IJMS, Vol. 20, Pages 4709: Activating Hippo Pathway via Rassf1 by Ursolic Acid Suppresses the Tumorigenesis of Gastric Cancer International Journal of Molecular Sciences doi: 10.3390/ijms20194709 Authors: Seong-Hun Kim Hua Jin Ruo Yu Meng Da-Yeah Kim Yu Chuan Liu Ok Hee Chai Byung Hyun Park Soo Mi Kim The Hippo pathway is often dysregulated in many carcinomas, which results in various stages of tumor progression. Ursolic acid (UA), a natural compound that exists...
Mon Sep 23, 2019 03:00
IJMS, Vol. 20, Pages 4708: Comparison between Fractionated Dose and Single Dose of Cu-64 Trastuzumab Therapy in the NCI-N87 Gastric Cancer Mouse Model International Journal of Molecular Sciences doi: 10.3390/ijms20194708 Authors: Javeria Zaheer Hyeongi Kim Yong-Jin Lee Sang Moo Lim Jin Su Kim For optimum radioimmunotherapy (RIT), deep penetration and uniform distribution into the tumor core is important. The solid tumor microenvironment, consisting of a highly fibrotic or...
Mon Sep 23, 2019 03:00
IJMS, Vol. 20, Pages 4707: The Impact of Lactoferrin on the Growth of Intestinal Inhabitant Bacteria
IJMS, Vol. 20, Pages 4707: The Impact of Lactoferrin on the Growth of Intestinal Inhabitant Bacteria International Journal of Molecular Sciences doi: 10.3390/ijms20194707 Authors: Alan Vega-Bautista Mireya de la Garza Julio César Carrero Rafael Campos-Rodríguez Marycarmen Godínez-Victoria Maria Elisa Drago-Serrano Lactoferrin (Lf) is an iron-binding milk glycoprotein that promotes the growth of selected probiotic strains. The effect of Lf on the growth and diversification...
Mon Sep 23, 2019 03:00
IJMS, Vol. 20, Pages 4710: Immunomonitoring of Tacrolimus in Healthy Volunteers: The First Step from PK- to PD-Based Therapeutic Drug Monitoring? International Journal of Molecular Sciences doi: 10.3390/ijms20194710 Authors: Aliede E. in ‘t Veld Hendrika W. Grievink Mahdi Saghari Frederik E. Stuurman Marieke L. de Kam Aiko P. J. de Vries Brenda C. M. de Winter Jacobus Burggraaf Adam F. Cohen Matthijs Moerland Therapeutic drug monitoring is routinely performed...
Mon Sep 23, 2019 03:00
IJMS, Vol. 20, Pages 4706: Soy Lecithin-Derived Liposomal Delivery Systems: Surface Modification and Current Applications International Journal of Molecular Sciences doi: 10.3390/ijms20194706 Authors: Ngoc Thuy Trang Le Van Du Cao Thi Nhu Quynh Nguyen Thi Thu Hong Le Thach Thao Tran Thai Thanh Hoang Thi The development of natural phospholipids for nanostructured drug delivery systems has attracted much attention in the past decades. Lecithin that was derived from naturally...
Mon Sep 23, 2019 03:00
JCDD, Vol. 6, Pages 34: Ca2+ Signaling in Cardiac Fibroblasts and Fibrosis-Associated Heart Diseases
JCDD, Vol. 6, Pages 34: Ca2+ Signaling in Cardiac Fibroblasts and Fibrosis-Associated Heart Diseases Journal of Cardiovascular Development and Disease doi: 10.3390/jcdd6040034 Authors: Jianlin Feng Maria K. Armillei Albert S. Yu Bruce T. Liang Loren W. Runnels Lixia Yue Cardiac fibrosis is the excessive deposition of extracellular matrix proteins by cardiac fibroblasts and myofibroblasts, and is a hallmark feature of most heart diseases, including arrhythmia, hypertrophy,...
Mon Sep 23, 2019 03:00
JCDD, Vol. 6, Pages 35: The Non-Fibrillar Side of Fibrosis: Contribution of the Basement Membrane, Proteoglycans, and Glycoproteins to Myocardial Fibrosis Journal of Cardiovascular Development and Disease doi: 10.3390/jcdd6040035 Authors: Michael Chute Preetinder Aujla Sayantan Jana Zamaneh Kassiri The extracellular matrix (ECM) provides structural support and a microenvironmentfor soluble extracellular molecules. ECM is comprised of numerous proteins which can be broadly classified...
