Publication date: Available online 30 October 2019Source: Human PathologyAuthor(s): Lori A. Erickson
Thu Oct 31, 2019 20:24
Publication date: Available online 30 October 2019Source: Human PathologyAuthor(s): Namrata Setia, Sangjeong Ahn, Hye S Han, Do Youn Park, Gregory Y LauwersSummaryThe Cancer Genome Atlas data on gastric carcinoma has identified four biologic pathways as potential drivers of gastric carcinogenesis and suggested targeted therapies based on the genomic alterations underscoring each subset. The correlation between morphology, biologic groups and their corresponding biomarkers has been eluded in several...
Thu Oct 31, 2019 20:24
In our study we report the unexpected discovery that chondroid bone, a cartilage‐bone intermediate tissue, extensively contributes to diametric limb bone growth in ducks up to late ontogeny (≥30 days posthatching age). Its protracted deposition period, spatial and temporal distribution, and cartilage‐like properties all suggest that chondroid bone plays a key role in accelerating avian skeletogenesis and thereby placing birds among the fastest growing extant vertebrates. Abstract Modern altricial...
Thu Oct 31, 2019 15:07
This study identifies key steps that characterise attrition of the spinal cord ventricular layer as it is re‐modelled to form the ependymal cell lining of the adult central canal – these include localised dorsal and ventral cell re‐arrangements, reduced cell proliferation and altered dorsal and ventral signalling. Abstract The ventricular layer of the spinal cord is remodelled during embryonic development and ultimately forms the ependymal cell lining of the adult central canal, which retains neural...
Thu Oct 31, 2019 14:06
Here we utilize micro‐CT scanning digitally to reconstruct and describe the endocranial anatomy of the dicynodont Rastodon procurvidens from the Rio do Rasto Formation (Middle‐Late Perrmian of Southern Brazil). The well‐preserved skull of R. procurvidens allowed us to build endocranial casts of the brain cavity, inner ears, nasal cavity, maxillary recesses, as well as some neurovascular canals and cranial nerves. When compared with other Therapsida, R. procurvidens retains a plesiomorphic endocranial...
Thu Oct 31, 2019 14:02
Using μCT volume data of a cadaveric lumbar spine, we visualized internal defects of two disrupted intervertebral discs and accompanying bone lesions. We showed that disc degeneration is characterized by a complex suite of pathological changes including endplate damage, circumferential tears, and disc height reduction. Abstract Gross features of disc degeneration (DD) that are associated with back pain include tears in the anulus fibrosus, structural changes of the endplates, and a collapse of...
Thu Oct 31, 2019 13:31
The developing atrioventricular node can only be identified when connection with the developing interatrial septum is achieved through the myocardializing vestibular spine, and concomitant with the invagination of the sulcus tissue and formation of the insulating mechanism of the atrioventricular junction. It becomes possible to distinguish between the atrioventricular node and the penetrating atrioventricular bundle, the latter of which is located below the forming insulation plane. Abstract Since...
Thu Oct 31, 2019 13:30
Cranial and bony labyrinth virtual endocasts inside the cranium of Chriacus baldwini (MCZ 20676). (A,B) lateral right, (C) lateral left, (D) dorsal and (E) ventral views. Scale bar: 10 mm (by permission of the Harvard Board of Trustees). Abstract The end‐Cretaceous mass extinction allowed placental mammals to diversify ecologically and taxonomically as they filled ecological niches once occupied by non‐avian dinosaurs and more basal mammals. Little is known, however, about how the neurosensory...
Wed Oct 30, 2019 21:00
We describe the morphological diversity of the quadrate bone in squamate reptiles, using both qualitative and quantitative methods. We found that ecology (especially fossorial) and the loss of a tympanic membrane are two important correlates of shape disparity. Abstract We examined the morphological diversity of the quadrate bone in squamate reptiles (i.e. lizards, snakes, amphisbaenians). The quadrate is the principal splanchnocranial element involved in suspending the lower jaw from the skull,...
Wed Oct 30, 2019 21:00
Clinical aspects dealing with the impairment of nephrogenesis in preterm and low birth weight babies were intensely researched. In this context it was shown that quite different noxae can harm nephron formation, and that the morphological damage in the fetal kidney is rather complex. Some pathological findings show that the impairment leads to changes in developing glomeruli that are restricted to the maturation zone of the outer cortex in the fetal human kidney. Other data show also imprints on...
Thu Oct 31, 2019 14:01
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