Related Articles[Preoperative risk and perioperative management of obese patients]. Rev Mal Respir. 2019 Sep 11;: Authors: De Jong A, Verzilli D, Chanques G, Futier E, Jaber S Abstract The obese patient is at an increased risk of perioperative complications. Most importantly, these include difficult access to the airways (intubation, difficult or impossible ventilation), and post-extubation respiratory distress secondary to the development of atelectasis...
Mon Sep 16, 2019 15:32
Related ArticlesThe impact of intranasal fluticasone on patients with obstructive sleep apnea: a prospective study. Braz J Otorhinolaryngol. 2019 Aug 31;: Authors: Tam YY, Shao IH, Wu CC, Hsieh ML Abstract INTRODUCTION: Obstructive sleep apnea is the most common type of sleep apnea, which is caused by complete or partial obstructions of the upper airway. Nasal obstruction is also considered as one of the independent risk factors of obstructive sleep...
Mon Sep 16, 2019 15:32
Related ArticlesPerioperative considerations in the management of obstructive sleep apnoea. Med J Aust. 2019 Sep 15;: Authors: Holt NR, Downey G, Naughton MT Abstract Obstructive sleep apnoea (OSA) is characterised by repetitive compromise of the upper airway, causing impaired ventilation, sleep fragmentation, and daytime functional impairment. It is a heterogeneous condition encompassing different phenotypes. The prevalence of OSA among patients presenting...
Mon Sep 16, 2019 15:32
Related ArticlesMultiple intracranial aneurysms caused by myxoma: case report and literature review. World Neurosurg. 2019 Sep 12;: Authors: Gai S, Lv N, Zhang Q, Zuo Q, Liu J, Huang Q Abstract OBJECTIVE: We present a case of multiple myxoma-related intracranial aneurysms and review the recent relevant literatures to investigate their natural course and reasonable treatment algorithm. METHOD: A new case of multiple myxoma-related intracranial...
Mon Sep 16, 2019 14:16
Related ArticlesA Multimodal Approach for the Treatment of a Hemorrhaged Mesencephalic Arteriovenous Malformation. World Neurosurg. 2019 Sep 12;: Authors: Bortolotti C, Bertolini G, Sorenson TJ, Cirillo L, Lanzino G, Sturiale C PMID: 31521752 [PubMed - as supplied by publisher]
Mon Sep 16, 2019 14:16
Related ArticlesDischarge Disposition after Anterior Cervical Discectomy and Fusion. World Neurosurg. 2019 Sep 12;: Authors: Karhade AV, Ogink PT, Thio QCBS, Cha TD, Hershman SH, Schoenfeld AJ, Bono CM, Schwab JH Abstract OBJECTIVE: Age and comorbidity burden of anterior cervical discectomy and fusion (ACDF) patients have increased significantly over the past two decades, resulting in increased expenditures. Non-home discharge after ACDF contributes...
Mon Sep 16, 2019 14:16
Related ArticlesLow-dose, Early Fresh frozen plasma Transfusion therapy after severe trauma brain injury: a clinical, prospective, randomized, controlled study (LEFT). World Neurosurg. 2019 Sep 12;: Authors: Zhang LM, Li R, Sun WB, Wang XP, Qi MM, Bai Y, Bai J, Zheng W Abstract BACKGROUND: To investigate the role of Low-dose, Early Fresh frozen plasma Transfusion (LEFT) therapy in preventing peri-operative coagulopathy and improving long-term outcome...
Mon Sep 16, 2019 14:16
Related ArticlesMorbidity and Mortality Conference Can Reduce Avoidable Morbidity in Neurosurgery: Its Educational Effect on Residents and Surgical Safety Outcomes. World Neurosurg. 2019 Sep 12;: Authors: Kashiwazaki D, Saito H, Uchino H, Akioka N, Hori E, Shibata T, Tomita T, Akai T, Kuwayama N, Kuroda S PMID: 31521755 [PubMed - as supplied by publisher]
Mon Sep 16, 2019 14:16
Related ArticlesElectromyographic response of facial nerve stimulation under partial neuromuscular blockade during resection of vestibular schwanoma. World Neurosurg. 2019 Sep 12;: Authors: Ran G, Chen K, Huang Y, Hu C, Shen X Abstract OBJECTIVE: To evaluate whether use of partial nondepolarizing neuromuscular blocking agents (NMBAs), at a train of four (TOF) level 1, compromise the facial nerve monitoring during vestibular schwanoma (VS) resection....
Mon Sep 16, 2019 14:16
Related ArticlesThe Effect of Hospital Transfer on Patient Outcomes After Rehabilitation for Spinal Injury. World Neurosurg. 2019 Sep 12;: Authors: Wilde H, Gamblin AS, Reese J, Garry JG, Guan J, Mortenson J, Flis A, Rosenbluth JP, Karsy M, Bisson EF, Dailey AT Abstract OBJECTIVE: Spine fractures, including associated spinal cord injury, account for 3-6% of all skeletal fractures annually in the U.S.. Patients who undergo interhospital transfer after...
Mon Sep 16, 2019 14:16
Related ArticlesRisk factors for cage retropulsion after lumbar interbody fusion: A systematic review and meta-analysis. World Neurosurg. 2019 Sep 12;: Authors: Liu K, Chang H, Wang L, Wang C, Chen T, Meng X Abstract PURPOSE: Although many risk factors for cage retropulsion (CR) following lumbar interbody fusion (LIF) have been described in the literature, they still remain controversial. The purpose of this study is to investigate the risk factors for...
Mon Sep 16, 2019 14:16
Related ArticlesRisk management of aneurysmal subarachnoid hemorrhage by age and treatment method from a nationwide database in Japan. World Neurosurg. 2019 Sep 12;: Authors: Ikawa F, Michihata N, Iihara K, Akiyama Y, Morita A, Fushimi K, Yasunaga H, Kurisu K Abstract OBJECTIVE: There has been no precise guide for treatment management of aneurysmal subarachnoid hemorrhage (aSAH) based on the patient's age and treatment method. This study clarifies each...
Mon Sep 16, 2019 14:16
Related ArticlesManagement of extracranial blunt cerebrovascular injuries: experience with an aspirin-based approach. World Neurosurg. 2019 Sep 12;: Authors: Catapano JS, Israr S, Whiting AC, Hussain OM, Snyder LA, Albuquerque FC, Ducruet AF, Nakaji P, Lawton MT, Weinberg JA, Zabramski JM Abstract BACKGROUND: Optimal management of patients with extracranial blunt cerebrovascular injury (BCVI) remains controversial, with both anticoagulation and antiplatelet...
Mon Sep 16, 2019 14:16
Related ArticlesPrognostic factors associated with achieving total oral diet following osteocutaneous microvascular free tissue transfer reconstruction of the oral cavity. Oral Oncol. 2019 Sep 12;98:1-7 Authors: Kansara S, Wang T, Koochakzadeh S, Liou NE, Graboyes EM, Skoner JM, Hornig JD, Sandulache VC, Day TA, Huang AT Abstract INTRODUCTION: Osteocutaneous microvascular free tissue transfer (OMFTT) is the current standard in reconstruction of large...
Mon Sep 16, 2019 14:24
Related ArticlesReferral rates for newborn hearing screening based on the test time. Int J Pediatr Otorhinolaryngol. 2019 Aug 30;127:109664 Authors: Chung YS, Oh SH, Park SK Abstract OBJECTIVES: To suggest the optimal timing for newborn hearing screening to obtain an ideal and stable referral rate in well babies and in babies in neonatal intensive care units (NICU). METHODS: This study analyzed nationwide hearing screening data of 71,596 newborns...
Mon Sep 16, 2019 14:25
Related Articles[Management of cancer patients with oral therapy at home in Brittany and Pays de la Loire areas: Survey (end of 2016) and cartography]. Bull Cancer. 2019 Sep 11;: Authors: Grudé F, Marhuenda F, Déniel-Lagadec D, Bessard R, Pracht M, Bourgeois H, Carlhant Kowalski D, Metges JP, Vidal AM, Ganem G Abstract INTRODUCTION: The Cancer Observatory, from the OMEDITs (Observatory for Medicines and Medical Devices and Treatment Innovations) of Bretagne...
Mon Sep 16, 2019 14:26
Publication date: Available online 15 September 2019Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Thomas M. Aherne, Tjun Y. Tang, Stewart R. Walsh
Mon Sep 16, 2019 14:28
Mesenchymal hamartoma is a benign tumor of the liver with a poorly understood pathogenesis. It is uncommon in older children, especially after 2 years of age. The signs and symptoms may be nonspecific; therefore, a high index of suspicion is required for diagnosis and treatment. We report a 5-year-old previously healthy male who presented with acute abdominal pain, fatigue, and fever. He was diagnosed with pneumonia initially and treated with antibiotics. A computed tomography (CT) scan done for...
Mon Sep 16, 2019 12:05
Related ArticlesMRI and fluorescence studies of Saccharomyces cerevisiae loaded with a bimodal Fe(III) T1 contrast agent. J Inorg Biochem. 2019 Sep 06;201:110832 Authors: Patel A, Asik D, Spernyak JA, Cullen PJ, Morrow JR Abstract Labeling of cells with paramagnetic metal complexes produces changes in MRI properties that have applications in cell tracking and identification. Here we show that fungi, specifically the budding yeast Saccharomyces cerevisiae,...
Mon Sep 16, 2019 14:35
546 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: medical science These pubmed results were generated on 2019/09/16PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Mon Sep 16, 2019 14:36
Conditions: Vasomotor Symptoms; Menopausal SymptomsInterventions: Drug: Estetrol oral tablet; Drug: Placebo oral tabletSponsors: Estetra; ICON Clinical ResearchNot yet recruiting
Mon Sep 16, 2019 15:15
Condition: the Position of Laryngeal Mask AirwayIntervention: Procedure: the fiberoptic laryngoscope (KARL STORZ 11301BN1, Germany) for confirmation of LMA positionSponsor: Beni-Suef UniversityRecruiting
Mon Sep 16, 2019 15:15
Condition: Breast CancerIntervention: Device: Optiflow/VentilatorSponsor: University Hospital, GhentRecruiting
Mon Sep 16, 2019 15:15
Publication date: November 2019Source: International Immunopharmacology, Volume 76Author(s): Qi Cheng, Yunxiao Shang, Wanjie Huang, Qinzhen Zhang, Xiang Li, Qianlan ZhouAbstractBackgroundBronchial asthma is affected by both environmental and genetic factors. The orosomucoid 1-like protein 3 (ORMDL3) gene is related to childhood asthma and is involved in airway inflammation and airway remodeling. The ORMDL3 promoter contains binding sites for the histone acetylase p300. Gene expression can be affected...
Mon Sep 16, 2019 15:40
Publication date: November 2019Source: International Immunopharmacology, Volume 76Author(s): Liuting Hu, Heyu Zhang, Bingyang Wang, Qiang Ao, Jing Shi, Zhiyi HeAbstractNeuroinflammation plays a critical role in the pathogenesis of intracerebral hemorrhage (ICH), contributing to detrimental brain injury and neurological function deficits. MicroRNA-23b (miR-23b) exerts anti-inflammatory effects in many diseases and is downregulated in patients with ICH. This study aimed to evaluate the involvement...
Mon Sep 16, 2019 15:40
24 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: ALCOHOL These pubmed results were generated on 2019/09/16PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Mon Sep 16, 2019 14:13
24 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: ALCOHOL These pubmed results were generated on 2019/09/16PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Mon Sep 16, 2019 16:20
Aim of this study is to analyze determinants of breech presentation using information from two regional databases of Lombardy (Italy) including data on consecutive singleton breech and vertex deliveries occurred in the Region, between January 2010 and December 2015. Breech presentation occurred in 3.8% of all single deliveries. Main determinants of breech presentation at birth were: gestational age and birth weight (the lower, the higher the incidence of breech presentation), maternal age (the older...
Mon Sep 16, 2019 16:30
Introduction. Nurses play an important role in caring for dying patients. However, little is known about the attitude towards death of the registered nurses in China. Materials and Methods. A knowledge, attitude, and the practice (KAP) survey using standardized questionnaires was conducted at eight teaching hospitals in Jiangsu Province, China. In total, 366 nursing interns were recruited and 357 turned in valid response. Data about the interns’ demographic characteristics and their attitudes to...
Mon Sep 16, 2019 16:30
N6-methyladenosine (m6A) is the most common internal modification in eukaryotic mRNA and associated with numerous cellular processes in health and disease. Up- and down-regulation of its "writer" or "eraser" proteins alter the global m6A level; however, modifying distinct m6A sites has remained elusive. We genetically fused the dioxygenase FTO responsible for m6A demethylation to RCas9 as an RNA-targeting module. The resulting RCas9-FTO retained demethylation activity and bound to RNA in a sequence-specific...
Mon Sep 16, 2019 16:30
Eukaryotic ribosomal protein L13a is a member of the conserved universal ribosomal uL13 protein family. Structurally, L13a is distinguished from its prokaryotic counterparts by the presence of an ~55 amino acid-long carboxy-terminal α-helical extension. The importance of these evolved residues in the carboxy-terminal extension for mammalian ribosome biogenesis as well as L13a's extraribosomal function in GAIT ( interferon-activated inhibitor of translation) complex-mediated translation silencing...
Mon Sep 16, 2019 16:30
There is increasing evidence from yeast to humans that pre-mRNA splicing occurs mainly cotranscriptionally, such that splicing and transcription are functionally coupled. Currently, there is little insight into the contribution of the core transcription elongation machinery to cotranscriptional spliceosome assembly and pre-mRNA splicing. Spt5 is a member of the core transcription elongation machinery and an essential protein, whose absence in budding yeast causes defects in pre-mRNA splicing. To...
Mon Sep 16, 2019 16:30
Alternative splicing of pre-mRNA is a major mechanism to diversify protein functionality in metazoans from a limited number of genes. The Drosophila melanogaster Down syndrome cell adhesion molecule (Dscam) gene, which is important for neuronal wiring and phagocytosis of bacteria, can generate up to 38,016 isoforms by mutually exclusive alternative splicing in four clusters of variable exons. However, it is not understood how a specific exon is chosen from the many variables and how variable exons...
Mon Sep 16, 2019 16:30
Argonaute (Ago) proteins interact with various binding partners and play a pivotal role in microRNA (miRNA)-mediated silencing pathways. By utilizing immunoprecipitation followed by mass spectrometry to determine cytoplasmic Ago2 protein complexes in mouse embryonic stem cells (mESCs), we identified a putative RNA-binding protein FAM120A (also known as OSSA/C9ORF10) as an Ago2 interacting protein. Individual nucleotide resolution cross-linking and immunoprecipitation (iCLIP) analysis revealed that...
Mon Sep 16, 2019 16:30
Polypyrimidine tract-binding proteins (PTBPs) are RNA binding proteins that regulate a number of posttranscriptional events. Human PTBP1 transits between the nucleus and cytoplasm and is thought to regulate RNA processes in both. However, information about PTBP1 mRNA isoforms and regulation of PTPB1 expression remains incomplete. Here we mapped the major PTBP1 mRNA isoforms in HEK293T cells and identified alternative 5' and 3' untranslated regions (5'-UTRs, 3'-UTRs), as well as alternative splicing...
Mon Sep 16, 2019 16:30
In the present work, 67 crystal structures of the aptamer domains of RNA riboswitches are chosen for analysis of the structure and strength of hydrogen bonding (pairing) interactions between nucleobases constituting the aptamer binding pockets and the bound ligands. A total of 80 unique base:ligand hydrogen-bonded pairs containing at least two hydrogen bonds were identified through visual inspection. Classification of these contacts in terms of the interacting edge of the aptamer nucleobase revealed...
Mon Sep 16, 2019 16:30
H/ACA small nucleolar ribonucleoproteins (snoRNPs) pseudouridylate RNA in eukaryotes and archaea. They target many RNAs site-specifically through base-pairing interactions between H/ACA guide and substrate RNA. Besides ribosomal RNA (rRNA) and small nuclear RNA (snRNA), H/ACA snoRNPs are thought to also modify messenger RNA (mRNA) with potential impacts on gene expression. However, the base pairing between known target RNAs and H/ACA guide RNAs varies widely in nature, and therefore the rules governing...
Mon Sep 16, 2019 16:30
Methylation of histone H3 on lysine 79 (H3K79) by DOT1L is associated with actively transcribed genes. Earlier, we described that DOT-1.1, the Caenorhabditis elegans homolog of mammalian DOT1L, cooperates with the chromatin-binding protein ZFP-1 (AF10 homolog) to negatively modulate transcription of highly and widely expressed target genes. Also, the reduction of ZFP-1 levels has consistently been associated with lower efficiency of RNA interference (RNAi) triggered by exogenous double-stranded RNA...
Mon Sep 16, 2019 16:30
Proteins bind mRNA through their entire life cycle from transcription to degradation. We analyzed c-Myc mRNA protein interactors in vivo using the HyPR-MS method to capture the crosslinked mRNA by hybridization and then analyzed the bound proteins using mass spectrometry proteomics. Using HyPR-MS, 229 c-Myc mRNA-binding proteins were identified, confirming previously proposed interactors, suggesting new interactors, and providing information related to the roles and pathways known to involve c-Myc....
Mon Sep 16, 2019 16:30
The precise spatial and temporal control of gene expression requires the coordinated action of genomic cis-regulatory elements (CREs), including transcriptional enhancers. However, our knowledge of enhancers in plants remains rudimentary and only a few plant enhancers have been experimentally defined. Here, we screened the Arabidopsis thaliana genome and identified >1900 unique candidate CREs that carry the genomic signatures of mammalian enhancers. These were termed putative enhancer-like elements...
Mon Sep 16, 2019 16:30
The tRNA m1R9 methyltransferase (Trm10) family is conserved throughout Eukarya and Archaea. Despite the presence of a single Trm10 gene in Archaea and most single-celled eukaryotes, metazoans encode up to three homologs of Trm10. Several disease states correlate with a deficiency in the human homolog TRMT10A, despite the presence of another cytoplasmic enzyme, TRMT10B. Here we investigate these phenomena and demonstrate that human TRMT10A (hTRMT10A) and human TRMT10B (hTRMT10B) are not biochemically...
Mon Sep 16, 2019 16:30
Polyadenylation at the 3'-end is a major regulator of messenger RNA and its length is known to affect nuclear export, stability, and translation, among others. Only recently have strategies emerged that allow for genome-wide poly(A) length assessment. These methods identify genes connected to poly(A) tail measurements indirectly by short-read alignment to genetic 3'-ends. Concurrently, Oxford Nanopore Technologies (ONT) established full-length isoform-specific RNA sequencing containing the entire...
Mon Sep 16, 2019 16:30
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