Cancers, Vol. 11, Pages 1779: Rationale for a Combination Therapy Consisting of MCL1- and MEK-Inhibitors in Acute Myeloid Leukemia Cancers doi: 10.3390/cancers11111779 Authors: Katja Seipel Karin Schmitter Ulrike Bacher Thomas Pabst Amplification and overexpression of the myeloid cell leukemia differentiation protein MCL1 and the murine double minute protein MDM2 have been reported in various human tumors as well as hematological malignancies including acute myeloid leukemia...
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IJMS, Vol. 20, Pages 5648: Radio-Enhancing Properties of Bimetallic Au:Pt Nanoparticles: Experimental and Theoretical Evidence International Journal of Molecular Sciences doi: 10.3390/ijms20225648 Authors: Daniela Salado-Leza Ali Traore Erika Porcel Diana Dragoe Antonio Muñoz Hynd Remita Gustavo García Sandrine Lacombe The use of nanoparticles, in combination with ionizing radiation, is considered a promising method to improve the performance of radiation therapies....
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IJMS, Vol. 20, Pages 5649: Role of MicroRNAs in Parkinson’s Disease International Journal of Molecular Sciences doi: 10.3390/ijms20225649 Authors: Suh Yee Goh Yin Xia Chao Shaikali Thameem Dheen Eng-King Tan Samuel Sam-Wah Tay Parkinson’s disease (PD) is a disabling neurodegenerative disease that manifests with resting tremor, bradykinesia, rigidity and postural instability. Since the discovery of microRNAs (miRNAs) in 1993, miRNAs have been shown to be important...
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Artificial intelligence (AI) proves to have enormous potential in many areas of healthcare including research and chemical discoveries. Using large amounts of aggregated data, the AI can discover and learn further transforming these data into “usable” knowledge. Being well aware of this, the world’s leading pharmaceutical companies have already begun to use artificial intelligence to improve their research regarding new drugs. The goal is to exploit modern computational biology and machine learning...
Mon Nov 11, 2019 14:05
Globally, the prevalence of metabolic syndrome (MetS) and its components which are the major cardiovascular disease (CVD) risk factors, is higher among patients with severe mental illness (SMI) compared to the general population. This is mainly due to the deleterious lifestyles characterized by physical inactivity, excessive alcohol consumption, smoking, and unhealthy diets common among patients with SMI as well as due to cardiometabolic effects of psychotropic medications. Despite these conditions...
Mon Nov 11, 2019 13:05
Kidney renal papillary renal cell carcinoma (KIRP) accounts for 10–15% of renal cell carcinoma (RCC). The need to find more therapeutic targets for KIRP is urgent because most targeted drugs have limited effects on advanced KIRP. Insulin-like growth factor (IGF) binding protein 5 (IGFBP5) is a secreted protein related to cell proliferation, cell adhesion, cell migration, the inflammatory response and fibrosis; these functions are independent of IGF. In our study, we determined the expression and...
Mon Nov 11, 2019 12:05
Today, the economic and social importance of occupational accidents is undeniable worldwide. Hence, research aimed at reducing this type of accident is considered a discipline of great interest for society in general. In this environment, working conditions play a fundamental role in the occurrence of accidents, and from their study, results can be obtained that provide information for decision-making that guarantee optimum conditions for the development of the employees’ tasks. Organizing the conditions...
Mon Nov 11, 2019 12:05
Background. Very few nationwide studies have focused on the variations in the incidence and prevalence of dementia and Alzheimer’s disease (AD) in Asian countries. This study aims to describe the gender and age differences in the incidence and prevalence of dementia and AD in Taiwan. Methods. The data on dementia and AD were acquired from the Taiwan National Health Insurance Research Database from 2004 to 2010. The sex and age-specific rates were standardized, and the differences of gender and age...
Mon Nov 11, 2019 12:05
For several years, research has been carried out on the effectiveness of solutions for perfusion and preservation of organs, including the liver. There is a search for an optimal pharmacological composition of these solutions, allowing to preserve or improve vital functions of the organ for as long as possible until it is transplanted into a recipient. Hormones due to their properties, often resulting from their pleiotropic effects, may be a valuable component for optimizing the composition of liver...
Mon Nov 11, 2019 12:05
Background. The pedicle screw is one of the main tools used in spinal deformity correction surgery. Robotic and navigated surgeries are usually used, and they provide superior accuracy in pedicle screw placement than free-hand and fluoroscopy-guided techniques. However, their high cost and space limitation are problematic. We provide a new solution using 3D printing technology to facilitate spinal deformity surgery. Methods. A workflow was developed to assist spinal deformity surgery using 3D printing...
Mon Nov 11, 2019 12:05
Polycystic ovary syndrome (PCOS) is a chronic metabolic disease that is associated with obesity and adipose tissue dysfunction. This study aimed to explore the roles of Dicer (an enzyme that processes primary microRNAs) and microRNAs in PCOS. Protein levels were detected by western blotting, and mRNA and microRNA levels were detected by RT-PCR. Dicer-deficient pre-adipocytes were established by lentiviral transfection, and an miR-223 mimic and miR-223 inhibitor were used to overexpress and inhibit...
