Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Wei Zhou, Xuejuan Yu, Shuang Sun, Xuehai Zhang, Wenjing Yang, Junpeng Zhang, Xin Zhang, Zheng JiangAbstractThe main characteristic of glioma is recurrence, even after intensive multidisciplinary treatment. Studies show that enhanced invasive ability will increase the ability of tumor cells to escape from the primary tumor mass, which is a key factor contributing to tumor relapse and recurrence. In this study,...
Sun Sep 01, 2019 13:44
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Bin Zheng, Qing-Qing Fang, Xiao-Feng Wang, Bang-Hui Shi, Wan-Yi Zhao, Chun-Ye Chen, Min-Xia Zhang, Li-Yun Zhang, Yan-Yan Hu, Peng Shi, Lie Ma, Wei-Qiang TanAbstractThe renin-angiotensin system (RAS) plays an important role in scar formation. We have previously shown that oral administration of ramipril and losartan could inhibit scarring. For easier application, here we developed a series of topical ramipril...
Sat Aug 31, 2019 18:19
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Fang Guo, Zhi Yang, Hagen Kulbe, Andreas E. Albers, Jalid Sehouli, Andreas M. KaufmannAbstractBackgroundDisulfiram (DSF) is a drug used for treatment of alcoholism that has also displayed promising anti-cancer activity. It unfolds its effects by inhibiting the enzyme activity of aldehyde dehydrogenase (ALDH) isoforms.MethodsMTT assay, spheroid formation, clonogenicity assay, qRT-PCR, and ALDH enzyme activity...
Sat Aug 31, 2019 18:19
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Xue Yang, Liankang Sun, Liang Wang, Bowen Yao, Huanye Mo, Wei YangAbstractLong noncoding RNAs (lncRNAs) play vital roles in the development and progression of hepatocellular carcinoma (HCC). The recent study finds a strong correlation between lncRNA small nucleolar RNA host gene 7 (SNHG7) and HCC metastasis. However, the molecular mechanism by which SNHG7 regulates HCC progression has not been investigated....
Sat Aug 31, 2019 18:19
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Shu Yang, Yuanli Chen, Yajun Duan, Chuanrui Ma, Lipei Liu, Qi Li, Jie Yang, Xiaoju Li, Buchang Zhao, Yong Wang, Ke Qian, Mengyang Liu, Yan Zhu, Xiaoxiao Yang, Jihong HanAbstractThe current treatment for diabetic nephropathy (DN) is still limited. NaoXinTong Capsule (NXT) is a Chinese Medicine prescribed to patients with cardiovascular disease. It can also ameliorate metabolic syndromes in patients indicating...
Sat Aug 31, 2019 18:19
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Yan-Fei Bin, Lu-Jia Wu, Xue-Jiao Sun, Yi Liang, Jing Bai, Jian-Quan Zhang, Mei-Hua Li, Xiao-Ning Zhong, Yu-Ji Liang, Zhi-Yi HeAbstractBackgroundCorticosteroid is one of the main treatments for interstitial lung disease (ILD). Cryptogenic-organizing pneumonia (COP) is sensitive to corticosteroid therapy, whereas idiopathic pulmonary fibrosis (IPF) is not. Glucocorticoid receptor-α (GR-α) and histone deacetylase...
Sat Aug 31, 2019 18:19
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Hanning Yang, Yue Sun, Jia Wei, Lirong Xu, Yueyue Tang, Lihong Yang, Xiaoqi Zhang, Yongping LuAbstractThis study investigated the value of using ultrasound-targeted microbubble destruction (UTMD) to deliver an IL-8 monoclonal antibody to inhibit the inflammatory response and increase plaque stability in a rabbit model of atherosclerosis (AS). An abdominal aortic atherosclerotic plaque model was established...
Fri Aug 30, 2019 15:01
Inhibition of AKT enhances the anti-cancer effects of Artemisinin in clear cell renal cell carcinoma
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Congcong Yu, Peiyu Sun, Yuehong Zhou, Bin Shen, Meihua Zhou, Lingzhi Wu, Min KongAbstractGiven studies have shown that Artemisinin (ART) reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis. In this study, we evaluated the roles of ART in clear cell renal cell carcinoma (ccRCC) progression. We measured the eff ;ects of ART on cancer cell proliferation, colony formation, migration,...
Fri Aug 30, 2019 15:01
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Chung-Hsiung Huang, Chiung-Yi Huang, Ming-Hsi HuangAbstractThe effect of antigen-adjuvant associations on antigen uptake and antigen-specific humoral immunity is studied in detail. After formulation with a squalene-based double emulsion (referred to as PELC), the protein ovalbumin (OVA) was intramuscularly injected in mice, in either a separation (OVA-PELCSE), a surface attachment (OVA-PELCSA) or an encapsulation...
