Related ArticlesTGF-β/SMAD4 signaling pathway activates the HAS2-HA system to regulate granulosa cell state. J Cell Physiol. 2019 Sep 06;: Authors: Li X, Du X, Yao W, Pan Z, Li Q Abstract Both TGF-β/SMAD4 signaling pathway and HAS2-HA system have been shown to control granulosa cell (GC) state in mammalian ovary. However, the regulatory relationship between TGF-β/SMAD4 signaling pathway and HA system in GCs is not well known. Here, we report that the...
Sat Sep 07, 2019 14:51
Related ArticlesMicroRNA-26b inhibits oligodendrocyte precursor cell differentiation by targeting adrenomedullin in spinal cord injury. J Cell Physiol. 2019 Sep 06;: Authors: Cheng L, Wang C, Yao F, Li Z, Liu W, Jing J Abstract Oligodendrocyte precursor cells (OPCs) serve as a reservoir of newborn oligodendrocytes (OLs) in pathological and homeostatic conditions. After spinal cord injury (SCI), OPCs are activated to generate myelinating OLs, contributing...
Sat Sep 07, 2019 14:51
Related ArticlesAccumulation of sphingomyelin in Niemann-Pick disease type C cells disrupts Rab9-dependent vesicular trafficking of cholesterol. J Cell Physiol. 2019 Sep 06;: Authors: Wanikawa M, Nakamura H, Emori S, Hashimoto N, Murayama T Abstract Niemann-Pick disease type C (NPC) is a genetic disorder in which patient cells have endosomal/lysosomal accumulation of cholesterol and sphingolipids. However, the relationship between sphingolipids and cholesterol...
Sat Sep 07, 2019 14:51
Related ArticlesNetwork-based analysis reveals novel gene signatures in the peripheral blood of patients with sporadic nonsyndromic thoracic aortic aneurysm. J Cell Physiol. 2019 Sep 06;: Authors: Xu H, Chen S, Zhang H, Zou Y, Zhao J, Yu J, Le S, Cui J, Jiang L, Wu J, Xia J Abstract Thoracic aortic aneurysm (TAA), a serious cardiovascular disease that causes morbidity and mortality worldwide. At present, few biomarkers can accurately diagnose the appearance...
Sat Sep 07, 2019 14:51
Related ArticlesLong intergenic noncoding RNA 00641 inhibits breast cancer cell proliferation, migration, and invasion by sponging miR-194-5p. J Cell Physiol. 2019 Sep 06;: Authors: Mao Q, Lv M, Li L, Sun Y, Liu S, Shen Y, Liu Z, Luo S Abstract Long noncoding RNAs have an essential role in the tumorigenesis of breast cancer (BC). Nonetheless, the consequences of long intergenic noncoding RNA 00641 (LINC00641) in BC remain unidentified. This study shows...
Sat Sep 07, 2019 14:51
Related ArticlesLung tissue extracellular matrix-derived hydrogels protect against radiation-induced lung injury by suppressing epithelial-mesenchymal transition. J Cell Physiol. 2019 Sep 06;: Authors: Zhou J, Wu P, Sun H, Zhou H, Zhang Y, Xiao Z Abstract This study aimed to examine whether lung tissue extracellular matrix (ECM) hydrogels have protective effects on radiation-induced lung injury (RILI). The cytocompatibility and histocompatibility were...
Sat Sep 07, 2019 14:51
Related ArticlesA large-scale transcriptome analysis identified ELANE and PRTN3 as novel methylation prognostic signatures for clear cell renal cell carcinoma. J Cell Physiol. 2019 Sep 06;: Authors: Wei Z, Wu B, Wang L, Zhang J Abstract DNA methylation was involved in the progress of many types of cancer including clear cell renal cell carcinomas (ccRCCs). This study aimed to identify the prognostic DNA methylation biomarkers for the ccRCCs by a large-scale...
Sat Sep 07, 2019 14:51
Related ArticlesMalate-aspartate shuttle promotes l-lactate oxidation in mitochondria. J Cell Physiol. 2019 Sep 06;: Authors: Altinok O, Poggio JL, Stein DE, Bowne WB, Shieh AC, Snyder NW, Orynbayeva Z Abstract Metabolism in cancer cells is rewired to generate sufficient energy equivalents and anabolic precursors to support high proliferative activity. Within the context of these competing drives aerobic glycolysis is inefficient for the cancer cellular...
Sat Sep 07, 2019 14:51
Related ArticlesEpigenetic Regulation and Drug Discovery for Cancer Therapy. Curr Top Med Chem. 2019;19(12):971 Authors: Yu B, Ouyang L AbstractPMID: 31486748 [PubMed - in process]
Fri Sep 06, 2019 18:36
Related ArticlesKRAS: A promising therapeutic target for cancer treatment. Curr Top Med Chem. 2019 Sep 05;: Authors: Wu HZ, Xiao JQ, Xiao SS, Cheng Y Abstract Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. Scientists have not successfully developed drugs...
Fri Sep 06, 2019 18:36
Related ArticlesProspects of Utilizing Computational Techniques for the Treatment of Human Diseases. Curr Top Med Chem. 2019;19(13):1071-1074 Authors: Nayarisseri A AbstractPMID: 31490742 [PubMed - in process]
Sat Sep 07, 2019 14:51
Related ArticlesSpinal osteoid osteoma recurring as an aggressive osteoblastoma. Neurocirugia (Astur). 2019 Sep 02;: Authors: López-Puerta JM, Fernández-Marín MR, Martín Benlloch JA, Lorente R Abstract We report an uncommon case of osteoid osteoma recurring as an aggressive osteoblastoma of the spine. A 15-years-old male consulted in our department with long-term painful scoliosis. The CT-scans and MRI revealed a sclerotic bone forming tumor of 7mm diameter...
Sat Sep 07, 2019 15:14
Related ArticlesAltitudinal variations in wing morphology of Aedes albopictus (Diptera, Culicidae) in Albania, the region where it was first recorded in Europe. Parasite. 2019;26:55 Authors: Prudhomme J, Velo E, Bino S, Kadriaj P, Mersini K, Gunay F, Alten B Abstract The rapid spread and settlement of Aedes albopictus mosquitoes across at least 28 countries in Europe, as well as several countries in Asia Minor, the Middle East and Africa, has made it...
Sat Sep 07, 2019 15:26
Abstract Iturin A is a very important cyclic lipopeptide produced by several B. subtilis strains and has large commercial and therapeutic application potentials but its production on industrial scale has not been realized yet. In the present study, we have observed that the strain ET-1 of Bacillus subtilis, a producer of Iturin A, can present at least three different colony morphologies, which we arbitrarily called Rough, Smooth, and Mucoid morphotypes (R-, S-, and M-form). Performing...
Sat Sep 07, 2019 03:00
Abstract Bacteria under stress increase the proportion of dormant cells to ensure their survival. Cold and osmotic stress are similar, because in both the availability of water is reduced. Glycine betaine (GB) is one of the most common osmoprotectants in bacteria and possesses cryoprotectant properties. Our aim was to determine whether GB modifies the proportion of dormant Deinococcus sp. UDEC-P1 and Psychrobacter sp. UDEC-A5 cells exposed to osmotic stress. Both bacterial strains...
Sat Sep 07, 2019 03:00
Related ArticlesC-Terminal HSP90 Inhibitors Block the HIF-1 Hypoxic Response by Degrading HIF-1α through the Oxygen-Dependent Degradation Pathway. Cell Physiol Biochem. 2019;53(3):480-495 Authors: Kataria N, Martinez CA, Kerr B, Zaiter SS, Morgan M, McAlpine SR, Cook KM Abstract BACKGROUND/AIMS: Hypoxia Inducible Factor-1α (HIF-1α) is involved in cancer progression and is stabilized by the chaperone HSP90 (Heat Shock Protein 90), preventing degradation....
Fri Sep 06, 2019 20:14
Related ArticlesMechanisms of hypoxia signalling: new implications for nephrology. Nat Rev Nephrol. 2019 Sep 05;: Authors: Schödel J, Ratcliffe PJ Abstract Studies of the regulation of erythropoietin (EPO) production by the liver and kidneys, one of the classical physiological responses to hypoxia, led to the discovery of human oxygen-sensing mechanisms, which are now being targeted therapeutically. The oxygen-sensitive signal is generated by 2-oxoglutarate-dependent...
Sat Sep 07, 2019 16:35
A growing number of older adults experience mild cognitive impairment (MCI) and dementia. Recent technological advances allow for traditional cognitive interventions to be administered via computers and other ...
Fri Sep 06, 2019 03:00
Falling is the most common accident of daily living and the second most prevalent cause of accidental death in the world. The complex nature of risk factors associated with falling makes those at risk amongst ...
Sat Sep 07, 2019 03:00
Related ArticlesInnervation and nerve-immune cell contacts in mouse Peyer's patches. Histol Histopathol. 2019 Sep 05;:18158 Authors: Al-Shalan HAM, Hu D, Nicholls PK, Greene WK, Ma B Abstract Neural regulation of the function of the gastrointestinal tract (GIT) relies on a delicate balance of the two divisions of its nervous system, namely, the intrinsic and extrinsic divisions. The intrinsic innervation is provided by the enteric nervous system (ENS),...
Fri Sep 06, 2019 17:12
Publication date: Available online 6 September 2019Source: Annals of Anatomy - Anatomischer AnzeigerAuthor(s): T. Sandulescu, F. Stoltenberg, H. Buechner, H. Schmidt-Park, F. Linnerz, J. Jast, M. Franzmann, T. Blaurock-Sandulescu, E.A. Naumova, W.-H. ArnoldAbstractObjectiveThe superficial musculoaponeurotic system connects the mimic muscles to the skin, allowing mimic expressions with regional morphological architectural differences. The aim of this study was to perform an architectural analysis...
Sat Sep 07, 2019 17:56
Triangulenes are of current interest for potential applications in molecular electronics. We describe here a three step synthesis of the 4,8,12‐trihydro[3]triangulenium cation by cascade cyclization of a tetra‐benzyl alcohol precursor in triflic acid solution. This stable carbocation is easily observed by NMR and optical spectroscopy and is highly fluorescent. Quenching of the cation into basic solutions or by hydride transfer from triethylsilane provides access to stable dihydro and tetrahydro[3]triangulenes....
Thu Sep 05, 2019 17:05
Described here is a new and viable approach to achieve advanced Pd‐catalyzed aerobic oxidation systems (AOSs) by circumventing oxidation and catalysis problems through all‐in‐one strategy within a robust metal‐organic framework (MOF). The rational assembly of PdII catalyst, phenanthroline ligand and CuII species (electron transfer mediator) into MOF facilitates the fast regeneration of PdII active species accomplished by the enhanced electron transfer from in situ generated Pd0 to CuII, and then...
Thu Sep 05, 2019 17:33
Despite the fact that anionic doping has been extensively used to broaden the visible‐light absorption of metal‐oxide based photoanodes, it can also result in detrimental effects, such as the dopant acting as a charge recombination center, that shorten the charge carrier lifetime. Therefore, developing an effective strategy for intrinsically activating these dopants to improve their visible‐light absorption while elongating the carrier lifetime is crucial. Here, a N‐doped TiO2 model reveals a conceptually...
Thu Sep 05, 2019 18:03
A mononuclear nonheme manganese(IV)‐oxo complex binding Ce4+ ion, [(dpaq)MnIV(O)]+‐Ce4+ (1‐Ce4+), was synthesized by reacting [(dpaq)MnIII(OH)]+ ( 2 ) with cerium ammonium nitrate (CAN). 1‐Ce4+ was well characterized using various spectroscopic techniques, such as UV‐vis, EPR, CSI‐MS, rRaman, XANES, and EXAFS, showing an Mn‐O bond distance of 1.69 Å with a rRaman band at 675 cm–1 . Electron‐transfer and oxygen atom transfer reactivities of 1‐Ce4+ were found to be greater than those of MnIV(O)...
Thu Sep 05, 2019 21:33
The strong binding ability of P‐ylides with transition metals limits the utilization of stabilized P‐ylide as nucleophiles in asymmetric organometallic catalysis. Herein we describe the first rhodium‐catalyzed asymmetric ring‐opening reaction of P‐ylides utilizing oxabicyclic alkenes as the electrophilic partner. Various P‐ylides including ester‐, ketone‐ and amide‐style P‐ylides are all applicable. This asymmetric reaction occurs through the cleavage of two bridgehead C−O bonds and the formation...
Fri Sep 06, 2019 12:04
Nuclear magnetic resonance (NMR) spectroscopy serves as an indispensable tool in chemistry and biology but often suffers from long experimental time. We present a proof‐of‐concept of application of deep learning and neural network for high‐quality, reliable, and very fast NMR spectra reconstruction from limited experimental data. We show that the neural network training can be achieved using solely synthetic NMR signal, which lifts the prohibiting demand for large volume of realistic training data...
Fri Sep 06, 2019 15:41
The development of energy storage devices has received increasing attentions as a vital transformative technology to realize low‐carbon economy and sustainable energy supply. Lithium–sulfur (Li–S) batteries are considered to be one of the most promising next‐generation energy storage devices due to their ultrahigh energy density. Despite the extraordinary progress in the last few years, the actual energy density of Li–S batteries is still far from satisfactory to meet the demand for practical applications....
Fri Sep 06, 2019 16:07
A convenient and efficient one step synthesis of 1,1,1‐triborylalkanes was achieved by sequential dehydrogenative borylation and double hydroborations of terminal alkynes with HBpin (HBpin = pinacolborane) catalyzed by inexpensive and easily available Cu(OAc)2. This protocol proceeded under mild conditions, furnishing 1,1,1‐tris(boronates) with wide substrate scope, excellent selectivity and good functional group tolerance, and is applicable to gram‐scale synthesis without loss of yield. The 1,1,1‐triborylalkanes...
Fri Sep 06, 2019 16:33
A highly efficient kinetic resolution of racemic amino alcohols has been achieved for the first time with a chiral tin catalyst. A chiral organotin with 3,4,5‐trifluorophenyl groups at the 3, 3’‐positions of binaphthyl framework enabled this transformation with excellent yield and high enantioselectivity. The process tolerates aryl‐ and alkyl‐substituted amino alcohols and a variety of other substrates affording the corresponding products in high enantioselectivity and with s factors up to > 500.
Fri Sep 06, 2019 16:33
Alkyne‐Directed Chemo‐ and Enantioselectivity. Highly enantioselective catalytic reductive coupling of allyl acetate with acetylenic ketones occurs in a chemoselective manner in the presence of aliphatic or aromatic ketones. This method was used to construct C14‐C23 of pladienolide D in half the steps previously required.
Fri Sep 06, 2019 17:04
Incorporation of monatomic 2 p ligands into the core of iron‐sulfur clusters has seen significant urgency ever since the discovery of interstitial carbide in the FeMo cofactor of Mo‐dependent nitrogenase, but this has proven to be a synthetic challenge. In this work, two distinct synthetic pathways have been rationalized to install nitride ligands into targeted positions of W‐Fe‐S clusters, generating unprecedented nitride‐ligated iron‐sulfur clusters, namely [(Tp*) 2 W 2 Fe 6 ( μ 4 ‐N)...
Fri Sep 06, 2019 18:18
An enantioselective three‐component radical reaction of quinolines or pyridines with enamides and α‐bromo carbonyl compounds via dual photoredox and chiral Brønsted acid catalysis is presented. A range of valuable chiral γ‐amino acid derivatives are accessible in high chemo‐, regio‐ and enantioselectivity from simple, readily available starting materials under mild conditions. Using the same strategy, the asymmetric synthesis of 1,2‐diamine derivatives is also reported.
Fri Sep 06, 2019 18:18
(–)‐Himeradine A is a complex lycopodium alkaloid with seven rings and ten stereogenic centers that shows anticancer activity against lymphoma L1210 cells. A total synthesis has been developed that builds off prior work on (+)‐fastigiatine. A 2,4,6‐trisubstitited piperidine ring forms the core of the quinolizidine segment, and was prepared by diastereoselective reduction of a pyridine and classic resolution of an intermediate. The remaining secondary amine was introduced with a catalyst‐controlled...
Fri Sep 06, 2019 21:03
A sequential cross‐coupling/annulation of ortho‐vinyl bromobenzenes with aromatic bromides was realized, providing a direct and modular approach to access polycyclic aromatic compounds. A vinyl‐coordinated palladacycle was proposed as the key intermediate for this sequential process. Excellent chemoselectivity and regioselectivity were observed in this transformation. The practicability of this method is highlighted by its broad substrate scope, excellent functional group tolerance, and rich transformations...
Fri Sep 06, 2019 19:04
Abstract Autoimmune pancreatitis (AIP) is an inflammatory process of the pancreas that occurs most commonly in elderly males and clinically can mimic pancreatic adenocarcinoma and present with jaundice, weight loss, and abdominal pain. Mass-forming lesions in the pancreas are seen in the focal form of AIP and both clinical and imaging findings can overlap those of pancreatic cancer. The accurate distinction of AIP from pancreatic cancer is of utmost importance as it means avoiding...
Fri Sep 06, 2019 03:00
Abstract Purpose To compare prevalence and severity of multi-compartment pelvic floor dysfunction between supine magnetic resonance defecography with defecation (MRD) and supine dynamic MRI during Valsalva, both with and without rectal distention. Methods This was an IRB-approved, HIPAA-compliant retrospective review of consecutive patients referred for MR...
Sat Sep 07, 2019 03:00
Abstract Introduction Trauma to the genitourinary system includes blunt and penetrating injuries to bladder and ureters. These are rare injuries and are overlooked as other abdominal and pelvic injuries often take priority. Delayed diagnosis can lead to significant morbidity and mortality. Computed tomography has taken a central role in the imaging of the ureters and bladder. ...
Sat Sep 07, 2019 03:00
Abstract Acute pancreatitis (AP) is the most common gastrointestinal disease resulting in hospitalization in the United States with reports of over 270,000 hospitalizations and costs up to 2.6 billion dollars per year. AP is highly variable in disease course and outcome. Established in 1992, the original Atlanta classification system aimed to categorize the wide spectrum of AP by creating consensus-based terminology for AP types, severity, and complications. Though the original...
Sat Sep 07, 2019 03:00
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