Mon Sep 23, 2019 03:00
JCM, Vol. 8, Pages 1529: Association between CSF1 and CSF1R Polymorphisms and Parkinson’s Disease in Taiwan Journal of Clinical Medicine doi: 10.3390/jcm8101529 Authors: Kuo-Hsuan Chang Yih-Ru Wu Yi-Chun Chen Hsiu-Chuan Wu Chiung-Mei Chen Background: CSF1/CSF1R neuroinflammatory signaling is emerging as an important pathway involved in the pathogenesis of Parkinson’s disease (PD). However, the genetic associations between CSF1/CSF1R and PD have not yet been explored....
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JCM, Vol. 8, Pages 1528: Adenoidal Disease and Chronic Rhinosinusitis in Children—Is there a Link? Journal of Clinical Medicine doi: 10.3390/jcm8101528 Authors: Bulfamante Saibene Felisati Rosso Pipolo Adenoid hypertrophy (AH) is an extremely common condition in the pediatric and adolescent populations that can lead to various medical conditions, including acute rhinosusitis, with a percentage of these progressing to chronic rhinosinusitis (CRS). The relationship between...
Mon Sep 23, 2019 03:00
JCM, Vol. 8, Pages 1526: NT5E/CD73 as Correlative Factor of Patient Survival and Natural Killer Cell Infiltration in Glioblastoma Journal of Clinical Medicine doi: 10.3390/jcm8101526 Authors: Jiao Wang Sandro Matosevic CD73, a cell-surface protein encoded by the gene NT5E, is overexpressed in glioblastoma (GBM), where it contributes to the tumor’s pathophysiology via the generation of immunosuppressive adenosine. Adenosinergic signaling, in turn, drives immunosuppression...
Mon Sep 23, 2019 03:00
JCM, Vol. 8, Pages 1524: Rethinking Lupus Nephritis Classification on a Molecular Level Journal of Clinical Medicine doi: 10.3390/jcm8101524 Authors: Salem Almaani Stephenie D. Prokopec Jianying Zhang Lianbo Yu Carmen Avila-Casado Joan Wither James W. Scholey Valeria Alberton Ana Malvar Samir V. Parikh Paul C. Boutros Brad H. Rovin Heather N. Reich The International Society of Nephrology/Renal Pathology Society (ISN/RPS) lupus nephritis (LN) classification...
Mon Sep 23, 2019 03:00
JCM, Vol. 8, Pages 1527: Association Between HDL Cholesterol and QTc Interval: A Population-Based Epidemiological Study Journal of Clinical Medicine doi: 10.3390/jcm8101527 Authors: Rosaria Del Giorno Sofia Gabutti Chiara Troiani Kevyn Stefanelli Raffaele Falciano Elisa Graziano Tommaso Rochat Negro Luca Gabutti Previous experimental studies showed that increasing high-density lipoprotein cholesterol (HDL) cholesterol shortens cardiac ventricular repolarization and...
Mon Sep 23, 2019 03:00
JoF, Vol. 5, Pages 89: Special Issue: Fungal–Bacterial Interactions—Current Knowledge and Future Perspectives Journal of Fungi doi: 10.3390/jof5040089 Authors: Paul L. Fidel Mairi C. Noverr We would like to thank all the contributors to the Special Issue on Fungal–Bacterial Interactions—Current Knowledge and Future Perspectives [...]
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Medicina, Vol. 55, Pages 625: Melatonin Action on the Activity of Phagocytes from the Colostrum of Obese Women Medicina doi: 10.3390/medicina55100625 Authors: Morais Honorio-França Fujimori de Quental Pessoa França de Abreu Background and objectives: Breastfeeding promotion is an important public health strategy for counter-balancing the negative effects of maternal overweight and obesity. Colostrum contains melatonin, which can attenuate the impacts of excessive...
Mon Sep 23, 2019 03:00
Medicina, Vol. 55, Pages 626: Role of Biological Markers for Cerebral Bleeding Risk STRATification in Patients with Atrial Fibrillation on Oral Anticoagulants for Primary or Secondary Prevention of Ischemic Stroke (Strat-AF Study): Study Design and Methodology Medicina doi: 10.3390/medicina55100626 Authors: Anna Poggesi Carmen Barbato Francesco Galmozzi Eleonora Camilleri Francesca Cesari Stefano Chiti Stefano Diciotti Silvia Galora Betti Giusti Anna Maria Gori Chiara...
Mon Sep 23, 2019 03:00
Medicina, Vol. 55, Pages 623: Comparison of X-Ray Imaging and Computed Tomography Scan in the Evaluation of Knee Trauma Medicina doi: 10.3390/medicina55100623 Authors: Mustafa Avci Nalan Kozaci Background and objectives: The aim of the study was to compare the accuracy of X-ray (XR) imaging according to computed tomography (CT) scanning in the diagnosis of knee bone fractures, and in the determination of fracture characteristics, and to identify CT scan indications in patients with...
Mon Sep 23, 2019 03:00
Medicina, Vol. 55, Pages 624: First Case of Chylous Ascites after Laparoscopic Myomectomy: A Case Report with a Literature Review Medicina doi: 10.3390/medicina55100624 Authors: Stoyan Kostov Angel Yordanov Stanislav Slavchev Strahil Strashilov Deyan Dzhenkov Introduction: Chylous ascites is a rare form of ascites characterized by milk-like peritoneal fluid, rich in triglycerides. Clinical signs and symptoms include abdominal distention, pain, nausea, and vomiting. In gynecology,...
Mon Sep 23, 2019 03:00
Membranes, Vol. 9, Pages 125: On the Morphological Characterization Procedures of Multilayer Hydrophobic Ceramic Membranes for Membrane Distillation Operations Membranes doi: 10.3390/membranes9100125 Authors: Mohamed K. Fawzy Felipe Varela-Corredor Serena Bandini The paper introduces some aspects of the characterization of hydrophobized multilayer ceramic membranes intended for use in membrane distillation (MD) operations. Four-layer hydrophobic carbon-based titania membranes,...
Mon Sep 23, 2019 03:00
Metabolites, Vol. 9, Pages 200: The metaRbolomics Toolbox in Bioconductor and beyond Metabolites doi: 10.3390/metabo9100200 Authors: Jan Stanstrup Corey D. Broeckling Rick Helmus Nils Hoffmann Ewy Mathé Thomas Naake Luca Nicolotti Kristian Peters Johannes Rainer Reza M. Salek Tobias Schulze Emma L. Schymanski Michael A. Stravs Etienne A. Thévenot Hendrik Treutler Ralf J. M. Weber Egon Willighagen Michael Witting Steffen Neumann Metabolomics...
Mon Sep 23, 2019 03:00
Microorganisms, Vol. 7, Pages 382: Metagenomic Insights and Genomic Analysis of Phosphogypsum and Its Associated Plant Endophytic Microbiomes Reveals Valuable Actors for Waste Bioremediation Microorganisms doi: 10.3390/microorganisms7100382 Authors: Ben Mefteh Bouket Daoud Luptakova Alenezi Gharsallah Belbahri The phosphogypsum (PG) endogenous bacterial community and endophytic bacterial communities of four plants growing in phosphogypsum-contaminated sites,...
Mon Sep 23, 2019 03:00
Microorganisms, Vol. 7, Pages 383: Food Preservatives Induce Proteobacteria Dysbiosis in Human-Microbiota Associated Nod2-Deficient Mice Microorganisms doi: 10.3390/microorganisms7100383 Authors: Lucia Hrncirova Vladimira Machova Eva Trckova Jan Krejsek Tomas Hrncir The worldwide incidence of many immune-mediated and metabolic diseases, initially affecting only the wealthy Western countries, is increasing rapidly. Many of these diseases are associated with the compositional...
Mon Sep 23, 2019 03:00
Molecules, Vol. 24, Pages 3457: A New Triterpenoid Glucoside from a Novel Acidic Glycosylation of Ganoderic Acid A via Recombinant Glycosyltransferase of Bacillus subtilis Molecules doi: 10.3390/molecules24193457 Authors: Te-Sheng Chang Chien-Min Chiang Yu-Han Kao Jiumn-Yih Wu Yu-Wei Wu Tzi-Yuan Wang Ganoderic acid A (GAA) is a bioactive triterpenoid isolated from the medicinal fungus Ganoderma lucidum. Our previous study showed that the Bacillus subtilis ATCC (American...
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Molecules, Vol. 24, Pages 3458: Metabolic Profiling of Alpinetin in Rat Plasma, Urine, Bile and Feces after Intragastric Administration Molecules doi: 10.3390/molecules24193458 Authors: Jieying Qiu Hongyu Wu Feng Feng Xiaoying He Caihong Wang Shenghui Chu Zheng Xiang Alpinetin, a bioactive flavonoid, has been known to have a diverse therapeutic effect, with namely anti-inflammatory, anticancer and antioxidant effects with low systemic toxicity. This study aimed to obtain...
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Molecules, Vol. 24, Pages 3455: A Simple, Rapid, and Practical Method for Distinguishing Lonicerae Japonicae Flos from Lonicerae Flos Molecules doi: 10.3390/molecules24193455 Authors: Zhang Shi Liu Zhang Yu Li Pu Lonicerae japonicae flos (LJF), the dried flower buds of Lonicera japonica Thunb., are often adulterated with Lonicerae. flos (LF), which is derived from the other four Lonicera species. Scholars at home and abroad have established several analytical...
