As people age, their tissues accumulate an increasing number of somatic mutations. Although most of these mutations are of little or no functional consequence, a mutation may arise that confers a fitness advantage on a cell. When this process happens in the hematopoietic system, a substantial proportion of circulating blood cells may derive from a single mutated stem cell. This outgrowth, called "clonal hematopoiesis," is highly prevalent in the elderly population. Here we discuss recent advances...
Thu Oct 31, 2019 00:00
CONCLUSIONS: These results suggest that patients with breast cancer treated with AIs do not have a significant risk of developing CVEs in comparison with the controls, and exemestane might not be considered as the alternative AI to the breast cancer patients from the perspective of CVEs. Further studies are recommended to investigate this association and the risk differences among different tumor types, AIs or treatment regimens. PMID: 31665091 [PubMed - in process] (Source: BMC Pharmacology...
06:40
Publication date: Available online 30 October 2019Source: Life SciencesAuthor(s): Bing Liu, Jiangping Chen, Song ZhangAbstractUbiquitin (Ub) is a small protein that can be attached to substrate proteins to direct their degradation via the proteasome. Deubiquitinating enzymes (DUBs) reverse this process by removing ubiquitin from its substrate protein. Over the past few decades, ubiquitin-specific protease 14 (USP14), a member of the DUBs, has emerged as an important player in various types of cancers....
06:39
Publication date: Available online 31 October 2019Source: Life SciencesAuthor(s): Simin Tang, Teng Huang, Huan Jing, Zhenxing Huang, Hongtao Chen, Youling Fan, Jiying Zhong, Jun ZhouAbstractObstructive renal injury and drug-induced nephrotoxicity are the two most common causes of renal fibrosis diseases. However, whether these two different pathogeny induced same pathological outcomes contain common genetic targets or signaling pathway, the current research has not paid great attention. GSE121190...
06:39
This article is the first to examine an anti-cancer medicine, namely Sorafenib tosylate, in terms of its solubility in SC-CO2. This was done in different ranges of pressure (120-270 bar) and temperature (308-338 K). For this purpose, solubility data correlation was performed via two main sets of techniques; these included (1) two equations of states (EoSs), namely Peng-Robinson (PR) and Soave–Redlich–Kwong (SRK) with vdW2 and Wong-Sandler mixing rules (with two activity models: NRTL and Wilson) and...
06:13
In this study, we aim to develop efficient materials as vectors for co-delivery of microRNA-122 (miR-122) and sorafenib (SRF). We successfully synthesized amphiphilic galactose-modified PEGylated poly(amino-co-ester) (Gal-PEG-PPMS) copolymers consisted of hydrophilic Gal-PEG5k chain segments and hydrophobic poly(ω-pentadecalactone-co-N-methyldiethyleneamine-co-sebacic acid) chain segments, which self-assembled to form cationic micelles at pH 5.2. The results showed that the micelles could encapsulate...
06:12
This study aimed to evaluate the combined effects of chronic exposure to cadmium (Cd) and elevated water temperature (23 °C) or parasite infection in juvenile rainbow trout (Oncorhynchus mykiss) using a multi-level biological approach, including RNA-sequencing. Fish were exposed to diet-borne Cd (6 μg Cd/g wet feed), individually and in combination with thermal (23 °C) or parasitic stressors, for 28 days. The parasite challenge consisted of a single exposure to glochidia (larvae) of the freshwater...
06:05
Publication date: Available online 30 October 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Jun Cheng, Xiaofeng Wang, Le Qiu, Yunkai Li, Najat Marraiki, Abdallah M. Elgorban, Li XueAbstractManagement of degenerative spine pathologies frequently leads to the need for bone growth. Rehmanniae Radix (RR), a Chinese herbal formulation was found to exhibit numerous therapeutic properties including its potent effect against cancer cell lines. However, the underlying mechanism...
05:14
Publication date: Available online 30 October 2019Source: Meta GeneAuthor(s): Jessyca Kalynne Farias Rodrigues, Sergio Crovella, Ronaldo Celerino da SilvaAbstractHLA-G gene encodes a non-classical molecule of major histocompatibility complex with important immunomodulatory properties, being expressed, primarily by cytotrophoblasts during pregnancy, or in pathological conditions (autoimmune diseases, cancer, transplants and viral infections). The insertion of 14 bp in HLA-G 3′UTR region has been related...
05:09
Publication date: Available online 30 October 2019Source: Genes & DiseasesAuthor(s): Manish Pratap Singh, Sandhya Rai, Ashutosh Pandey, Nand K. Singh, Sameer SrivastavaAbstractMolecular subtypes-based therapies offer new potential framework for desired and precise outcome in clinical settings. Current treatment strategies in colorectal cancer is largely ‘one drug fit all’ model for patients that display same pathological conditions. However, CRC is a very heterogenous set of malignancy that does...
05:09
Publication date: Available online 30 October 2019Source: European UrologyAuthor(s): Fatima Karzai, Ravi A. Madan, William L. Dahut (Source: European Urology)
04:41
Publication date: Available online 30 October 2019Source: European UrologyAuthor(s): Nirmish Singla (Source: European Urology)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
04:41
ConclusionThe current model incorporates histopathological and clinical factors. It emphasizes the importance of tumor biological factors like tumor deposits in predicting overall and disease-free survival in rectal cancer.SummaryRectal cancer outcomes are associated with certain clinical and pathological factors that can be evaluated. Tumor deposits are one such factor that can affect overall and disease-free survival. (Source: The American Journal of Surgery)
04:11
ConclusionsSeven new signals that were not included in the current label were identified for TNF α inhibitors and should be updated and monitored.Key Points•Large-scale spontaneous AE reporting data and data mining techniques are useful for detecting signals of rare AEs as well as common AEs induced by drugs.•Drug labels should be updated to reflect signals that are newly discovered by continuous monitoring. (Source: Clinical Rheumatology)
00:00
Authors: Khorana AA PMID: 31665801 [PubMed - in process] (Source: Thrombosis and Haemostasis)
00:00
(Source: Patient Preference and Adherence)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Thu Oct 31, 2019 23:31
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου