IJMS, Vol. 20, Pages 4386: OsCAF1, a CRM Domain Containing Protein, Influences Chloroplast Development International Journal of Molecular Sciences doi: 10.3390/ijms20184386 Authors: Qiang Zhang Lan Shen Zhongwei Wang Guanglian Hu Deyong Ren Jiang Hu Li Zhu Zhenyu Gao Guangheng Zhang Longbiao Guo Dali Zeng Qian Qian The chloroplast RNA splicing and ribosome maturation (CRM) domain proteins are involved in the splicing of chloroplast gene introns. Numerous...
Fri Sep 06, 2019 03:00
IJMS, Vol. 20, Pages 4388: Gene Therapy for ALS—A Perspective International Journal of Molecular Sciences doi: 10.3390/ijms20184388 Authors: Marisa Cappella Chiara Ciotti Mathilde Cohen-Tannoudji Maria Grazia Biferi Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease (MND) with no cure. Recent advances in gene therapy open a new perspective to treat this disorder—particularly for the characterized genetic forms. Gene therapy approaches, involving the...
Fri Sep 06, 2019 03:00
IJMS, Vol. 20, Pages 4384: A Fragmenting Protocol with Explicit Hydration for Calculation of Binding Enthalpies of Target-Ligand Complexes at a Quantum Mechanical Level International Journal of Molecular Sciences doi: 10.3390/ijms20184384 Authors: István Horváth Norbert Jeszenői Mónika Bálint Gábor Paragi Csaba Hetényi Optimization of the enthalpy component of binding thermodynamics of drug candidates is a successful pathway of rational molecular design. However, the large...
Fri Sep 06, 2019 03:00
IJMS, Vol. 20, Pages 4385: An Overview of Circular RNAs and Their Implications in Myotonic Dystrophy
IJMS, Vol. 20, Pages 4385: An Overview of Circular RNAs and Their Implications in Myotonic Dystrophy International Journal of Molecular Sciences doi: 10.3390/ijms20184385 Authors: Karol Czubak Saam Sedehizadeh Piotr Kozlowski Marzena Wojciechowska Circular RNAs (circRNAs) are a class of single-stranded covalently closed RNA rings. Biogenesis of circRNAs, which may occur co-transcriptionally and post-transcriptionally via a back-splicing mechanism, requires the presence of complementary...
Fri Sep 06, 2019 03:00
IJMS, Vol. 20, Pages 4382: Maternal Exposure to Bisphenol A Combined with High-Fat Diet-Induced Programmed Hypertension in Adult Male Rat Offspring: Effects of Resveratrol International Journal of Molecular Sciences doi: 10.3390/ijms20184382 Authors: Chien-Ning Hsu Yu-Ju Lin You-Lin Tain Maternal exposure to endocrine disrupting chemicals (EDCs) and a high-fat intake may induce the developmental programming of hypertension in adult offspring. Bisphenol A (BPA) is one of the most...
Fri Sep 06, 2019 03:00
IJMS, Vol. 20, Pages 4381: Human Induced Pluripotent Stem-Cell-Derived Cardiomyocytes as Models for Genetic Cardiomyopathies International Journal of Molecular Sciences doi: 10.3390/ijms20184381 Authors: Andreas Brodehl Hans Ebbinghaus Marcus-André Deutsch Jan Gummert Anna Gärtner Sandra Ratnavadivel Hendrik Milting In the last few decades, many pathogenic or likely pathogenic genetic mutations in over hundred different genes have been described for non-ischemic, genetic...
Fri Sep 06, 2019 03:00
IJMS, Vol. 20, Pages 4383: Ring Formation and Hydration Effects in Electron Attachment to Misonidazole International Journal of Molecular Sciences doi: 10.3390/ijms20184383 Authors: Milan Ončák Rebecca Meißner Eugene Arthur-Baidoo Stephan Denifl Thomas F. M. Luxford Andriy Pysanenko Michal Fárník Jiří Pinkas Jaroslav Kočišek We study the reactivity of misonidazole with low-energy electrons in a water environment combining experiment and theoretical modelling....
Fri Sep 06, 2019 03:00
IJMS, Vol. 20, Pages 4380: Contribution of Corticotropin-Releasing Factor Receptor 1 (CRF1) to Serotonin Receptor 5-HT2CR Function in Amygdala Neurons in a Neuropathic Pain Model International Journal of Molecular Sciences doi: 10.3390/ijms20184380 Authors: Guangchen Ji Volker Neugebauer The amygdala plays a key role in emotional-affective aspects of pain and in pain modulation. The central nucleus (CeA) serves major amygdala output functions related to emotional-affective behaviors...
Fri Sep 06, 2019 03:00
IJMS, Vol. 20, Pages 4378: Impact of PPAR-Alpha Polymorphisms—The Case of Metabolic Disorders and Atherosclerosis International Journal of Molecular Sciences doi: 10.3390/ijms20184378 Authors: Massimiliano Ruscica Marco Busnelli Enrico Runfola Alberto Corsini Cesare R. Sirtori Peroxisome proliferator activated receptor α (PPARα) has the most relevant biological functions among PPARs. Activation by drugs and dietary components lead to major metabolic changes,...
Fri Sep 06, 2019 03:00
IJMS, Vol. 20, Pages 4379: Flow Cytometry Reveals the Nature of Oncotic Cells International Journal of Molecular Sciences doi: 10.3390/ijms20184379 Authors: Anna Vossenkamper Gary Warnes The term necrosis is commonly applied to cells that have died via a non-specific pathway or mechanism but strictly is the description of the degradation processes involved once the plasma membrane of the cell has lost integrity. The signalling pathways potentially involved in accidental cell death...
Fri Sep 06, 2019 03:00
IJMS, Vol. 20, Pages 4377: Salicylic Acid Binding Proteins (SABPs): The Hidden Forefront of Salicylic Acid Signalling International Journal of Molecular Sciences doi: 10.3390/ijms20184377 Authors: Igor Pokotylo Volodymyr Kravets Eric Ruelland Salicylic acid (SA) is a phytohormone that plays important roles in many aspects of plant life, notably in plant defenses against pathogens. Key mechanisms of SA signal transduction pathways have now been uncovered. Even though details are...
Fri Sep 06, 2019 03:00
IJMS, Vol. 20, Pages 4376: The Highly Conserved Barley Powdery Mildew Effector BEC1019 Confers Susceptibility to Biotrophic and Necrotrophic Pathogens in Wheat International Journal of Molecular Sciences doi: 10.3390/ijms20184376 Authors: Yi Zhang Kedong Xu Deshui Yu Zhihui Liu Chunfeng Peng Xiaoli Li Ju Zhang Yinghui Dong Yazhen Zhang Pan Tian Tiancai Guo Chengwei Li Effector proteins secreted by plant pathogens play important roles in promoting colonization....
Fri Sep 06, 2019 03:00
IJMS, Vol. 20, Pages 4374: CaMKII Activity in the Inflammatory Response of Cardiac Diseases International Journal of Molecular Sciences doi: 10.3390/ijms20184374 Authors: Maria Rosaria Rusciano Elena Sommariva Victorine Douin-Echinard Michele Ciccarelli Paolo Poggio Angela Serena Maione Inflammation is a physiological process by which the body responds to external insults and stress conditions, and it is characterized by the production of pro-inflammatory mediators such...
Fri Sep 06, 2019 03:00
IJMS, Vol. 20, Pages 4375: Gentamicin Targets Acid Sphingomyelinase in Cancer: The Case of the Human Gastric Cancer NCI-N87 Cells International Journal of Molecular Sciences doi: 10.3390/ijms20184375 Authors: Elisabetta Albi Samuela Cataldi Maria Rachele Ceccarini Carmela Conte Ivana Ferri Katia Fettucciari Federica Filomena Patria Tommaso Beccari Michela Codini Emerging literature implicates acid sphingomyelinase in tumor sensitivity/resistance to anticancer...
Fri Sep 06, 2019 03:00
IJNS, Vol. 5, Pages 33: Wisconsin’s Screening Algorithm for the Identification of Newborns with Congenital Adrenal Hyperplasia International Journal of Neonatal Screening doi: 10.3390/ijns5030033 Authors: Eric R. Bialk Michael R. Lasarev Patrice K. Held Newborn screening for congenital adrenal hyperplasia (CAH) has one of the highest false positive rates of any of the diseases on the Wisconsin panel. This is largely due to the first-tier immune assay cross-reactivity and physiological...
Fri Sep 06, 2019 03:00
JCDD, Vol. 6, Pages 33: Arterial Structural and Functional Characteristics at End of Early Childhood and Beginning of Adulthood: Impact of Body Size Gain during Early, Intermediate, Late and Global Growth Journal of Cardiovascular Development and Disease doi: 10.3390/jcdd6030033 Authors: Juan M. Castro Victoria García-Espinosa Agustina Zinoveev Mariana Marin Cecilia Severi Pedro Chiesa Daniel Bia Yanina Zócalo An association between nutritional characteristics in...
Fri Sep 06, 2019 03:00
JCDD, Vol. 6, Pages 32: The Influence of Exercise Workload Progression Across 36 Sessions of Cardiac Rehabilitation on Functional Capacity Journal of Cardiovascular Development and Disease doi: 10.3390/jcdd6030032 Authors: Truman Haeny Rachael Nelson Jeremy Ducharme Micah Zuhl Defining time frames throughout cardiac rehabilitation (CR) to progress exercise workloads may lead to improve functional capacity outcomes. The purpose of this study was to investigate the role of exercise...
Fri Sep 06, 2019 03:00
JCM, Vol. 8, Pages 1417: The QT Interval Dynamic in a Human Experimental Model of Controlled Heart Rate and QRS Widening Journal of Clinical Medicine doi: 10.3390/jcm8091417 Authors: Santiago Colunga Remigio Padrón Daniel García-Iglesias José Manuel Rubín Diego Pérez Raquel del Valle Pablo Avanzas César Morís David Calvo Background: there is increasing interest for computing corrected QT intervals in patients with prolonged depolarization. We aimed to analyze...
03:00
JCM, Vol. 8, Pages 1415: Physiological and Pathological Role of Circadian Hormones in Osteoarthritis: Dose-Dependent or Time-Dependent? Journal of Clinical Medicine doi: 10.3390/jcm8091415 Authors: Farhad Md. Hossain Yunkyung Hong Yunho Jin Jeonghyun Choi Yonggeun Hong Osteoarthritis (OA), the most common form of arthritis, may be triggered by improper secretion of circadian clock-regulated hormones, such as melatonin, thyroid-stimulating hormone (TSH), or cortisol. The imbalance...
Sun Sep 08, 2019 03:00
JCM, Vol. 8, Pages 1416: Physician Adherence to Treat-to-Target and Practice Guidelines in Rheumatoid Arthritis Journal of Clinical Medicine doi: 10.3390/jcm8091416 Authors: Batko Batko Krzanowski Żuber Principles of treat-to-target (T2T) have been widely adopted in both multinational and regional guidelines for rheumatoid arthritis (RA). Several questionnaire studies among physicians and real-world data have suggested that an evidence–practice gap exists in RA...
Sun Sep 08, 2019 03:00
JCM, Vol. 8, Pages 1414: The Risky Health Behaviours of Male Adolescents in the Southern Italian Region: Implications for Sexual and Reproductive Disease Journal of Clinical Medicine doi: 10.3390/jcm8091414 Authors: Anna Perri Danilo Lofaro Giulia Izzo Benedetta Aquino Massimo Bitonti Giuseppe Ciambrone Sandro La Vignera Carlotta Pozza Daniele Gianfrilli Antonio Aversa Recent epidemiological studies suggest an increase of sexual and reproductive chronic diseases...
Sun Sep 08, 2019 03:00
JCM, Vol. 8, Pages 1410: Management and Treatment of Varicocele in Children and Adolescents: An Endocrinologic Perspective Journal of Clinical Medicine doi: 10.3390/jcm8091410 Authors: Rossella Cannarella Aldo E. Calogero Rosita A. Condorelli Filippo Giacone Antonio Aversa Sandro La Vignera Pediatric varicocele has an overall prevalence of 15%, being more frequent as puberty begins. It can damage testicular function, interfering with Sertoli cell proliferation and hormone...
Sun Sep 08, 2019 03:00
JCM, Vol. 8, Pages 1413: The Role of Mesenchymal Stem Cells in Atherosclerosis: Prospects for Therapy via the Modulation of Inflammatory Milieu Journal of Clinical Medicine doi: 10.3390/jcm8091413 Authors: Armita Mahdavi Gorabi Maciej Banach Željko Reiner Matteo Pirro Saeideh Hajighasemi Thomas P. Johnston Amirhossein Sahebkar Atherosclerosis is a chronic, inflammatory disease that mainly affects the arterial intima. The disease is more prevalent in middle-age and older...
Sun Sep 08, 2019 03:00
JCM, Vol. 8, Pages 1411: Tachycardiomyopathy in Patients without Underlying Structural Heart Disease
JCM, Vol. 8, Pages 1411: Tachycardiomyopathy in Patients without Underlying Structural Heart Disease Journal of Clinical Medicine doi: 10.3390/jcm8091411 Authors: Giulia Stronati Federico Guerra Alessia Urbinati Giuseppe Ciliberti Laura Cipolletta Alessandro Capucci Tachycardiomyopathy (TCM) is an underestimated cause of reversible left ventricle dysfunction. The aim of this study was to identify the predictors of recurrence and incidence of major cardiovascular events...
Sun Sep 08, 2019 03:00
JCM, Vol. 8, Pages 1412: Assessment of Inner Retinal Layers and Choroidal Thickness in Type 1 Diabetes Mellitus: A Cross-Sectional Study Journal of Clinical Medicine doi: 10.3390/jcm8091412 Authors: Marc Carbonell Núria Alonso Esmeralda Castelblanco Jordi Real Anna Ramírez-Morros Rafael Simó Cristina Hernández Carme Jurjo Alícia Traveset Xavier Valldeperas Dídac Mauricio Recent studies have shown that retinal neurodegeneration may precede visible vascular...
Sun Sep 08, 2019 03:00
JCM, Vol. 8, Pages 1409: Multimodal Imaging Assessment of Vascular and Neurodegenerative Retinal Alterations in Type 1 Diabetic Patients without Fundoscopic Signs of Diabetic Retinopathy Journal of Clinical Medicine doi: 10.3390/jcm8091409 Authors: Riccardo Sacconi Marco Casaluci Enrico Borrelli Giacomo Mulinacci Francesca Lamanna Francesco Gelormini Adriano Carnevali Lea Querques Gianpaolo Zerbini Francesco Bandello Giuseppe Querques The aim of this cross-sectional...
Sun Sep 08, 2019 03:00
JCM, Vol. 8, Pages 1408: Early Nuclear Events after Herpesviral Infection Journal of Clinical Medicine doi: 10.3390/jcm8091408 Authors: Florian Full Armin Ensser Herpesviruses are important pathogens that can cause significant morbidity and mortality in the human population. Herpesviruses have a double-stranded DNA genome, and viral genome replication takes place inside the nucleus. Upon entering the nucleus, herpesviruses have to overcome the obstacle of cellular proteins in order...
Sat Sep 07, 2019 03:00
JCM, Vol. 8, Pages 1407: Improved Quality of Life Following Addiction Treatment Is Associated with Reductions in Substance Use Journal of Clinical Medicine doi: 10.3390/jcm8091407 Authors: Victoria Manning Joshua B. B. Garfield Tina Lam Steve Allsop Lynda Berends David Best Penny Buykx Robin Room Dan I. Lubman People seeking treatment for substance use disorders (SUD) ultimately aspire to improve their quality of life (QOL) through reducing or ceasing their substance...
Fri Sep 06, 2019 03:00
JCM, Vol. 8, Pages 1402: Lung Metastases in Patients with Stage IV Pancreatic Cancer: Prevalence, Risk Factors, and Survival Impact Journal of Clinical Medicine doi: 10.3390/jcm8091402 Authors: Liu Hung Hsueh Chang Chen Lu Chen Yeh Huang Tsang Hung Chou The aim of this study was to evaluate the prevalence, the clinicopathological variables associated with probability of lung metastases, and the impact of lung metastases on survival outcome...
Fri Sep 06, 2019 03:00
JCM, Vol. 8, Pages 1406: Genetic Variants of lncRNA MALAT1 Exert Diverse Impacts on the Risk and Clinicopathologic Characteristics of Patients with Hepatocellular Carcinoma Journal of Clinical Medicine doi: 10.3390/jcm8091406 Authors: Yuan Chang Lee Yang Su Lin Yang Chien The long noncoding (lnc)RNA, metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), plays a crucial role in the development of hepatocellular carcinoma (HCC). However, potential...
Fri Sep 06, 2019 03:00
JCM, Vol. 8, Pages 1404: Simultaneous Depression of Immunological Synapse and Endothelial Injury is Associated with Organ Dysfunction in Community-Acquired Pneumonia Journal of Clinical Medicine doi: 10.3390/jcm8091404 Authors: Menéndez Méndez Almansa Ortega Alonso Suescun Ferrando Feced Bermejo-Martin Rationale: A depressed expression of antigen presentation is, along with endothelial dysfunction, a recognized signature of severe community-acquired pneumonia...
Fri Sep 06, 2019 03:00
JCM, Vol. 8, Pages 1403: Restless Leg Syndrome in Peripheral Artery Disease: Prevalence among Patients with Claudication and Benefits from Low-Intensity Exercise Journal of Clinical Medicine doi: 10.3390/jcm8091403 Authors: Lamberti López-Soto Rodríguez-Borrego Straudi Basaglia Zamboni Manfredini Manfredini Restless leg syndrome (RLS) disrupts sleep, affecting the quality of life of patients with various chronic diseases. We assessed the prevalence of RLS...
Fri Sep 06, 2019 03:00
JCM, Vol. 8, Pages 1405: Poor Control of Blood Glucose, Lifestyle, and Cardiometabolic Parameters in Younger Adult Patients with Type 2 Diabetes Mellitus Journal of Clinical Medicine doi: 10.3390/jcm8091405 Authors: Nam Han Joo Kang Lim Kim Park This study investigated the awareness, treatment, and control of type 2 diabetes mellitus (T2DM), lifestyle factors, and cardiometabolic parameters according to age groups among patients with T2DM. Data of 1507 patients...
Fri Sep 06, 2019 03:00
JCM, Vol. 8, Pages 1399: Tracking Photodynamic- and Chemotherapy-Induced Redox-State Perturbations in 3D Culture Models of Pancreatic Cancer: A Tool for Identifying Therapy-Induced Metabolic Changes Journal of Clinical Medicine doi: 10.3390/jcm8091399 Authors: Mans Broekgaarden Anne-Laure Bulin Jane Frederick Zhiming Mai Tayyaba Hasan The metabolic plasticity of cancer cells is considered a highly advantageous phenotype that is crucial for disease progression and acquisition...
Fri Sep 06, 2019 03:00
JCM, Vol. 8, Pages 1400: Oncogenic Role of Secreted Engrailed Homeobox 2 (EN2) in Prostate Cancer Journal of Clinical Medicine doi: 10.3390/jcm8091400 Authors: Gómez-Gómez E. Jiménez-Vacas J. M. Pedraza-Arévalo S. López-López F. Herrero-Aguayo V. Hormaechea-Agulla D. Valero-Rosa J. Ibáñez-Costa A. León-González A. J. Sánchez-Sánchez R. González-Serrano T. Requena-Tapia M. J. Castaño J. P. Carrasco-Valiente J. Gahete M. D. Luque R. M. Engrailed...
Fri Sep 06, 2019 03:00
JCM, Vol. 8, Pages 1401: Comparative Volume Analysis of Alveolar Defects by 3D Simulation Journal of Clinical Medicine doi: 10.3390/jcm8091401 Authors: Pang-Yun Chou Rafael Denadai Rami R. Hallac Sarayuth Dumrongwongsiri Wei-Chuan Hsieh Betty CJ Pai Lun-Jou Lo A precise volumetric assessment of maxillary alveolar defects in patients with cleft lip and palate can reduce donor site morbidity or allow accurate preparation of bone substitutes in future applications. However,...
Fri Sep 06, 2019 03:00
JCM, Vol. 8, Pages 1396: The Changing Landscape of Acute Kidney Injury in Pregnancy from an Obstetrics Perspective Journal of Clinical Medicine doi: 10.3390/jcm8091396 Authors: Angela Vinturache Joyce Popoola Ingrid Watt-Coote Pregnancy-related acute kidney injury (PR-AKI) is a heterogeneous disorder with multiple aetiologies that can occur at any time throughout pregnancy and the post-partum period. PR-AKI is an important obstetric complication that is associated with significant...
Fri Sep 06, 2019 03:00
JCM, Vol. 8, Pages 1397: The Effect of In Vitro Electrolytic Cleaning on Biofilm-Contaminated Implant Surfaces Journal of Clinical Medicine doi: 10.3390/jcm8091397 Authors: Christoph Ratka Paul Weigl Dirk Henrich Felix Koch Markus Schlee Holger Zipprich Purpose: Bacterial biofilms are a major problem in the treatment of infected dental and orthopedic implants. The purpose of this study is to investigate the cleaning effect of an electrolytic approach (EC) compared to a...
Fri Sep 06, 2019 03:00
JCM, Vol. 8, Pages 1395: Medical Nutrition Therapy in Critically Ill Patients Treated on Intensive and Intermediate Care Units: A Literature Review Journal of Clinical Medicine doi: 10.3390/jcm8091395 Authors: Andrea Kopp Lugli Aude de Watteville Alexa Hollinger Nicole Goetz Claudia Heidegger Medical nutrition therapy in critically ill patients remains challenging, not only because of the pronounced stress response with a higher risk for complications, but also due to their...
Fri Sep 06, 2019 03:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου