(American Thoracic Society) Only about 6 in 10 lung cancer patients in the United States receive the minimal lung cancer treatments recommended by the National Comprehensive Cancer Network guidelines, according to new research published online in the Annals of the American Thoracic Society.
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(DOE/Lawrence Berkeley National Laboratory) New at Berkeley Lab: Gamers can help speed up biomedical research by designing protein structures with a shape modeling game called Foldit, experiments show dramatic changes in the gut microbiome after switching between raw and cooked foods, and a new porous material can pull an industrial pollutant from the air.
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(Parkinson's UK) A new partnership between two leading medical research charities has launched today to explore how improving the brain's waste disposal system could be the key to preventing Parkinson's and Alzheimer's disease.
Thu Oct 31, 2019 06:00
(University of Iowa Health Care) Scientists led by University of Iowa researcher Paul McCray, Jr., MD, are using simple peptides to deliver gene-editing tools into notoriously hard-to-access lung and airway cells with the goal of creating new treatments for people with diseases like cystic fibrosis, COPD, and asthma.
Thu Oct 31, 2019 06:00
(New Jersey Institute of Technology) Simon Garnier, assistant professor of biological sciences at NJIT, recently joined the exclusive company of up-and-coming researchers in the nation with a prestigious 2019 Young Faculty Award from the US Defense Advanced Research Projects Agency (DARPA).
Thu Oct 31, 2019 06:00
(Massachusetts General Hospital) Research suggests that the complex meshwork of proteins and potentially other biomolecules that provides structural and biochemical support to surrounding cells in the brain may play an important role in Alzheimer's disease.
Thu Oct 31, 2019 06:00
(Forsyth Institute) Humans are known to be genetically similar to our primate relatives. But major differences can be found in our saliva, according to new research by scientists at the Forsyth Institute and the University of Buffalo.
Thu Oct 31, 2019 06:00
(UT Southwestern Medical Center) A phase three clinical trial that UT Southwestern participated in determined that a 3-drug combination improved lung function and reduced symptoms in cystic fibrosis (CF) patients who have a single copy of the most common genetic mutation for the disease.
Thu Oct 31, 2019 06:00
(University of California - Los Angeles Health Sciences) The prostate cancer program at the UCLA Jonsson Comprehensive Cancer Center and UCLA Health has been awarded an $8.7 million Specialized Program of Research Excellence, or SPORE, grant from the National Cancer Institute.
Thu Oct 31, 2019 06:00
(Huntsman Cancer Institute) Cellular machines that control chromosome structure, such as the RSC complex, are mutated in about one-fifth of all human cancers. Now, for the first time, scientists have developed a high-resolution visual map of this multi-protein machine, elucidating how the RSC complex works and what role it has in healthy and cancer cells.
Thu Oct 31, 2019 06:00
(The Mount Sinai Hospital / Mount Sinai School of Medicine) FastER Track will provide rapid access to care for low-acuity conditions, such as sore throats, rashes, and common colds.
Thu Oct 31, 2019 06:00
(University of California - Los Angeles Health Sciences) Three researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have received awards totaling more than $18 million from the California Institute for Regenerative Medicine, the state's stem cell agency.
Thu Oct 31, 2019 06:00
(American Society of Hematology) A survey of US hematology-oncology fellows suggests medical school plays an important role in shaping their interest in pursuing careers in hematology, particularly when students are exposed to hematology and oncology as part of core clerkships in internal medicine and pediatrics.
Thu Oct 31, 2019 06:00
(The Mount Sinai Hospital / Mount Sinai School of Medicine) Atlanta Falcons and Atlanta United owner Arthur Blank and Nina Bhardwaj, MD, Ph.D., will be honored for their contributions to prostate cancer research.
Thu Oct 31, 2019 06:00
(Penn State) The parasite that causes malaria expresses genes that code for the proteins it will need in later life stages, but uses two separate schemes to prevent these proteins from actually being made until they are needed.
Thu Oct 31, 2019 06:00
(Fundação de Amparo à Pesquisa do Estado de São Paulo) Scientists plan to develop a modified strain of U. guianensis and use its own metabolism to scale up the production of therapeutic compounds.
Thu Oct 31, 2019 06:00
(Salk Institute) Little is known about the molecular and cellular events that occur during early embryonic development in primate species. Now, an internationally renowned team of scientists in China and the United States has created a method to allow primate embryos to grow in the laboratory longer than ever before, enabling the researchers to obtain molecular details of key developmental processes for the first time. This research, while done in nonhuman primate cells, can have direct implications...
Thu Oct 31, 2019 06:00
(Lehigh University) Lehigh University Art Galleries is one of 18 institutions in the U.S. to receive a prestigious federal grant from the Institute of Museum and Library Services (IMLS). The 'Museums Empowered' grant will support the museum's work over the next two years to create and implement a strategic plan; train staff in outcomes-based, visitor-centered practices; and bring guest experts to Lehigh.
Thu Oct 31, 2019 06:00
(Boston University) A new study from Boston University, published in Science, is the first to illustrate that the brain's cerebrospinal fluid pulses during sleep, and that these motions are closely tied with brain wave activity and blood flow. It may confirm the hypothesis that CSF flow and slow-wave activity both help flush toxic, memory-impairing proteins from the brain.
Thu Oct 31, 2019 06:00
(Oregon Health & Science University) Oregon Health & Science University is developing vaccine adjuvants, or vaccine additives that improve our immune response, to help make vaccines work better. Though adjuvants have been used since the 1930s, only five are currently approved for clinical use in the US.
Thu Oct 31, 2019 06:00
(University of Copenhagen The Faculty of Health and Medical Sciences) One third of all approved drugs target the same family of receptors: the G-Protein-Coupled Receptors (GPCRs). Now, researchers from the University of Copenhagen along with two American labs have expanded the known network of peptides that activate GPCRs by 19 percent.
Thu Oct 31, 2019 06:00
(Johns Hopkins University Bloomberg School of Public Health) A suicide risk screening tool that Johns Hopkins Medicine implemented in its pediatric emergency department six years ago appears to provide an accurate gauge of which youth are most vulnerable and has identified more than 2,000 patients who might benefit from mental health treatment and resources, according to a study led by researchers at Johns Hopkins Bloomberg School of Public Health and Johns Hopkins Medicine.
Thu Oct 31, 2019 06:00
(Johns Hopkins Medicine) In what is believed to be the most comprehensive molecular characterization to date of the most common -- and often treatment-resistant -- form of kidney cancer, researchers at Johns Hopkins' departments of pathology and oncology, Johns Hopkins Kimmel Cancer Center, and the Johns Hopkins University School of Medicine report evidence for at least three distinct subtypes of clear cell renal cell carcinoma (ccRCC), along with new revelations about the proteins that define them....
Thu Oct 31, 2019 06:00
Dynamic transition of the blood-brain barrier in the development of non-small cell lung cancer brain
(Impact Journals LLC) Effective drug delivery through the BTB is one of the greatest therapeutic obstacles in treating brain metastases.Using an experimental model, the researchers defined key changes within the BTB and the BBB in the brain around the tumor region over time.These data provide a comprehensive analysis of the BTB in NSCLC brain metastasis.
Thu Oct 31, 2019 06:00
(Clemson University) Clemson University researcher Jennifer Mason created a mutated version of RAD51, a DNA repair protein, to better understand its critical functions at key steps in the cell replication process during times of stress. This work may help cancer biology scientists better understand how cells protect DNA from damage during replication. Defects in this pathway may play a role in causing cancer and a better understanding of the process may lead to better treatment strategies someday.
Thu Oct 31, 2019 06:00
(University of Gothenburg) Managers who have received training in mental health issues, and whose workplaces run general information campaigns on mental health, are significantly more likely to work preventively in this area vis-à-vis their subordinates, a study shows. This applies irrespective of organization size and managers' own experiences of mental ill-health.
Thu Oct 31, 2019 06:00
(JAMA Network) Researchers investigated the association between the Affordable Care Act and changes in the percentage of patients with insurance among 130,000 people with head and neck cancer across varying socioeconomic and demographic backgrounds.
Thu Oct 31, 2019 06:00
(Rice University) Rice bioscientists find a way to predict the sensitivity of acute myeloid leukemia to mitochondria-damaging molecules and develop cocktails to fight the cancer. The discoveries could improve personalized cancer treatment.
Thu Oct 31, 2019 06:00
(NYU Langone Health / NYU School of Medicine) The inheritance, not only of DNA, but of changes to proteins that package it, maintains the identity of cells as they multiply, a new study finds.
Thu Oct 31, 2019 06:00
(JAMA Network) What the association is between decreasing the number of opioid tablets prescribed to patients after corneal surgery and their opiod use and pain control was the focus of this observational study.
Thu Oct 31, 2019 06:00
(Dana-Farber Cancer Institute) Many non-white minority cancer survivors place importance on seeing doctors who share or understand their culture, but are less likely than non-Hispanic whites to be able to see such physicians, according to a new study from Dana-Farber Cancer Institute.
Thu Oct 31, 2019 06:00
(DZNE - German Center for Neurodegenerative Diseases) During embryonic development, nerve cells form thin, long extensions, which they use to wire up a complex network, the brain. Scientists from the German Center for Neurodegenerative Diseases (DZNE) in Bonn have now identified a protein that regulates the growth of these extensions by pulling a brake. In the long run, their findings could help to develop new approaches for the treatment of spinal cord injuries. The study is published in the journal...
Thu Oct 31, 2019 06:00
(Boston University School of Medicine) Researchers from Boston University School of Medicine (BUSM) have conducted a craniometric study (measuring the main part of the skull) on understudied and marginalized groups and found that skull dimensions of Dominicans and Haitians, who occupy a relatively small island of Hispaniola, are different from each other.
Thu Oct 31, 2019 06:00
(McMaster University) Researchers at McMaster University who examine the impact of exercise on the brain have found that high-intensity workouts improve memory in older adults.
Thu Oct 31, 2019 06:00
(University of Alabama at Birmingham) An unexplored kinase in heart muscle cells may be a good target to treat heart failure, a disease that is only incrementally delayed by existing therapies. Failing human hearts showed reduced amounts of this kinase, and preclinical experiments showed that restoring the amount of this kinase in a kinase-depleted mouse model rescued the animal from heart failure.
Thu Oct 31, 2019 06:00
(Politecnico di milano) Two new laboratories of the Politecnico di Milano, 'MINERVA' and 'ATHENA', called 'TechnoBiology' labs, have been officially presented today to the scientific community.The main purpose of the TechnoBiology labs is the realization of forefront technological devices and cellular models for the study of biochemical mechanisms that involve multiple organs and biological systems of our body, both in physiological and pathological conditions.
Thu Oct 31, 2019 06:00
(Children's National Hospital) Controlled entry of calcium ions into the mitochondria, the cell's energy powerhouses, makes the difference between whether muscles grow strong or easily tire and perish from injury, according to research published in Cell Reports.
Thu Oct 31, 2019 06:00
(University of Zurich) Stem cells of the teeth can contribute to the regeneration of non-dental organs, namely mammary glands. According to a new study from researchers at the University of Zurich, dental epithelial stem cells from mice can generate mammary ducts and even milk-producing cells when transplanted into mammary glands. This could be used for post-surgery tissue regeneration in breast cancer patients.
Thu Oct 31, 2019 06:00
(American Chemical Society) Halloween season wouldn't be the same without the undead. This week on Reactions, we unpack the chemistry that might have inspired one of our favorites: the vampire: https://youtu.be/hTtitLeGvV0.
Thu Oct 31, 2019 06:00
(Lund University) Insulin which is released by pancreatic beta-cells is the main regulator of blood sugar. Previous and current studies by a research group at Lund University in Sweden have identified around hundred different receptors on the surface of the beta-cells, with a diverse functional impact on the beta-cells. Now researchers at Lund University in collaboration with researchers at University of Sharjah, United Arab Emirates have discovered that one of these receptors plays a key role in...
Thu Oct 31, 2019 06:00
(University of Dundee) Researchers at the University of Dundee have discovered a new enzyme that inhibits the LRRK2 pathway. Mutations of the LRRK2 gene are the most common cause of genetic Parkinson's disease.The enzyme they found - called PPM1H - has been shown to possess remarkable properties to reverse the biology triggered by LRRK2.
Thu Oct 31, 2019 06:00
(University of Pennsylvania School of Nursing) A new study from the University of Pennsylvania School of Nursing (Penn Nursing) shows the first evidence supporting a role for glucagon-like peptide-1 (GLP-1) receptor agonists in opioid reinforcement and analgesic responses. Using recently established models of opioid-taking and -seeking behaviors in rats, researchers have shown that systemic administration of the GLP-1 receptor agonist exendin-4 reduced oxycodone self-administration and the reinstatement...
Thu Oct 31, 2019 06:00
(Radiological Society of North America) Radiology: Cardiothoracic Imaging has published a special report on lung injury resulting from the use of electronic cigarettes, or 'vaping.' Researchers aim to raise awareness among radiologists and other medical professionals on how to identify e-cigarette or vaping product use-associated lung injury.
Thu Oct 31, 2019 06:00
(University of Warwick) A previously unknown component of our cells that delivers proteins like a bike courier in heavy traffic could shed light on the mechanisms that allow cells to spread in diseases such as cancer.
Thu Oct 31, 2019 06:00
(Immanuel Kant Baltic Federal University) Granulocyte colony-stimulating factor (G-CSF)has a significant regulatory effect not only on innate, but also on adaptive immunity. That's what scientists from the IKBFU and Research Institute of Fundamental and Clinical Immunology have found.
Thu Oct 31, 2019 06:00
(Kanazawa University) A Japanese research team at Kanazawa University developed a reaction for creating functionalized ketones. Using an N-heterocyclic carbene (NHC) organocatalyst, with no need for metals or light irradiation, an acyl and an alkyl group are added across the double bond of an alkene. The NHC gives regioselective control over a relay process involving electron transfer followed by successive addition of two radicals onto the alkene. The diverse products are useful building blocks...
Thu Oct 31, 2019 06:00
(Centro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.)) Dr Miguel Torres, of the Centro Nacional de Investigaciones Cardiovasculares (CNIC), leads a new project that will receive 8 million in funding over 5 years, 1,380,000 of which will be directly managed at the CNIC
Thu Oct 31, 2019 06:00
(Nara Institute of Science and Technology) Scientists at Nara Institute of Science and Technology (NAIST), Japan, report a new deep learning tool based on Bayesian U-Net architecture that can segment individual muscles from CT images. The high accuracy of the results offers a new level of personalized biomechanical modeling for patients for better therapies and athletes for better performance.
Wed Oct 30, 2019 06:00
(Mayo Clinic) A Mayo Clinic-led study involving 488 cardiac patients whose cases were followed for up to 12 years finds that microvascular endothelial dysfunction, a common early sign of cardiovascular disease, is associated with a greater than twofold risk of cancer.
Thu Oct 31, 2019 06:00
(Johns Hopkins Medicine) In a bid to determine factors linked to the most debilitating forms of multiple sclerosis (MS), Johns Hopkins Medicine researchers say they have identified three so-called 'complement system' genes that appear to play a role in MS-caused vision loss. The researchers were able to single out these genes -- known to be integral in the development of the brain and immune systems -- by using DNA from MS patients along with high-tech retinal scanning.
Thu Oct 31, 2019 06:00
(Seattle Children's) Within seconds after an infected mosquito bites, the malaria parasite navigates the host skin and blood vessels to invade the liver, where it will stay embedded until thousands of infected cells launch malaria's deadly blood-stage infection. Now, for the first time, a team from Seattle Children's Research Institute describes how malaria Plasmodium parasites prepare for this journey. Researchers say this knowledge may help identify new strategies to block transmission of the parasite.
Thu Oct 31, 2019 06:00
(Max Planck Institute for Psycholinguistics) Do people with autism have differently organized brains? A large-scale MRI study, published in Nature Communications, reports fewer differences between the right and left hemispheres in people with autism spectrum disorder. An international team -- led by scientists from the Max Planck and Donders institutes in Nijmegen, the Netherlands and the University of Southern California -- found differences in brain asymmetry between people with and without autism,...
Thu Oct 31, 2019 06:00
(St. Michael's Hospital) A new study publishing in the Journal of the American Heart Association found that people living in neighborhoods considered to be the least walkable were up to 33% more likely to have a high predicted 10-year cardiovascular risk compared to individuals living in the most walkable neighborhoods.
Thu Oct 31, 2019 06:00
(University of Texas at San Antonio) About half of all women in the US will suffer a bone fracture due to osteoporosis. For women, the incidence of this condition is greater than that of heart attack, stroke and breast cancer combined. Now, researchers at UTSA have received multimillion-dollar funding to reexamine bone mineral density, a measure of bone fracture risks, and another critical component in bone known as proteoglycans.
Thu Oct 31, 2019 06:00
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