The present study examined the characteristics of somatosensory processing in healthy prepubescent children (mean age: 124.9 ± 3.8 months) compared with young adults. Somatosensory evoked potentials at the frontal (Fz) and centroparietal (C3′) electrodes were recorded by delivering an electrical stimulus to the right median nerve at a rate of 3 Hz. The characteristics of somatosensory evoked potential waveforms at C3′ were markedly different between the two groups, while those at Fz were similar....
Fri Oct 11, 2019 03:00
Gliomas are the most common malignant primary brain tumors with poor prognosis. The migration-inducing gene-7 (Mig-7) protein is a cysteine-rich protein. Vasculogenic mimicry can replace endothelium-dependent blood vessels and supply blood to tumors, thus promoting tumor invasion and metastasis. They have also been shown to play critical roles in the development and progression of various cancers. We attempted to explore the role of Mig-7 and vasculogenic mimicry in glioma progression. We demonstrated...
Fri Oct 11, 2019 03:00
Berberine, an isoquinoline alkaloid isolated from traditional Chinese medicine, has been widely studied for its efficacy in the treatment of neurodegenerative diseases. However, berberine-mediated neuroprotection in the pathogenesis of Parkinson’s disease is still uncertain. In this study, the effects of berberine on rotenone-induced neurotoxicity in SH-SY5Y cells were investigated. The results showed that berberine treatment significantly alleviated rotenone-induced decrease in the cell viability...
Fri Oct 11, 2019 03:00
Hyperactivity of the hypothalamic-pituitary-adrenal axis and impairment of the central corticotropin-releasing factor system are factors in the pathogenesis of depression. Though several antagonists of the corticotropin-releasing factor 1 receptor were effective in the recognized behavioral tests for antidepressant activity, there is still little information on the potential interactions between corticotropin-releasing factor 1 receptor inhibitors and conventional antidepressant therapy. The aim...
Fri Oct 11, 2019 03:00
The blood–brain barrier (BBB) plays critical roles in maintaining the stability of the brain's internal milieu, providing nutrients for the brain, and preventing toxic materials from the blood from entering the brain. The cellular structure of the BBB is mainly composed of brain microvascular endothelial cells (BMVECs), which are surrounded by astrocytic endfeet that are connected by tight junction proteins, pericytes and astrocytes. Recently, several studies have shown that aberrant increase in...
Fri Oct 11, 2019 03:00
As a basic organizing principle of the human brain, hemispheric specialization is an important perspective to explore the pathology of schizophrenia. However, it remains unclearly whether the hemispheric specialization of functional connectivity plays a role in mediating auditory verbal hallucinations in schizophrenia. In this study, 18 schizophrenic patients with auditory verbal hallucinations, 18 patients without auditory verbal hallucinations, and 18 matched healthy controls underwent resting-state...
Fri Oct 11, 2019 03:00
Torrance Test of Creative Thinking is the most widely used form of creativity test. Although creativity assessed using the figural form of Torrance Test of Creative Thinking has been considered non-unidimensional, the structural correlates for each separable dimension have yet to be explored. The present study investigated the underlying cortical structure of separable dimensions for creativity using the figural Torrance Test of Creative Thinking. To this end, we recruited healthy young adults and...
Fri Oct 11, 2019 03:00
BACKGROUND AND PURPOSE:Quantification of blood flow using a 4D-DSA would be useful in the diagnosis and treatment of cerebrovascular diseases. A protocol optimizing identification of density variations in the time-density curves of a 4D-DSA has not been defined. Our purpose was to determine the contrast injection protocol most likely to result in the optimal pulsatility signal strength.MATERIALS AND METHODS:Two 3D-printed patient-specific models were used and connected to a pulsatile pump and flow...
Thu Oct 31, 2019 17:59
BACKGROUND AND PURPOSE:Moyamoya disease is a chronic neurovascular steno-occlusive disease of the internal carotid artery and its main branches, associated with the development of compensatory vascular collaterals. Literature is lacking about the precise description of these compensatory vascular systems. Usually, the posterior circulation is less affected, and its vascular flow could compensate the hypoperfusion of the ICA territories. The aim of this study was to describe these natural connections...
Thu Oct 31, 2019 15:57
SUMMARY:Lyme disease is the most common tick-borne disease in Canada and the United States, caused by Borrelia burgdorferi, which affects multiple organ systems. Epidemiology, clinical presentation, and neuroimaging findings are reviewed.
Thu Oct 31, 2019 15:57
A recent study, carried out in rats, investigates which neural pathways and neurotransmitters might play a role in impulsive behavior.
Thu Oct 31, 2019 16:00
Acute cerebellar ataxia is a disorder in children that causes a loss of coordination and movement control. Learn about the causes and treatments in this article.
Thu Oct 31, 2019 08:00
Feeling dizzy after a workout is sometimes a sign that a person has overexerted themselves, is dehydrated, or has low blood pressure. Learn more about these and other causes in this article.
Thu Oct 31, 2019 04:00
Residual sensorimotor deficits are common following stroke. While it has been demonstrated that targeted practice can result in improvements in functional mobility years post stroke, there is little to support...
Tue Oct 29, 2019 02:00
Epilepsy affects nearly 1% of the world’s population. A third of epilepsy patients suffer from a kind of epilepsy that cannot be controlled by current medications. For those where surgery is not an option, neu...
Tue Oct 29, 2019 02:00
Accurate measurement of physical behaviour is paramount to better understand lifestyle, health, and functioning, particularly in adults with physical disability as they may be at higher risk of sedentary lifes...
Tue Oct 29, 2019 02:00
Abstract Purpose of Review Defective cell–mediated immunity is a major risk factor for cryptococcosis, a fatal disease if untreated. Cryptococcal meningitis (CM), the main presentation of disseminated disease, occurs through hematogenous spread to the brain from primary pulmonary foci, facilitated by yeast virulence factors. We revisit remarkable recent improvements in the prevention, diagnosis and management of CM. ...
Thu Oct 31, 2019 02:00
Publication date: November 2019Source: Clinical Neurology and Neurosurgery, Volume 186Author(s):
Thu Oct 31, 2019 12:48
Publication date: Available online 31 October 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Zhihong Li, Feifei Xu, Yuqian Li, Runfeng Wang, Zhiguo Zhang, Yan QuAbstractObjectivesintracranial pressure (ICP) monitoring has now been a standard technique for the treatment of severe traumatic brain injury (sTBI), while the effect of ICP monitoring for moderate traumatic brain injury (mTBI) is not clear. Moreover, evidence comparing the two types of ICP monitoring: ventricular drainage (VD)...
Thu Oct 31, 2019 12:48
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