Abstract Small nucleolar RNA host gene 16 (SNHG16) is reported to be involved in the tumorigenesis of various kinds of tumors. SNHG16 expression was reported to be upregulated in colon cancer, however, the underlying mechanism of how SNHG16 affects the colon cancer development remains poorly elucidated. In our study, with the aim to identify the role of SNHG16 on colon cell proliferation, SNHG16 was overexpressed or knocked down in vitro, respectively. SNHG16 overexpression accelerated...
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Publication date: Available online 7 September 2019Source: Acta HistochemicaAuthor(s): Yutaro Yamamoto, Tetsuya Saita, Yuta Yamamoto, Rintaro Sogawa, Sakiko Kimura, Yutaka Narisawa, Shinya Kimura, Masashi ShinAbstractAfatinib, a second-generation tyrosine kinase inhibitor, was designed to bind covalently to and irreversibly inhibit active ErbB family receptors. The major metabolites of afatinib in human plasma are adducts of afatinib covalently bound to plasma proteins via. the Michael addition reaction....
Sat Sep 07, 2019 19:43
Publication date: Available online 7 September 2019Source: Acta HistochemicaAuthor(s): Lumei Chi, Dan Jiao, Guangxian Nan, Honghua Yuan, Jing Shen, Yu GaoAbstractIschemic stroke (IS) is a cerebrovascular disease with serious neurological function impairment, which may activate endoplasmic reticulum (ER) stress. However, the underlying regulatory mechanism of ER stress under IS remains unclear. miR-9-5p is enriched in the brain tissues and plays a role in the pathological process of IS. Therefore,...
Sat Sep 07, 2019 19:43
Publication date: Available online 6 September 2019Source: Human PathologyAuthor(s): Simone B S P Terra, Hao Xie, Jennifer M Boland, Aaron S Mansfield, Julian R. Molina, Anja C RodenSummaryLoss of alpha thalassemia/mental retardation syndrome X-linked (ATRX), a chromatin regulator, is associated with worse prognosis in pancreatic neuroendocrine tumors. We investigated ATRX expression in pulmonary carcinoid tumors (PCT) and its diagnostic and prognostic role in these patients. Resected PCTs (1997–2017)...
Sat Sep 07, 2019 15:59
Abstract RET proto-oncogene (RET) mutations were proved to be related to the development of medullary thyroid carcinoma (MTC). We aimed to analyze the role of RET mutations in cervical lymph node metastasis in patients with MTC. Forty-nine patients with preoperatively diagnosed MTC by fine-needle aspiration cytology (FNAC) who underwent bilateral total thyroidectomy with cervical lymphadenectomy were included. Postoperative RET gene test and pathological analysis were performed...
Sat Sep 07, 2019 03:00
Publication date: Available online 6 September 2019Source: Pathology - Research and PracticeAuthor(s): Zhiqin Fu, Conghui Wang, Yaqing Chen, Xiang Zhang, Xinyu Wang, Xing XieAbstractObjectiveFrequent resistance to paclitaxel and carboplatin based chemotherapy remains a therapeutic challenge in ovarian cancer. UTP23, a small sub-unit processome component, is down-regulated in a paclitaxel-resistant cell line SKOV3-TR30 compared with its parental SKOV3 cells based on our previous study. However, the...
Fri Sep 06, 2019 17:12
Publication date: Available online 6 September 2019Source: Pathology - Research and PracticeAuthor(s): Osama Elfituri
Fri Sep 06, 2019 17:12
Publication date: Available online 5 September 2019Source: Pathology - Research and PracticeAuthor(s): Yasuhiro Kuraishi, Takeshi Uehara, Yukihiro Kobayashi, Tomoyuki Nakajima, Takayuki Watanabe, Akira Shimizu, Hiroyoshi Ota, Eiji TanakaAbstractPancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer. Previous studies have established leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) as a cancer stem cell marker in gastrointestinal cancers. However, few...
Fri Sep 06, 2019 17:12
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