Mon Nov 11, 2019 11:05
Direct-acting antivirals (DAAs) are modern treatments for chronic hepatitis C infection, but majority of available evidence on its treatment effect covers genotypes 1 to 4. Therefore, the efficacy and safety of DAAs for genotypes 5 and 6 need to be analysed. Studies were identified from Medline, Scopus, and CENTRAL and a Chinese database CNKI, from inception until Dec 4, 2018. Clinical trials were included if they enrolled patients with genotypes 5 and/or 6 infection, any type of second-generation...
Mon Nov 11, 2019 11:05
Disintegration of municipal waste activated sludge (WAS) using thermo-alkaline (TA) and electro-Fenton (EF) methods was investigated and compared in terms of the efficiency of sludge solubilisation and enhancement of anaerobic biodegradability. Performance of organic matter solubilisation (soluble COD, proteins, polysaccharides) of sludge pretreated with EF was proved to be better than that with TA pretreatment, which resulted in the enhancement of anaerobic biodegradability. Comparison of results...
Mon Nov 11, 2019 11:05
Background. To evaluate the feasibility and applicability of using office hysteroscopy in women with intact hymen. Methods. We recruited 836 patients with intact hymen with different indications who underwent diagnostic hysteroscopy without anesthesia in an outpatient setting from 2007 to 2016 at Chang Gung Memorial Hospital at Linkou. Results. Patients’ mean age was 35 ± 10.6 years (range 3–69 years). Most patients (86.4%) with postmenopausal bleeding had intrauterine lesions, and they were especially...
Mon Nov 11, 2019 10:05
Publication date: Available online 10 November 2019Source: Palaeogeography, Palaeoclimatology, PalaeoecologyAuthor(s): Jesús Reolid, Matías ReolidAbstractAnalyses of X-ray microfluorescence (XRF) elemental maps of the ichnofossil assemblages from the upper Pliensbachian-lower Toarcian marl-limestone rhythmite of the South Iberian Palaeomargin (Betic Cordillera, SE Spain) show that the compositions of burrow infills are geochemically and mineralogically different with respect to the surrounding sediment....
Mon Nov 11, 2019 14:25
Zusammenfassung Hintergrund Die Lungentransplantation ist die etablierte Behandlung von nichtmalignen Lungenerkrankungen im Endstadium nach Ausschöpfung alternativer chirurgischer und medikamentöser Behandlungen. Ziel der Arbeit ist es, einen Überblick über neue Entwicklungen in einzelnen Bereichen der Lungentransplantation zu geben. Material und Methode ...
Mon Nov 11, 2019 02:00
Zusammenfassung Das chromophobe Nierenzellkarzinom (ChRCC) ist einer von 4 malignen Nierentumorsubtypen. Das ChRCC bereitet aufgrund seiner morphologischen Varianz in der klinisch-pathologischen Routinediagnostik immer wieder Probleme. Der Tumor kann mit aggressiveren bzw. gutartigen Tumoren verwechselt werden. In beiden Fällen sind die Auswirkungen der Fehldiagnose auf die Therapieentscheidung gravierend. Aufgrund der morphologischen Varianz des Tumors ist es bisher nicht gelungen,...
Mon Nov 11, 2019 02:00
Mon Nov 11, 2019 02:00
Bello Abdullahi Ibrahim, Mohammed Abdullahi Talle, Faruk Buba, Sa'ad YaubaNigerian Journal of Cardiology 2019 16(2):116-119 Ebstein's anomaly (EA) is an uncommon congenital heart disease characterized by apical displacement of the tricuspid valve and atrialization of the right ventricle (RV). EA is associated with accessory pathways, especially right-sided, often multiple, providing a substrate for supraventricular tachycardia (SVT). Stretching and fibrosis of the right atrium and dysplastic RV...
Mon Nov 11, 2019 00:00
Jospin Karel Bassakouahou Makani, Meo Stéphane Ikama, Louis Igor Kafata Ondze, Gisele Suzy Kimbally KakyNigerian Journal of Cardiology 2019 16(2):111-112 We report a case of global heart failure revealing aortic regurgitation in a 50-year-old male with acromegalic dysmorphism. The echocardiography noted a hypertrophy and dilatation of left ventricular and severe aortic regurgitation. A large pituitary adenoma was visualized using magnetic resonance imaging. Growth hormone was high.
Mon Nov 11, 2019 00:00
Ishaya Ibrahim Abok, Benjamin Andeyaba, Tina Slusher, Fidelia Bode-ThomasNigerian Journal of Cardiology 2019 16(2):98-102 Background: Rheumatic heart disease is the leading cause of acquired valvular heart disease in low- and middle-income countries and sometimes requires mechanical valve replacement. Postsurgical management of these patients is vital and includes lifelong anticoagulation with close monitoring. This study aims to report our experience with anticoagulation monitoring of patients...
