Related ArticlesChildhood nosocomial viral acute respiratory tract infections in teaching hospital Anuradhapura, Sri Lanka. BMC Res Notes. 2019 Sep 14;12(1):581 Authors: Sampath Jayaweera JAA, Reyes M Abstract OBJECTIVES: We have assessed the risk factors for the occurrence of hospital-acquired (HA) and community-acquired (CA) viral acute respiratory tract infections (ARTIs) in children. Children (1-60 months) who were having ARTI on admission (CA) and...
Mon Sep 16, 2019 15:55
Related ArticlesRespiratory Syncytial Virus Infections in Children 0-24 Months of Age in the Community. J Infect. 2019 Sep 12;: Authors: Toivonen L, Karppinen S, Schuez-Havupalo L, Teros-Jaakkola T, Mertsola J, Waris M, Peltola V Abstract OBJECTIVES: Respiratory syncytial virus (RSV) is a major cause of hospitalization in young children, but there are little data on RSV infections in early childhood in the community. We conducted a prospective population-based...
Mon Sep 16, 2019 15:55
Related ArticlesComparative Impact of C-Reactive Protein Testing in Hospitalized Patients with Acute Respiratory Tract Infection: A Retrospective Cohort Study. Adv Ther. 2019 Sep 14;: Authors: Giannini O, Del Giorno R, Zasa A, Gabutti L Abstract INTRODUCTION: Evidence-based data on the usefulness of C-reactive protein (CRP) monitoring in patient outcomes are lacking. CRP testing in patients with acute respiratory tract infections (ARTIs) showed wide...
Mon Sep 16, 2019 15:55
Related ArticlesPatient-reported outcomes in randomised clinical trials of bladder cancer: an updated systematic review. BMC Urol. 2019 Sep 14;19(1):86 Authors: Van Hemelrijck M, Sparano F, Josephs D, Sprangers M, Cottone F, Efficace F Abstract BACKGROUND: Despite international recommendations of including patient-reported outcomes (PROs) in randomised clinical trials (RCTs), a 2014 review concluded that few RCTs of bladder cancer (BC) report PRO as...
Mon Sep 16, 2019 14:58
Related ArticlesProspects for combining immune checkpoint blockade with PARP inhibition. J Hematol Oncol. 2019 Sep 14;12(1):98 Authors: Li A, Yi M, Qin S, Chu Q, Luo S, Wu K Abstract The immunogenicity of a cancer cell is derived from accumulated somatic mutations. However, on the contrary to increased immunogenicity, anti-cancer immune response tends to be feeble. This impaired anti-cancer immunity could be attributed to multiple factors including loss...
Mon Sep 16, 2019 14:58
Related ArticlesProgress in cancer survival, mortality, and incidence in seven high-income countries 1995-2014 (ICBP SURVMARK-2): a population-based study. Lancet Oncol. 2019 Sep 11;: Authors: Arnold M, Rutherford MJ, Bardot A, Ferlay J, Andersson TM, Myklebust TÅ, Tervonen H, Thursfield V, Ransom D, Shack L, Woods RR, Turner D, Leonfellner S, Ryan S, Saint-Jacques N, De P, McClure C, Ramanakumar AV, Stuart-Panko H, Engholm G, Walsh PM, Jackson C, Vernon S, Morgan E,...
Mon Sep 16, 2019 14:58
Related ArticlesEvolution of treatment strategies for oligometastatic NSCLC patients - A systematic review of the literature. Cancer Treat Rev. 2019 Aug 28;80:101892 Authors: Schanne DH, Heitmann J, Guckenberger M, Andratschke NHJ Abstract BACKGROUND: The concept of oligometastatic disease (OMD) has expanded the scope of potentially curative therapy for metastatic NSCLC. However, large uncertainties remain regarding its definition and optimal management...
Mon Sep 16, 2019 14:58
Related ArticlesPD-L1 and CD47 co-expression in pulmonary sarcomatoid carcinoma: a predictor of poor prognosis and potential targets of future combined immunotherapy. J Cancer Res Clin Oncol. 2019 Sep 14;: Authors: Yang Z, Xu J, Li R, Gao Y, He J Abstract PURPOSE: Combined immunotherapy with anti-programmed cell death-ligand 1 (PD-L1) and an inhibitor of cluster of differentiation 47 (CD47) have exhibited preliminary anti-tumor effect. Our study attempted...
Mon Sep 16, 2019 14:58
Related ArticlesIn Vitro Evaluation of CMV Specific CD8+T Cells Function in CMV+ Colorectal Cancer Patients Compared to Healthy Controls. Iran J Allergy Asthma Immunol. 2019 Aug 17;18(4):379-392 Authors: Shaker Ardakani M, Pak F, Kokhaei P, Fazeli MS, Shakiba Y, Tabatabaei Yazdi SM, Abbasian A, Nourizadeh M Abstract The oncogenic role of human cytomegalovirus (HCMV) has been recently shown in different cancers like colorectal cancer (CRC). According...
Mon Sep 16, 2019 14:58
Abstract Introduction The role of intraoperative neurophysiological monitoring (IONM) during surgery for Chiari I malformation has not been fully elucidated. Questions remain regarding its utility as an adjunct to foramen magnum decompression surgery, specifically, does IONM improve the safety profile of foramen magnum decompression surgery and can IONM parameters help in intraoperative surgical decision-making. This study aimed...
Mon Sep 16, 2019 13:59
Mon Sep 16, 2019 13:59
Abstract Purpose Despite decades of experience and research, the etiology and management of Chiari I malformations (CM-I) continue to raise more questions than answers. Controversy abounds in every aspect of management, including the indications, timing, and type of surgery, as well as clinical and radiographic outcomes. This review aims to outline past experiences, consolidate current evidence, and recommend directions for the future...
Mon Sep 16, 2019 13:59
Abstract The complex Chiari, characterized by abnormal craniocervical bony anatomy in addition to Chiari tonsillar herniation, is a relatively recent addition to the concepts surrounding the Chiari literature. The primary findings of complex Chiari include craniocervical kyphosis and retroflexed odontoid, both of which can be described with radiographic measurements. This manuscript will outline the background literature regarding Chiari craniocervical morphometrics and supply...
Mon Sep 16, 2019 13:59
Abstract Purpose Chiari malformation type I (CMI) is a common pediatric neurologic anomaly that can be associated with a variety of genetic disorders; however, it is not always clear whether the observed associations are real or random. The knowledge of the real associations could provide useful guidance to clinicians. Furthermore, it could be of help to better understand the still unknown genetic etiology of CMI. ...
Mon Sep 16, 2019 13:59
Abstract Purpose Describe presentation and management of Chiari type 1 malformation. We report our surgical case series proposing a decision making scheme for helping surgeons decide which surgical procedure to perform and when. Methods We retrospectively examined a series of surgically treated patients with Chiari type 1 malformation. Treatment...
Mon Sep 16, 2019 13:59
Abstract Purpose Chiari malformation type I is identified as radiological appearance of cerebellar tonsil herniation below the foramen magnum. The wide spectrum of clinical manifestations variably associated sometimes encompasses signs and symptoms whose correlation with the malformation remains debatable. However, a correct clinical framework is relevant in tailoring the strategy of management, and in particular, establishing the...
Mon Sep 16, 2019 13:59
Abstract Objective In this “how we do it” survey, we review our management regimen of symptomatic CM1 and provide an analysis of our institutional case series of “bony only” decompression of the craniocervical junction without dural opening. Methods In regard to the latter clinical symptomatology, neurological status, electrophysiology data,...
Mon Sep 16, 2019 13:59
Abstract Purpose The aim of this study was to evaluate the outcomes and complications for individual surgeons at British Columbia Children’s Hospital for the treatment of Chiari I Malformation (CMI) in children. Methods This was a retrospective review of patients with CMI who had surgery from 1986 to 2015. We assessed the Chicago Chiari Outcome...
