Related ArticlesContext-dependent effect of sPLA2-IIA induced proliferation on murine hair follicle stem cells and human epithelial cancer. EBioMedicine. 2019 Sep 11;: Authors: Chovatiya GL, Sunkara RR, Roy S, Godbole SR, Waghmare SK Abstract BACKGROUND: Tissue stem cells (SCs) and cancer cells proliferation is regulated by many common signalling mechanisms. These mechanisms temporally balance proliferation and differentiation events during normal tissue...
Mon Sep 16, 2019 15:16
Related ArticlesDifferential Regulation of ANP and BNP in Acute Decompensated Heart Failure: Deficiency of ANP. JACC Heart Fail. 2019 Sep 07;: Authors: Reginauld SH, Cannone V, Iyer S, Scott C, Bailey K, Schaefer J, Chen Y, Sangaralingham SJ, Burnett JC Abstract OBJECTIVES: This study investigated the differential regulation of circulating atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) in patients with acute decompensated heart...
Mon Sep 16, 2019 15:16
Related ArticlesPEGylated gold nanorods are not cytotoxic to human endothelial cells but affect kruppel-like factor signaling pathway. Toxicol Appl Pharmacol. 2019 Sep 12;:114758 Authors: Li X, Tang Y, Chen C, Qiu D, Cao Y Abstract Gold (Au) nanomaterials (NMs), particularly those with PEG surface functionalization, are generally considered to be biocompatible for biomedical applications due to relatively low cytotoxicity. Herein, we investigated the...
Mon Sep 16, 2019 15:16
Related ArticlesHIV-1 Tat protein inhibits the hematopoietic support function of human bone marrow mesenchymal stem cells. Virus Res. 2019 Sep 12;:197756 Authors: Yuan Y, Zhou C, Yang Q, Ma S, Wang X, Guo X, Ding Y, Tang J, Zeng Y, Li D Abstract Most HIV-1-infected patients experience hematopoiesis suppression complications. Bone marrow mesenchymal stem cells (BMSCs) are involved in regulation of hematopoietic homeostasis, so we investigated the role...
Mon Sep 16, 2019 15:16
Related ArticlesGalectin-3 and TRIM16 coregulate osteogenic differentiation of human bone marrow-derived mesenchymal stem cells at least partly via enhancing autophagy. Bone. 2019 Sep 12;:115059 Authors: Chen WT, Zhang F, Zhao XQ, Yu B, Wang BW Abstract BACKGROUND: The osteogenic differentiation of human bone marrow-derived mesenchymal stem cells (hBMSCs) is critical for bone homeostasis. Here, we investigated the regulation of Galectin-3 and tripartite...
Mon Sep 16, 2019 15:16
Related ArticlesMicroRNA miR-1002 Enhances NMNAT-Mediated Stress Response by Modulating Alternative Splicing. iScience. 2019 Aug 30;19:1048-1064 Authors: Park J, Zhu Y, Tao X, Brazill JM, Li C, Wuchty S, Zhai RG Abstract Understanding endogenous regulation of stress resistance and homeostasis maintenance is critical to developing neuroprotective therapies. Nicotinamide mononucleotide adenylyltransferase (NMNAT) is a conserved essential enzyme that confers...
Mon Sep 16, 2019 15:16
Related ArticlesImmunophenotyping of Human Regulatory T Cells. Methods Mol Biol. 2019;2032:141-177 Authors: Staats J Abstract Regulatory T cells, also known as Tregs, play a pivotal role in maintaining homeostasis of the immune system and self-tolerance. Tregs express CD3, CD4, CD25, and FOXP3 but lack CD127. CD4 and CD3 identify helper T lymphocytes, of which Tregs are a subset. CD25 is IL-2Rα, an essential activation marker that is expressed in high...
Mon Sep 16, 2019 15:16
Related ArticlesUnusual localization and aggressive progression of large infantile fibrosarcoma. Acta Orthop Traumatol Turc. 2019 Sep 11;: Authors: Atalay İB, Togral G Abstract Infantile fibrosarcoma is a very rare soft tissue tumor in infants and children most commonly located in extremities. It constitutes less then 1 percent of all childhood cancers. Prognosis and clinical course of it is relatively good compared to adult forms. Local recurrence is...
Mon Sep 16, 2019 14:19
Related ArticlesAcquisition of basic ear surgery skills: a randomized comparison between endoscopic and microscopic techniques. BMC Med Educ. 2019 Sep 14;19(1):357 Authors: Anschuetz L, Stricker D, Yacoub A, Wimmer W, Caversaccio M, Huwendiek S Abstract BACKGROUND: Endoscopic ear surgery is gaining increasing popularity and has an important impact on teaching middle ear anatomy and basic surgical skills among residents and fellows. Due to the wide-angled...
Mon Sep 16, 2019 14:25
Related ArticlesKetogenic diet combined with antioxidant N-acetylcysteine inhibits tumor growth in a mouse model of anaplastic thyroid cancer. Surgery. 2019 Sep 11;: Authors: Aggarwal A, Yuan Z, Barletta JA, Lorch JH, Nehs MA Abstract BACKGROUND: Anaplastic thyroid cancer is an aggressive and fatal malignancy. Many advanced cancers are characterized by glucose dependency, leading to oxidative stress and cellular proliferation. Therefore, we sought to...
Mon Sep 16, 2019 14:25
Related ArticlesDoes intravenous acetaminophen reduce perioperative opioid use in pediatric tonsillectomy? Am J Otolaryngol. 2019 Sep 09;:102294 Authors: Chisholm AG, Sathyamoorthy M, Seals SR, Carron JD Abstract OBJECTIVE: Postoperative pain control is of significant interest in pediatric otolaryngology given the safety concerns with opioid use. We sought to determine if addition of intraoperative intravenous acetaminophen decreases perioperative morphine...
Mon Sep 16, 2019 14:25
Related ArticlesBilateral infrahyoid muscle, myofascial and myoperichondrial flaps in laryngectomy. Oral Oncol. 2019 Sep 11;: Authors: Varghese BT Abstract BACKGROUND: Protection of suture line of neopharynx after a laryngectomy or near total laryngectomy with vascularized tissues is of utmost importance in preventing a wound related complication. METHOD: A simple technique of harvesting bilateral pedicled infrahyoid muscle myofascial or myoperichondrial...
Mon Sep 16, 2019 14:25
Related ArticlesThe impact of intranasal fluticasone on patients with obstructive sleep apnea: a prospective study. Braz J Otorhinolaryngol. 2019 Aug 31;: Authors: Tam YY, Shao IH, Wu CC, Hsieh ML Abstract INTRODUCTION: Obstructive sleep apnea is the most common type of sleep apnea, which is caused by complete or partial obstructions of the upper airway. Nasal obstruction is also considered as one of the independent risk factors of obstructive sleep...
Mon Sep 16, 2019 14:25
Related ArticlesExtended Endoscopic Endonasal Clipping of Intracranial Aneurysms: An Anatomical Feasibility Study. World Neurosurg. 2019 Sep 12;: Authors: Montaser AS, Prevedello DM, Gomez M, Lima L, Beer-Furlan A, Servian D, Otto BA, Carrau RL Abstract BACKGROUND: Intracranial aneurysms located in the midline region represent formidable challenge owing to their deep location. OBJECTIVE: The purpose of this study is to assess feasibility and...
Mon Sep 16, 2019 14:25
Related ArticlesPrognostic factors associated with achieving total oral diet following osteocutaneous microvascular free tissue transfer reconstruction of the oral cavity. Oral Oncol. 2019 Sep 12;98:1-7 Authors: Kansara S, Wang T, Koochakzadeh S, Liou NE, Graboyes EM, Skoner JM, Hornig JD, Sandulache VC, Day TA, Huang AT Abstract INTRODUCTION: Osteocutaneous microvascular free tissue transfer (OMFTT) is the current standard in reconstruction of large...
Mon Sep 16, 2019 14:25
Related ArticlesThe potential use of big data in oncology. Oral Oncol. 2019 Sep 12;98:8-12 Authors: Willems SM, Abeln S, Feenstra KA, de Bree R, van der Poel EF, Baatenburg de Jong RJ, Heringa J, van den Brekel MWM Abstract In this era of information technology, big data analysis is entering biomedical sciences. But what is big data, where do they come from and what can we do with it? In this commentary, the main sources of big data are explained, especially...
Mon Sep 16, 2019 14:25
Related ArticlesReferral rates for newborn hearing screening based on the test time. Int J Pediatr Otorhinolaryngol. 2019 Aug 30;127:109664 Authors: Chung YS, Oh SH, Park SK Abstract OBJECTIVES: To suggest the optimal timing for newborn hearing screening to obtain an ideal and stable referral rate in well babies and in babies in neonatal intensive care units (NICU). METHODS: This study analyzed nationwide hearing screening data of 71,596 newborns...
Mon Sep 16, 2019 14:25
Related ArticlesRat Model of Ménière's Attack: Intratympanic Injection of Potassium Chloride Produces Direction-Changing Spontaneous Nystagmus and Hearing Fluctuations. Audiol Neurootol. 2019 Sep 13;:1-7 Authors: Kamakura T, Kitahara T, Kondo M, Horii A, Hanada Y, Takimoto Y, Ishida Y, Nakamura Y, Imai T, Inohara H, Shimada S Abstract The major symptoms of Ménière's disease are episodic vertigo, fluctuating hearing loss, and tinnitus. Direction-changing...
Mon Sep 16, 2019 14:25
Related ArticlesUtility of Preoperative Ultrasonography in Transferred Patients with Suspicious Malignancy on Ultrasonography-Guided Fine-Needle Aspiration Cytology of Thyroid Nodules: A Single-Center Retrospective Study. Med Sci Monit. 2019 Sep 15;25:6943-6949 Authors: Kang T, Kim DW, Shin GW, Park JY, Lee YJ, Choo HJ, Cho YJ, Jung SJ, Park HK, Ha TK, Kim DH, Park JS, Moon SH, Ahn KJ, Baek HJ Abstract BACKGROUND This study aimed to assess the utility...
Mon Sep 16, 2019 14:25
Related ArticlesEfficacy of the Topical Calcineurin Inhibitors Tacrolimus and Pimecrolimus in the Treatment of Vitiligo in Infants Under 2 Years of Age: A Randomized, Open-Label Pilot Study. Clin Drug Investig. 2019 Sep 14;: Authors: Hu W, Xu Y, Ma Y, Lei J, Lin F, Xu AE Abstract BACKGROUND: The efficacy of topical calcineurin inhibitors (TCIs) for the treatment of infants with vitiligo aged less than 2 years remains to be fully determined. ...
Mon Sep 16, 2019 14:25
Related ArticlesSugar and the Mosaic of Autoimmunity. Am J Case Rep. 2019 Sep 15;20:1364-1368 Authors: Moling O, Gandini L Abstract BACKGROUND Recent discoveries in the field of immunometabolism, and on the role of the serine-threonine kinase mTOR as a sensor of nutrients, integrator of cellular signaling pathways, and regulator of metabolism, have widened our understanding of the connection between nutrition, health, and diseases. Epidemiological studies...
Mon Sep 16, 2019 15:26
Related ArticlesComparison of cyanoacrylate and hookwire for localizing small pulmonary nodules: a propensity-matched cohort study. Int J Surg. 2019 Sep 12;: Authors: Wang J, Yao J, Xu L, Shan L, Zhai R, Gao L, Liu L, Yao F Abstract BACKGROUND: Localizing small pulmonary nodules (SPNs) is a challenge during thoracoscopic resection, but preoperative computed tomography (CT)-guided localization using either cyanoacrylate or hookwire can be helpful. This...
Mon Sep 16, 2019 14:43
Related ArticlesMinimally invasive percutaneous nephrolithotomy versus retrograde intrarenal surgery in surgical management of upper urinary stones - A systematic review with meta-analysis. Int J Surg. 2019 Sep 12;: Authors: Jiao B, Luo Z, Xu X, Zhang M, Zhang G Abstract OBJECTIVE: The purpose of this study was to retrospectively assess the efficacy and safety of minimally invasive nephrolithotomy (MPCNL) versus retrograde intrarenal surgery (RIRS) in...