Fri Aug 30, 2019 15:01
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Fangyan He, Rong Dai, Xiufang Li, Xiaonan Zhou, Xuelan Song, Hanwen Yan, Qingting Meng, Cui Yang, Qing LinAbstractObjectiveCerebral ischemia reperfusion injury (CIRI) is a major cause of ischemic stroke (IS) deterioration. Considering the intricate mechanism of the pathological process of CIRI, most drugs only work on one target. The neurovascular unit (NVU) puts forward the concept of neuroprotection from...
Fri Aug 30, 2019 15:01
Publication date: August 2019Source: Clinical Therapeutics, Volume 41, Issue 8Author(s):
Fri Aug 30, 2019 12:58
Publication date: August 2019Source: Clinical Therapeutics, Volume 41, Issue 8Author(s):
Fri Aug 30, 2019 12:58
Publication date: August 2019Source: Clinical Therapeutics, Volume 41, Issue 8Author(s): Patrice Fardellone, Stefano Lello, Antonio Cano, Eloisa de Sá Moreira, Renato Watanabe de Oliveira, Guilherme Silva Julian, Boxiong TangAbstractPurposeBisphosphonate therapy is a well-established and effective treatment for postmenopausal osteoporosis and the prevention of osteoporotic fracture. However, poor adherence to and poor persistence with bisphosphonate therapy may reduce its benefits. Previous studies...
Fri Aug 30, 2019 12:58
Summary Purpose BAL101553, the prodrug of the microtubule-destabilizer BAL27862, previously showed signs of antitumor activity when administered as a 2-h infusion, but its use was limited by vascular toxicity. We investigated an alternative dosing strategy aimed at improving the safety profile of BAL101553. Methods This multicenter, open-label, Phase 1 dose-escalation study used a 3 + 3 design to determine the maximum tolerated dose (MTD), dose-limiting toxicities (DLTs), pharmacokinetics,...
Fri Aug 30, 2019 03:00
Publication date: Available online 31 August 2019Source: Radiotherapy and OncologyAuthor(s): William R. Kennedy, Prashant Gabani, John Nikitas, Clifford G. Robinson, Jeffrey D. Bradley, Michael C. RoachAbstractPurposeOptimal management of isolated local recurrences after stereotactic body radiation therapy (SBRT) for early non-small cell lung cancer (NSCLC) is unknown and literature describing repeat SBRT for in-field recurrences after initial SBRT are sparse. We investigate the safety and efficacy...
Sun Sep 01, 2019 17:42
Publication date: Available online 30 August 2019Source: Radiotherapy and OncologyAuthor(s): Alberto Traverso, Michal Kazmierski, Mattea L. Welch, Jessica Weiss, Sandra Fiset, Warren D. Foltz, Adam Gladwish, Andre Dekker, David Jaffray, Leonard Wee, Kathy HanAbstractPurposeThe aims of this study are to evaluate the stability of radiomic features from Apparent Diffusion Coefficient (ADC) maps of cervical cancer with respect to: (1) reproducibility in inter-observer delineation, and (2) image pre-processing...
Sat Aug 31, 2019 15:11
Publication date: November 2019Source: International Immunopharmacology, Volume 76Author(s): Qiulei Zhang, Kehao Le, Ming Xu, Jun Zhou, Yunxiao Xiao, Wen Yang, Yujia Jiang, Zihan Xi, Tao HuangAbstractTumor-associated macrophages (TAMs) are closely related to poor prognosis in triple-negative breast cancer (TNBC). Thus, gaining insight into how TAMs support cancer progression could contribute to effective therapies. We utilized the 4 T1 murine TNBC cell line and murine bone marrow-derived macrophages...
Sun Sep 01, 2019 16:13
Publication date: November 2019Source: International Immunopharmacology, Volume 76Author(s): Michelle de Oliveira Pedrosa Rolim, Anderson Rodrigues de Almeida, Maira Galdino da Rocha Pitta, Moacyr Jesus Barreto de Melo Rêgo, Lucindo José Quintans-Júnior, Jullyana de Souza Siqueira Quintans, Luana Heimfarth, Luciana Scotti, Marcus Tullius Scotti, Ryldene Marques Duarte da Cruz, Reinaldo Nóbrega de Almeida, Teresinha Gonçalves da Silva, Jonata Augusto de Oliveira, Michel Leandro de Campos, Pascal Marchand,...
