The pinched nasal tip deformity often results as sequelae of prior nasal surgery. Conventional tip surgery techniques that overemphasize tip narrowing often deform the lateral crura and weaken support for the alar margin. The pinched nasal tip is characterized by the demarcation between the nasal tip and the alar lobule, isolating the tip from the surrounding nasal subunits. Lateral crural strut grafts with or without repositioning offer the surgeon a powerful maneuver that can help correct this...
The cephalic trim technique is a popular maneuver that often leads to tip deformities, most notably postsurgical alar retraction (PSAR). We advocate using the external rhinoplasty approach to correct PSAR by (1) releasing and repositioning the retracted alar margin, (2) strengthening and immobilizing the central tip complex using a septal extension graft, (3) suspending and longitudinally tightening the mobilized lateral crural remnant by adjusting crural length to match the sidewall span, and (4)...
Complications of rhytidectomy are well known, yet often preventable. A thorough preoperative history and physical along with realistic patient expectations provide the surgeon and patient with insight into potential complications and postoperative management. Understanding of surgical pitfalls and avoidance are crucial in beginning to manage facelift complications. Possible complications of facelift techniques should not discourage surgeons from pursuing a particular technique as the majority of...
Aesthetic procedures of the face and neck are increasing in popularity with emergence of innovative techniques and a shift in the social stigma of plastic surgery. With this rise, we are seeing an onslaught of patients with poor results or significant complications following cosmetic operations. Although knowledge of potential risks in aesthetic surgery is abundant, comprehensive information on management of these complications is lacking.
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Characteristics of true vocal fold vibration such as the proportion of closed phase of vibration to open phase, longitudinal tension, and the amount of medial compression are used to define four conditions during Estill Voice Training. However, it is unknown whether trainees achieve these phonatory differences after training. Acoustic and aerodynamic measures were used to determine differences in Slack, Thick, Thin, and Stiff conditions. Twenty-four female speech-language pathology graduate students...
There are many reports of the efficacy of laryngeal reinnervation on voice, but there is a paucity of literature regarding its impact on swallowing function. The goal of this study was to explore the impact of laryngeal reinnervation on swallowing outcomes among unilateral vocal fold paralysis (UVFP) patients.
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African American and Hispanic children are more likely to have a diagnosis of asthma and significantly higher disease related morbidity in comparison to non-Hispanic white children. Mortality rates are likewise higher as African American children are 8 times more likely than non-Hispanic white children to die from asthma 1. The cause of this striking health disparity is not clearly understood. Socioeconomic related risk factors, such as exposure to environmental pollutants and lack of or inadequate...
Guidelines recommend that children and families receive education about and demonstration of effective inhaler technique, as part of asthma self-management education.1 For youth, improved inhaler technique is associated with better quality of life and decreased healthcare utilization,2,3 yet technique remains suboptimal.2 To understand potential reasons for differences in inhaler skills, this study examined individual and healthcare level factors associated with effective inhaler technique among...
Atopic dermatitis (AD) is a common chronic relapsing skin disease.Genetic variants have been associated with skin barrier function and immune regulation. Thymic stromal lymphopoietin (TSLP), an immune regulator, has been previously associated with AD.
Alpha-gal allergy is associated with immunoglobulin E (IgE) antibodies to galactose-α-1,3-galactose (alpha-gal), a carbohydrate found in beef, pork, and lamb. First described in the adult population in 2009 by Commins et al., this syndrome is associated with delayed anaphylaxis, angioedema, and urticaria with symptom onset 3 to 6 hours after eating red meat.1,2,3 Bites from ticks, namely the Lone Star Tick (Amblyomma americanum) in the United States, are associated with production of IgE antibodies...
Effect of cysLTR1 blockade on aeroallergen-induced nasal recruitment of CD49d expressing neutrophils
Asthma and atopic diseases have been increasing worldwide1. One risk factor for the development of asthma and atopy is a severe respiratory viral infection in infancy. The viruses most associated with this risk are Respiratory Syncytial Virus (RSV) and Rhinovirus. Using the murine parainfluenza virus, Sendai virus (closely related to RSV), we have described a pathway that translates the severe respiratory viral infection into development of atopy and airway disease in mice. Critical to this translation...
Hypersensitivity reactions (HSRs) to platinum-based chemotherapies have increased as platin use expanded with rising cancer rates. Patients with HSRs to platinum-based chemotherapeutics are often treated with second or third line treatments, leading to inferior outcomes and decreased survival.1
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Abstract Aliphatic ketones, such as 2-butanone and 3-hexanone, with only one carbon difference among side chains adjacent to the carbonyl carbon are difficult to be reduced enantioselectively. In this study, we utilized an acetophenone reductase from Geotrichum candidum NBRC 4597 (GcAPRD) to reduce challenging aliphatic ketones such as 2-butanone (methyl ethyl ketone) and 3-hexanone (ethyl propyl ketone) to their corresponding (S)-alcohols with 94% ee and > 99% ee, respectively....
Abstract The capability of Escherichia coli to catabolize d-xylonate is a crucial component for building and optimizing the Dahms pathway. It relies on the inherent dehydratase and keto-acid aldolase activities of E. coli. Although the biochemical characteristics of these enzymes are known, their inherent expression regulation remains unclear. This knowledge is vital for the optimization of d-xylonate assimilation, especially in addressing the problem of d-xylonate accumulation,...
Abstract While numerous reports exist on the axenic culturing of different hydrogen-oxidizing bacteria (HOB), knowledge about the enrichment of microbial communities growing on hydrogen, oxygen, and carbon dioxide as sole carbon and energy sources remains negligible. We want to elucidate if in such enrichments, most enriched populations are HOBs or heterotrophic organisms. In the present study, bacteria enriched from a soil sample and grown over 5 transfers using a continuous supply...
Abstract The environmental accumulation of polycyclic aromatic hydrocarbons (PAHs) is of great concern due to potential carcinogenic and mutagenic risks, as well as their resistance to remediation. While many fungi have been reported to break down PAHs in environments, the details of gene-based metabolic pathways are not yet comprehensively understood. Specifically, the genome-scale transcriptional responses of fungal PAH degradation have rarely been reported. In this study, we...
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Abstract Purpose To compare the International Ovarian Tumor Analysis (IOTA) simple rules, simple rules risk ultrasound models, alone or in combination with magnetic resonance (MR) score to predict malignancy in women with adnexal masses. Methods 171 women with adnexal masses were included from February 2014 to February 2016. 120 women had histopathological...
Abstract Purpose To explore the utility of two different fat quantification methods in the liver and pancreas and to test the accuracy of multi-echo Dixon as a single sequence in detecting early stage of fat deposition. Methods 58 healthy potential liver donors underwent abdominal 3T MRI, prospectively. Single-voxel MR Spectroscopy (MRS), dual-echo Dixon,...
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ΑπάντησηΔιαγραφήComplications of Facelift
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