Cells, Vol. 8, Pages 1372: Wnt-3a Induces Cytokine Release in Human Mast Cells Cells doi: 10.3390/cells8111372 Authors: Julia Tebroke Joris E. Lieverse Jesper Säfholm Gunnar Schulte Gunnar Nilsson Elin Rönnberg Mast cells are well known for their detrimental effects in allergies and asthma, and Wnt signaling has recently been implicated in asthma and other airway diseases. However, it is not known if or how Wnts affect human mast cells. Since Wnt expression is elevated...
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Οι άνδρες που έχουν στο αίμα τους αυξημένα επίπεδα δύο ορμονών, της «ελεύθερης» τεστοστερόνης και του ινσουλινομιμητικού αυξητικού παράγοντα (IGF-I), είναι πιθανότερο να διαγνωσθούν…
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Οι ορμόνες είναι ουσίες που παράγονται από τους ενδοκρινείς αδένες, κυκλοφορούν με το αίμα και μεταφέρουν χημικά σήματα σε όλα τα όργανα και τους…
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Oncology drug development is among the most challenging of any therapeutic area, with first‐in‐human trials expected to deliver information on both safety and activity. Until recently, therapeutic approaches in oncology focused on cytotoxic chemotherapy agents, ruling out even the possibility of enrolling normal healthy volunteers (NHVs) in clinical trials due to safety considerations. The emergence of noncytotoxic modalities, including molecularly targeted agents with more favorable safety profiles,...
Thu Oct 31, 2019 20:19
Abstract The antiplatelet agent clopidogrel, a prodrug that requires bioactivation through the cytochrome P450 2C19 (CYP2C19) enzyme, is commonly prescribed post‐percutaneous coronary intervention (PCI). Genetic variation in CYP2C19 contributes to individual variability in clopidogrel response, and can lead to adverse cardiovascular events. Incorporating CYP2C19 testing during routine clinical care helps identify high‐risk patients, and provides the opportunity for pharmacotherapeutic interventions...
Wed Oct 30, 2019 17:04
Abstract The purpose of this study was to assess the safety, tolerability, pharmacokinetics, pharmacodynamics, and immunogenicity of BOS161721, a humanized immunoglobulin G1 (IgG1) triple mutation (YTE) (M252Y/S254T/T256E) monoclonal antibody that inhibits interleukin‐21 (IL‐21) bioactivity. This randomized, single‐center, double‐blind, placebo‐controlled study randomized healthy volunteers 3:1 to single ascending intravenous and subcutaneous doses of BOS161721 (range: 1‐240 mg) or placebo. BOS161721...
Wed Oct 30, 2019 17:04
Abstract Population pharmacokinetic/pharmacodynamic modeling (via NONMEM) was used to describe longitudinal exposure‐response relationships for total cariprazine (sum of cariprazine and its major active metabolites) in 2558 patients with schizophrenia or bipolar mania. Drug exposure metrics were explored for potential relationships with efficacy and safety endpoints. Total cariprazine exposures were significantly related to reductions in PANSS or YMRS total scores in schizophrenia or bipolar mania,...
Wed Oct 30, 2019 17:04
Abstract Zanamivir is a potent and highly selective inhibitor of influenza neuraminidase where the inhibition of this enzyme prevents the virus from infecting other cells and specifically prevents release of the new virion from the host cell membrane. It is available as an oral powder for inhalation and tintravenous formulations. The current population pharmacokinetic model based on data from eight studies of subjects treated with the intravenous formulation (125 healthy adults and 533 hospitalized...
Wed Oct 30, 2019 17:02
Abstract The oral bioavailability of ibrutinib is low and variable, mainly due to extensive first‐pass metabolism by CYP3A4. The unpredictable exposure can compromise its safe and effective dosing. We examined the impact of itraconazole on ibrutinib pharmacokinetics. In a randomized crossover study, 11 healthy subjects were administered itraconazole 200 mg or placebo twice on day 1, and once on days 2‐4. On day 3, 1 hour after itraconazole (placebo) and breakfast, ibrutinib (140 mg during placebo;...
Wed Oct 30, 2019 17:00
Abstract Background Antipsychotic polypharmacy (“polypharmacy”) is the concurrent prescribing of more than one antipsychotic. It is widely practised, as reported in the literature, and is known to increase the risk of adverse outcomes for patients. Objective To quantify the prevalence and magnitude of polypharmacy in patients with schizophrenia or schizoaffective disorder and identify potential factors contributing to this practice. Setting Armadale Mental Health Service (a public...
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Abstract Background: In the United States, emergency medicine clinical pharmacists have become more common over the last several decades. Despite being a vital component of the emergency department interdisciplinary team, there is very limited information published regarding the direct impact emergency medicine clinical pharmacists have on other emergency department-based professions. Objective: To determine if the addition of an emergency medicine clinical pharmacist improves...
Thu Oct 31, 2019 02:00
Abstract Background The roles of Allied Health Care Professionals (AHPs) in Head and Neck Cancer (HNC) are wide ranging but not clearly defined. Inter‐regional variability in practice results from a lack of standardisation in approaches to the Multidisciplinary Team (MDT) make‐up and structure. Traditionally the follow‐up of HNC patients is clinician led with multiple scheduled follow‐up appointments. The increasing population of HNC patients provides logistical, monetary and efficiency challenges....
Thu Oct 31, 2019 15:39
Abstract Background Recently, sclerostin, a bone-derived protein, has been shown to play a key role in atherosclerosis progression. However, few studies have investigated the influence of sclerostin on cardiovascular disease prognosis. We investigated the relationship between serum sclerostin levels and adverse outcomes in elderly patients with stable coronary artery disease (SCAD) who were undergoing percutaneous coronary intervention...
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Abstract Background The purpose of this study was to compare the h-index, and subsequently the research productivity, among different ophthalmic subspecialties in the United States. Methods A cohort of over 15,000 academic ophthalmologists residing in the United States (US) was identified out of the physician list of the American Academy of...
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Abstract Purpose Pilocytic (PA) and pilomyxoid astrocytomas (PMA) are related low-grade tumors which occur predominantly in children. PMAs have a predilection for a supratentorial location in younger children with worse outcomes. However, the two have similar imaging characteristics. Quantitative MR sequences such as dynamic susceptibility contrast (DSC) perfusion and diffusion (DWI) were assessed for significant differences between the...
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Abstract This document sets out standards for training in Interventional Neuroradiology (INR) in Europe. These standards have been developed by a working group of the European Society of Neuroradiology (ESNR) and the European Society of Minimally Invasive Neurological Therapy (ESMINT) on the initiative and under the umbrella of the Division of Neuroradiology/Section of Radiology of the European Union of Medical Specialists (UEMS).
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JCM, Vol. 8, Pages 1811: Genes and Variants Underlying Human Congenital Lactic Acidosis—From Genetics to Personalized Treatment Journal of Clinical Medicine doi: 10.3390/jcm8111811 Authors: Irene Bravo-Alonso Rosa Navarrete Ana Isabel Vega Pedro Ruíz-Sala María Teresa García Silva Elena Martín-Hernández Pilar Quijada-Fraile Amaya Belanger-Quintana Sinziana Stanescu María Bueno Isidro Vitoria Laura Toledo María Luz Couce Inmaculada García-Jiménez Ricardo...
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JCM, Vol. 8, Pages 1813: High Betaine, a Trimethylamine N-Oxide Related Metabolite, Is Prospectively Associated with Low Future Risk of Type 2 Diabetes Mellitus in the PREVEND Study Journal of Clinical Medicine doi: 10.3390/jcm8111813 Authors: Erwin Garcia Maryse C. J. Osté Dennis W. Bennett Elias J. Jeyarajah Irina Shalaurova Eke G. Gruppen Stanley L. Hazen James D. Otvos Stephan J. L. Bakker Robin P.F. Dullaart Margery A. Connelly Background: Gut microbiota-related...
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JCM, Vol. 8, Pages 1812: Prognostic Implication of Metastatic Lymph Node Ratio in Colorectal Cancers: Comparison Depending on Tumor Location Journal of Clinical Medicine doi: 10.3390/jcm8111812 Authors: Jung-Soo Pyo Young-Min Shin Dong-Wook Kang Background: The proportion of the number of involved lymph nodes (LNs) to the number of examined LNs—defined as metastatic LN ratio (mLNR)—has been considered as a prognostic parameter. This study aims to elucidate the...
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JCM, Vol. 8, Pages 1814: The SGLT2 Inhibitor Empagliflozin Ameliorates the Inflammatory Profile in Type 2 Diabetic Patients and Promotes an Antioxidant Response in Leukocytes Journal of Clinical Medicine doi: 10.3390/jcm8111814 Authors: Francesca Iannantuoni Aranzazu M. de Marañon Noelia Diaz-Morales Rosa Falcon Celia Bañuls Zaida Abad-Jimenez Victor M. Victor Antonio Hernandez-Mijares Susana Rovira-Llopis Sodium–glucose co-transporter 2 inhibitors (iSGLT2)...
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JCM, Vol. 8, Pages 1809: Arginase Isoform Expression in Chronic Rhinosinusitis Journal of Clinical Medicine doi: 10.3390/jcm8111809 Authors: Diana Vlad Silviu Albu Nitric oxide (NO) has emerged as an important regulator of upper airway inflammation, mainly as part of the local naso-sinusal defense mechanisms. Increased arginase activity can reduce NO levels by decreasing the availability of its precursor, L-arginine. Chronic rhinosinusitis (CRS) has been associated with low levels...
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Under the research collaboration and licensing agreement, the companies will work on the worldwide development and commercialisation of DCR-HBVS, Dicerna’s investigational therapy in phase 1 clinical development for The post Roche, Dicerna sign $1.67bn deal for HBV infection treatment appeared first on Pharmaceutical Business review.
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Abstract Originally Lipid droplets (LDs) were considered as being droplets for lipid storage only. Increasing evidence, however, demonstrates that LDs fulfill a pleiotropy of additional functions. Among them is the modulation of protein as well as lipid homeostasis. Under unfavorable pro-oxidative conditions, proteins can form aggregates which may exceed the overall proteolytic capacity of the proteasome. After stress termination LDs can adjust and support the removal of these...
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