Sun Sep 01, 2019 16:13
Publication date: November 2019Source: International Immunopharmacology, Volume 76Author(s): Fatemeh Heidary, Sussan K. Ardestani, Hassan Ghasemi, Mohammad Ali Javadi, Mahmoud Mahmoudi, Roya Yaraee, Jalaledin Shams, Faramarz Falahi, Mohamad Reza Sedighi moghadam, Shamsa Shariatpanahi, Raheleh Shakeri, Mohammad Mehdi Naghizadeh, Tooba GhazanfariAbstractIntroductionIn this study, the serum levels of soluble intercellular adhesion molecule 1 (ICAM-1), P-, E-, and L-selectins were investigated in seriously...
Sun Sep 01, 2019 16:13
Publication date: November 2019Source: International Immunopharmacology, Volume 76Author(s): Weiyun Pan, Na Wei, Weiling Xu, Gang Wang, Fangchao Gong, Na LiAbstractObjectiveAcute lung injury (ALI) is a severe lung disease with high mortality rate. Research has highlighted that the immune response to ALI is associated with significant changes in the expression of several microRNAs (miRNAs) in the lungs. In our research, we speculated that miR-124 moderated the severity of ALI through comprehensive...
Sat Aug 31, 2019 13:34
Publication date: November 2019Source: International Immunopharmacology, Volume 76Author(s): Xiaowei Fei, Chen Chen, Sun Kai, Xiaojun Fu, Weitao Man, Boyun Ding, Chongwu Wang, Ruxiang XuAbstractBackgroundIntracranial hemorrhage (ICH) is one of the most common brain traumas, and inflammation caused by ICH seriously affects the quality of life and prognosis of patients. Eupatilin has been shown to have anti-inflammatory effects in various diseases. However, only one paper has reported that Eupatilin...
Sat Aug 31, 2019 13:34
Publication date: November 2019Source: International Immunopharmacology, Volume 76Author(s): Kechao Zhu, Chao Yang, Huiyong Dai, Juehong Li, Wei Liu, Yao Luo, Xianlong Zhang, Qi WangAbstractWear particle-induced periprosthetic inflammatory osteolysis and resultant aseptic loosening are major causes of orthopedic implant failure, for which there are no effective treatments other than revision surgery. Crocin, a carotenoid compound derived from crocus flowers, has anti-inflammatory properties, but...
Fri Aug 30, 2019 17:04
Publication date: Available online 29 August 2019Source: Journal of Bodywork and Movement TherapiesAuthor(s): Sasha Chaitow
Sat Aug 31, 2019 15:03
Publication date: Available online 29 August 2019Source: Journal of Bodywork and Movement TherapiesAuthor(s): Dimitrios Kostopoulos
Fri Aug 30, 2019 15:03
Publication date: Available online 31 August 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): M.T.F. Pires, A.D. Pereira, S.M.B. Durães, M.C.A. Issa, Marianna PiresAbstractBackgroundLaser-assisted MAL-PDT has been reported to increase the effectiveness of conventional PDT. Nonetheless, clinical effects of this association when reducing MAL incubation time is poorly discussed. Furthermore, the association of acoustic pressure wave ultrasound with laser-assisted MAL-PDT with short incubation...
Sun Sep 01, 2019 13:40
Publication date: Available online 31 August 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Jingying Wang, Songshan Li, Junpeng Li, Zhijia Li, Qi Wang, Xiaoming Peng, Minglan Shi, Qilei Che, Hui Liu, Lifen Jiang, Kang ZengAbstractBackgroundAminolaevulinic acid-mediated photodynamic therapy (ALA-PDT) is used to treat condyloma acuminata (CA), yielding a high clearance rate and low recurrence rate. Consecutive human papillomavirus (HPV) DNA detection can be used to dynamically monitor...
Sun Sep 01, 2019 13:40
Publication date: Available online 31 August 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Xing Wang, Jianqiu Jin, Wenwen Li, Qian Wang, Ying Han, Hongwei LiuAbstractObjectivesThe clinical effect of 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) may be correlated with the degree of dysplasia of cancer tissues, but much is still unknown regarding the differences in its effectiveness, especially in oral cancer and precancerous lesions. The aim of this study is to compare...
Sun Sep 01, 2019 13:40
Publication date: Available online 31 August 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Maryam Pourhajibagher, Steven Parker, Nasim Chiniforush, Abbas BahadorAbstractBackgroundRecently, antimicrobial photodynamic therapy (aPDT) as an alternative treatment modality has been used adjunctively in the treatment of periodontitis and peri-implantitis. Photosensitizing agents in the form of nanoparticles are designed for improving the efficiency of aPTD. Graphene quantum dots are a special...
Sun Sep 01, 2019 13:40
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου