Related ArticlesPleomorphic Invasive Lobular Carcinoma of the Male Breast: Two Case Reports with Opposite Hormone Receptor Status. Ann Clin Lab Sci. 2019 Sep;49(4):534-538 Authors: Murzabdillaeva A, Ali Y, Aakash N, Armstrong J, Ghorbani R, Zhang S Abstract Male breast cancer represents <1% of breast cancers, with invasive lobular carcinoma in male breast being extremely rare. Only four cases of male breast with pleomorphic lobular carcinoma (PLC)...
Sun Sep 01, 2019 13:12
Related ArticlesLarotrectinib, a highly selective tropomyosin receptor kinase (TRK) inhibitor for the treatment of TRK fusion cancer. Expert Rev Clin Pharmacol. 2019 Aug 30;: Authors: Federman N, McDermott R Abstract Introduction: Detecting oncogenic drivers across multiple cancers has brought about a shift towards a more targeted therapeutic approach. Neurotrophic tyrosine receptor kinase (NTRK) gene fusions are genomic rearrangements containing the...
Sat Aug 31, 2019 14:31
Related ArticlesDark-matter matters: Discriminating subtle blood cancers using the darkest DNA. PLoS Comput Biol. 2019 Aug 30;15(8):e1007332 Authors: Parida L, Haferlach C, Rhrissorrakrai K, Utro F, Levovitz C, Kern W, Nadarajah N, Twardziok S, Hutter S, Meggendorfer M, Walter W, Baer C, Haferlach T Abstract The confluence of deep sequencing and powerful machine learning is providing an unprecedented peek at the darkest of the dark genomic matter, the...
Sat Aug 31, 2019 14:31
Related ArticlesMolecular Imaging and Therapy for Neuroendocrine Tumors. Curr Treat Options Oncol. 2019 Aug 29;20(10):78 Authors: Desai H, Borges-Neto S, Wong TZ Abstract OPINION STATEMENT: Neuroendocrine tumors (NETs) are relatively rare, with 12,000-15,000 new cases diagnosed annually in the USA. Although NETs are a diverse group of neoplasms, they share common molecular targets that can be exploited using nuclear medicine techniques for both imaging...
Sat Aug 31, 2019 13:01
Related Articles[Rare skin cancers : Early diagnosis and the right treatment]. Hautarzt. 2019 Aug 29;: Authors: Terheyden P, Dippel E PMID: 31468070 [PubMed - as supplied by publisher]
Sat Aug 31, 2019 13:01
Related Articles[Atypical fibroxanthoma and pleomorphic dermal sarcoma]. Hautarzt. 2019 Aug 29;: Authors: Ziemer M, Jäger IM, Dippel E Abstract Atypical fibroxanthoma (AFX) or undifferentiated pleomorphic sarcoma (UPS) is a rare malignant neoplastic disease of the skin. At the beginning of the 1960s AFX was described as an independent entity and superficial variant of malignant fibrous histiocytoma (MFH). Since then, many controversies on the classification...
Sat Aug 31, 2019 13:01
Related ArticlesPrimary small cell carcinoma of the upper urinary tract: A case report. Urol Case Rep. 2019 Nov;27:100995 Authors: Rupert V, Clifton MM, Fulmer BR, Mori RL, Williams H, Park A Abstract Small cell carcinoma of the urinary tract is an aggressive malignancy that comprises less than 1% of urinary bladder cancers. The renal pelvis and ureter, also lined by urothelium, are rare sites for small cell carcinoma. The diagnosis and staging of upper...
Sat Aug 31, 2019 13:01
Related Articles[Management of metastatic testicular germ cell tumors]. Bull Cancer. 2019 Aug 26;: Authors: Lavaud P, Baciarello G, Fizazi K Abstract Metastatic testicular germ cell tumors are rare entities with a high cure rate owing to their major chemosensitivity. Current guidelines should be strictly followed to ensure maximal cure rate. Germ cell tumor treatment requires multidisciplinary skills and is based on cisplatin-based chemotherapy. The...
Sat Aug 31, 2019 13:01
Related ArticlesBasal Cell Carcinoma, Squamous Cell Carcinoma, and Cutaneous Melanoma in Skin of Color Patients. Dermatol Clin. 2019 Oct;37(4):519-526 Authors: Hogue L, Harvey VM Abstract Skin cancers are relatively rare in patients with skin of color; however, they are an important public health concern because of disparities in patient outcomes. Gaps in skin cancer knowledge exist because of lack of large-scale studies involving people of color, and...
Sat Aug 31, 2019 13:01
Related ArticlesPredictors of Outcomes in Patients with EGFR-Mutated Non-Small Cell Lung Cancer Receiving EGFR Tyrosine Kinase Inhibitors: A Systematic Review and Meta-Analysis. Cancers (Basel). 2019 Aug 28;11(9): Authors: Buonerba C, Iaccarino S, Dolce P, Pagliuca M, Izzo M, Scafuri L, Costabile F, Riccio V, Ribera D, Mucci B, Carrano S, Picozzi F, Bosso D, Formisano L, Bianco R, De Placido S, Di Lorenzo G Abstract Some commonly available patient or...
Sat Aug 31, 2019 13:01
Related ArticlesOcular manifestations of Sturge-Weber syndrome. Curr Opin Ophthalmol. 2019 Sep;30(5):301-305 Authors: Silverstein M, Salvin J Abstract PURPOSE OF REVIEW: Sturge-Weber syndrome (SWS) is a rare, congenital disease which frequently involves the eye. It is important that ophthalmologists recognize this syndrome and are aware of its range of ocular manifestations. The aim of this article is to present our understanding of the pathogenesis...
Sat Aug 31, 2019 13:01
Related Articles[Rare type of dedifferentiated liposarcomas: report of two cases]. Zhonghua Bing Li Xue Za Zhi. 2019 07 08;48(7):559-561 Authors: Ke ZY, Yang SJ PMID: 31288314 [PubMed - indexed for MEDLINE]
Sat Aug 31, 2019 13:01
Related ArticlesIntraosseous synovial sarcoma of the distal ulna: a case report and review of the literature. BMC Cancer. 2019 Feb 01;19(1):116 Authors: Fujibuchi T, Miyawaki J, Kidani T, Imai H, Kiyomatsu H, Kitazawa R, Miura H Abstract BACKGROUND: Synovial sarcoma is a relatively rare type of soft tissue sarcoma. The commonly observed symptom is a deep-seated palpable mass accompanied by pain or tenderness. Thus, it is considered a soft tissue sarcoma...
Sat Aug 31, 2019 13:01
Related Articles[Orbital lymphoma in a rare location : Case report of optic neuropathy]. J Fr Ophtalmol. 2019 Feb;42(2):e63-e66 Authors: Palacin A, Zmuda M, Rousseau A, de Menthon M, Adam C, Galatoire O PMID: 30679125 [PubMed - indexed for MEDLINE]
Sat Aug 31, 2019 13:01
Related ArticlesAfatinib in the Treatment of Advanced Non-Small Cell Lung Cancer with Rare EGFR (in exon 18-T179X) Mutation - a Case Report. Klin Onkol. Fall 2018;31(5):380-383 Authors: Helena Č, Rostislav V Abstract INTRODUCTION: Exon 18-T719X EGFR mutation in non-small cell lung cancer is rare, only 1-5% of all EGFR mutations. The efficacy of EGFR tyrosin kinase inhibitors in tumours with uncommon mutations is still unclear and the prediction of response...
Sat Aug 31, 2019 13:01
Related ArticlesSolid Pseudopapillary Tumor of the Pancreas - Rare Neoplastic Disease in 20-Year-Old Woman. Klin Onkol. Fall 2018;31(5):376-379 Authors: Jakub F, Tomáš S, Josef V, Vladislav T, Radek T, Ondřej H Abstract INTRODUCTION: Benign cystic tumors represent only 2% of all pancreatic tumors (pancreatic cancer - PC). In contrast to malignant cystic tumors, these tumors occur typically in young women. A solid pseudopapillary tumor is a relatively...
Sat Aug 31, 2019 13:01
Related ArticlesTumor-to-Tumor Metastasis - a Unique Case of Clear Cell Renal Cell Carcinoma Harboring Metastasis of Adenocarcinoma of Unknown Origin. Klin Onkol. Fall 2018;31(5):366-370 Authors: Bartoš V Abstract BACKGROUND: The tumor-to-tumor metastasis is exclusively rare finding, in which one malignant neoplasia metastasizes to another tumor of different origin. CASE: The author describes an 68-year-old woman, who was found to have a solitary...
Sat Aug 31, 2019 13:01
Related ArticlesAssessment of Incidence and Character of Neurologic/ Neuropsychiatric Complications in a Group of Patients with Malignant Melanoma Treated with Adjuvant High Dose Interferon. Klin Onkol. Fall 2018;31(5):361-365 Authors: Jarmila P, Jiří G, Jindřich K, Peter P, Iva P, Petronela T, Věra J, Adam P, Šárka L, Filip Abstract BACKGROUND: Authors describe the incidence and character of neurologic and neuropsychiatric complications - particularly...
Sat Aug 31, 2019 13:01
Related ArticlesReal-life treatment practice for malignant pleural mesothelioma in Belgium. Lung Cancer. 2018 11;125:258-264 Authors: Rosskamp M, Macq G, Nackaerts K, Praet M, Van Eycken L, Van Meerbeeck JP, De Schutter H Abstract OBJECTIVES: Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer, for which treatment is often limited to palliative combination chemotherapy. Multimodality-therapy, including radical surgery, is largely restricted...
Sat Aug 31, 2019 13:01
Related ArticlesProspective study revealed prognostic significance of responses in leptomeningeal metastasis and clinical value of cerebrospinal fluid-based liquid biopsy. Lung Cancer. 2018 11;125:142-149 Authors: Xu Y, Hu M, Zhang M, Zhong W, Yin X, Sun Y, Chen M, Zhao J, Si X, Wang H, Zhang X, Zhang L, Li J, Guan H, Yang Z, Wang M Abstract OBJECTIVE: Leptomeningeal metastasis (LM) secondary to non-small cell lung cancer (NSCLC) is a devastating complication...
Sat Aug 31, 2019 13:01
Related Articles[Autoimmune reactions and paraneoplastic syndromes]. Radiologe. 2018 Dec;58(12):1080-1090 Authors: Lieb JM, Naumann N, Ahlhelm FJ Abstract CLINICAL ISSUE: Autoimmune disorders of the central nervous system (CNS) are common but are also a heterogeneous group of diseases. The most common form is multiple sclerosis (MS), others are clinically isolated syndrome (CIS), acute demyelinating encephalomyelitis (ADEM) and neuromyelitis optica...
Sat Aug 31, 2019 13:01
Related ArticlesThe Next Generation of Anticancer Metallopharmaceuticals: Cancer Stem Cell-Active Inorganics. Chembiochem. 2018 11 02;19(21):2246-2253 Authors: Laws K, Suntharalingam K Abstract Cancer stem cells (CSCs) are heavily linked to fatal incidences of cancer relapse and metastasis. Conventional cancer therapies such as surgery, chemotherapy and radiation are largely futile against CSCs. Therefore, highly original approaches are needed to overcome...
Sat Aug 31, 2019 13:01
Related Articles[A rare tympanic lesion - paracentesis led to an interesting diagnosis]. Laryngorhinootologie. 2018 Sep;97(9):636-638 Authors: Stapper MC, Kirchesch D, Krömeke O, Glaas MF, Zollner B, Albert NL, Kunz M PMID: 30001563 [PubMed - indexed for MEDLINE]
Sat Aug 31, 2019 13:01
Related ArticlesDynamic Allostery in PLCγ1 and Its Modulation by a Cancer Mutation Revealed by MD Simulation and NMR. Biophys J. 2018 07 03;115(1):31-45 Authors: Koss H, Bunney TD, Esposito D, Martins M, Katan M, Driscoll PC Abstract Phosphatidylinositol phospholipase Cγ (PLCγ) is an intracellular membrane-associated second-messenger signaling protein activated by tyrosine kinases such as fibroblast growth factor receptor 1. PLCγ contains the regulatory...