Mon Sep 23, 2019 03:00
Molecules, Vol. 24, Pages 3456: Integrative Analysis of Terpenoid Profiles and Hormones from Fruits of Red-Flesh Citrus Mutants and Their Wild Types Molecules doi: 10.3390/molecules24193456 Authors: Cuihua Liu Min He Zhuang Wang Juan Xu In citrus color mutants, the levels of carotenoid constituents and other secondary metabolites are different in their corresponding wild types. Terpenoids are closely related to coloration, bitterness, and flavor. In this study, terpenoid profiles...
Mon Sep 23, 2019 03:00
Molecules, Vol. 24, Pages 3454: Solution-Based Synthesis and Characterization of Cu2ZnSnS4 (CZTS) Thin Films Molecules doi: 10.3390/molecules24193454 Authors: Ubaidah Syafiq Narges Ataollahi Rosa Di Maggio Paolo Scardi Cu2ZnSnS4 (CZTS) ink was synthesized from metal chloride precursors, sulfur, and oleylamine (OLA), as a ligand by a simple and low-cost hot-injection method. Thin films of CZTS were then prepared by spin coating, followed by thermal annealing. The effects of the...
Mon Sep 23, 2019 03:00
Molecules, Vol. 24, Pages 3453: The Effects of Vinegar Processing on the Changes in the Physical Properties of Frankincense Related to the Absorption of the Main Boswellic Acids Molecules doi: 10.3390/molecules24193453 Authors: Dongrui Liang Zhangchi Ning Zhiqian Song Chun Wang Yuanyan Liu Xiaoying Wan Shitao Peng Zhenli Liu Aiping Lu Boswellic acids (BAs), as the main components of frankincense, exhibit notable anti-inflammatory properties. However, their pharmaceutical...
Mon Sep 23, 2019 03:00
Molecules, Vol. 24, Pages 3451: Synthesis, Physicochemical Properties, and Biological Activities of 4-(S-Methyl-N-(2,2,2-Trifluoroacetyl)Sulfilimidoyl) Anthranilic Diamide Molecules doi: 10.3390/molecules24193451 Authors: Hwan Jung Lim Won Hyung Lee Seong Jun Park Novel anthranilic diamides with sulfilimidoyl and sulfoximidoyl functionalities were successfully prepared. Among newly-prepared organosulfur compounds, 3-bromo-1-(3-chloropyridin-2-yl)-N-(2-methyl-6-(methylcarbamoyl)-4-(methylthio)phenyl)-1H-pyrazole-5-carboxamide...
Mon Sep 23, 2019 03:00
Molecules, Vol. 24, Pages 3452: Metabolomics of Aurantio-Obtusin-Induced Hepatotoxicity in Rats for Discovery of Potential Biomarkers Molecules doi: 10.3390/molecules24193452 Authors: Longlong Xu Jian Li Xianglin Tang Yuguang Wang Zengchun Ma Yue Gao Aurantio-obtusin is an anthraquinone derived from Cassia obtusifolia (cassiae semen). It is also used as a tool and a detection index for the identification of cassiae semen, as stipulated by the Chinese Pharmacopoeia. Anthraquinones,...
Mon Sep 23, 2019 03:00
Nanomaterials, Vol. 9, Pages 1364: Microwave-Assisted Synthesis of SPION-Reduced Graphene Oxide Hybrids for Magnetic Resonance Imaging (MRI) Nanomaterials doi: 10.3390/nano9101364 Authors: Marina Llenas Stefania Sandoval Pedro M. Costa Judith Oró-Solé Silvia Lope-Piedrafita Belén Ballesteros Khuloud T. Al-Jamal Gerard Tobias Magnetic resonance imaging (MRI) is a useful tool for disease diagnosis and treatment monitoring. Superparamagnetic iron oxide nanoparticles...
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Nanomaterials, Vol. 9, Pages 1363: Two-Step Exfoliation of WS2 for NO2, H2 and Humidity Sensing Applications Nanomaterials doi: 10.3390/nano9101363 Authors: Valentina Paolucci Seyed Mahmoud Emamjomeh Michele Nardone Luca Ottaviano Carlo Cantalini WS2 exfoliated by a combined ball milling and sonication technique to produce few-layer WS2 is characterized and assembled as chemo-resistive NO2, H2 and humidity sensors. Microstructural analyses reveal flakes with average dimensions...
