IJERPH, Vol. 16, Pages 3273: Ambient Air Pollution and Sudden Infant Death Syndrome in Korea: A Time-Stratified Case-Crossover Study International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16183273 Authors: Myung-Jae Hwang Hae-Kwan Cheong Jong-Hun Kim Sudden infant death syndrome (SIDS) is an occasional cause of unexpected mortality in infancy. While various etiological factors have been hypothesized, air pollution has been consistently presented as...
Fri Sep 06, 2019 03:00
IJERPH, Vol. 16, Pages 3274: Demographic and Clinical Characteristics of Military Service Members Hospitalized Following a Suicide Attempt versus Suicide Ideation International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16183274 Authors: Brianne J. George Sissi Ribeiro Su Yeon Lee-Tauler Allison E. Bond Kanchana U. Perera Geoffrey Grammer Jennifer Weaver Marjan Ghahramanlou-Holloway Psychiatric hospitalization for a suicide attempt (SA),...
Fri Sep 06, 2019 03:00
IJMS, Vol. 20, Pages 4424: FMK, an Inhibitor of p90RSK, Inhibits High Glucose-Induced TXNIP Expression via Regulation of ChREBP in Pancreatic β Cells International Journal of Molecular Sciences doi: 10.3390/ijms20184424 Authors: Jung-Hwa Han Suji Kim Suji Kim Heejung Lee So-Young Park Chang-Hoon Woo Hyperglycemia is the major characteristic of diabetes mellitus, and a chronically high glucose (HG) level causes β-cell glucolipotoxicity, which is characterized by...
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IJMS, Vol. 20, Pages 4423: Lysine Acetylation is an Important Post-Translational Modification that Modulates Heat Shock Response in the Sea Cucumber Apostichopus japonicus International Journal of Molecular Sciences doi: 10.3390/ijms20184423 Authors: Dongxue Xu Xuan Wang Heat stress (HS) is an important factor for the survival of the marine organism Apostichopus japonicus. Lysine acetylation is a pivotal post-translational modification that modulates diverse physiological processes...
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IJMS, Vol. 20, Pages 4421: Apoptotic Effects of Drug Targeting Conjugates Containing Different GnRH Analogs on Colon Carcinoma Cells International Journal of Molecular Sciences doi: 10.3390/ijms20184421 Authors: Lajkó Hegedüs Mező Kőhidai The wide range of cellular target reactions (e.g., antitumor) of gonadotropin-releasing hormone (GnRH) variants provides the possibility to develop multifunctional GnRH conjugates. The aim of our work was to compare the cytotoxic/apoptotic...
Sun Sep 08, 2019 03:00
IJMS, Vol. 20, Pages 4422: Coelonin, an Anti-Inflammation Active Component of Bletilla striata and Its Potential Mechanism International Journal of Molecular Sciences doi: 10.3390/ijms20184422 Authors: Fusheng Jiang Meiya Li Hongye Wang Bin Ding Chunchun Zhang Zhishan Ding Xiaobo Yu Guiyuan Lv Ethanol extract of Bletilla striata has remarkable anti-inflammatory and anti-pulmonary fibrosis activities in the rat silicosis model. However, its active substances and molecular...
Sun Sep 08, 2019 03:00
IJMS, Vol. 20, Pages 4418: Chinese Herbal Medicine Ganoderma tsugae Displays Potential Anti-Cancer Efficacy on Metastatic Prostate Cancer Cells International Journal of Molecular Sciences doi: 10.3390/ijms20184418 Authors: Wen-Chin Huang Meng-Shiun Chang Shih-Yin Huang Ching-Ju Tsai Pin-Hung Kuo Han-Wen Chang Sheng-Teng Huang Chao-Lin Kuo Shou-Lun Lee Ming-Ching Kao Resistance to the current therapies is the main clinical challenge in the treatment of lethal...
Sun Sep 08, 2019 03:00
IJMS, Vol. 20, Pages 4419: Ethanol Elevates Excitability of Superior Cervical Ganglion Neurons by Inhibiting Kv7 Channels in a Cell Type-Specific and PI(4,5)P2-Dependent Manner International Journal of Molecular Sciences doi: 10.3390/ijms20184419 Authors: Kwon-Woo Kim Keetae Kim Hyosang Lee Byung-Chang Suh Alcohol causes diverse acute and chronic symptoms that often lead to critical health problems. Exposure to ethanol alters the activities of sympathetic neurons that control...
Sun Sep 08, 2019 03:00
IJMS, Vol. 20, Pages 4420: miR-34a-5p Increases Hepatic Triglycerides and Total Cholesterol Levels by Regulating ACSL1 Protein Expression in Laying Hens International Journal of Molecular Sciences doi: 10.3390/ijms20184420 Authors: Wei-Hua Tian Zhang Wang Ya-Xin Yue Hong Li Zhuan-Jian Li Rui-Li Han Ya-Dong Tian Xiang-Tao Kang Xiao-Jun Liu Accumulating evidence has shown that miR-34a serves as a posttranscriptional regulatory molecule of lipid metabolism in mammals....
Sun Sep 08, 2019 03:00
IJMS, Vol. 20, Pages 4416: Reconstitution in Proteoliposomes of the Recombinant Human Riboflavin Transporter 2 (SLC52A2) Overexpressed in E. coli International Journal of Molecular Sciences doi: 10.3390/ijms20184416 Authors: Lara Console Maria Tolomeo Matilde Colella Maria Barile Cesare Indiveri Background: the SLC52A2 gene encodes for the riboflavin transporter 2 (RFVT2). This transporter is ubiquitously expressed. It mediates the transport of Riboflavin across cell membranes....
Sun Sep 08, 2019 03:00
IJMS, Vol. 20, Pages 4417: Advances in Molecular Biology and Targeted Therapy of Mantle Cell Lymphoma International Journal of Molecular Sciences doi: 10.3390/ijms20184417 Authors: Pavel Klener Mantle cell lymphoma (MCL) is a heterogeneous malignancy with a broad spectrum of clinical behavior from indolent to highly aggressive cases. Despite the fact that MCL remains in most cases incurable by currently applied immunochemotherapy, our increasing knowledge on the biology of MCL in the...
Sun Sep 08, 2019 03:00
IJMS, Vol. 20, Pages 4415: Changes in the Substrate Source Reveal Novel Interactions in the Sediment-Derived Methanogenic Microbial Community International Journal of Molecular Sciences doi: 10.3390/ijms20184415 Authors: Anna Szafranek-Nakonieczna Anna Pytlak Jarosław Grządziel Adam Kubaczyński Artur Banach Andrzej Górski Weronika Goraj Agnieszka Kuźniar Anna Gałązka Zofia Stępniewska Methanogenesis occurs in many natural environments and is used in biotechnology...
Sun Sep 08, 2019 03:00
IJMS, Vol. 20, Pages 4414: Independent Component Analysis for Unraveling the Complexity of Cancer Omics Datasets International Journal of Molecular Sciences doi: 10.3390/ijms20184414 Authors: Nicolas Sompairac Petr V. Nazarov Urszula Czerwinska Laura Cantini Anne Biton Askhat Molkenov Zhaxybay Zhumadilov Emmanuel Barillot Francois Radvanyi Alexander Gorban Ulykbek Kairov Andrei Zinovyev Independent component analysis (ICA) is a matrix factorization approach...
Sat Sep 07, 2019 03:00
IJMS, Vol. 20, Pages 4413: Immune and Inflammatory Cells in Thyroid Cancer Microenvironment International Journal of Molecular Sciences doi: 10.3390/ijms20184413 Authors: Ferrari Fallahi Galdiero Ruffilli Elia Ragusa Paparo Patrizio Mazzi Varricchi Marone Antonelli A hallmark of cancer is the ability of tumor cells to avoid immune destruction. Activated immune cells in tumor microenvironment (TME) secrete proinflammatory cytokines and chemokines...
Sat Sep 07, 2019 03:00
IJMS, Vol. 20, Pages 4411: Vascular Endothelial Cell Biology: An Update International Journal of Molecular Sciences doi: 10.3390/ijms20184411 Authors: Krüger-Genge Blocki Franke Jung The vascular endothelium, a monolayer of endothelial cells (EC), constitutes the inner cellular lining of arteries, veins and capillaries and therefore is in direct contact with the components and cells of blood. The endothelium is not only a mere barrier between blood and tissues but also...
Sat Sep 07, 2019 03:00
IJMS, Vol. 20, Pages 4412: Multipoint TvDAAO Mutants for Cephalosporin C Bioconversion International Journal of Molecular Sciences doi: 10.3390/ijms20184412 Authors: Denis L. Atroshenko Mikhail D. Shelomov Sophia A. Zarubina Nikita Y. Negru Igor V. Golubev Svyatoslav S. Savin Vladimir I. Tishkov d-amino acid oxidase (DAAO, EC 1.4.3.3) is used in many biotechnological processes. The main industrial application of DAAO is biocatalytic production of 7-aminocephalosporanic...
Sat Sep 07, 2019 03:00
IJMS, Vol. 20, Pages 4409: A Yersinia ruckeri TIR Domain-Containing Protein (STIR-2) Mediates Immune Evasion by Targeting the MyD88 Adaptor International Journal of Molecular Sciences doi: 10.3390/ijms20184409 Authors: Tao Liu Wen-Yan Wei Kai-Yu Wang Er-Long Wang Qian Yang TIR domain-containing proteins are essential for bacterial pathogens to subvert host defenses. This study describes a fish pathogen, Yersinia ruckeri SC09 strain, with a novel TIR domain-containing protein...
Sat Sep 07, 2019 03:00
IJMS, Vol. 20, Pages 4410: Production of IFNβ by Conventional Dendritic Cells after Stimulation with Viral Compounds and IFNβ-Independent IFNAR1-Signaling Pathways are Associated with Aggravation of Polymicrobial Sepsis International Journal of Molecular Sciences doi: 10.3390/ijms20184410 Authors: Magdalena Howe Jens Bauer Anja Schulze Sonja Kropp Richard M. Locksley Judith Alferink Heike Weighardt Stefanie Scheu Viral infections are associated with increased incidence...
Sat Sep 07, 2019 03:00
IJMS, Vol. 20, Pages 4408: Role of a RhoA/ROCK-Dependent Pathway on Renal Connexin43 Regulation in the Angiotensin II-Induced Renal Damage International Journal of Molecular Sciences doi: 10.3390/ijms20184408 Authors: Gonzalo I. Gómez Victoria Velarde Juan C. Sáez In various models of chronic kidney disease, the amount and localization of Cx43 in the nephron is known to increase, but the intracellular pathways that regulate these changes have not been identified. Therefore, we...
Sat Sep 07, 2019 03:00
IJMS, Vol. 20, Pages 4407: Interplay Between Mitochondrial Peroxiredoxins and ROS in Cancer Development and Progression International Journal of Molecular Sciences doi: 10.3390/ijms20184407 Authors: Tayaba Ismail Youni Kim Hongchan Lee Dong-Seok Lee Hyun-Shik Lee Mitochondria are multifunctional cellular organelles that are major producers of reactive oxygen species (ROS) in eukaryotes; to maintain the redox balance, they are supplemented with different ROS scavengers, including...
Sat Sep 07, 2019 03:00
IJMS, Vol. 20, Pages 4406: Extracellular Vesicles Containing MicroRNA-92a-3p Facilitate Partial Endothelial-Mesenchymal Transition and Angiogenesis in Endothelial Cells International Journal of Molecular Sciences doi: 10.3390/ijms20184406 Authors: Nami O. Yamada Kazuki Heishima Yukihiro Akao Takao Senda Extracellular vesicles (EVs) are nanometer-sized membranous vesicles used for primitive cell-to-cell communication. We previously reported that colon cancer-derived EVs contain...
Sat Sep 07, 2019 03:00
IJMS, Vol. 20, Pages 4404: The Phosphatase SHP-2 Activates HIF-1α in Wounds In Vivo by Inhibition of 26S Proteasome Activity International Journal of Molecular Sciences doi: 10.3390/ijms20184404 Authors: Yvonn Heun Katharina Grundler Groterhorst Kristin Pogoda Bjoern F Kraemer Alexander Pfeifer Ulrich Pohl Hanna Mannell Vascular remodeling and angiogenesis are required to improve the perfusion of ischemic tissues. The hypoxic environment, induced by ischemia, is a potent...
Sat Sep 07, 2019 03:00
IJMS, Vol. 20, Pages 4405: The Role of International Databases in Understanding the Aetiology and Consequences of Differences/Disorders of Sex Development International Journal of Molecular Sciences doi: 10.3390/ijms20184405 Authors: Salma Rashid Ali Angela Lucas-Herald Jillian Bryce Syed Faisal Ahmed The International Disorders of Sex Development (I-DSD) and International Congenital AdrenalHyperplasia registry (I-CAH) Registries were originally developed over 10 years ago and...
Sat Sep 07, 2019 03:00
IJMS, Vol. 20, Pages 4401: Claudin 19 Is Regulated by Extracellular Osmolality in Rat Kidney Inner Medullary Collecting Duct Cells International Journal of Molecular Sciences doi: 10.3390/ijms20184401 Authors: Annalisa Ziemens Svenja R. Sonntag Vera C. Wulfmeyer Bayram Edemir Markus Bleich Nina Himmerkus The inner medullary collecting duct (IMCD) is subject to severe changes in ambient osmolality and must either allow water transport or be able to seal the lumen against...
Sat Sep 07, 2019 03:00
IJMS, Vol. 20, Pages 4402: Omega-3 Fatty Acid-Derived Resolvin D2 Regulates Human Placental Vascular Smooth Muscle and Extravillous Trophoblast Activities International Journal of Molecular Sciences doi: 10.3390/ijms20184402 Authors: Arzu Ulu Prakash K. Sahoo Ana G. Yuil-Valdes Maheswari Mukherjee Matthew Van Ormer Philma Glora Muthuraj Maranda Thompson Ann Anderson Berry Corrine K. Hanson Sathish Kumar Natarajan Tara M. Nordgren Omega-3 fatty acids are...
Sat Sep 07, 2019 03:00
IJMS, Vol. 20, Pages 4400: The Interaction of Helicobacter pylori with TFF1 and Its Role in Mediating the Tropism of the Bacteria Within the Stomach International Journal of Molecular Sciences doi: 10.3390/ijms20184400 Authors: Marguerite Clyne Felicity E. B. May Helicobacter pylori colonises the human stomach and has tropism for the gastric mucin, MUC5AC. The majority of organisms live in the adherent mucus layer within their preferred location, close to the epithelial surface where...
Sat Sep 07, 2019 03:00
IJMS, Vol. 20, Pages 4403: Identification of Structural Variation from NGS-Based Non-Invasive Prenatal Testing International Journal of Molecular Sciences doi: 10.3390/ijms20184403 Authors: Ondrej Pös Jaroslav Budis Zuzana Kubiritova Marcel Kucharik Frantisek Duris Jan Radvanszky Tomas Szemes Copy number variants (CNVs) are an important type of human genome variation, which play a significant role in evolution contribute to population diversity and human genetic diseases....
Sat Sep 07, 2019 03:00
IJMS, Vol. 20, Pages 4399: Social Learning of Acquiring Novel Feeding Habit in Mandarin Fish (Siniperca chuatsi) International Journal of Molecular Sciences doi: 10.3390/ijms20184399 Authors: Jian Peng Ya-Qi Dou Hui Liang Shan He Xu-Fang Liang Lin-Jie Shi Social learning plays important roles in gaining new foraging skills and food preferences. However, the potential role and molecular mechanism of social learning in acquiring new feeding habits is less clear in fish....
Sat Sep 07, 2019 03:00
IJMS, Vol. 20, Pages 4398: Protein Kinase CK2—A Putative Target for the Therapy of Diabetes Mellitus? International Journal of Molecular Sciences doi: 10.3390/ijms20184398 Authors: Emmanuel Ampofo Lisa Nalbach Michael D. Menger Mathias Montenarh Claudia Götz Since diabetes is a global epidemic, the development of novel therapeutic strategies for the treatment of this disease is of major clinical interest. Diabetes is differentiated in two types: type 1 diabetes mellitus (T1DM)...
Sat Sep 07, 2019 03:00
IJMS, Vol. 20, Pages 4397: Future Needs in Mast Cell Biology International Journal of Molecular Sciences doi: 10.3390/ijms20184397 Authors: Varricchi de Paulis Marone Galli The pathophysiological roles of mast cells are still not fully understood, over 140 years since their description by Paul Ehrlich in 1878. Initial studies have attempted to identify distinct “subpopulations” of mast cells based on a relatively small number of biochemical characteristics....
Fri Sep 06, 2019 03:00
IJMS, Vol. 20, Pages 4396: Downregulation of POFUT1 Impairs Secondary Myogenic Fusion Through a Reduced NFATc2/IL-4 Signaling Pathway International Journal of Molecular Sciences doi: 10.3390/ijms20184396 Authors: Audrey Der Vartanian Julien Chabanais Claire Carrion Abderrahman Maftah Agnès Germot Past work has shown that the protein O-fucosyltransferase 1 (POFUT1) is involved in mammal myogenic differentiation program. Pofut1 knockdown (Po –) in murine C2C12 cells...
Fri Sep 06, 2019 03:00
IJMS, Vol. 20, Pages 4392: Current Challenges in Understanding the Cellular and Molecular Mechanisms in Niemann–Pick Disease Type C1 International Journal of Molecular Sciences doi: 10.3390/ijms20184392 Authors: Anja U. Bräuer Angela Kuhla Carsten Holzmann Andreas Wree Martin Witt Rare diseases are a heterogeneous group of very different clinical syndromes. Their most common causes are defects in the hereditary material, and they can therefore be passed on to descendants....
Fri Sep 06, 2019 03:00
IJMS, Vol. 20, Pages 4395: Electrospun Chitosan/Poly (Vinyl Alcohol)/Graphene Oxide Nanofibrous Membrane with Ciprofloxacin Antibiotic Drug for Potential WoundDressing Application International Journal of Molecular Sciences doi: 10.3390/ijms20184395 Authors: Yang Zhang Zhang In this paper, nanofibrous membranes based on chitosan (CS), poly (vinyl alcohol) (PVA) and graphene oxide (GO) composites, loaded with antibiotic drugs, such as Ciprofloxacin (Cip) and Ciprofloxacin hydrochloride...
Fri Sep 06, 2019 03:00
IJMS, Vol. 20, Pages 4393: Targeting ROS and cPLA2/COX2 Expressions Ameliorated Renal Damage in Obese Mice with Endotoxemia International Journal of Molecular Sciences doi: 10.3390/ijms20184393 Authors: Jia-Feng Chang Jih-Chen Yeh Chun-Ta Ho Shih-Hao Liu Chih-Yu Hsieh Ting-Ming Wang Shu-Wei Chang I-Ta Lee Kuo-Yang Huang Jen-Yu Wang Wei-Ning Lin Obesity is associated with metabolic endotoxemia, reactive oxygen species (ROS), chronic inflammation, and obese...
Fri Sep 06, 2019 03:00
IJMS, Vol. 20, Pages 4394: Crystal Structures of Pyrophosphatase from Acinetobacter baumannii: Snapshots of Pyrophosphate Binding and Identification of a Phosphorylated Enzyme Intermediate International Journal of Molecular Sciences doi: 10.3390/ijms20184394 Authors: Yunlong Si Xing Wang Guosong Yang Tong Yang Yuying Li Gabriela Jaramillo Ayala Xumin Li Hao Wang Jiyong Su All living things have pyrophosphatases that hydrolyze pyrophosphate and release energy....
Fri Sep 06, 2019 03:00
IJMS, Vol. 20, Pages 4391: Roles of Glutamate Receptors in Parkinson’s Disease International Journal of Molecular Sciences doi: 10.3390/ijms20184391 Authors: Zhu Zhang Shiqing Zhang Pengfei Fu Zhang Zhang Kaili Lin Joshua Ka-Shun Ko Ken Kin-Lam Yung Parkinson’s disease is a progressive neurodegenerative disorder resulting from the degeneration of pigmented dopaminergic neurons in the substantia nigra pars compacta. It induces a series of functional modifications...
Fri Sep 06, 2019 03:00
IJMS, Vol. 20, Pages 4389: Effect of Tff3 Deficiency and ER Stress in the Liver International Journal of Molecular Sciences doi: 10.3390/ijms20184389 Authors: Kate Šešelja Iva Bazina Jessica Welss Martin Schicht Friedrich Paulsen Nikola Bijelić Edi Rođak Anita Horvatić Andrea Gelemanović Martina Mihalj Mirela Baus Lončar Endoplasmic reticulum (ER) stress, a cellular condition caused by the accumulation of unfolded proteins inside the ER, has been recognized...
Fri Sep 06, 2019 03:00
IJMS, Vol. 20, Pages 4390: Oxidation of Human Copper Chaperone Atox1 and Disulfide Bond Cleavage by Cisplatin and Glutathione International Journal of Molecular Sciences doi: 10.3390/ijms20184390 Authors: Maria I. Nardella Antonio Rosato Benny D. Belviso Rocco Caliandro Giovanni Natile Fabio Arnesano Cancer cells cope with high oxidative stress levels, characterized by a shift toward the oxidized form (GSSG) of glutathione (GSH) in the redox couple GSSG/2GSH. Under these...
Fri Sep 06, 2019 03:00
IJMS, Vol. 20, Pages 4387: Differential Regulation of Anthocyanins in Green and Purple Turnips Revealed by Combined De Novo Transcriptome and Metabolome Analysis International Journal of Molecular Sciences doi: 10.3390/ijms20184387 Authors: Hongmei Zhuang Qian Lou Huifang Liu Hongwei Han Qiang Wang Zhonghua Tang Yanming Ma Hao Wang Purple turnip Brassica rapa ssp. rapa is highly appreciated by consumers but the metabolites and molecular mechanisms underlying the...
Fri Sep 06, 2019 03:00
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