CASE REPORT,
Verruciform xanthoma in recessive dystrophic epidermolysis bullosa and keratitis‐ichthyosis‐deafness syndrome: Report of two cases and a review of the literature
Eric Evan‐Browning MD  Jillian Rork MD  Patrick O’Donnell DO  Zendee Elaba MD  April Deng MD  Karen Wiss MD
First published: 11 November 2019 https://doi.org/10.1111/pde.14046

Abstract
Verruciform xanthoma is a benign, wart‐like lesion that can clinically mimic squamous cell carcinoma. We describe two teenage patients with severe genodermatoses, recessive dystrophic epidermolysis bullosa (RDEB), and keratitis‐ichthyosis‐deafness (KID) syndrome, respectively, each found to have plaques suspicious for malignancy, later demonstrated on histopathologic examination to be verruciform xanthoma. We discuss the connection between these severe genodermatoses and the suspected pathophysiology of verruciform xanthoma. In addition, we highlight the importance of recognizing verruciform xanthoma as a clinical mimicker of squamous cell carcinoma, for which patients with RDEB and KID syndrome are at increased risk.