Related ArticlesMiT family translocation renal cell carcinomas: A 15th anniversary update. Histol Histopathol. 2019 Sep 06;:18159 Authors: Gandhi JS, Malik F, Amin MB, Argani P, Bahrami A Abstract Microphthalmia (MiT) family translocation renal cell carcinomas (RCCs) are a heterogeneous category of renal tumors which all express MiT transcription factors, typically from chromosomal translocation and rarely from gene amplification. This tumor family has...
Sun Sep 08, 2019 02:17
Related ArticlesIntrasphenoidal encephalocele (ISE) with spontaneous CSF rhinorrhea in idiopathic intracranial hypertension: A need for clarity in terminology & imaging delineation. World Neurosurg. 2019 Sep 03;: Authors: Manjubashini D, Kiran M, Akshaya S, Nagarajan K Abstract BACKGROUND: Magnetic Resonance (MR) imaging plays an important role in identification of any underlying structural cause in spontaneous cerebrospinal fluid (CSF) leaks - either...
Sun Sep 08, 2019 04:30
Background. To determine the impact of HTRA1 rs1120638, TIMP3 rs9621532, VEGFA rs833068, CFI rs10033900, ERCC6 rs3793784, and KCTD10 rs56209061 genotypes on the development of age-related macular degeneration (AMD) in the Lithuanian population. Methods. A total of 916 subjects were examined: 309 patients with early AMD, 301 patients with exudative AMD, and 306 healthy controls. The genotyping of HTRA1 rs11200638, TIMP3 rs9621532, VEGFA rs833068, CFI rs10033900, ERCC6 rs3793784, and KCTD10 rs56209061...
Sun Sep 08, 2019 03:05
In this paper, we used tongue coating to obtain metabolites in patients with coronary heart disease (CHD) and chronic renal failure (CRF). The metabolites were analyzed to discover the substance that serves as the underlying basis of the damp phlegm pattern. This analysis is based on the Traditional Chinese Medicine (TCM) theory of “different diseases have the same pattern.” The metabolic spectrum was obtained through the Gas Chromatography Mass Spectrometry coupling techniques and analyzed by searching...
Sun Sep 08, 2019 03:05
The focus of sepsis has shifted from inflammation to organ dysfunction on the basis of a recent definition based on the sequential organ failure score (SOFA). A diagnostic and prognostic marker is necessary under this definition but is currently unknown. We enrolled 80 sepsis patients consecutively admitted to an intensive care unit through the emergency department and 80 healthy control patients who received routine health check-ups from August 2018 to January 2019. SEPSIS-3 criteria were used for...
Sun Sep 08, 2019 03:05
Liver fibrosis consists in the accumulation of extracellular matrix components mainly derived from activated hepatic stellate cells. This is commonly the result of chronic liver injury repair and represents an important health concern. As liver biopsy is burdened with many drawbacks, not surprisingly there is great interest to find new reliable noninvasive methods. Among the many are new potential fibrosis biomarkers under study, some of the most promising represented by the growth arrest-specific...
Sun Sep 08, 2019 03:05
Our immediate objective is to determine whether infectivity of lytic podophage T3 has a relatively high persistence in the blood of a mouse, as suggested by previous data. Secondarily, we determine whether the...
Thu Sep 05, 2019 03:00
HIV-1 rapidly establishes a persistent infection that can be contained under life-long antiretroviral therapy (ART) but not cured. One major viral reservoir is the peripheral lymph node (LN) follicles. Studyin...
Fri Sep 06, 2019 03:00
Background and Objectives To evaluate the feasibility and efficacy of single‐fiber laser ablation (LA) under ultrasound guidance and appropriate ablation modes in the treatment of selected metastatic lymph nodes of papillary thyroid carcinoma (PTC) and benign cold thyroid nodules Study Design/Materials and Methods A total of 18 patients (consisting of 8 patients with 18 metastatic lymph nodes of PTC and 10 patients with 10 benign cold thyroid nodules) each underwent one session of single‐fiber...
Thu Sep 05, 2019 19:19
Background and Objectives Photobiomodulation (PBM) therapy with 830 nm wavelength or 660 wavelength to compare the effects with parameters of 30 mW, 0.028 cm2, 9.34 seconds, and 3.64 J on the total integration of total skin grafts in rats submitted to nicotine. Study Design/Materials and Methods Sixty male Wistar rats were divided in six groups: Sham—skin‐grafting surgery; 830 nm—skin‐grafting followed by 830 nm irradiation; 660 nm—skin grafting followed by 660 nm irradiation; Nicotine—subjected...
Sat Sep 07, 2019 21:19
Background and Objective Laser ablation can be used to treat atrial fibrillation by thermally isolating pulmonary veins. In this study, we evaluated the feasibility of high‐resolution (<1 mm) ultrasound thermal imaging to monitor spatial temperature distribution during laser ablation on ex vivo cardiac tissue. Study Design/Materials and Methods Laser ablation (808 nm) was performed on five porcine cardiac tissue samples. A thermocouple was used to measure the interstitial tissue temperature...
Sat Sep 07, 2019 21:20
Related ArticlesTumor Dormancy and Interplay with Hypoxic Tumor Microenvironment. Int J Mol Sci. 2019 Sep 03;20(17): Authors: Butturini E, Carcereri de Prati A, Boriero D, Mariotto S Abstract The tumor microenvironment is a key factor in disease progression, local resistance, immune-escaping, and metastasis. The rapid proliferation of tumor cells and the aberrant structure of the blood vessels within tumors result in a marked heterogeneity in the perfusion...
Fri Sep 06, 2019 17:28
Related ArticlesREV7 has a dynamic adaptor region to accommodate small GTPase RAN/Shigella IpaB ligands and its activity is regulated by RanGTP/GDP switch. J Biol Chem. 2019 Sep 04;: Authors: Wang X, Pernicone N, Pertz L, Hua D, Zhang T, Listovsky T, Xie W Abstract REV7, also termed mitotic arrest-deficient 2-like 2 (MAD2L2 or MAD2B), acts as an interaction module in a broad array of cellular pathways, including translesion DNA synthesis, cell-cycle...
Fri Sep 06, 2019 17:28
Related ArticlesMink Enteritis Virus Infection Induces Mitochondrion-mediated Apoptosis by the Viral Nonstructural Protein 1. J Virol. 2019 Sep 04;: Authors: Lin P, Cheng Y, Song S, Qiu J, Yi L, Cao Z, Li J, Cheng S, Wang J Abstract Mink enteritis virus (MEV), an autonomous parvovirus, causes acute hemorrhagic enteritis in minks. The molecular pathogenesis of MEV infection has not been fully understood. In this study, we observed a significantly increased...
Fri Sep 06, 2019 17:28
Related ArticlesProoxidative Activity of Celastrol Induces Apoptosis, DNA Damage, and Cell Cycle Arrest in Drug-Resistant Human Colon Cancer Cells. Oxid Med Cell Longev. 2019;2019:6793957 Authors: Moreira H, Szyjka A, Paliszkiewicz K, Barg E Abstract Cancer resistance to chemotherapy is closely related to tumor heterogeneity, i.e., the existence of distinct subpopulations of cancer cells in a tumor mass. An important role is assigned to cancer stem cells...
Fri Sep 06, 2019 17:28
Related ArticlesmiR‑5191 functions as a tumor suppressor by targeting RPS6KB1 in colorectal cancer. Int J Oncol. 2019 Aug 30;: Authors: An HJ, Park M, Kim J, Han YH Abstract MicroRNAs (miRNAs/miRs) are a class of small non‑coding RNAs that play pivotal roles in cancer physiology as important epigenetic regulators of gene expression. Several miRNAs have been previously discovered that regulate the proliferation of the colorectal cancer (CRC) cell line...
Fri Sep 06, 2019 17:28
Related ArticlesExpression profile‑driven discovery of AURKA as a treatment target for liposarcoma. Int J Oncol. 2019 Aug 23;: Authors: Yen CC, Chen SC, Hung GY, Wu PK, Chua WY, Lin YC, Yen CH, Chen YC, Wang JY, Yang MH, Chao Y, Chang MC, Chen WM Abstract Liposarcoma (LPS) is one of the most frequently reported type of soft‑tissue sarcoma (STS). Well‑differentiated (WD) LPS and dedifferentiated (DD) LPS are the two most common subtypes. Chemotherapy...
Fri Sep 06, 2019 17:28
Related ArticlesBromodomain inhibitor jq1 induces cell cycle arrest and apoptosis of glioma stem cells through the VEGF/PI3K/AKT signaling pathway. Int J Oncol. 2019 Aug 29;: Authors: Wen N, Guo B, Zheng H, Xu L, Liang H, Wang Q, Wang D, Chen X, Zhang S, Li Y, Zhang L Abstract Bromodomain and extraterminal domain proteins, especially bromodomain‑containing protein 4 (Brd4), have recently emerged as therapeutic targets for several cancers, although the...
Fri Sep 06, 2019 17:28
Related ArticlesPiperlongumine induces autophagy in biliary cancer cells via reactive oxygen species-activated Erk signaling pathway. Int J Mol Med. 2019 Aug 23;: Authors: Chen SY, Huang HY, Lin HP, Fang CY Abstract Biliary cancer (BC) is an aggressive neoplasm with high mortality. BC can be categorized into three groups: Intrahepatic cholangiocarcinoma (CCA; also known as bile duct cancer), extrahepatic cholangiocarcinoma and gallbladder cancer. Due...
Fri Sep 06, 2019 17:28
Related ArticlesMicroRNA‑192 inhibits cell proliferation and induces apoptosis in human breast cancer by targeting caveolin 1. Oncol Rep. 2019 Aug 30;: Authors: Chen P, Feng Y, Zhang H, Shi X, Li B, Ju W, Yu X, Zhang N, Luo X Abstract It has been demonstrated that microRNA‑192 (miR‑192) serves important roles in different cancer types, including breast cancer, prostate cancer and colorectal cancer. However, its biological role and function in breast...
Fri Sep 06, 2019 17:28
Related ArticlesMTMR3 is upregulated in patients with breast cancer and regulates proliferation, cell cycle progression and autophagy in breast cancer cells. Oncol Rep. 2019 Aug 23;: Authors: Wang Z, Zhang M, Shan R, Wang YJ, Chen J, Huang J, Sun LQ, Zhou WB Abstract As a member of the myotubularin family, myotubularin related protein 3 (MTMR3) has been demonstrated to participate in tumor development, including oral and colon cancer. However, little...
Fri Sep 06, 2019 17:28
Related ArticlesDCR2, a Cellular Senescent Molecule, Is a Novel Marker for Assessing Tubulointerstitial Fibrosis in Patients with Immunoglobulin A Nephropathy. Kidney Blood Press Res. 2019 Sep 05;:1-12 Authors: Chen J, Hu W, Xiao F, Lin L, Chen K, Wang L, Wang X, He Y Abstract BACKGROUND/AIMS: Stress-induced cell senescence, which contributes to cell cycle arrest and is independent of age, plays an important role in chronic kidney disease (CKD) progression....
Fri Sep 06, 2019 17:28
Related ArticlesIncidence of Endocrine Dysfunction Following the Use of Different Immune Checkpoint Inhibitor Regimens: A Systematic Review and Meta-analysis. JAMA Oncol. 2018 Feb 01;4(2):173-182 Authors: Barroso-Sousa R, Barry WT, Garrido-Castro AC, Hodi FS, Min L, Krop IE, Tolaney SM Abstract Importance: If not promptly recognized, endocrine dysfunction can be life threatening. The incidence and risk of developing such adverse events (AEs) following...
Sat Sep 07, 2019 13:46
Related ArticlesAssociation of First-in-Class Immune Checkpoint Inhibition and Targeted Therapy With Survival in Patients With Stage IV Melanoma. JAMA Oncol. 2018 Jan 01;4(1):126-128 Authors: Sinnamon AJ, Neuwirth MG, Gimotty PA, Gangadhar TC, Amaravadi RK, Schuchter LM, Karakousis GC PMID: 29145547 [PubMed - indexed for MEDLINE]
Sat Sep 07, 2019 13:46
Related ArticlesClinical and Molecular Characteristics Associated With Survival Among Patients Treated With Checkpoint Inhibitors for Advanced Non-Small Cell Lung Carcinoma: A Systematic Review and Meta-analysis. JAMA Oncol. 2018 Feb 01;4(2):210-216 Authors: Lee CK, Man J, Lord S, Cooper W, Links M, Gebski V, Herbst RS, Gralla RJ, Mok T, Yang JC Abstract Importance: Checkpoint inhibitors have replaced docetaxel as the new standard second-line therapy...
Sat Sep 07, 2019 13:46
Related ArticlesThe AHR represses nucleotide excision repair and apoptosis and contributes to UV-induced skin carcinogenesis. Cell Death Differ. 2018 11;25(10):1823-1836 Authors: Pollet M, Shaik S, Mescher M, Frauenstein K, Tigges J, Braun SA, Sondenheimer K, Kaveh M, Bruhs A, Meller S, Homey B, Schwarz A, Esser C, Douki T, Vogel CFA, Krutmann J, Haarmann-Stemmann T Abstract Ultraviolet B (UVB) radiation induces mutagenic DNA photoproducts, in particular...
Sat Sep 07, 2019 13:46
Related ArticlesZika virus E protein alters the properties of human fetal neural stem cells by modulating microRNA circuitry. Cell Death Differ. 2018 11;25(10):1837-1854 Authors: Bhagat R, Prajapati B, Narwal S, Agnihotri N, Adlakha YK, Sen J, Mani S, Seth P Abstract Zika virus (ZV) infects neural stem cells (NSCs) and causes quiescence in NSCs, reducing the pool of brain cells, leading to microcephaly. Despite conscientious efforts, the molecular mechanisms...
Sat Sep 07, 2019 13:46
Related Articlesp53 accumulation following cytokinesis failure in the absence of caspase-2. Cell Death Differ. 2018 11;25(11):2050-2052 Authors: Lim Y, De Bellis D, Dorstyn L, Kumar S AbstractPMID: 30082771 [PubMed - indexed for MEDLINE]
Sat Sep 07, 2019 13:46
Related ArticlesSynthesis and Cytotoxic Study of a Platinum(IV) Anticancer Prodrug with Selectivity toward Luteinizing Hormone-Releasing Hormone (LHRH) Receptor-Positive Cancer Cells. Inorg Chem. 2019 Aug 19;58(16):11076-11084 Authors: Yao H, Xu Z, Li C, Tse MK, Tong Z, Zhu G Abstract Platinum drugs including cisplatin are widely used in clinics to treat various types of cancer. However, the lack of cancer-cell selectivity is one of the major problems...
Sat Sep 07, 2019 13:46
Related ArticlesEstablishment of a Parvovirus B19 NS1-Expressing Recombinant Adenoviral Vector for Killing Megakaryocytic Leukemia Cells. Viruses. 2019 Sep 04;11(9): Authors: Xu P, Wang X, Li Y, Qiu J Abstract Adenoviral viral vectors have been widely used for gene-based therapeutics, but commonly used serotype 5 shows poor transduction efficiency into hematopoietic cells. In this study, we aimed to generate a recombinant adenovirus serotype 5 (rAd5)...
Sat Sep 07, 2019 13:46
Related ArticlesResponse of neuroblastoma cells to RF currents as a function of the signal frequency. BMC Cancer. 2019 Sep 05;19(1):889 Authors: Hernández-Bule ML, Medel E, Colastra C, Roldán R, Úbeda A Abstract BACKGROUND: Capacitive-resistive electric transfer (CRET) is a non-invasive therapeutic strategy that applies radiofrequency electric currents within the 400-600 kHz range to tissue repair and regeneration. Previous studies by our group have...
Sat Sep 07, 2019 13:46
Related ArticlesOncogenic Akt-FOXO3 loop favors tumor-promoting modes and enhances oxidative damage-associated hepatocellular carcinogenesis. BMC Cancer. 2019 Sep 05;19(1):887 Authors: Lu M, Hartmann D, Braren R, Gupta A, Wang B, Wang Y, Mogler C, Cheng Z, Wirth T, Friess H, Kleeff J, Hüser N, Sunami Y Abstract BACKGROUND: Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer, accounting for 80-90% of cases. Mutations are commonly...