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Nanomaterials, Vol. 9, Pages 1362: Porous Hybrid Nanofibers Comprising ZnSe/CoSe₂/Carbon with Uniformly Distributed Pores as Anodes for High-Performance Sodium-Ion Batteries Nanomaterials doi: 10.3390/nano9101362 Authors: Sun Young Jeong Jung Sang Cho Well-designed porous structured bimetallic ZnSe/CoSe₂/carbon composite nanofibers with uniformly distributed pores were prepared as anodes for sodium-ion batteries by electrospinning and subsequent simple heat-treatment processes. Size-controlled...
Mon Sep 23, 2019 03:00
Nutrients, Vol. 11, Pages 2281: Characterization of Sarcopenia in an IBD Population Attending an Italian Gastroenterology Tertiary Center Nutrients doi: 10.3390/nu11102281 Authors: Marco Pizzoferrato Roberto de Sire Fabio Ingravalle Maria Chiara Mentella Valentina Petito Anna Maria Martone Francesco Landi Giacinto Abele Donato Miggiano Maria Cristina Mele Loris Riccardo Lopetuso Elisa Schiavoni Daniele Napolitano Laura Turchini Andrea Poscia Nicola...
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Nutrients, Vol. 11, Pages 2280: Reduced Salivary Mucin Binding and Glycosylation in Older Adults Influences Taste in an In Vitro Cell Model Nutrients doi: 10.3390/nu11102280 Authors: Rose-Anna G. Pushpass Nicola Pellicciotta Charles Kelly Gordon Proctor Guy H. Carpenter Background: Taste loss is a significant problem in older adults, affecting quality of life and nutrition. Altered salivary rheology and loss of mucin function may contribute to taste loss by reducing mucosal...
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Nutrients, Vol. 11, Pages 2282: Comparative Nutrient Profiling of Retail Goat and Cow Milk Nutrients doi: 10.3390/nu11102282 Authors: Sokratis Stergiadis Natalja P. Nørskov Stig Purup Ian Givens Michael R. F. Lee Goat milk is globally consumed but nutritional profiling at retail level is scarce. This study compared the nutrient composition of retail cow and goat milk (basic solids, fatty acids, minerals, and phytoestrogens) throughout the year and quantified the potential...
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Nutrients, Vol. 11, Pages 2279: A Novel Anti-Inflammatory Role of Omega-3 PUFAs in Prevention and Treatment of Atherosclerosis and Vascular Cognitive Impairment and Dementia Nutrients doi: 10.3390/nu11102279 Authors: Marialaura Simonetto Marco Infante Ralph L. Sacco Tatjana Rundek David Della-Morte Atherosclerosis is an inflammatory chronic disease affecting arterial vessels and leading to vascular diseases, such as stroke and myocardial infarction. The relationship between...
Mon Sep 23, 2019 03:00
Nutrients, Vol. 11, Pages 2277: Regulation of Gut Microbiota and Metabolic Endotoxemia with Dietary Factors Nutrients doi: 10.3390/nu11102277 Authors: Nobuo Fuke Naoto Nagata Hiroyuki Suganuma Tsuguhito Ota Metabolic endotoxemia is a condition in which blood lipopolysaccharide (LPS) levels are elevated, regardless of the presence of obvious infection. It has been suggested to lead to chronic inflammation-related diseases such as obesity, type 2 diabetes mellitus, non-alcoholic...
Mon Sep 23, 2019 03:00
Nutrients, Vol. 11, Pages 2278: Adherence to the Mediterranean Diet, Dietary Patterns and Body Composition in Women with Polycystic Ovary Syndrome (PCOS) Nutrients doi: 10.3390/nu11102278 Authors: Luigi Barrea Angela Arnone Giuseppe Annunziata Giovanna Muscogiuri Daniela Laudisio Ciro Salzano Gabriella Pugliese Annamaria Colao Silvia Savastano Polycystic ovary syndrome (PCOS) is the most common female endocrine disorder and is characterized by chronic anovulation,...
Mon Sep 23, 2019 03:00
Pharmaceutics, Vol. 11, Pages 489: Theranostic Sorafenib-Loaded Polymeric Nanocarriers Manufactured by Enhanced Gadolinium Conjugation Techniques Pharmaceutics doi: 10.3390/pharmaceutics11100489 Authors: Feczkó Piiper Pleli Schmithals Denk Hehlgans Rödel Vogl Wacker : Today, efficient delivery of sorafenib to hepatocellular carcinoma remains a challenge for current drug formulation strategies. Incorporating the lipophilic molecule into biocompatible and...
Mon Sep 23, 2019 03:00
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