Τρίτη 3 Σεπτεμβρίου 2019


Dimerization of the Sodium/Iodide Symporter
Thyroid, Ahead of Print.
liebertpub1
Fri Aug 30, 2019 10:00
Allergy promotes alopecia areata in a subset of patients
Abstract In this commentary, we focus on allergy as a facilitating factor in the pathogenesis of alopecia areata (AA). From previous studies on AA, it is well known that subsets of patients can have one or more of; seasonal relapse, comorbid atopic rhinitis, asthma and dermatitis, lesional infiltrating eosinophils and plasma cells, high levels of total IgE, specific IgE for house dust mites (HDM), and/or disrupted skin barrier function by the evaluation of fillagrin. Allergy and AA share a similar...
Experimental Dermatology
Tue Sep 03, 2019 20:19
Are patients in haemodialysis good candidates for immunotherapy treatment?
The effectiveness and safety of nivolumab, an anti-programmed cell death protein 1 mAbmonoclonal antibody, in patients with renal replacement therapy is unclear, with limited evidence supporting its usefulness in this context. Therefore, we report a case of recurrent metastatic melanoma in a patient on haemodialysis successfully treated with nivolumab. As seen in patients without renal impairment, significant regression of the lesions was observed after 8 weeks of treatment, reaching complete clinical...
Melanoma Research - Current Issue
Tue Sep 03, 2019 23:59
Disseminated intravascular coagulation and melanoma: a novel case occurring in metastatic melanoma with: BRAF: and: NRAS: mutations and systematic review
Disseminated intravascular coagulation is a complex and potentially lethal complication of malignancy, in which the fundamental abnormality is excessive activation of the coagulation system. It is a rare complication of melanoma which can be difficult to diagnose in some circumstances, leading to delay in treatment. Herein, we describe the first case of disseminated intravascular coagulation occurring in BRAF and NRAS-mutant metastatic melanoma, and systematically review the literature regarding...
Melanoma Research - Current Issue
Tue Sep 03, 2019 23:59
Global microRNA profiling of metastatic conjunctival melanoma
This study aimed to investigate the microRNA (miRNA) profile in primary tumors from conjunctival melanoma with and without subsequent metastatic spread along with their coupled distant metastases to identify miRNAs likely to be involved in metastatic progression. This observational study included 13 patients with metastatic conjunctival melanoma (follow-up: 1–39 years) treated at a Danish referral center. Twenty-five patients with nonmetastatic conjunctival melanoma (follow-up: 5–17 years) were included...
Melanoma Research - Current Issue
Tue Sep 03, 2019 23:59
Inflammatory side effects of BRAF and MEK inhibitors
The aim of this study was to describe inflammatory side effects in patients treated with BRAF and MEK inhibitors at a single tertiary care institution. This was a retrospective chart review of patients prescribed single-agent or combination BRAF and MEK inhibitors from January 2010 until May 2015. The primary outcome was the presence of inflammatory side effects. Among 124 patients, 56.4% were male, the median age was 59 years, and most (91.1%) were treated for metastatic melanoma. Most patients...
Melanoma Research - Current Issue
Tue Sep 03, 2019 23:59
Nuclear morphometric analysis in tissue as an objective tool with potential use to improve melanoma staging
Alterations in nuclear size and shape are commonly observed in cancers, and its objective evaluation may provide valuable clinical information about the outcome of the disease. Here, we applied the nuclear morphometric analysis in tissues in hematoxylin and eosin-digitized slides of nevi and melanoma, to objectively contribute to the prognostic evaluation of these tumors. To this, we analyzed the nuclear morphometry of 34 melanomas classified according to the TNM stage. Eight cases of melanocytic...
Melanoma Research - Current Issue
Tue Sep 03, 2019 23:59
Semaphorin-5A downregulation is associated with enhanced migration and invasion of BRAF-positive melanoma cells under vemurafenib treatment in melanomas with heterogeneous BRAF status
Tumor heterogeneity affects the efficacy of anticancer treatment as tumor subclones with distinct molecular patterns may be present within one tumor, leading to differing sensitivities to chemotherapeutic agents. In the present study, six melanoma tissue fragments were obtained from different parts of tumor of four patients and then the effect of vemurafenib treatment on biological characteristics and molecular processes of cell cultures was estimated by using MTT-test, apoptosis, migration and invasion...
Melanoma Research - Current Issue
Tue Sep 03, 2019 23:59
Evaluation of the contribution of germline variants in BRCA1 and BRCA2 to uveal and cutaneous melanoma
Germline mutations of BRCA1 and BRCA2 predispose individuals to a high risk of breast and ovarian cancer, and elevated risk of other cancers, including those of the pancreas and prostate. BRCA2 mutation carriers may have increased risk of uveal melanoma (UM) and cutaneous melanoma (CM), but associations with these cancers in BRCA1 mutation carriers have been mixed. Here, we further assessed whether UM and CM are associated with BRCA1 or BRCA2 by assessing the presence, segregation and reported/predicted...
Melanoma Research - Current Issue
Tue Sep 03, 2019 23:59
Biomarkers, measured during therapy, for response of melanoma patients to immune checkpoint inhibitors: a systematic review
Immune checkpoint inhibitors (ICIs), which target CTLA-4 or PD-(L)1 molecules, have shown impressive therapeutic results. Durable responses, however, are only observed in a segment of the patient population and must be offset against severe off-target immune toxicity and high costs. This calls for biomarkers that predict response during ICI treatment. Although many candidate biomarkers exist, as yet, there has been no systematic overview of biomarkers predictive during. Here, we provide a systematic...
Melanoma Research - Current Issue
Tue Sep 03, 2019 23:59
Neuroblastoma RAS viral oncogene homolog mRNA is differentially spliced to give five distinct isoforms: implications for melanoma therapy
Neuroblastoma RAS viral oncogene homolog is a commonly mutated oncogene in melanoma, and therapeutic targeting of neuroblastoma RAS viral oncogene homolog has proven difficult. We characterized the expression and phenotypic functions of five recently discovered splice isoforms of neuroblastoma RAS viral oncogene homolog in melanoma. Canonical neuroblastoma RAS viral oncogene homolog (isoform-1) was expressed to the highest degree and its expression was significantly increased in melanoma metastases...
Melanoma Research - Current Issue
Tue Sep 03, 2019 23:59
Effectiveness of dabrafenib in the treatment of patients with BRAF V600–mutated metastatic melanoma in a Named Patient Program
Given the approval of dabrafenib in patients with BRAF-mutant metastatic melanoma, a better understanding of treatment patterns and clinical outcomes with dabrafenib in a clinical setting is warranted. We performed a retrospective chart review of patients who received dabrafenib in a compassionate use setting through the Named Patient Program (DESCRIBE I study) during December 2010–August 2013 in Europe, New Zealand and Australia. Of the 331 Named Patient Program patients included, the majority (95.8%)...
Melanoma Research - Current Issue
Tue Sep 03, 2019 23:59
Prognostic significance of CD163 expression and its correlation with cyclooxygenase-2 and vascular endothelial growth factor expression in cutaneous melanoma
In several cancers, tumor progression is associated with the infiltration of tumor-associated macrophages (TAMs). The aim was to evaluate the prognostic significance of expression of CD163 and CD68 (TAMs’ markers) and their correlation with vascular endothelial growth factor (VEGF) and cyclooxygenase-2 (COX-2) expression in cutaneous melanoma. Diagnostic tissues from 102 patients of cutaneous melanoma were evaluated by immunohistochemistry for their CD68, CD163, VEGF, and COX-2 expression. Correlations...
Melanoma Research - Current Issue
Tue Sep 03, 2019 23:59
Protein kinase C-α is upregulated by IMP1 in melanoma and is linked to poor survival
The oncofetal mRNA-binding protein, IMP1 or insulin-like growth factor-2 mRNA-binding protein 1 (IGF2BP1), promotes the overexpression of several oncogenic proteins by binding to and stabilizing their mRNAs. IMP1 is frequently overexpressed in melanoma and is associated with a poor prognosis, but the full spectrum of IMP1 target transcripts remains unknown. Here, we report the identification of protein kinase C-α (PKCα), as a novel molecular target of IMP1. Overexpression of IMP1 resulted in increased...
Melanoma Research - Current Issue
Tue Sep 03, 2019 23:59
Prognostic role of disease extent and lymphocyte–monocyte ratio in advanced melanoma
Advanced melanoma (AM) represents the leading cause of death from skin cancer. To date, the crucial role of the immune system in AM pathogenesis and progression is well known, but the prognostic value of clinicopathological characteristics remains unclear. Lactate dehydrogenase (LDH) is an ascertained prognostic indicator and previous data showed that AM patients treated with BRAF and MEK inhibitors with normal LDH values and fewer than three metastatic sites achieved a better outcome. Moreover,...
Melanoma Research - Current Issue
Tue Sep 03, 2019 23:59
Immune-related pancreatitis associated with checkpoint blockade in melanoma
Recognizing and treating rare checkpoint inhibitor related adverse events may be a clinical challenge in melanoma therapy. One of rather rare affected organs is the pancreas. Immune-related pancreatitis is difficult to recognize due to its variable clinical characteristics. Asymptomatic elevations of serum lipase and/or amylase during therapy with immune-checkpoint blockade impede the diagnostic process. We present a patient who developed an immune-related pancreatitis within the first 4 months of...
Melanoma Research - Current Issue
Tue Sep 03, 2019 23:59
Acute neurological adverse events during immune checkpoint inhibition therapy in patients with melanoma brain metastases
The common adverse effects of immune checkpoint blockade therapy are well recognised. However, neurological adverse effects of checkpoint inhibitor therapy are less widely appreciated, and their clinical management remains challenging. Therefore, we report our experience of managing acute, life-threatening neurological toxicity during immune checkpoint inhibitor therapy. Five male patients with stage IV melanoma underwent anti-programmed cell death protein 1 therapy (monotherapy or combination therapy...
Melanoma Research - Current Issue
Tue Sep 03, 2019 23:59
Severe gastrointestinal toxicity of MEK inhibitors
Gastrointestinal toxicities of MEK inhibitors in melanoma patients are frequent. In clinical trials, the most common digestive adverse events were nausea, vomiting, and diarrhoea. However, severe toxicities such as colitis and gastrointestinal perforation, some with fatal outcomes, have been reported. These rare but severe adverse events are not well described. We performed a retrospective analysis of all patients with stage IV and unresectable stage III melanoma treated with a MEK inhibitors at...
Melanoma Research - Current Issue
Tue Sep 03, 2019 23:59
Observatory on Artificial Labour-induction Methods and Measuring Immediate Postpartum Maternal Satisfaction
Condition:   Labor InductionIntervention:   Sponsor:   Centre Hospitalier Universitaire de NīmesNot yet recruiting
ClinicalTrials
Mon Sep 02, 2019 19:00
Prophylactic Central Neck Dissection in Clinically Node-negative Papillary Thyroid Carcinoma
Condition:   Papillary Thyroid CancerIntervention:   Procedure: central neck dissectionSponsor:   Assiut UniversityRecruiting
ClinicalTrials
Mon Sep 02, 2019 19:00
Expression of NIS, VEGF-A and Thyroid Autoantibody in Papillary Thyroid Carcinoma with or without Hashimoto’s Disease
Background: Since the incidence of papillary thyroid carcinoma (PTC) combined with Hashimoto’s thyroiditis (HT) has increased year by year, but the mechanism is still unknown, the goal of this study was to investigate the expression of Na+/I– symporter (NIS), vascular endothelial growth factor (VEGF)-A and thyroid autoantibodies in HT combined with PTC, and to explore the relationship between HT and PTC. Methods: Real-time fluorescence quantitative polymerase chain reaction was used to detect the...
O.R.L. Journal for oto-rhino-laryngology and its borderlands
Tue Sep 03, 2019 16:52
Pharyngeal dysfunction associated with early and late onset sleep disordered breathing in children
Publication date: Available online 3 September 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Marie Lyons, Timothy Cooper, Dominic Cave, Manisha Witmans, Hamdy El-HakimAbstractObjectiveTo compare the frequency and type of diagnoses associated with pharyngeal dysfunction (PD) in children presenting with early versus late onset sleep disordered breathing (SDB)MethodsThis was a retrospective, cross-sectional study. A consecutive series of children ≤3 years old who underwent...
Pediatric Otorhinolaryngology
Tue Sep 03, 2019 15:37
Evaluation of nasal obstruction in children by acoustic rhinometry: a prospective study
Publication date: Available online 2 September 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Léa Distinguin, Bruno Louis, Geneviève Baujat, Alessandro Amaddeo, Brigitte Fauroux, Vincent Couloigner, François Simon, Nicolas LeboulangerAbstractIntroductionacoustic rhinometry (AR) is a non-invasive method measuring the nasal volume (NV) and the nasal minimal cross-sectional area (MCA), reflecting nasal obstruction. The first objective of this study was to measure and compare...
Pediatric Otorhinolaryngology
Tue Sep 03, 2019 15:37
Survival outcomes of marijuana users in p16 positive oropharynx cancer patients
Oropharynx squamous cell carcinoma (OPSCC) has become the predominant subsite for head and neck mucosal cancers (HNC) due to the rise of human papillomavirus (HPV) related disease. Previous studies have sugges...
Journal of Otolaryngology - Head & Neck Surgery
Mon Sep 02, 2019 03:00
Determinants influencing success rates of myringoplasty in daily practice: a retrospective analysis
Abstract Objectives The aim of this study was to determine influencing factors on tympanic membrane closure and their consequence on absolute risks of closure and hearing improvement in myringoplasties. Design Retrospective cohort. Setting Medium-sized medical centrum. ...
European Archives of Oto-Rhino-Laryngology
Tue Sep 03, 2019 03:00

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