16, 2019 14:19
Related ArticlesHippocampal low-frequency stimulation improves cognitive function in pharmacoresistant epileptic rats. Epilepsy Res. 2019 Sep 11;:106194 Authors: Wang L, Shi H, Kang Y, Guofeng W Abstract OBJECTIVE: The aims of the present study were to observe the changes of cognitive function in a pilocarpine-induced rat model of epilepsy, and to investigate the effects of hippocampal low-frequency stimulation (Hip-LFS) on cognitive function in rats...
Mon Sep 16, 2019 14:19
Related ArticlesPrognostic factors and seizure outcome in posterior reversible encephalopathy syndrome (PRES) in children with hematological malignancies and bone marrow failure: A retrospective monocentric study. Seizure. 2019 Aug 15;72:1-10 Authors: Danhofer P, Tomečková M, Černá D, Zapletalová D, Horák O, Aulická Š, Juříková L, Domanský J, Kovalčíková P, Pavlík T, Štěrba J, Ošlejšková H Abstract PURPOSE: The aim of this study was to evaluate seizure...
Mon Sep 16, 2019 14:19
Related ArticlesAn explorative literature review of the multifactorial causes of osteoporosis in epilepsy. Epilepsy Behav. 2019 Sep 12;100(Pt A):106511 Authors: Diemar SS, Sejling AS, Eiken P, Andersen NB, Jørgensen NR Abstract PURPOSE: Patients with epilepsy have a greatly increased risk of osteoporosis and fractures. The literature is diverse and contradictory when dealing with the underlying pathophysiological mechanisms. Consequently, the purpose...
Mon Sep 16, 2019 14:19
Related ArticlesTowards pixel-to-pixel deep nucleus detection in microscopy images. BMC Bioinformatics. 2019 Sep 14;20(1):472 Authors: Xing F, Xie Y, Shi X, Chen P, Zhang Z, Yang L Abstract BACKGROUND: Nucleus is a fundamental task in microscopy image analysis and supports many other quantitative studies such as object counting, segmentation, tracking, etc. Deep neural networks are emerging as a powerful tool for biomedical image computing; in particular,...
Mon Sep 16, 2019 15:01
Related ArticlesA purely bioinformatic pipeline for the prediction of mammalian odorant receptor gene enhancers. BMC Bioinformatics. 2019 Sep 14;20(1):474 Authors: Degl'Innocenti A, Meloni G, Mazzolai B, Ciofani G Abstract BACKGROUND: In most mammals, a vast array of genes coding for chemosensory receptors mediates olfaction. Odorant receptor (OR) genes generally constitute the largest multifamily (> 1100 intact members in the mouse). From the whole...
Mon Sep 16, 2019 15:01
Related ArticlesHH-suite3 for fast remote homology detection and deep protein annotation. BMC Bioinformatics. 2019 Sep 14;20(1):473 Authors: Steinegger M, Meier M, Mirdita M, Vöhringer H, Haunsberger SJ, Söding J Abstract BACKGROUND: HH-suite is a widely used open source software suite for sensitive sequence similarity searches and protein fold recognition. It is based on pairwise alignment of profile Hidden Markov models (HMMs), which represent multiple...
Mon Sep 16, 2019 15:01
Related ArticlesA multiscale mathematical model of cell dynamics during neurogenesis in the mouse cerebral cortex. BMC Bioinformatics. 2019 Sep 14;20(1):470 Authors: Postel M, Karam A, Pézeron G, Schneider-Maunoury S, Clément F Abstract BACKGROUND: Neurogenesis in the murine cerebral cortex involves the coordinated divisions of two main types of progenitor cells, whose numbers, division modes and cell cycle durations set up the final neuronal output....
Mon Sep 16, 2019 15:01
Related ArticlesIdentifying protein complexes based on an edge weight algorithm and core-attachment structure. BMC Bioinformatics. 2019 Sep 14;20(1):471 Authors: Wang R, Liu G, Wang C Abstract BACKGROUND: Protein complex identification from protein-protein interaction (PPI) networks is crucial for understanding cellular organization principles and functional mechanisms. In recent decades, numerous computational methods have been proposed to identify...
Mon Sep 16, 2019 15:01
Related ArticlesBest Practices for Conducting and Interpreting Studies to Validate Self-Report Dietary Assessment Methods. J Acad Nutr Diet. 2019 Sep 11;: Authors: Kirkpatrick SI, Baranowski T, Subar AF, Tooze JA, Frongillo EA Abstract Careful consideration of the validity and reliability of methods intended to assess dietary intake is central to the robustness of nutrition research. A dietary assessment method with high validity is capable of providing...