Mon Sep 16, 2019 13:59
Related ArticlesDoes systemically administered azithromycin have an effect on gingival overgrowth? A systematic review. Oral Surg Oral Med Oral Pathol Oral Radiol. 2019 Aug 17;: Authors: Fuchs MD, Signer-Buset SL, Mendes S, Schmidt JC, Walter C Abstract OBJECTIVE: The aim of this systematic review was to evaluate studies that analyzed the effect of systemically administered azithromycin (AZM) on cyclosporine A (CsA)-mediated gingival overgrowth (GO)....
Mon Sep 16, 2019 15:59
Related ArticlesNavigated minimally invasive facet fusion during percutaneous lumbar pedicle screw insertion: Technical note. J Clin Neurosci. 2019 Sep 11;: Authors: Liu YL, Mehra RN, Chou D Abstract OBJECTIVE: Minimally invasive surgery (MIS), or percutaneous, lumbar pedicle screw placement is commonly done, but the percutaneous nature of this makes posterior arthrodesis extremely difficult. Many times, surgeons will simply forego posterior arthrodesis,...
Mon Sep 16, 2019 16:04
Related ArticlesMisleading non-epileptic epileptiform activities on intracranial recordings. J Clin Neurosci. 2019 Sep 11;: Authors: Sasagawa A, Enatsu R, Suzuki H, Yokoyama R, Hirano T, Arihara M, Kuribara T, Ochi S, Mikuni N Abstract Numerous non-epileptic physiological electroencephalographic (EEG) patterns morphologically mimic epileptiform activity. However, misleading non-epileptic findings of electrocorticography (ECoG) have not yet been examined...
Mon Sep 16, 2019 16:04
Related ArticlesThe effect of HMG-CoA reductase inhibitors on thrombolysis-induced haemorrhagic transformation. J Clin Neurosci. 2019 Sep 11;: Authors: Wu Y, Lu D, Xu A Abstract Thrombolysis-induced haemorrhagic transformation is the most challenging preventable complication in thrombolytic therapy. This condition is often associated with poor functional outcome and long-term disease burden. Statins, or 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA)...
Mon Sep 16, 2019 16:04
Related ArticlesPeer-assisted learning (PAL): skills lab tutors' experiences and motivation. BMC Med Educ. 2019 Sep 14;19(1):353 Authors: Bugaj TJ, Blohm M, Schmid C, Koehl N, Huber J, Huhn D, Herzog W, Krautter M, Nikendei C Abstract BACKGROUND: Peer-assisted learning (PAL) is a common teaching and learning method in medical education worldwide. In the setting of skills laboratories (skills labs), student tutors are often employed as an equivalent alternative...
Mon Sep 16, 2019 16:07
Related ArticlesStrategic elements of residency training in China: transactional leadership, self-efficacy, and employee-orientation culture. BMC Med Educ. 2019 Sep 14;19(1):355 Authors: Deng G, Zhao D, Lio J, Chen X, Ma X, Liang L, Feng C Abstract BACKGROUND: The standardized training of resident physicians in China is significant and robust. During the training, clinical teachers act as leaders. The training taking place in public hospitals requires...
Mon Sep 16, 2019 16:07
Related ArticlesThese may not be the courses you are seeking: a systematic review of open online courses in health professions education. BMC Med Educ. 2019 Sep 14;19(1):356 Authors: Rowe M, Osadnik CR, Pritchard S, Maloney S Abstract INTRODUCTION: Open Online Courses (OOCs) are increasingly presented as a possible solution to the many challenges of higher education. However, there is currently little evidence available to support decisions around the...
Mon Sep 16, 2019 16:07
Related ArticlesAdding to the debate on the numbers of options for MCQs: the case for not being limited to MCQs with three, four or five options. BMC Med Educ. 2019 Sep 14;19(1):354 Authors: Tweed M Abstract BACKGROUND: There is a significant body of literature that indicates that the number of options for single-best answer multiple choice questions (MCQs) can be reduced from five to three or four without adversely affecting the quality of the questions...
Mon Sep 16, 2019 16:07
Related ArticlesAcquisition of basic ear surgery skills: a randomized comparison between endoscopic and microscopic techniques. BMC Med Educ. 2019 Sep 14;19(1):357 Authors: Anschuetz L, Stricker D, Yacoub A, Wimmer W, Caversaccio M, Huwendiek S Abstract BACKGROUND: Endoscopic ear surgery is gaining increasing popularity and has an important impact on teaching middle ear anatomy and basic surgical skills among residents and fellows. Due to the wide-angled...
Mon Sep 16, 2019 16:07
Related ArticlesRelationship between students' perceptions of the adequacy of M1 and M2 curricula and their performance on USMLE step 1 examination. BMC Med Educ. 2019 Sep 14;19(1):358 Authors: Khalil MK, Wright WS, Spearman KA, Gaspard AC Abstract BACKGROUND: Performance on United States Medical Licensing Exam® (USMLE®) Step 1 examination (Step 1) is an important milestone for medical students. It is necessary for their graduation, and selection to...
Mon Sep 16, 2019 16:07
Related ArticlesUtilization of high-fidelity simulation to address challenges with the basic science immunology education of preclinical medical students. BMC Med Educ. 2019 Sep 14;19(1):352 Authors: Cavuoto Petrizzo M, Barilla-LaBarca ML, Lim YS, Jongco AM, Cassara M, Anglim J, Stern JNH Abstract BACKGROUND: Immune function and dysfunction are highly complex basic science concepts introduced in the preclinical medical school curriculum. A challenge...
Mon Sep 16, 2019 16:07
Related ArticlesCorrelation between the skull base fracture and the incidence of intracranial hemorrhage in patients with traumatic brain injury. Chin J Traumatol. 2019 Aug 16;: Authors: Faried A, Halim D, Widjaya IA, Badri RF, Sulaiman SF, Arifin MZ Abstract PURPOSE: A head injury (HI) may cause a skull fracture, which may or may not be associated with injury to the brain. In essence, a skull base fracture (SBF) is a linear fracture at the base of the...
Mon Sep 16, 2019 16:05
Related ArticlesThe mixed sellar barrier: a new subtype of this novel concept. World Neurosurg. 2019 Sep 12;: Authors: Villalonga JF, Centeno TR, Sáenz A, Solari D, Cervio A, Campero A Abstract BACKGROUND: The use of the recent concept of sellar barrier revealed that a specific group of patients were difficult to categorize. For this reason, we propose to add a new subtype: The mixed sellar barrier. The aim of this work is to define the new mixed barrier...
Mon Sep 16, 2019 16:05
Related ArticlesExtended Endoscopic Endonasal Clipping of Intracranial Aneurysms: An Anatomical Feasibility Study. World Neurosurg. 2019 Sep 12;: Authors: Montaser AS, Prevedello DM, Gomez M, Lima L, Beer-Furlan A, Servian D, Otto BA, Carrau RL Abstract BACKGROUND: Intracranial aneurysms located in the midline region represent formidable challenge owing to their deep location. OBJECTIVE: The purpose of this study is to assess feasibility and...
Mon Sep 16, 2019 16:05
Related ArticlesDefining Clinical Indications of Proton Beam Therapy at National Level in the Kingdom of Saudi Arabia. Saudi Med J. 2019 Sep;40(9):879-886 Authors: AlHussain H, Balbaid A, Malyapa R, AlOthman M, Bahadur YA, Tunio MA, Al Asiri M Abstract The Saudi Particle Therapy Centre (SPTC) is establishing proton beam therapy (PBT) services within Kingdom of Saudi Arabia (KSA). Thus, national guidelines for the pertinent draft, and recommendations...
Mon Sep 16, 2019 16:05
Related ArticlesDeep multiphysics: Coupling discrete multiphysics with machine learning to attain self-learning in-silico models replicating human physiology. Artif Intell Med. 2019 Jul;98:27-34 Authors: Alexiadis A Abstract OBJECTIVES: The objective of this study is to devise a modelling strategy for attaining in-silico models replicating human physiology and, in particular, the activity of the autonomic nervous system. METHOD: Discrete Multiphysics...
Mon Sep 16, 2019 16:17
Related ArticlesMesenchymal Stromal Cells Modulate Peripheral Stress-Induced Innate Immune Activation Indirectly Limiting the Emergence of Neuroinflammation-Driven Depressive and Anxiety-like Behaviors. Biol Psychiatry. 2019 Jul 29;: Authors: Gallagher D, Siddiqui F, Fish J, Charlat M, Chaudry E, Moolla S, Gauthier-Fisher A, Librach C Abstract BACKGROUND: Hyperactivation of innate immunity has been implicated in the etiology of mood disorders, including...
Mon Sep 16, 2019 16:17
Related ArticlesTau-induced mitochondrial membrane perturbation is dependent upon cardiolipin. Biochim Biophys Acta Biomembr. 2019 Sep 12;:183064 Authors: Camilleri A, Ghio S, Caruana M, Weckbecker D, Schmidt F, Kamp F, Leonov A, Ryazanov S, Griesinger C, Giese A, Cauchi RJ, Vassallo N Abstract Misfolding and aggregate formation by the tau protein has been closely related with neurotoxicity in a large group of human neurodegenerative disorders, which...
Mon Sep 16, 2019 16:17
Related ArticlesDifferential Regulation of ANP and BNP in Acute Decompensated Heart Failure: Deficiency of ANP. JACC Heart Fail. 2019 Sep 07;: Authors: Reginauld SH, Cannone V, Iyer S, Scott C, Bailey K, Schaefer J, Chen Y, Sangaralingham SJ, Burnett JC Abstract OBJECTIVES: This study investigated the differential regulation of circulating atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) in patients with acute decompensated heart...
Mon Sep 16, 2019 16:17
Related ArticlesInvolvement of neural substrates in reward and aversion to methamphetamine addiction: Testing the reward comparison hypothesis and the paradoxical effect hypothesis of abused drugs. Neurobiol Learn Mem. 2019 Sep 12;:107090 Authors: Bo Han He A, Lei Huang C, Kozłowska A, Chien Chen J, Wu CW, Chih Wei Huang A, Qin Liu Y Abstract Clinical studies of drug addiction focus on the reward impact of abused drugs that produces compulsive drug-seeking...
Mon Sep 16, 2019 16:17
Related ArticlesDownregulation of hepatic stem cell factor by Vivo-Morpholino treatment inhibits mast cell migration and decreases biliary damage/senescence and liver fibrosis in Mdr2-/- mice. Biochim Biophys Acta Mol Basis Dis. 2019 Sep 13;:165557 Authors: Meadows V, Kennedy L, Hargrove L, Demieville J, Meng F, Virani S, Reinhart E, Kyritsi K, Invernizzi P, Yang Z, Wu N, Liangpunsakul S, Alpini G, Francis H Abstract Primary sclerosing cholangitis (PSC)...
Mon Sep 16, 2019 16:17
Related ArticlesSocial touch alters newborn monkey behavior. Infant Behav Dev. 2019 Sep 12;57:101368 Authors: Simpson EA, Maylott SE, Lazo RJ, Leonard KA, Kaburu SSK, Suomi SJ, Paukner A, Ferrari PF Abstract In humans, infants respond positively to slow, gentle stroking-processed by C-tactile (CT) nerve fibers-by showing reductions in stress and increases in eye contact, smiling, and positive vocalizations. More frequent maternal touch is linked to greater...
Mon Sep 16, 2019 16:17
Related ArticlesComparative metatranscriptomic profiling and microRNA sequencing to reveal active metabolic pathways associated with a dinoflagellate bloom. Sci Total Environ. 2019 Sep 06;699:134323 Authors: Yu L, Zhang Y, Li M, Wang C, Lin X, Li L, Shi X, Guo C, Lin S Abstract Harmful algal blooms (HABs) have increased as a result of global climate and environmental changes, exerting increasing impacts on the aquatic ecosystem, coastal economy, and...
Mon Sep 16, 2019 16:17
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