Sat Aug 31, 2019 13:01
Related ArticlesScientific Advances and New Frontiers in Mesothelioma Therapeutics. J Thorac Oncol. 2018 09;13(9):1269-1283 Authors: Mutti L, Peikert T, Robinson BWS, Scherpereel A, Tsao AS, de Perrot M, Woodard GA, Jablons DM, Wiens J, Hirsch FR, Yang H, Carbone M, Thomas A, Hassan R Abstract Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer that arises from the mesothelial surface of the pleural and peritoneal cavities, the pericardium,...
Sat Aug 31, 2019 13:01
Related ArticlesCurrent Treatment of Endolymphatic Sac Tumor of the Temporal Bone. Adv Ther. 2018 07;35(7):887-898 Authors: Mendenhall WM, Suárez C, Skálová A, Strojan P, Triantafyllou A, Devaney KO, Williams MD, Rinaldo A, Ferlito A Abstract An endolymphatic sac tumor (ELST) is a rare, indolent but locally aggressive tumor arising in the posterior petrous ridge. Patients present with sensorineural hearing loss and tinnitus. As the tumor progresses,...
Sat Aug 31, 2019 13:01
Related ArticlesOcular surface squamous neoplasia in a setting of fungal keratitis: a rare co-occurrence. Int Ophthalmol. 2019 06;39(6):1209-1210 Authors: Palamar M, Egrilmez S, Yilmaz SG, Polat SH, Gunduz OU PMID: 29691697 [PubMed - indexed for MEDLINE]
Sat Aug 31, 2019 13:01
Related ArticlesGiant Mediastinal Liposarcoma: A Rare Yet Distinct Clinical Entity. Ann Thorac Surg. 2018 09;106(3):e117-e119 Authors: Nguyen DC, Olatubosun O, Yu W, Loor G, Burt BM Abstract Mediastinal liposarcomas are rare tumors that occasionally present as unusually large and rapidly growing mediastinal masses resulting in compressive symptoms. We present a case of a 48-year-old woman undergoing resection of a mediastinal liposarcoma of massive...
Sat Aug 31, 2019 13:01
Related ArticlesUtility of Site-Specific Biopsy for Diagnosis of Desmoplastic Malignant Mesothelioma. Ann Thorac Surg. 2018 09;106(3):e125-e128 Authors: Sakai T, Tane K, Usui Y, Miyoshi T, Matsumoto S, Aokage K, Goto K, Suzuki M, Ishii G, Tsuboi M Abstract Desmoplastic malignant mesothelioma (DMM) is a relatively rare histologic subtype of malignant pleural mesothelioma (MPM). Among MPMs, the diagnosis of DMM is particularly difficult because the tumor...
Sat Aug 31, 2019 13:01
Related ArticlesHighly specific and sensitive point-of-care detection of rare circulating tumor cells in whole blood via a dual recognition strategy. Biosens Bioelectron. 2019 Aug 21;143:111604 Authors: Yang J, Huang X, Gan C, Yuan R, Xiang Y Abstract Despite the fact that the identification and detection of circulating tumor cells (CTCs) plays a critical role in cancer monitoring and diagnosis, it remains a major challenge to isolate and detect these...
Fri Aug 30, 2019 14:31
Related ArticlesCase report of hepatic pseudocyst: A rare manifestation of liver metastasis from an anal squamous cell carcinoma. Int J Surg Case Rep. 2019 Aug 17;62:77-84 Authors: Bekki T, Takakura Y, Kochi M, Kushitani K, Mori K, Arihiro K, Teraoka Y, Egi H, Ohdan H Abstract INTRODUCTION: Liver metastasis of an anal squamous cell carcinoma (SCC) with a pseudocyst is uncommon. There are many diseases which form hepatic cystic lesions and sometimes it...
Fri Aug 30, 2019 14:31
Related ArticlesCoexistence of colon adenocarcinoma, diffuse large B-cell lymphoma, and myelodysplastic syndrome: A case report. Medicine (Baltimore). 2019 Aug;98(35):e16742 Authors: Wang W, Li P Abstract RATIONALE: Cases of coexistence of 2 cancers, such as colorectal cancer and diffuse large B-cell lymphoma (DLBCL), colorectal cancer and myelodysplastic syndrome (MDS), and DLBCL with MDS, have been reported, whereas the coexistence of 3 different cancers...
Fri Aug 30, 2019 14:31
Related ArticlesEvaluation of the contribution of germline variants in BRCA1 and BRCA2 to uveal and cutaneous melanoma. Melanoma Res. 2019 Oct;29(5):483-490 Authors: Johansson PA, Nathan V, Bourke LM, Palmer JM, Zhang T, Symmons J, Howlie M, Patch AM, Read J, Holland EA, Schmid H, Warrier S, Glasson W, Höiom V, Wadt K, Jönsson G, Olsson H, Ingvar C, Mann G, Brown KM, Hayward NK, Pritchard AL Abstract Germline mutations of BRCA1 and BRCA2 predispose individuals...
Fri Aug 30, 2019 14:31
Related ArticlesExceptional Response to Nivolumab in a 13-Year-Old Female with Metastatic HPV-Negative Cervical Carcinoma. DNA Cell Biol. 2019 Aug 29;: Authors: Oved JH, Graul A, Burger RA, Schwartz LE, Reyes MC, Balis FM Abstract Cervical carcinoma is associated with high-risk human papillomavirus (HPV) DNA integration and usually occurs after age 21 (peak 45 years), as reflected in screening guidelines. Between 1999 and 2008, cervical carcinoma rate...
Fri Aug 30, 2019 14:31
Related ArticlesPrimary pleural liposarcoma: A rare entity. Lung India. 2019 Sep-Oct;36(5):438-440 Authors: Prabhakar N, Vaiphei K, Vishwajeet V, Ramamoorthy E, Gorsi U, Dhooria S, Kapoor R, Sandhu MS Abstract Primary pleural liposarcoma (PPL) is a rare malignant tumor of the pleura. The diagnosis of PPL may be suspected on chest imaging based on radiologic features such as large pleural mass showing areas of fat with or without calcification. Herein,...
Fri Aug 30, 2019 14:31
Related ArticlesPoorly Differentiated Neuroendocrine Carcinoma of the Head and Neck: HPV Tumor Status / p16 Status and Impact on Overall Survival. Histopathology. 2019 Aug 29;: Authors: Benzerdjeb N, Traverse-Glehen A, Philouze P, Bishop J, Devouassoux-Shisheboran M Abstract AIMS: Poorly differentiated neuroendocrine carcinoma (PDNEC) in the head and neck is a rare high-grade neuroendocrine neoplasms. Human papillomavirus (HPV) status and p16 status...
Fri Aug 30, 2019 13:30
Related ArticlesWhat is new in endothelial neoplasia? Virchows Arch. 2019 Aug 28;: Authors: Papke DJ, Hornick JL Abstract The classification of vascular neoplasms continues to evolve as we accumulate more genetic and clinical data, particularly for rare tumor types. Because of tumor rarity, changes to classification schema, overlapping histologic features, and in some cases, lack of morphologic evidence of vasoformation, vascular neoplasms present a...
Fri Aug 30, 2019 14:31
Related ArticlesMDSC targeting with Gemtuzumab ozogamicin restores T cell immunity and immunotherapy against cancers. EBioMedicine. 2019 Aug 19;: Authors: Fultang L, Panetti S, Ng M, Collins P, Graef S, Rizkalla N, Booth S, Lenton R, Noyvert B, Shannon-Lowe C, Middleton G, Mussai F, De Santo C Abstract BACKGROUND: Targeting of MDSCs is a major clinical challenge in the era of immunotherapy. Antibodies which deplete MDSCs in murine models can reactivate...
Fri Aug 30, 2019 13:30
Related Articles[A case of rare laryngeal neurogenic tumor]. Wiad Lek. 2019;72(7):1413-1414 Authors: Czubak J, Frączek M, Morawski K Abstract Laryngeal schwannoma is a rare benign tumour of the larynx. Schwannomas derive from the Schwann cells. Magnetic resonance imaging (MRI) is the best imaging tool for suggesting the diagnosis. We report case of laryngeal schwannoma. The case was a 61-year-old man with a 1-year history of dysphonia and stridor. Laryngoscopy...
Fri Aug 30, 2019 13:30
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