Mon Sep 16, 2019 15:05
Related ArticlesLentivirus-mediated CDglyTK gene-modified free flaps by intra-artery perfusion show targeted therapeutic efficacy in rat model of breast cancer. BMC Cancer. 2019 Sep 14;19(1):921 Authors: Zhang J, Liu Y, Zang M, Zhu S, Chen B, Li S, Xue B, Yan L Abstract BACKGROUND: Free flap-mediated gene therapy in the tumor bed following surgical resection is a promising approach in cancer targeted treatment of residual disease. We investigated the...
Mon Sep 16, 2019 15:09
Related ArticlesZinc-finger protein p52-ZER6 accelerates colorectal cancer cell proliferation and tumour progression through promoting p53 ubiquitination. EBioMedicine. 2019 Sep 11;: Authors: Huang C, Wu S, Li W, Herkilini A, Miyagishi M, Zhao H, Kasim V Abstract BACKGROUND: Aberrant expression of p53 and its downstream gene p21 is closely related to alterations in cell cycle and cell proliferation, and is common among cancer patients. However, the underlying...
Mon Sep 16, 2019 15:09
Related ArticlesTuberculosis of the wrist mimicking rheumatoid arthritis - A rare case. Int J Surg Case Rep. 2019 Sep 05;63:13-18 Authors: Latief W, Asril E Abstract INTRODUCTION: Mycobacterium tuberculosis causes infection in approximately one-third of the world's population. Arthritis due to Mycobacteriurn tuberculosis usually presents as a chronic, slowly progressive, monoarticular infection that predominantly involves the weight-bearing joints and...
Mon Sep 16, 2019 15:08
Related ArticlesPatient-reported outcomes in randomised clinical trials of bladder cancer: an updated systematic review. BMC Urol. 2019 Sep 14;19(1):86 Authors: Van Hemelrijck M, Sparano F, Josephs D, Sprangers M, Cottone F, Efficace F Abstract BACKGROUND: Despite international recommendations of including patient-reported outcomes (PROs) in randomised clinical trials (RCTs), a 2014 review concluded that few RCTs of bladder cancer (BC) report PRO as...
Mon Sep 16, 2019 14:58
Related ArticlesProspects for combining immune checkpoint blockade with PARP inhibition. J Hematol Oncol. 2019 Sep 14;12(1):98 Authors: Li A, Yi M, Qin S, Chu Q, Luo S, Wu K Abstract The immunogenicity of a cancer cell is derived from accumulated somatic mutations. However, on the contrary to increased immunogenicity, anti-cancer immune response tends to be feeble. This impaired anti-cancer immunity could be attributed to multiple factors including loss...
Mon Sep 16, 2019 14:58
Related ArticlesProgress in cancer survival, mortality, and incidence in seven high-income countries 1995-2014 (ICBP SURVMARK-2): a population-based study. Lancet Oncol. 2019 Sep 11;: Authors: Arnold M, Rutherford MJ, Bardot A, Ferlay J, Andersson TM, Myklebust TÅ, Tervonen H, Thursfield V, Ransom D, Shack L, Woods RR, Turner D, Leonfellner S, Ryan S, Saint-Jacques N, De P, McClure C, Ramanakumar AV, Stuart-Panko H, Engholm G, Walsh PM, Jackson C, Vernon S, Morgan E,...
Mon Sep 16, 2019 14:58
Related ArticlesEvolution of treatment strategies for oligometastatic NSCLC patients - A systematic review of the literature. Cancer Treat Rev. 2019 Aug 28;80:101892 Authors: Schanne DH, Heitmann J, Guckenberger M, Andratschke NHJ Abstract BACKGROUND: The concept of oligometastatic disease (OMD) has expanded the scope of potentially curative therapy for metastatic NSCLC. However, large uncertainties remain regarding its definition and optimal management...
Mon Sep 16, 2019 14:58
Related ArticlesPD-L1 and CD47 co-expression in pulmonary sarcomatoid carcinoma: a predictor of poor prognosis and potential targets of future combined immunotherapy. J Cancer Res Clin Oncol. 2019 Sep 14;: Authors: Yang Z, Xu J, Li R, Gao Y, He J Abstract PURPOSE: Combined immunotherapy with anti-programmed cell death-ligand 1 (PD-L1) and an inhibitor of cluster of differentiation 47 (CD47) have exhibited preliminary anti-tumor effect. Our study attempted...
Mon Sep 16, 2019 14:58
Related ArticlesIn Vitro Evaluation of CMV Specific CD8+T Cells Function in CMV+ Colorectal Cancer Patients Compared to Healthy Controls. Iran J Allergy Asthma Immunol. 2019 Aug 17;18(4):379-392 Authors: Shaker Ardakani M, Pak F, Kokhaei P, Fazeli MS, Shakiba Y, Tabatabaei Yazdi SM, Abbasian A, Nourizadeh M Abstract The oncogenic role of human cytomegalovirus (HCMV) has been recently shown in different cancers like colorectal cancer (CRC). According...
Mon Sep 16, 2019 14:58
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