The instability of medical knowledge, especially in oncology, often leads to therapeutic decisions that lead to regret down the road, as this case study highlights.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
10h
Immunotherapy could replace chemotherapy in some patients with recurrent/metastatic cervical and vaginal or vulvar cancers. (Source: CancerNetwork)
10h
Mushrooms reportedly have anticancer and antitumor properties, so researchers in Japan investigated to see if there was a link between mushroom intake and prostate cancer. (Source: CancerNetwork)
10h
According to the American Cancer Society, cancer screening increases the chance of detecting certain cancers early, when they might be easier to treat. More good news from the National Cancer Institute shows that cancer survival rates are at an all-time high and cancer-related deaths are declining. Experts are attributing the improved outcomes to treatment advances, prevention awareness efforts — and screenings. Fortunately, today’s imagi ng technology provides an important tool in the...
16h
1. The breast is the most heavily guarded and protected part of a woman ’s body. This means there is good reason to worry less. Did you know that a mammogram is one of only two imaging tests (the other being a low-dose lung cancer screening for former or current heavy smokers) paid for by insurance companies in the U.S. for asymptomatic patients without any risk facto rs? It is the only part of a woman’s body which gets scrutinized every year. Finding breast cancer early (stage 1: less than…...
16h
The fundraiser highlights the fifth anniversary of the Upstate Cancer Center. (Source: SUNY Upstate Medical)
16h
According to the American Cancer Society, cancer screening increases the chance of detecting certain cancers early, when they might be easier to treat. More good news from the National Cancer Institute shows that cancer survival rates are at an all-time high and cancer-related deaths are declining. Experts are attributing the improved outcomes to treatment advances, prevention awareness efforts — and screenings. Fortunately, today’s imagi ng technology provides an important tool in the...
20h
Roche today announced that results from a number of studies across its comprehensive oncology portfolio, covering a broad range of cancers including bladder, lung and breast will be presented at the European Society for Medical Oncology (ESMO) 2019 Congress, taking place from 27 September - 1 October in Barcelona, Spain. (Source: Roche Investor Update)
20h
1. The breast is the most heavily guarded and protected part of a woman ’s body. This means there is good reason to worry less. Did you know that a mammogram is one of only two imaging tests (the other being a low-dose lung cancer screening for former or current heavy smokers) paid for by insurance companies in the U.S. for asymptomatic patients without any risk facto rs? It is the only part of a woman’s body which gets scrutinized every year. Finding breast cancer early (stage 1: less than…...
20h
Discussion Pulmonary embolism (PE) is potentially life-threatening but fortunately rare event especially in the pediatric population. It was first described in children in 1861. PE is likely underreported because of minimal or non-specific clinical symptoms. The incidence is estimated at 0.05-4.2% with the 4.2% based on autopsy reports. It is probably also increasing as more central venous catheters (CVC) are used, and more children are surviving previously poor prognostic diseases. There is a bimodal...
20h
When should immunotherapy be considered in patients with NSCLC and actionable driver mutations?Annals of Oncology (Source: Medscape Today Headlines)
21h
Despite the very real risk of financial burden, cost is discussed only in about 1 of 4 visits to the oncologist.Journal of Oncology Practice (Source: Medscape Today Headlines)
21h
Journal of Medicinal Food, Ahead of Print.
2h
Journal of Medicinal Food, Ahead of Print.
2h
Thyroid, Ahead of Print.
2h
Planta MedDOI: 10.1055/a-1008-1238Bixin is the main natural apocarotenoid extracted from the seeds of Bixa orellana, widely used as a cosmetic and textile colorant. Despite the description of several pharmacological properties of B. orellana extracts, little has been studied regarding the pharmacological properties of bixin. Then we aimed to investigate the potential anti-inflammatory and antinociceptive effect of bixin in preclinical models of inflammation and acute pain. The anti-inflammatory activity...
2h
Abstract Objective Dysphagia after uncomplicated thyroidectomy is commonly reported and it includes a broad spectrum of swallowing complaints. Though various causes have been hypothesized, it remains not completely understood. Methods A systematic review was performed to identify studies concerning dysphagia post uncomplicated thyroid surgery....
2h
Abstract Background The discomfort and complications have always been problems for nasal packing materials. This study provided a new nasal packing material called high expansion degradable cotton (HEDC). Methods Nasal endoscopic surgery was used to establish a dog model of nasal bleeding, and wound surfaces were filled with Merocel, Nasopore...
2h
Abstract Purpose The purpose of this study was to examine the malpractice litigations pertaining to otorhinolaryngology in Japan. Methods A retrospective review was undertaken of cases tried in the Japanese civil court system during the 26-year period from 1990 to 2015 as identified in a computerized legal database. Data including patient demographics,...
2h
Abstract Purpose Nowadays, the use of otoendoscopy is becoming increasingly popular in ear surgery. Data on endoscopic tympanoplasty are quite current but not yet sufficient. This study aims to present the anatomical and functional results of endoscopic butterfly inlay myringoplasty in large perforations. Methods The graft success rates and...
2h
Abstract Objective The purpose of this study was to investigate and summarize the characteristics of spontaneous cerebrospinal fluid rhinorrhea cases and the efficacy of transnasal endoscopic repair of spontaneous cerebrospinal fluid rhinorrhea with the assistance of computer-assisted navigation system. Methods This is a retrospective study...
2h
Abstract Purpose Eating-related problems are among the most frequent issues in olfactory impairment, causing a noticeable loss of quality of life for some of the affected persons. To what extent olfactory dysfunction impacts on the sensory perception of food is less explored. The aim of the present study was to examine the impact of olfactory dysfunction on the perception of food aromas, as well as the perception of the “basic tastes”...
2h
Abstract Purpose The objective of this study was to investigate the prognostic role of three inflammatory markers: the neutrophil to lymphocyte ratio (NLR), the lymphocyte to monocyte ratio (LMR), and the platelet to lymphocyte ratio (PLR) as prognostic indicators in squamous cell carcinoma of the head and neck (HNSCC). Methods Patients with...
2h
Abstract Purpose To determine the minimum lymph node yield (LNY) in patients with laryngeal squamous cell carcinoma (LSCCs). Methods This retrospective study was performed in a tertiary care hospital setting and included 42 LSCC patients aged 39–81 years (females, n = 2; males, n = 40) who underwent a total or partial laryngectomy and elective...
2h
Abstract Purpose To present the utility of a smartphone-enabled otoscope as a teaching adjunct in pre-clinical otoscopy training. Methods 60 pre-clinical medical students were randomized into either a control group using a conventional otoscope or an experimental group using a smartphone-enabled otoscope. Participants in each group were trained...
2h
Abstract Purpose Virtual reality (VR) training of mastoidectomy is effective in surgical training—particularly if organized as distributed practice. However, centralization of practice facilities is a barrier to implementation of distributed simulation training. Decentralized training could be a potential solution. Here, we aim to assess the feasibility, use, and barriers to decentralized VR mastoidectomy training using a freeware,...
2h
Abstract Objective To evaluate the effect of a wireless Bluetooth device (WBD) in word and sentence recognition in patients with bone conduction devices (BCDs) while using mobile phones. Methods We performed a prospective study evaluating speech and sentence recognition in both quiet and noised conditions. A total of nine patients, audiologically...
2h
Abstract Introduction The tissues of the laryngeal region only rarely harbor primary cartilaginous lesions, and squamous cell carcinoma remains the most frequently encountered malignant tumor in this area. Materials and Methods We reviewed the salient histological features of cartilaginous laryngeal lesions to provide differential diagnostics...
2h
Abstract Purpose We aimed to determine the position and size of the sphenoid sinus (SS) in our study and compare the results of the measurements relative to age, gender, and the presence of pituitary adenoma using multidetector computerized tomography (MDCT). Methods We retrospectively evaluated the paranasal sinus computerized tomography (CT)...
2h
Abstract Purpose Warthin tumour (WT) is the second most common benign tumour of the parotid gland. The aim of this study was to assess the value of the FNAB in the diagnosis and treatment decision in patients with WT. Materials and methods We performed a retrospective study of patients treated for parotid gland mass between 2006 and 2016. Patients...
2h
Abstract Purpose To describe the procedures and investigate the hearing outcomes and complications after revision surgery for patients with otosclerosis in Sweden and compare these with previously published reports and to investigate factors that may predict the outcomes of revision surgery. Methods A total of 254 patients from the Swedish Quality...
14h
Journal of Adolescent and Young Adult Oncology, Ahead of Print.
3h
Journal of Adolescent and Young Adult Oncology, Ahead of Print.
3h
Mechanistic target of rapamycin (MTOR) is a highly conserved serine/threonine kinase that critically regulates cell growth, proliferation, differentiation, and survival. Previously, we have implicated Mtor as a plasmacytoma-resistance locus, Pctr2, in mice. Here, we report that administration of the tumor-inducing agent pristane decreases Mtor gene expression to a greater extent in mesenteric lymph nodes of BALB/cAnPt mice than of DBA/2N mice. We identified six allelic variants in the Mtor promoter...
3h
N-linked glycans play important roles in various cellular and immunological events. Endo-β-N-acetylglucosaminidase (ENGase) can release or transglycosylate N-glycans and is a promising tool for the chemoenzymatic synthesis of glycoproteins with homogenously modified glycans. The ability of ENGases to act on core-fucosylated glycans is a key factor determining their therapeutic utility because mammalian N-glycans are frequently α-1,6-fucosylated. Although the biochemistries and structures of various...
3h
Lipid droplets (LDs) are evolutionarily conserved organelles that play critical roles in mammalian lipid storage and metabolism. However, the molecular mechanisms governing the biogenesis and growth of LDs remain poorly understood. Phosphatidic acid (PA) is a precursor of phospholipids and triacylglycerols and substrate of CDP-diacylglycerol (CDP-DAG) synthase 1 (CDS1) and CDS2, which catalyze the formation of CDP-DAG. Here, using siRNA-based gene knockdowns and CRISPR/Cas9-mediated gene knockouts,...
3h
Doxycycline is a tetracycline-class antimicrobial labeled by the United States (U.S.) Food and Drug Administration for children >8 years of age for many common childhood infections. Doxycycline is not labeled for children ≤8 years of age, due to the association between tetracycline class antibiotics and tooth staining, although doxycycline may be used off-label in severe conditions. Accordingly, there is a paucity of pharmacokinetic (PK) data to guide dosing in children 8 years and younger. We...
3h
Background: Ceftazidime/avibactam (CAZ-AVI) may improve outcomes among patients with carbapenem-resistant Enterobacteriaceae (CRE) infections compared to conventional therapies. However, CAZ-AVI's cost-effectiveness is unknown.Methods: We used a decision analytic model to estimate the health and economic consequences of CAZ-AVI-based therapy compared to colistin-based therapy (COL) for a hypothetical cohort of patients with CRE pneumonia or bacteremia over a 5-year horizon. Model inputs were from...
3h
We evaluated the in vitro susceptibility to the first-in-class spiropyrimidinetrione zoliflodacin among recent consecutive clinical Neisseria gonorrhoeae isolates cultured in Thailand (n=99; 2018) and South Africa (n=100; 2015-2017). Zoliflodacin was highly active in vitro against all tested isolates (MIC range: 0.004-0.25; MIC50: 0.064, MIC90: 0.125 μg/ml), with no cross-resistance to any of the seven comparator antimicrobials. Our data support the initiation of the global zoliflodacin phase 3 randomized...
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