Sat Sep 07, 2019 13:46
Related ArticlesSolid state fermentation process with Aspergillus kawachii enhances the cancer-suppressive potential of silkworm larva in hepatocellular carcinoma cells. BMC Complement Altern Med. 2019 Sep 05;19(1):241 Authors: Cho HD, Min HJ, Won YS, Ahn HY, Cho YS, Seo KI Abstract BACKGROUND: Mulberry silkworm larvae (Bombyx mori) are known as the oldest resource of food and traditional medicine. Although silkworm larvae have been reported to treat...
Sat Sep 07, 2019 13:46
Related ArticlesFirst-in-class phosphorylated-p68 inhibitor RX-5902 inhibits β-catenin signaling and demonstrates anti-tumor activity in triple-negative breast cancer. Mol Cancer Ther. 2019 Sep 05;: Authors: Capasso A, Bagby SM, Dailey KL, Currimjee N, Yacob BW, Ionkina A, Frank JG, Kim DJ, George C, Lee YB, Benaim E, Gittleman B, Hartman SJ, Tan AC, Kim J, Pitts TM, Eckhardt SG, Tentler JJ, Diamond JR Abstract RX-5902 is a first-in-class anti-cancer...
Sat Sep 07, 2019 13:46
Related ArticlesPHF2 histone demethylase prevents DNA damage and genome instability by controlling cell cycle progression of neural progenitors. Proc Natl Acad Sci U S A. 2019 Sep 05;: Authors: Pappa S, Padilla N, Iacobucci S, Vicioso M, Álvarez de la Campa E, Navarro C, Marcos E, de la Cruz X, Martínez-Balbás MA Abstract Histone H3 lysine 9 methylation (H3K9me) is essential for cellular homeostasis; however, its contribution to development is not well...
Sat Sep 07, 2019 13:46
Related ArticlesMetformin inhibits cervical cancer cell proliferation via decreased AMPK O-GlcNAcylation. Anim Cells Syst (Seoul). 2019;23(4):302-309 Authors: Kim MY, Kim YS, Kim M, Choi MY, Roh GS, Lee DH, Kim HJ, Kang SS, Cho GJ, Shin JK, Choi WS Abstract Metformin is a widely used drug for the treatment of type 2 diabetes. Antidiabetic drugs are also known to influence cancer progression, as high glucose levels affect both cancer and diabetes. Metformin...
Sat Sep 07, 2019 13:46
Related ArticlesShRNA-mediated matrix metalloproteinase-2 gene silencing protects normal cells and sensitizes cancer cells against ionizing-radiation induced damage. J Cell Biochem. 2019 Sep 06;: Authors: Shailender G, Patanla K, Malla RR Abstract INTRODUCTION: Ionizing radiation (IR) affects healthy tissues during the treatment of cancer radiation therapy and other nuclear and radiological accidents. Some natural compounds showed nonspecific radioprotective...
Sat Sep 07, 2019 14:47
Related ArticlesSSi6 promotes cell death by apoptosis through cell cycle arrest and inhibits migration and invasion of MDA-MB-231 human breast cancer cells. Anticancer Drugs. 2019 Sep 03;: Authors: Luna-Dulcey L, da Silva JA, Cominetti MR Abstract Triple-negative breast cancer subtype is the most aggressive type of breast cancer due to the lack of specific therapeutic targets, having limited treatment options, low survival prognosis and high recurrence...
Sat Sep 07, 2019 14:47
Related ArticlesAntiproliferative activity of vanadium compounds: effects on the major malignant melanoma molecular pathways. Metallomics. 2019 Sep 06;: Authors: Pisano M, Arru C, Serra M, Galleri G, Sanna D, Garribba E, Palmieri G, Rozzo C Abstract Malignant melanoma (MM) is the most fatal skin cancer, whose incidence has critically increased in the last decades. Recent molecular therapies are giving excellent results in the remission of melanoma but...
Sat Sep 07, 2019 14:47
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