Survival of patients with uveal melanoma liver metastases is strongly correlated with disease control in the liver. Unfortunately, there are no standardized treatments for this chemo-resistant disease. Selective Internal Radiation Therapy (SIRT) has been tested as salvage therapy but no data exist about its use as first-line therapy. The purpose of this study was to investigate the safety and efficacy of SIRT used as first-line therapy in patients with uveal melanoma metastatic to the liver. Methods:...
Tue Sep 03, 2019 17:12
The cell cycle is a progression of four distinct phases (G1, S, G2, M), with various cycle proteins being essential in regulating this process. In breast cancer, alterations in the cell cycle and uncontrolled proliferation led to several studies interrogating the relationship between cyclins and their counterpart cyclin-dependent-kinases (CDKs). We aimed to develop a radiolabeled CDK4/6 inhibitor for breast cancer imaging. Our transfluorinated analog ([18F]-CDKi) was evaluated and validated as a...
Tue Sep 03, 2019 17:12
Purpose: To evaluate the glucose metabolism of the inferior colliculi (IC) and primary auditory cortices (PAC) in patients with asymmetric hearing loss (AHL) using positron emission tomopgraphy (PET). Methods: Normalized regional [18F]FDG uptake of the IC and PAC (reference: cerebellum) was assessed in thirteen subjects with AHL using a fully digital clinical PET/CT system (Philips Vereos). Results: Regional metabolism of both, the IC and PAC was significantly reduced contralateral to...
Tue Sep 03, 2019 17:12
Aim: To evaluate the interobserver agreement in 18F-sodium fluoride (NaF) PET/CT for the detection of bone metastases in patients with prostate cancer (PCa). Materials and Methods:NaF PET/CT scans were retrieved from all patients who participated in four recent prospective trials. Two experienced observers independently evaluated the NaF PET/CTs on a patient level using a three-category scale (no bone metastases [M0], equivocal for bone metastases, and bone metastases present [M1]) and on a dichotomous...
Tue Sep 03, 2019 17:12
The aim of this study was to associate and predict B-Rapidly Accelerated Fibrosarcoma Valine 600 (BRAFV600) mutation status with both conventional- and radiomics fluorodeoxyglucose Positron Emission Tomography/Computer Tomography (18F-FDG PET/CT) features, while exploring several methods of feature selection in melanoma radiomics. Methods: Seventy unresectable stage III-IV melanoma patients who underwent a baseline 18F-FDG PET/CT scan were identified. Patients were assigned to the BRAFV600 group...
Tue Sep 03, 2019 17:12
Prostate cancer is a very heterogeneous disease and contemporary management is focused on identification and treatment of the prognostically adverse high-risk tumors while minimizing overtreatment of indolent, low-risk tumors. In recent years, imaging has gained increasing importance in the detection, staging, posttreatment assessment and detection of recurrence of prostate cancer. Several imaging modalities including conventional and functional methods are used in different clinical scenarios with...
Tue Sep 03, 2019 17:12
Biochemically recurrent prostate cancer (BCR) is the main indication to perform prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT). However, localizing a BCR with PSMA PET/CT remains challenging in patients with low prostate-specific antigen (PSA) values. Here, we studied the impact of advanced PET image-reconstruction methods on BCR localization and interobserver agreement with 18F-DCFPyL PET/CT scans in patients with BCR and low PSA values. Methods:...
Tue Sep 03, 2019 17:12
Tue Sep 03, 2019 17:12
Publication date: November 2019Source: World Neurosurgery, Volume 131Author(s): Akshay Gadiya, Giuseppe Lambros Morassi, Olakunle Badmus, Ann Marriot, Masood ShafafyBackgroundProximal junctional failure (PJF) is a major and sometimes devastating problem following adult spinal deformity (ASD) correction surgery. Common consensus still lags on guidelines for preventing and managing these complications. Surgical treatment of scoliosis in the presence of osteogenesis imperfecta (OI) in the pediatric...
Tue Sep 03, 2019 15:32
Publication date: November 2019Source: World Neurosurgery, Volume 131Author(s): Toshihiro Ogiwara, Yoshinari Miyaoka, Takuya Nakamura, Keita Tsukada, Daisuke Yamazaki, Kiyoshi Ito, Yoshiki Hanaoka, Jun-ichi Koyama, Tetsuyoshi Horiuchi, Kazuhiro HongoBackgroundThe endoscopic endonasal approach for the craniovertebral junction (CVJ), instead of the microscopic transoral approach, has been widely adopted and accepted, especially in resection of the odontoid process for basilar invagination. However,...
Tue Sep 03, 2019 15:32
Abstract Purpose Endovascular therapy benefits selected adults with acute stroke while data are lacking for children. The purpose of this study was to assess physician practice and institutional preparedness for endovascular therapy in pediatric stroke. Methods A link to an anonymous online survey was sent to members of the International Pediatric Stroke...
Tue Sep 03, 2019 03:00
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