Mon Sep 16, 2019 14:43
Background. Vogt–Koyanagi–Harada (VKH) syndrome is a multisystemic autoimmune disease of uncertain pathogenesis. Infectious aetiology has been proposed which is suggested to lead to the loss of melanocytes in the skin, inner ear, meninges, and uvea in those who are genetically predisposed. Information regarding VKH syndrome is scanty among the African population. Case Presentation. We report a 28-year-old HIV-uninfected Ugandan woman who had previously been well and presented with chronic bilateral...
Mon Sep 16, 2019 12:05
Publication date: Available online 15 September 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): James A. Leonard, Ryan S. Ference, Michael S. Weinstock, John P. BentAbstractObjectiveTo compare closure rate, reduction in air-bone-gap, and operative time of Butterfly Tympanoplasty (BT) to underlay tympanoplasty (UT).MethodsRetrospective cohort study of children (age <18y) undergoing Type I tympanoplasty between 2009-2017. Patients were excluded if they had <6 months...
Mon Sep 16, 2019 13:49
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Polar and phase domain walls with conducting interfacial states in a Weyl semimetal MoTe<sub>2</sub>
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Nature Communications, Published online: 16 September 2019; doi:10.1038/s41467-019-12050-7The entire mRNA interactome capture has been established but identification of specific mRNA-binding proteins has been challenging. Here, the authors developed an in vivo RNA–protein crosslinking and RNA pulldown approach and characterized novel interactors of the C. elegans gld-1 mRNA, including DAZ-1 and miR-84.
Mon Sep 16, 2019 03:00
Nature Communications, Published online: 16 September 2019; doi:10.1038/s41467-019-12248-9To unlock the potential of biological semiconductors for printed flexible electronics, experimental evidence that reveals the material’s charge transport mechanism is required. Here, the authors report the charge transport mechanism in hydrogen-bonded DNA topoisomerase inhibitors.
Mon Sep 16, 2019 03:00
Nature Communications, Published online: 16 September 2019; doi:10.1038/s41467-019-12218-1Sulphur isotopes track recycling of subducted crustal material, yet few igneous rocks preserve these signals over Earth history. Here, the authors investigate a billion-year-old alkaline province in Greenland and are able to reconstruct a recycled mantle source, thus alkaline rocks can be used to reveal crustal recycling through geological time.
Mon Sep 16, 2019 03:00
Nature Communications, Published online: 16 September 2019; doi:10.1038/s41467-019-12224-3Amino acid biosynthetic pathways are an attractive alternative to treat chronic infections such as Mycobacterium tuberculosis (Mtb). Here, the authors investigate the metabolic response to disruption of the aspartate pathway in persistent Mtb and identify essential enzymes as potential new targets for drug development.
Mon Sep 16, 2019 03:00
Nature Communications, Published online: 16 September 2019; doi:10.1038/s41467-019-12032-9Natural killer/T cell lymphoma (NKTCL) is a rare and aggressive disease. Here, the authors identify recurrent somatic mutations of GNAQ in NKTCL, and model how this mutation contributes to NKTCL pathogenesis.
Mon Sep 16, 2019 03:00
Nature Communications, Published online: 16 September 2019; doi:10.1038/s41467-019-12110-ySPA proteins repress plant photomorphogenesis by promoting the E3 ligase activity of COP1. Here the authors show that SPAs also act as serine/threonine kinase and are required for phyB-mediated light-dependent phosphorylation and degradation of the PIF1 transcription factor.
Mon Sep 16, 2019 03:00
Nature Communications, Published online: 16 September 2019; doi:10.1038/s41467-019-11699-4Accurately characterizing the noise influencing quantum devices is instrumental to improve coherence properties and design more robust control protocols. Sung et al. demonstrate non-Gaussian noise spectroscopy with a superconducting qubit, enabling the detection and characterization of dephasing noise without assuming Gaussian statistics.
Mon Sep 16, 2019 03:00
Nature Communications, Published online: 16 September 2019; doi:10.1038/s41467-019-12130-8Epistasis underlies the complexity of genotype-phenotype maps. Here, the authors analyze 8,192 mutants that link two phenotypically distinct variants of the Entacmaea quadricolor fluorescent protein, and show the existence, but also the sparsity, of high-order epistatic interactions.
Mon Sep 16, 2019 03:00
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