Mon Nov 11, 2019 00:00
Modupe Akinrele Kuti, Abiodun Moshood Adeoye, Samuel Ayodeji Agboola, Tolulope Olutosin OmilakinNigerian Journal of Cardiology 2019 16(2):93-97 Context: Measurement of lipids and apoproteins are essential components aimed at reducing the global burden of atherosclerotic cardiovascular disease. Carotid intima-media thickness (CIMT) has been widely accepted as an index of subclinical atherosclerosis. A relationship between CIMT and the parameters of the traditional lipid profile has been described. ...
Mon Nov 11, 2019 00:00
Kelechi E Okonta, Praise K Briggs, Christain E Amadi, Sandra N Ofori, Emmanuel O Ocheli, Petronilla N Tabansi, Barbara E OtaigbeNigerian Journal of Cardiology 2019 16(2):103-106 Background: The aim of the study was to identify the spectrum of cardiothoracic and vascular surgical cases in the University of Port Harcourt Teaching Hospital (UPTH) and identify the limitations to service delivery and recommend solutions to improve service delivery to patients. Methods: A cross-sectional study of all...
Mon Nov 11, 2019 00:00
Yalcin Boduroglu, Nazan SonNigerian Journal of Cardiology 2019 16(2):113-115 Retinal vein occlussion (RVO) is one of the retinal vascular disease which may occur due to atherosclerosis in elderly, but young patients may have connective tissue diseases (such as systemic lupus erythematosus [SLE]) or thrombophilia. Antiphospholipid antibodies (lupus anticoagulant [LA], anticardiolipin [anti-CL]) are well-known risk factors for thrombotic complications in SLE. We present a case of SLE with RVO. ...
Mon Nov 11, 2019 00:00
Bonny Adah Ejeh, Yekeen Ayodele Ayoola, Henry Ifeanyichukwu Okolie, Solomon Sule DanbauchiNigerian Journal of Cardiology 2019 16(2):107-110 Situs inversus with dextrocardia refers to complete inversion of the position of the thoracic and abdominal viscera. Dextrocardia occurs when the heart is located in the right side of the thoracic cavity with its base-to-apex axis directed to the right and inferiorly. It may be isolated or associated with cardiac or alimentary malformations. Our patient had...
Mon Nov 11, 2019 00:00
Bertrand F Ellenga-Mbolla, Daria Motsambo, Solange Mongo Ngamami, Suzy-Gisele Kimbally KakyNigerian Journal of Cardiology 2019 16(2):120-121
Mon Nov 11, 2019 00:00
Diagnostics, Vol. 9, Pages 185: Prenatal Diagnosis of Autosomal Recessive Renal Tubular Dysgenesis with Anhydramnios Caused by a Mutation in the AGT Gene Diagnostics doi: 10.3390/diagnostics9040185 Authors: Ma Chen Wu Chang Chang Lin Chen Autosomal recessive renal tubular dysgenesis (ARRTD) is a rare and lethal disorder that causes stillbirth or early neonatal death. Most of the reported cases are diagnosed postnatally by a histopathological hallmark of the absence...
Mon Nov 11, 2019 02:00
Diagnostics, Vol. 9, Pages 184: Quantification of Carotid Intraplaque Hemorrhage: Comparison between Manual Segmentation and Semi-Automatic Segmentation on Magnetization-Prepared Rapid Acquisition with Gradient-Echo Sequences Diagnostics doi: 10.3390/diagnostics9040184 Authors: Young Ju Song Hyo Sung Kwak Gyung Ho Chung Seongil Jo Purpose: Carotid intraplaque hemorrhage (IPH) increases risk of territorial cerebral ischemic events, but different sequences or criteria have been...
Mon Nov 11, 2019 02:00
Related ArticlesImpaired inflammasome activation and bacterial clearance in G6PD deficiency due to defective NOX/p38 MAPK/AP-1 redox signaling. Redox Biol. 2019 Nov 02;28:101363 Authors: Yen WC, Wu YH, Wu CC, Lin HR, Stern A, Chen SH, Shu JC, Tsun-Yee Chiu D Abstract Glucose-6-phosphate dehydrogenase (G6PD) is the rate-limiting enzyme of the pentose phosphate pathway that modulates cellular redox homeostasis via the regeneration of NADPH. G6PD-deficient...
Mon Nov 11, 2019 14:21
Purpose We assessed how improved static magnetic field (B0) homogeneity with a dynamic multicoil shimming can influence the blood oxygen level dependent (BOLD) contrast to noise when echo planar imaging (EPI) sequence is used for a motor task functional MRI study. We showed that a multicoil shim setup can be a proper choice for dynamic shimming of 2 spatially distant areas with different inhomogeneity distributions. Methods A 16‐channel multicoil shim setup is used to provide improved B0 homogeneity...
Mon Nov 11, 2019 12:25
Purpose To assess the sodium MRI signal loss resulting from typically used RF excitation pulses in human skeletal muscle, patellar cartilage, and skin. Methods A double flip‐angle experiment was performed 3 times on the knees of 5 healthy volunteers with prescribed ω 1 = γB1 of 1.67 kHz, 0.333 kHz, and 0.167 kHz. This was done to search for ω 1‐dependent increased rates of sodium‐23 central resonance flipping known to result from residual quadrupole splitting (ωQ), as this flip‐angle effect...
Mon Nov 11, 2019 12:24
Chemosensors, Vol. 7, Pages 51: Optical Sensing of Nitrogen, Phosphorus and Potassium: A Spectrophotometrical Approach toward Smart Nutrient Deployment Chemosensors doi: 10.3390/chemosensors7040051 Authors: Filipe Monteiro-Silva Pedro A. S. Jorge Rui C. Martins The feasibility of a compact, modular sensing system able to quantify the presence of nitrogen, phosphorus and potassium (NPK) in nutrient-containing fertilizer water was investigated. Direct UV-Vis spectroscopy combined...
Tue Oct 29, 2019 02:00
Related ArticlesZebrafish etv2 knock-in line labels vascular endothelial and blood progenitor cells. Dev Dyn. 2019 Nov 09;: Authors: Chestnut B, Sumanas S Abstract BACKGROUND: ETS transcription factor Etv2 / Etsrp is one of the earliest markers for vascular and hematopoietic progenitors and functions as a key regulator of hematovascular development in multiple vertebrates, including zebrafish. Therefore transgenic etv2 reporter lines provide a valuable...
Mon Nov 11, 2019 14:12
Importance of seeds and fruits characteristics based on scanning electron microscopy (SEM) techniques. Systematic comparison and investigation to elucidate the taxonomic importance of seeds and fruits in the genus Delphinium L. (sensu lato). To find out potential characters for the phylogenetic relationships among the species of the genus Delphinium L. (sensu lato). Abstract In present research, micromorphological characters of the genus Delphinium L. (sensu lato) Ranunculaceae seeds...
Mon Nov 11, 2019 12:23
Publication date: Available online 10 November 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Peter Wostyn, Peter Paul De Deyn
Mon Nov 11, 2019 14:08
I find it fascinating how citizens in the United States take for granted the amazing aspects of the statistics in our healthcare system. We simply don’t even think about things like survival rates for procedures or how predictable amazingly difficult procedures have become. Recently a friend of mine had a hip replacement procedure performed. Ten to fifteen years ago, this surgery would have required a hospital stay of a week or longer. My friend also would have been flat on their back for several...
Mon Nov 11, 2019 14:00
Publication date: Available online 10 November 2019Source: Biological PsychologyAuthor(s): Chrysanthi Leonidou, Olga Pollatos, Georgia PanayiotouAbstractThis study investigated the effect of interoceptive attention on emotional responses during illness imagery, and the moderating role of illness anxiety. 101 students (81 female; 18-35 years old) with low, moderate and high levels of illness anxiety had to imagine personally relevant illness scenarios and standardized fearful, joyful and neutral scenarios,...
Mon Nov 11, 2019 13:59
Abstract DNA strand breaks present a complex challenge for our cells, and the integrity of the DNA damage response machinery is critical for preventing cancer, premature aging, and neurodegenerative syndromes amongst other ailments. This multi-author review issue presents emerging topics relevant to understanding the fundamental structural mechanisms of DNA strand break sensing, signaling, and repair.
Mon Nov 11, 2019 02:00
Abstract Cell-based therapies using adult stem cells are promising options for the treatment of a number of diseases including autoimmune and cardiovascular disorders. Among these, vascular wall-derived mesenchymal stem cells (VW-MSCs) might be particularly well suited for the protection and curative treatment of vascular damage because of their tissue-specific action. Here we report a novel method for the direct conversion of human skin fibroblasts towards MSCs using a VW-MSC-specific...
Mon Nov 11, 2019 02:00
Abstract This study examined the contributions of low-, mid- and high-level visual motion information to vection. We compared the vection experiences induced by hand-drawn and computer-generated animation clips to those induced by versions of these movies that contained only their pure optic flow. While the original movies were found to induce longer and stronger vection experiences than the pure optic flow, vection onsets were not significantly altered by removing the mid- and...
Mon Nov 11, 2019 02:00
Nature Communications, Published online: 11 November 2019; doi:10.1038/s41467-019-13090-9Metal-organic frameworks with luminescence and chirality are promising for luminescent sensors for chiral molecules. Here, the authors use cation exchange to introduce chirality in multifunctional metal-organic framework systems for rapid enantioselective luminescent sensing.
Mon Nov 11, 2019 02:00
Nature Communications, Published online: 11 November 2019; doi:10.1038/s41467-019-12963-3Dielectric nano-antennas may be used as a platform for boosting light-matter coupling in 2D semiconductors. Here, the authors demonstrate the coupling of atomically thin WSe $${}_{2}$$ 2 with low-loss, high-refractive-index GaP nano-antennas and observe a 10000-fold WSe $${}_{2}$$ 2 photoluminescence enhancement.
Mon Nov 11, 2019 02:00
Nature Communications, Published online: 11 November 2019; doi:10.1038/s41467-019-13106-4Small nucleolar RNAs, SNORD50A/B are frequently deleted in cancers and can inhibit KRAS but by unclear means. Here, the authors show that KRAS trafficking and enrichment on the plasma membrane is mediated by SNARE vesicle transport proteins and that SNORD50A/B compete with these proteins to antagonise these effects.
Mon Nov 11, 2019 02:00
Nature Communications, Published online: 11 November 2019; doi:10.1038/s41467-019-13091-8EMT is a developmental process that is aberrantly activated in metastasizing cancer cells, but how multiple transcription factors regulate EMT is unclear. Here, the authors uncover a gene regulatory network between Prrx1 and Snail1 that selects EMT mode in developing vertebrates and cancer cells.
Mon Nov 11, 2019 02:00
Nature Communications, Published online: 11 November 2019; doi:10.1038/s41467-019-13060-1Proper ovarian differentiation requires RUNX1. Here, the authors show that double knockout of Runx1/Foxl2 results in masculinization of fetal ovaries, and that RUNX1 and FOXL2 jointly occupy common chromatin regions to maintain pre-granulosa cell identity in the fetal ovary.
Mon Nov 11, 2019 02:00
Abstract Background Proton radiotherapy (PRT) may be a less toxic alternative to photon radiotherapy (XRT) for patients with head and neck squamous cell carcinoma (HNSCC). However, the molecular responses of HNSCC cells to PRT vs XRT are unclear. Methods Proteomics analyses of protein expression profiles by reverse‐phase protein arrays were done for two human papillomavirus [HPV]‐negative and two HPV+ cell lines. Expression patterns of 175 proteins involved in several signaling pathways...
Mon Nov 11, 2019 13:00
Microorganisms, Vol. 7, Pages 553: Computational Modelling of Metabolic Burden and Substrate Toxicity in Escherichia coli Carrying a Synthetic Metabolic PathwayMicroorganisms doi: 10.3390/microorganisms7110553Authors:Martin DemkoLukáš ChrástPavel DvořákJiří DamborskýDavid ŠafránekIn our previous work, we designed and implemented a synthetic metabolic pathway for 1,2,3-trichloropropane (TCP) biodegradation in Escherichia coli. Significant effects of metabolic burden and toxicity exacerbation were...
Mon Nov 11, 2019 02:00
Key points •This is the first long‐term human clinical trial to report on effects of NR on skeletal muscle mitochondrial function, content and morphology •NR supplementation decreases NAMPT protein abundance in skeletal muscle •NR supplementation do not affect NAD metabolite concentrations in skeletal muscle •Respiration, distribution, and quantity of muscle mitochondria are unaffected by NR •NAMPT in skeletal muscle correlates positively with OXPHOS Complex I, SIRT3, and SDH Abstract...
Mon Nov 11, 2019 12:49
Related ArticlesEffects of a swallowing and oral care intervention for patients following endotracheal extubation: a pre- and post-intervention study. Crit Care. 2019 Nov 09;23(1):350 Authors: Wu CP, Xu YJ, Wang TG, Ku SC, Chan DC, Lee JJ, Wei YC, Hsiao TY, Chen CC Abstract BACKGROUND: For patients who survive a critical illness and have their oral endotracheal tube removed, dysphagia is highly prevalent, and without intervention, it may persist far...
Mon Nov 11, 2019 13:27
Related ArticlesEvaluation of hyoid movement during swallowing using a bend sensor. J Oral Rehabil. 2019 Nov 09;: Authors: Murakami K, Minagi Y, Hori K, Uehara F, Salazar SE, Inoue M, Maeda Y, Ikebe K, Ono T Abstract BACKGROUND: Movement of the hyoid and laryngeal complex is critical for preventing aspiration, as well as smooth bolus passage through the pharynx. We have developed a non-invasive system for measuring laryngeal movement during swallowing...
Mon Nov 11, 2019 13:27
Publication date: Available online 10 November 2019Source: Artificial Intelligence in MedicineAuthor(s): Nan Han, Shaojie Qiao, Guan Yuan, Ping Huang, Dingxiang Liu, Kun YueAbstractTraditional Chinese medicine (TCM) has become popular and been viewed as an effective clinical treatment across the world. Accordingly, there is an ever-increasing interest in performing data analysis over TCM data. Aiming to cope with the problem of excessively depending on empirical values when selecting cluster centers...
Mon Nov 11, 2019 13:15
Patient outcomes are influenced by intraoperative temperature management. Oesophageal/pharyngeal temperature monitoring is the standard of care at our institute but is not well tolerated in awake patients. Man...
Sat Nov 09, 2019 02:00
Publication date: Available online 10 November 2019Source: European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): O. Laccourreye
Mon Nov 11, 2019 12:57
Viruses, Vol. 11, Pages 1050: The Capsid Protein of Hepatitis E Virus Inhibits Interferon Induction via Its N-terminal Arginine-Rich Motif Viruses doi: 10.3390/v11111050 Authors: Shaoli Lin Yonglin Yang Yuchen Nan Zexu Ma Liping Yang Yan-Jin Zhang Hepatitis E virus (HEV) causes predominantly acute and self-limiting hepatitis. However, in HEV-infected pregnant women, the case fatality rate because of fulminant hepatitis can be up to 30%. HEV infection is zoonotic for some...
Mon Nov 11, 2019 02:00
Antioxidants, Vol. 8, Pages 542: Antioxidants versus Food Antioxidant Additives and Food Preservatives Antioxidants doi: 10.3390/antiox8110542 Authors: Rafael Franco Gemma Navarro Eva Martínez-Pinilla Natural and processed foods are fragile and can become unpalatable and/or rotten. The processed food industry uses preservatives to enable distribution, even to different continents, and to extend the useful life of their products. Preservatives impede oxidation, a mandatory step...
Mon Nov 11, 2019 02:00
Antioxidants, Vol. 8, Pages 543: Nitrosative Stress in Retinal Pathologies: Review Antioxidants doi: 10.3390/antiox8110543 Authors: Antolin Cantó Teresa Olivar Francisco Javier Romero María Miranda Nitric oxide (NO) is a gas molecule with diverse physiological and cellular functions. In the eye, NO is used to maintain normal visual function as it is involved in photoreceptor light transduction. In addition, NO acts as a rapid vascular endothelial relaxant, is involved in the...
Mon Nov 11, 2019 02:00
Abstract Purpose Polycystic ovarian syndrome (PCOS) is one of the most common metabolic and endocrine disorders. Functional foods like pomegranate and probiotics are those that are considered to have beneficial effects on metabolic diseases beyond their basic nutritional value. So, we aimed to evaluate the effect of synbiotic pomegranate juice (SPJ) on cardiovascular risk factors on PCOS patients. ...
Mon Nov 11, 2019 02:00
Abstract Despite the consolidated belief that the macaque superior parietal lobule (SPL) is entirely occupied by Brodmann’s area 5, recent data show that macaque SPL also hosts a large cortical region with structural and functional features similar to that of Brodmann’s area 7. According to these data, the anterior part of SPL is occupied by a somatosensory-dominated cortical region that hosts three architectural and functional distinct regions (PE, PEci, PEip) and the caudal half...
Mon Nov 11, 2019 02:00
Flatfish undergo extreme morphological development and settle to a benthic in the adult stage, and are likely to be more susceptible to environmental stress. Heat shock proteins 70 (hsp70) are involved in embryonic development and stress response in metazoan animals. However, the evolutionary history and functions of hsp70 in flatfish are poorly understood. Here, we identified 15 hsp70 genes in the genome of Japanese flounder (Paralichthys olivaceus), a flatfish endemic to northwestern Pacific Ocean....
Mon Nov 11, 2019 02:00
Vitis vinifera can be divided into two subspecies, V. vinifera subsp. vinifera, one of the most important agricultural crops in the world, and its wild ancestor, V. vinifera subsp. sylvestris. Three flower types can be observed: hermaphrodite and female (on some varieties) in vinifera, and male or female flowers in sylvestris. It is assumed that the different flower types in the wild ancestor arose through specific floral patterns of organ abortion. A considerable amount of data about the diversity...
Mon Nov 11, 2019 02:00
The acute effect of match-play on hip range of motion and isometric strength in elite tennis players
Background Groin injuries are some of the most common injuries tennis players suffer. Several factors (e.g., post-match decrease in hip adductor (ADD) strength) have been proposed as possible mechanisms for increasing the incidence of this type of injury. However, the risk factors of developing groin injuries after a tennis match have not yet been delineated. Objective The aim of this study was to determine the effect of tennis match-play on isometric ADD and abductor (ABD) strength and...
Mon Nov 11, 2019 02:00
We critically re-examine nine of the ten fossil specimens currently assigned to Hepialidae. Three fossils with impressions of wing veins and scales placed in the fossil genus Prohepialus Piton, 1940, and two mummified larvae that show apomorphic characters, have features that support placement in Hepialidae. The other four fossils that we evaluate, Prohepialus incertus Piton, 1940; Oiophassus nycterus Zhang, 1989; Protohepialus comstocki Pierce, 1945; and a fossil scale, lack definitive hepialid...
Mon Nov 11, 2019 02:00
Animal furs are encountering more and more the detriment of public opinion, that is increasingly sensitive to animals, their welfare and protection. The feeling of outrage against animal suffering is particularly intense when cats and dogs are involved, since these are the most popular pets in Western countries. However, in some Asian countries breeding of dogs and cats for the fur industry is a common practice. These furs and their finished garments are often mislabelled in order to be imported...
Mon Nov 11, 2019 02:00
Background Genomic data play an important role in plant research because of its implications in studying genomic evolution, phylogeny, and developing molecular markers. Although the information of invasive alien plants was collected, the genomic data of those species have not been intensively studied. Methods We employ the next generation sequencing and PCR methods to explore the genomic data as well as to develop and test the molecular markers. Results In this study, we characterize...
Mon Nov 11, 2019 02:00
China has experienced intensive urbanization over the past decades. However, it is still unclear about the influence of urbanization on urban thermal comfort and how the effect varies with climate condition. Based on long-term daily meteorological data from 1990 to 2015 in four Chinese cities undergoing rapid urbanization, our study tried to detect the long-term dynamics of summer urban thermal comfort across different climate zones and analyze their relationships with urbanization. Our results showed...
Mon Nov 11, 2019 02:00
Crossbreeding is widely used aimed at improving crossbred performance for poultry and livestock. Alleles that are specific to different purebreds will yield a large number of heterozygous single-nucleotide polymorphisms (SNPs) in crossbred individuals, which are supposed to have the power to alter gene function or regulate gene expression. For pork production, a classic three-way crossbreeding system of Duroc × (Landrace × Yorkshire) (DLY) is generally used to produce terminal crossbred pigs with...
Mon Nov 11, 2019 02:00
Population matrix models are important tools in resource management, in part because they are used to calculate the finite rate of growth (“dominant eigenvalue”). But understanding how a population matrix model converts life history traits into the finite rate of growth can be tricky. We introduce interactive software (“IsoPOPd”) that uses the characteristic equation to display how vital rates (survival and fertility) contribute to the finite rate of growth. Higher-order interactions among vital...
Mon Nov 11, 2019 02:00
Invasion by alien species (AS) is one of the most serious threats to ecosystems. In Europe, the Natura 2000 habitats network was established to protect habitats vital for the conservation of biodiversity and function of ecosystems. Therefore, the appearance of AS in Natura 2000 habitats is a warning signal that the most valuable European habitats may be endangered. However, quantitative studies encompassing a wide spectrum of habitats are lacking, and there is no insight into the differences in the...
Mon Nov 11, 2019 02:00
Verticillium dahliae causes disease symptoms in its host plants; however, due to its rapid variability, V. dahliae is difficult to control. To analyze the reason for this pathogenic differentiation, 22 V. dahliae strains with different virulence were isolated from a cotton farm. The genetic diversity of cotton varieties make cotton cultivars have different Verticillium wilt resistance, so the Xinluzao 7 (susceptible to V. dahliae), Zhongmian 35 (tolerant), and Xinluzao 33 (resistant) were used to...
Mon Nov 11, 2019 02:00
Sun Nov 10, 2019 09:31
Η Ωνάσειος Βιβλιοθήκη διοργανώνει το Διεθνές Θερινό Σχολείο Καβάφη (29 Ιουνίου-4 Ιουλίου 2019), με θέμα: Η διαμεσολάβηση του Καβάφη. Το Διεθνές Θερινό Σχολείο Καβάφη είναι μια ετήσια πρωτοβουλία του Αρχείου Καβάφη και του Ιδρύματος Ωνάση, που εστιάζει στον Καβάφη, στο έργο του και στον αντίκτυπο αυτού του έργου στον κόσμο.
Mon Nov 11, 2019 10:11
Η Εταιρεία Σπουδών Νεοελληνικού Πολιτισμού και Γενικής Παιδείας (Ιδρυτής: Σχολή Μωραΐτη) διοργανώνει εκδήλωση με θέμα: Το πρόσωπο και το έργο: Τίτος Πατρίκιος. Ο Τίτλος Πατρίκιος συνομιλεί με τη Λίζυ Τσιριμώκου και τον Θανάση Χατζόπουλο. Η εκδήλωση θα γίνει την Πέμπτη 28 Νοεμβρίου και ώρα 18.30, στον Πολυχώρο του Συλλόγου των Φίλων της Μουσικής του Μεγάρου Μουσικής Αθηνών.
Mon Nov 11, 2019 10:01
Η Ακαδημία Αθηνών διοργανώνει Ημερίδα για την ενίσχυση των κλασικών γραμμάτων στην ελληνική δευτεροβάθμια και τριτοβάθμια εκπαίδευση. Η ημερίδα θα γίνει στις 4 Δεκεμβρίου 2019 στην Ανατολική Αίθουσα της Ακαδημίας Αθηνών.
Mon Nov 11, 2019 09:52
Biomedicines, Vol. 7, Pages 90: Temozolomide in Glioblastoma Therapy: Role of Apoptosis, Senescence and Autophagy. Comment on Strobel et al., Temozolomide and Other Alkylating Agents in Glioblastoma Therapy. Biomedicines 2019, 7, 69 Biomedicines doi: 10.3390/biomedicines7040090 Authors: Bernd Kaina Temozolomide, a DNA methylating drug, is currently being used first-line in glioblastoma therapy. Although the mode of action of this so-called SN1 alkylating agent is well described, including...
Mon Nov 11, 2019 02:00
Abstract Ceftazidime is a third‐generation cephalosporin used for the treatment of Gram‐negative bacteria only approved for parenteral use by intravenous and intramuscular route. In some clinical situations, off‐label subcutaneous injection could be a salvage route for the administration of antibiotics, especially in geriatrics, despite the paucity of evidence about efficacy and safety. We report a case of a successful and well‐tolerated subcutaneous ceftazidime therapy in a 90‐year‐old woman for...
Mon Nov 11, 2019 11:29
Publication date: December 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Volume 1866, Issue 12Author(s):
Mon Nov 11, 2019 11:49
As a new expression system, Dunaliella salina (D. salina) has bright prospects and applications in various fields. However, its application is currently restricted because of the low expression and instability of...
Sat Nov 09, 2019 02:00
To effectively utilize the tropical cassava (Manihot esculenta Crantz) foliage (CF) resources, the CF silages were prepared with microbial additives, including Chikuso-1 (CH1, Lactobacillus plantarum), Snow Lact ...
Sat Nov 09, 2019 02:00
Survival of inoculated fungal strains in a new environment plays a critical role in functional performance, but few studies have focused on strain-specific quantitative PCR (qPCR) methods for monitoring benefi...
Sat Nov 09, 2019 02:00
Mon Nov 11, 2019 10:05
Authors assessed trends in cigarette and/or cigar (ie, smoked tobacco) and marijuana use among 18- to 22-year-old US young adults who were in or not in college.
Mon Nov 11, 2019 10:05
Abstract The development of chronic inflammation, called inflammaging, contributes to the pathogenesis of age-related diseases. Although it is known that both B and T lymphocyte compartments of the adaptive immune system deteriorate with advancing age, the impact of aging on immune functions of Th17-type CD161-expressing innate immune cells and their role in inflammaging remain incompletely understood. Here, utilizing the nonhuman primate model of rhesus macaques, we report that...
Mon Nov 11, 2019 02:00
Abstract Purpose Oral vancomycin use has generally increased as a consequence of the need to treat and/or prevent Clostridium (Clostridiodes) difficile-associated disease (CDAD). This review examines the cumulative scientific evidence that guides therapeutic monitoring of oral vancomycin therapy. Methods The existing publications were reviewed from the time...
Mon Nov 11, 2019 02:00
AM POLYMERS GmbH expands its powder portfolio for laser sintering with a new polypropylene powder. In contrast to most of the materials on the market, the material has exceptionally high elongation at break of more than 200 %. At the same time, the material has excellent processing conditions on common machine systems. AM POLYMERS GmbH presents its fourth series material from the ROLASERIT® family at FORMNEXT 2019 in Frankfurt and starts the BETA phase for the newly developed ROLASERIT® PP03O....
Mon Nov 11, 2019 10:00
A new edition of the 3D Printing Congress in Argentina wrapped up last Thursday after two days of workshops, supplier stands and speakers talking about the challenges and solutions of manufacturing using 3D printing. From biomaterials to resins, 3D printing in the automotive industry, 3D medical simulators and biomedical inventions, some of the most innovative uses for the technology show that it is advancing in the country, albeit somewhat slower than expected. Sergio Cavaliere, Product and Applications...
Mon Nov 11, 2019 09:59
Mon Nov 11, 2019 10:34
We regularly get questions from authors about the various versions of an article and our policy for them. Phil Hurst, Publisher at the Royal Society, answers your common questions. Preprint The original, un-refereed version of the article J. C. Maxwell’s, ‘Dynamical theory of the electromagnetic field’, 1864. From The Royal Society, PT/72/7 Q1. Does the Royal Society see posting on a preprint server as ‘prior publication’? No. We encourage authors to post their preprint on an appropriate...
Mon Nov 11, 2019 10:00
We aimed to determine the anatomical fissural variations during routine forensic autopsies. This and previous similar studies demonstrate that there exist several different anatomical fissural variations in the lungs. Clinicians, radiologists and surgeons should kept them in mind to better evaluate and treat their patients. Abstract Background We aimed to document the anatomical variations of pulmonary fissures found during routine forensic autopsies. Methods A total of 256 pairs of...
Sun Nov 10, 2019 21:40
Prevalence and significance of race and ethnicity subgroup analyses in Cochrane intervention reviews
Clinical Trials, Ahead of Print.
Mon Nov 11, 2019 09:19
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