Chronic obstructive pulmonary disease (COPD) is caused by the chronic inhalation of toxic particles and gases that are primarily but not exclusively derived from cigarette smoke that may be either actively or passively inhaled, which initiates a persistent innate and adaptive immune response in the lung. This immune response is associated with an aberrant tissue repair and remodeling process that results in varying degrees of chronic inflammation with excess production of mucus in the central airways...
Tue Sep 03, 2019 11:13
Background: Adequate target lobe selection for endobronchial valve (EBV) treatment in patients with severe emphysema is essential for treatment success and can be based on emphysema destruction, lobar perfusion, lobar volume, and collateral ventilation. As some patients have #x3e;1 target lobe for EBV treatment, we were interested whether we could identify the least functional lobe. Objectives: The objective of this study was to investigate the relationship between endoscopic lobar measurement of...
Tue Sep 03, 2019 11:19
Lemurs in disturbed habitats exhibited reduced gut microbial diversity Abstract Deforestation continues to jeopardize Malagasy primates as viable habitats become smaller, more fragmented, and more disturbed. This deforestation can lead to changes in diet, microhabitat, and gene flow between populations of endangered species, and it remains unclear how these changes may affect gut microbiome (GM) characteristics. The black‐and‐white ruffed lemur (Varecia variegata), which is among Madagascar's...
Mon Sep 02, 2019 22:00
Tue Sep 03, 2019 11:05
Purpose. KIF20A is essential in the process of spindle assembly and cytokinesis regulation. The role of KIF20A during tumorigenesis and tumor development has been well studied in several cancers. But the association between the KIF20A clinical role and prostate cancer (PCa) has not been reported yet. In this study, we investigated its potential prognostic effect and its role in progression of prostate cancer. Methods. Real-time quantitative polymerase chain reaction and Western blots were used to...
Tue Sep 03, 2019 11:05
Malignant germ cell tumors (GCT) are the most common malignant tumors in young men between 18 and 40 years. The correct identification of histological subtypes, in difficult cases supported by immunohistochemistry, is essential for therapeutic management. Furthermore, biomarkers may help to understand pathophysiological processes in these tumor types. Two GCT cell lines, TCam-2 with seminoma-like characteristics, and NTERA-2, an embryonal carcinoma-like cell line, were compared by a quantitative...
Tue Sep 03, 2019 11:05
We report the first case of miltefosine rescue treatment carried out for visceral leishmaniasis (VL) relapse patient. Despite undergoing treatment regimens of liposomal amphotericin B (LAMB) 5 mg/kg (standard: 10 mg/kg) daily for 3 days during the first episode followed by LAMB 5 mg/kg stat and paromomycin 15 mg/kg IM for 10 days against the second episode, the patient suffered from a third relapse and was eventually treated with miltefosine 50 mg BID directly observed treatment for 28 days. Prior...
Tue Sep 03, 2019 12:05
Background and Objectives On the basis of reported immediate and short‐term excruciating pain by patients in the post‐procedural period of computed tomography (CT)‐guided percutaneous laser disc decompression (PLDD) in our clinic, we present our initial clinical experience with a novel combi‐therapy using a combination of CT‐guided PLDD and CT‐guided epidural nerve blocks, which proved effective in managing the pain. Study Design/Materials and Methods A total of 100 patients who met the criteria...
Mon Sep 02, 2019 12:43
Light pollution has become one of the top issues in environmental pollution, especially concerning how secondary light pollution, such as from traffic reflective materials, influences animal distribution and behavior. In this study, 15 camera traps were set up at sites with or without reflective warning markers (RWM) in coniferous forests on Cangshan Mountain located in Dali Prefecture, China. The results showed that the number of independent photographs and species at sites without RWMs were significantly...
Tue Sep 03, 2019 03:00
Objective This study aims to identify effective gene networks and biomarkers to predict response and prognosis for HER2-negative breast cancer patients who received sequential taxane-anthracycline neoadjuvant chemotherapy. Materials and Methods Transcriptome data of training dataset including 310 HER2-negative breast cancer who received taxane-anthracycline treatment and an independent validation set with 198 samples...
Tue Sep 03, 2019 03:00
Kombucha, a fermented tea beverage with an acidic and effervescent taste, is composed of a multispecies microbial ecosystem with complex interactions that are characterized by both cooperation and conflict. In kombucha, a complex community of bacteria and yeast initiates the fermentation of a starter tea (usually black or green tea with sugar), producing a biofilm that covers the liquid over several weeks. This happens through several fermentative phases that are characterized by cooperation and...
Tue Sep 03, 2019 03:00
The “red siltstone” member of the Upper Triassic Chinle Formation in the Eagle Basin of Colorado contains a diverse assemblage of dinosauromorphs falling outside of Dinosauria. This assemblage is the northernmost known occurrence of non-dinosaurian dinosauromorphs in North America, and probably falls within the Revueltian land vertebrate estimated biochronozone (215–207 Ma, middle to late Norian). Lagerpetids are represented by proximal femora and a humerus referable to Dromomeron romeri. Silesaurids...
Tue Sep 03, 2019 03:00
Background Previous studies reported that reduced gray matter volume (GMV) was associated with violent-related behaviors. However, the previous studies were conducted on adults and no study has studied the association between GMV and violent behaviors on adolescents. The purpose of the study was to investigate GMV’s effects in adolescent violent offenders based on a Chinese Han population, which can address the problem of possible confounding factors in adult studies. ...
Tue Sep 03, 2019 03:00
Related ArticlesAccuracy of virtual surgical planning-assisted management for maxillary hypoplasia in adult patients with cleft lip and palate. J Plast Reconstr Aesthet Surg. 2019 Aug 07;: Authors: Wang Y, Li J, Xu Y, Huang N, Shi B, Li J Abstract PURPOSE: Management of maxillary hypoplasia in patients with cleft lip and palate (CLP) remains a significant clinical challenge. The objective of this retrospective study is to evaluate the accuracy of virtual...
Tue Sep 03, 2019 13:05
Related ArticlesReconstruction of medial epicanthal fold using v-y advancement and turnover flap. J Plast Reconstr Aesthet Surg. 2019 Aug 07;: Authors: Lee TY, Shin YH, Choi DI Abstract BACKGROUND: Since the 1900s, many methods have been developed to correct the epicanthal fold. Increased use of epicanthoplasty has yielded unsatisfactory results. OBJECTIVES: To describe a method of epicanthal fold reconstruction using V-Y advancement and turnover...
Tue Sep 03, 2019 13:05
Related ArticlesAssessment of craniofacial hyperhidrosis and flushing by sphenopalatine blockade - a randomized trial. Rhinology. 2019 Sep 02;: Authors: Lehrer E, Nogues A, Jaume F, Mullol J, Alobid I Abstract BACKGROUND: Craniofacial hyperhidrosis (CFH) and flushing express nervous system autonomic dysfunction. Available reference treatments lack good compliance. The study objective was to investigate variations of CFH/flushing after two methods of...
Tue Sep 03, 2019 13:07
Related ArticlesTraining Surgeons and Anesthesiologists to Facilitate End-of-Life Conversations With Patients and Families: A Systematic Review of Existing Educational Models. J Surg Educ. 2018 May - Jun;75(3):702-721 Authors: Bakke KE, Miranda SP, Castillo-Angeles M, Cauley CE, Lilley EJ, Bernacki R, Bader AM, Urman RD, Cooper Z Abstract OBJECTIVE: Despite caring for patients near the end-of-life (EOL), surgeons and anesthesiologists report low confidence...
Tue Sep 03, 2019 13:10
Related ArticlesOncofertility: Meeting the Fertility Goals of Adolescents and Young Adults With Cancer. Cancer J. 2018 Nov/Dec;24(6):328-335 Authors: Irene Su H, Lee YT, Barr R Abstract Adolescents and young adults aged 15 to 39 years who are diagnosed with cancer (AYA survivors) undergo a range of therapies for cancer cure but subsequently may be at risk of treatment-related infertility, and for female AYA survivors, adverse pregnancy outcomes. Future...
Tue Sep 03, 2019 13:10
Related ArticlesLook me in the eye: evaluating the accuracy of smartphone-based eye tracking for potential application in autism spectrum disorder research. Biomed Eng Online. 2019 May 03;18(1):51 Authors: Strobl MAR, Lipsmeier F, Demenescu LR, Gossens C, Lindemann M, De Vos M Abstract BACKGROUND: Avoidance to look others in the eye is a characteristic symptom of Autism Spectrum Disorders (ASD), and it has been hypothesised that quantitative monitoring...
Tue Sep 03, 2019 13:10
Related ArticlesPortrait of a cancer: mutational signature analyses for cancer diagnostics. BMC Cancer. 2019 May 15;19(1):457 Authors: Van Hoeck A, Tjoonk NH, van Boxtel R, Cuppen E Abstract BACKGROUND: In the past decade, systematic and comprehensive analyses of cancer genomes have identified cancer driver genes and revealed unprecedented insight into the molecular mechanisms underlying the initiation and progression of cancer. These studies illustrate...
Tue Sep 03, 2019 13:10
Related ArticlesRomiplostim in patients with refractory aplastic anaemia previously treated with immunosuppressive therapy: a dose-finding and long-term treatment phase 2 trial. Lancet Haematol. 2019 Aug 29;: Authors: Lee JW, Lee SE, Jung CW, Park S, Keta H, Park SK, Kim JA, Oh IH, Jang JH Abstract BACKGROUND: Aplastic anaemia is a rare, life-threatening condition, characterised by pancytopenia with hypocellular bone marrow. Haematopoietic stem cells...
Tue Sep 03, 2019 13:10
Related ArticlesArtificial Intelligence in the Management of Glioma: Era of Personalized Medicine. Front Oncol. 2019;9:768 Authors: Sotoudeh H, Shafaat O, Bernstock JD, Brooks MD, Elsayed GA, Chen JA, Szerip P, Chagoya G, Gessler F, Sotoudeh E, Shafaat A, Friedman GK Abstract Purpose: Artificial intelligence (AI) has accelerated novel discoveries across multiple disciplines including medicine. Clinical medicine suffers from a lack of AI-based applications,...
Tue Sep 03, 2019 13:10
Related ArticlesLiquid Biopsy in Oligometastatic Prostate Cancer-A Biologist's Point of View. Front Oncol. 2019;9:775 Authors: Stelcer E, Konkol M, Głȩboka A, Suchorska WM Abstract Prostate cancer (PCa) is the main cause of cancer-related mortality in males and the diagnosis, treatment, and care of these patients places a great burden on healthcare systems globally. Clinically, PCa is highly heterogeneous, ranging from indolent tumors to highly aggressive...
Tue Sep 03, 2019 13:10
Related ArticlesCombination therapies of Artemisinin and its derivatives as a viable approach for future cancer treatment. Curr Pharm Des. 2019 Sep 02;: Authors: Kumar MS, Yadav TT, Khair RR, Peters GJ, Yergeri MC Abstract BACKGROUND: Many anticancer drugs have been developed for clinical usage till now, but the major problem is the development of drug-resistance over a period of time in the treatment of cancer. Anticancer drugs produce huge adverse...
Tue Sep 03, 2019 13:10
Related ArticlesThe cross-talk between adipokines and miRNAs in health and obesity-mediated diseases. Clin Chim Acta. 2019 Aug 30;: Authors: Ghasemi A, Hashemy SI, Azimi-Nezhad M, Dehghani A, Saeidi J, Mohtashami M Abstract BACKGROUND: Multiple studies have revealed a direct correlation between obesity and the development of multiple comorbidities, including metabolic diseases, cardiovascular disorders, chronic inflammatory disease, and cancers. However,...
Tue Sep 03, 2019 13:10
Related ArticlesIntraosseous Petrous Apex Schwannoma: Case Report and Review of Literature. World Neurosurg. 2019 Aug 30;: Authors: Rozman PA, Benjamin CG, Kondziolka D, Sen C, Roland JT, Zagzag D, Snuderl M, Gordon D Abstract BACKGROUND: Intraosseous petrous apex schwannomas are an exceedingly rare entity; little is known about their epidemiology, natural history, and post-operative outcomes. CASE DESCRIPTION: Here, we present the fourth known...
Tue Sep 03, 2019 13:10
Related ArticlesImmunotherapy and urothelial carcinoma: An overview and future prospectives. Crit Rev Oncol Hematol. 2019 Aug 26;143:46-55 Authors: Pierantoni F, Maruzzo M, Gardi M, Bezzon E, Gardiman MP, Porreca A, Basso U, Zagonel V Abstract BACKGROUND: Urothelial carcinoma (UC) is a common malignancy with a high mortality rate when metastatic. Traditionally, systemic therapy consisted in platinum-based regimens as first-line, with Taxanes or Vinflunine...
Tue Sep 03, 2019 13:10
Prenatal imaging of anorectal malformations — 10-year experience at a tertiary center in Switzerland
Abstract Background Anorectal malformation is a spectrum of congenital defects of the distal bowel, mostly diagnosed at birth. Objective To describe the prenatal imaging findings of anorectal malformations, explore the causes of the low rates of prenatal diagnosis, compare the accuracy of prenatal ultrasound (US) and magnetic resonnance imaging [MRI] and...
Tue Sep 03, 2019 03:00
Related ArticlesA standardized, incremental protocol to increase human tolerance to the cross-coupled illusion. J Vestib Res. 2019 Aug 24;: Authors: Bretl KN, Sherman SO, Dixon JB, Mitchell TR, Clark TK Abstract BACKGROUND: Humans can adapt to the "Coriolis" cross-coupled illusion with repeated exposure, improving the tolerability of faster spin rates and enabling short-radius, intermittent centrifugation for artificial gravity implementation. ...
Tue Sep 03, 2019 13:12
Related ArticlesGaze stability in the elite athlete: A normative observational study. J Vestib Res. 2019 Aug 28;: Authors: Massingale S, Alexander A, Gerkin R, Leddon C, McQueary E, Allred RC, Pardini JE Abstract BACKGROUND: The ability to clearly perceive an object while the head is in motion is important in athletics, as it relates to performance and potentially to injury prevention. Normative data for healthy adults on measures of gaze stability have...
Tue Sep 03, 2019 13:12
Related ArticlesPrognostic impact of intra- and postoperative management of dural tear on postoperative complications in primary degenerative lumbar diseases. Bone Joint J. 2019 Sep;101-B(9):1115-1121 Authors: Takenaka S, Makino T, Sakai Y, Kashii M, Iwasaki M, Yoshikawa H, Kaito T Abstract AIMS: The aim of this study was to explore risk factors for complications associated with dural tear (DT), including the types of DT, and the intra- and postoperative...
Tue Sep 03, 2019 13:12
Related ArticlesA sore throat. J Stomatol Oral Maxillofac Surg. 2019 Aug 30;: Authors: Debelmas A, Lanciaux S, Bontemps P, Khonsari RH PMID: 31476541 [PubMed - as supplied by publisher]
Tue Sep 03, 2019 13:12
Related ArticlesNocturia and increase in nocturnal blood pressure: the Nagahama study. J Hypertens. 2018 11;36(11):2185-2192 Authors: Matsumoto T, Tabara Y, Murase K, Setoh K, Kawaguchi T, Nagashima S, Kosugi S, Nakayama T, Wakamura T, Hirai T, Matsuda F, Chin K, Nagahama study group Abstract OBJECTIVE: Abnormalities in circadian blood pressure (BP) variation, particularly increase in nocturnal BP, have been reported to be risk factors for cardiovascular...
Tue Sep 03, 2019 13:14
Related ArticlesPopulation-Based Evaluation of Lumbar Puncture Opening Pressures. Front Neurol. 2019;10:899 Authors: Wang F, Lesser ER, Cutsforth-Gregory JK, Bhatti MT, Kilgore KP, Hodge DO, Graff-Radford J, Petersen RC, Knopman DS, Mielke MM, Lanzino G, Leavitt JA, Chen JJ Abstract Importance: Prior studies evaluating opening pressure (OP) have mostly involved lumbar puncture (LP) for diagnosis of neurologic disease or small cohorts of healthy volunteers...
Tue Sep 03, 2019 13:14
Related ArticlesNocturnal supports for patients with central sleep apnea and heart failure: a systemic review and network meta-analysis of randomized controlled trials. Ann Transl Med. 2019 Jul;7(14):337 Authors: Chen C, Wen T, Liao W Abstract Background: Sleep apnea probably brings poor outcomes of chronic heart failure (CHF), and some methods show benefit to patients with heart failure (HF) and central sleep apnea (CSA). Our study based on the randomized...
Tue Sep 03, 2019 13:14
Related ArticlesUnderstanding adherence to noninvasive ventilation in youth with Duchenne muscular dystrophy. Pediatr Pulmonol. 2019 Sep 01;: Authors: Pascoe JE, Sawnani H, Hater B, Sketch M, Modi AC Abstract Duchenne muscular dystrophy (DMD) is an X-linked, progressive neuromuscular disorder that results in chronic respiratory insufficiency and subsequently failure requiring noninvasive ventilation (NIV). Adherence to NIV in neuromuscular disorders...
Tue Sep 03, 2019 13:14
Related ArticlesPediatric obstructive sleep apnea screening questionnaire and post-operative outcomes: A prospective observational study. Int J Pediatr Otorhinolaryngol. 2019 Aug 28;127:109661 Authors: Raman VT, Geyer E, Miller R, Tumin D, Splaingard M, Jatana KR, Tobias JD Abstract INTRODUCTION: Obstructive Sleep Apnea (OSA) and Sleep Disordered Breathing (SDB) in children tend to be a more complex and multifactorial disease than in adults. Although...
Tue Sep 03, 2019 13:14
Related ArticlesA Positioning Device for the Placement of Mice During Intranasal siRNA Delivery to the Central Nervous System. J Vis Exp. 2019 Aug 15;(150): Authors: Ullah I, Chung K, Beloor J, Lee SK, Kumar P Abstract Intranasal (IN) drug delivery to the brain has emerged as a promising method to bypass the blood-brain barrier (BBB) for the delivery of drugs into the central nervous system (CNS). Recent studies demonstrate the use of a peptide, RVG9R,...
Tue Sep 03, 2019 13:16
Related ArticlesA Rapid Method for Modeling a Variable Cycle Engine. J Vis Exp. 2019 Aug 13;(150): Authors: Yu B, Miao R, Shu W Abstract The variable cycle engines (VCE) that combine the advantages of turbofan and turbojet engines, are widely considered to be the next generation aircraft engines. However, developing VCE requires high costs. Thus, it is essential to build a mathematical model when developing an aircraft engine, which may avoid a large...
Tue Sep 03, 2019 13:16
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