In order to make of recent cancer incidence rates between Japan and other countries, we abstracted the age-standardized incidence rates (ASRs) by three age categories (0–59, 60–74 and 75+) from the Cancer Incidence in Five Continents Vol. XI (CI5) (1). International Agency for Research on Cancer provides the CI5 databases on the incidence of cancer recorded by cancer registries (regional and national) worldwide. We used ASRs from the following cancer registries: the United States of America, Beijing...
Fri Sep 06, 2019 03:00
AbstractBackgroundNew Japanese ethical guidelines for medical researches and the Clinical Trials Act have come into effect and monitoring is mandated for intervention studies. Methods of monitoring can be modified according to a study risk, but there is no established method in Japan regarding how to assess a study risk. EORTC assesses a study risk using their own study risk calculator and classifies their trials into three categories. For each category, different levels of monitoring are applied....
Fri Sep 06, 2019 03:00
Fri Sep 06, 2019 03:00
Fri Sep 06, 2019 03:00
Fri Sep 06, 2019 03:00
Fri Sep 06, 2019 03:00
Fri Sep 06, 2019 03:00
Fri Sep 06, 2019 03:00
Fri Sep 06, 2019 03:00
Nature Communications, Published online: 06 September 2019; doi:10.1038/s41467-019-11933-zThe relationship between metabolomic and behavioral changes is not well understood. Here, the authors analyze metabolome changes in D. melanogaster heads and bodies during hunger and satiety, and develop the Flyscape tool to visualize the resulting metabolic networks and integrate them with other omics data.
Fri Sep 06, 2019 03:00
Nature Communications, Published online: 06 September 2019; doi:10.1038/s41467-019-12028-5CRISPR-Cas9 genome editing is presumed to knock out gene function by generating a frameshift during NHEJ repair. Here, the authors investigate mRNA and protein expression in edited lines and find genome editing can generate internal ribosome entry sites or alternatively spliced variants.
Fri Sep 06, 2019 03:00
Nature Communications, Published online: 06 September 2019; doi:10.1038/s41467-019-12030-xDesigning reliable piezoresistive pressure sensors based on percolative nanoparticle (NP) arrays remains a challenge. Here, the authors propose a percolative NP array sensor deposited on a flexible membrane with ultra-high sensitivity and resolution by modifying the thickness of the membrane.
Fri Sep 06, 2019 03:00
Nature Communications, Published online: 06 September 2019; doi:10.1038/s41467-019-12023-wEstimates of mutation rates differ between species. Here, Lindsay et al. perform side-by-side analyses of germline mutation rates using multi-sibling mouse and human pedigrees and find different mutation rates between species, also stratified by sex and temporal stage of mutation acquisition.
Fri Sep 06, 2019 03:00
Nature Communications, Published online: 06 September 2019; doi:10.1038/s41467-019-11942-yPer-O-acetylated unnatural monosaccharides are popular tools for glycan labeling in live cells but can undergo unwanted side reactions with cysteines. Here, the authors develop unnatural sugars in a partially esterified form that are inert towards cysteines, and use them to probe O-GlcNAcylation in mESCs.
Fri Sep 06, 2019 03:00
Nature Communications, Published online: 06 September 2019; doi:10.1038/s41467-019-12004-zNicotine reduces food intake and increases energy expenditure in brown adipose tissue. Here the authors show that nicotine also induces white adipose tissue browning via central kappa opioid receptor action.
Fri Sep 06, 2019 03:00
Nature Communications, Published online: 06 September 2019; doi:10.1038/s41467-019-12002-1Brassicaceae produce glucosinolates to protect against herbivory and pathogens. Here the authors show that auxin-sensitive Aux/IAA repressor proteins regulate aliphatic glucosinolate levels in Arabidopsis and this promotes stomatal closure via reactive oxygen species during drought stress.
Fri Sep 06, 2019 03:00
Nature Communications, Published online: 06 September 2019; doi:10.1038/s41467-019-12082-zHomologous recombination uses a template to accurately repair DNA double-strand breaks and stalled replication forks to maintain genome stability. Here authors use electron microscopy to investigate the role of Rad54 in homology search and synaptic complex formation.
Fri Sep 06, 2019 03:00
Fri Sep 06, 2019 03:00
Oncogenesis, Published online: 06 September 2019; doi:10.1038/s41389-019-0151-1Reciprocal regulatory mechanism between miR-214-3p and FGFR1 in FGFR1-amplified lung cancer
Fri Sep 06, 2019 03:00
Solitary fibrous tumors are spindle cell neoplasms of mesenchymal origin that rarely occur in the larynx and may be mistaken for other pathologies. This case presentation and systematic review investigates presentation, treatment modalities, and outcomes of this unusual tumor.
Fri Sep 06, 2019 03:00
The study aimed to investigate the effect of five inactive yeasts on the metabolites of Chardonnay dry white wines vinified in 2016 in Shacheng Manor Wine Co. Ltd., Hebei province, China. In this research, pro...
Thu Sep 05, 2019 03:00
Classical swine fever (CSF) is a contagious disease that causes a high mortality to domestic and wild pigs. Its causative agent is an enveloped Pestivirus named Classical Swine Fever Virus (CSFV). Due to the huge...
Thu Sep 05, 2019 03:00
Bioengineers have developed a method to significantly extend the life of gene circuits used to instruct microbes to do things like produce and deliver drugs, break down chemicals and sense the environment. Most circuits synthetic biologists insert into microbes break or vanish after a certain period of time -- typically days to weeks -- because of various mutations. Researchers demonstrated they can keep genetic circuits going much longer.
Thu Sep 05, 2019 21:53
Evolutionary biologists have published findings on sex determinates of house flies. The work examines the slight difference in genetic makeup of male flies who hail from the north and those from the south. Though minute, the difference between the two types of flies is the position of the Y chromosome in the sequence of the genes.
Thu Sep 05, 2019 21:54
Researchers studying how plants evolved the abilities to make natural chemicals, which they use to adapt to stress, have uncovered how an enzyme called chalcone isomerase evolved to enable plants to make products vital to their own survival. The researchers' hope is that this knowledge will inform the manufacture of products that are beneficial to humans, including medications and improved crops.
Fri Sep 06, 2019 20:40
Abstract Objectives Prognostic significance of perineural invasion (PNI) in oral squamous cell carcinoma (OSCC) characterized as unifocal and multifocal was compared to depth of invasion (DOI) and extranodal extension (ENE). Materials and Methods Univariable and multivariable analyses of 861 consecutive patients with OSCC undergoing treatment between 1995 and 2018 were performed, with local failure (LF) and disease‐specific mortality (DSS) as the primary endpoints. Results After adjusting...
Thu Sep 05, 2019 16:21
Abstract The systemic delivery of tamoxifen (Tam) to activate inducible CreERT2-loxP transgenic mouse systems is now widely used in neuroscience studies. This critical technological advancement allows temporal control of DNA-cre recombination, avoidance of embryonically lethal phenotypes, and minimization of residual cell labeling encountered in constitutively active drivers. Despite its advantages, the use of Tam has the potential to cause long-lasting, uncharacterized side effects...
Sat Sep 07, 2019 03:00
Fossil evidence suggests that extant North American lizard genera (north of Mexico) evolved during the Miocene. Although fossils of the clade Phrynosomatidae (spiny lizards and sand lizards) have been reported...
Fri Sep 06, 2019 03:00
Abstract Rapid inflammatory responses to cytosolic threats are mediated by inflammasomes – large macromolecular signalling complexes that control the activation of the pro‐inflammatory cytokines IL‐1β and IL‐18, as well as cell death by pyroptosis. Different inflammasome sensors are activated by diverse direct and indirect signals, and subsequently nucleate the polymerization of the adaptor molecule ASC to form signalling platforms macroscopically observed as ASC specks. Caspase‐1 is autocatalytically...
Fri Sep 06, 2019 18:21
Key points We developed a novel metabolic imaging approach that provides direct measures of the rate of mitochondrial energy conversion with single‐cell and subcellular resolution by evaluating NADH autofluorescence kinetics during the mitochondrial redox after cyanide experiment (mitoRACE). Measures of mitochondrial NADH flux by mitoRACE are sensitive to physiological and pharmacological perturbations in vivo. Metabolic imaging with mitoRACE provides a highly adaptable platform for evaluating...
Fri Sep 06, 2019 18:21
Key points DNA methylation may play an important role in regulating gene expression in skeletal muscle to adapt to physical activity and inactivity. Neuronal nitric oxide synthase (nNOS) in skeletal muscle is a key regulator of skeletal muscle mass; however, it is unclear whether nNOS expression is regulated by DNA methylation. We found that 1‐week cast immobilization increased nNOS DNA methylation levels and downregulated nNOS gene expression in atrophic slow‐twitch soleus muscle from mouse...
Fri Sep 06, 2019 18:21
Abstract Relationships between females of different groups in female philopatric species are typically antagonistic, whereas those in female dispersing species can be more moderate. Such nonantagonistic relationships among females of neighboring groups may allow immigrant females to minimize dispersal costs by migrating into those groups, whereas the frequency of female migration among neighboring groups is little understood in female dispersing species. Bonobos (Pan paniscus)...
Sat Sep 07, 2019 03:00
The emergence of the CRISPR-Cas9 system has triggered a technical revolution in mammalian genome editing. Compared to traditional gene-targeting strategies, CRISPR-Cas9 technology offers a more efficient and cost-effective approach for generating genetically modified animal models. However, off-target cleavage in CRISPR-mediated genome editing is a major concern in the analysis of phenotypes as well as the selection of therapeutic targets. Here, we analyzed whole-genome sequencing (WGS) data from...
Fri Sep 06, 2019 23:02
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου