Journal of Cutaneous Medicine and Surgery, Ahead of Print. BackgroundMalignant neoplasms of the auricle make up 6% of all skin cancers. Management of cutaneous neoplasms of the conchal bowl presents a unique challenge in visualizing and defining margins that may extend into the external auditory canal (EAC).ObjectivesThe objective of this study was to create a multidisciplinary pathway for cutaneous carcinoma of the conchal bowl extending into the EAC.MethodsWe present a series of patients that were...
Tue Nov 19, 2019 03:48
Abstract The consequences of Spanish colonial/capitalist intrusions in highland Guatemala are an emerging focus of archaeological investigation. While providing insight into the entanglements between colonialism and capitalism and their effects on Maya communities, it is critical not to fixate only on extractive and exploitative labor regimes to the exclusion of other patterns of practice and production central to the experience of people in the past. In our analyses, a singular...
Tue Nov 19, 2019 02:00
Identification errors between closely related, co-occurring, species may lead to misdirected social interactions such as costly interbreeding or misdirected aggression. This selects for divergence in traits involved in species identification among co-occurring species, resulting from character displacement. On the other hand, predation may select for crypsis, potentially leading co-occurring species that share the same environment and predators to have a similar appearance. However, few studies have...
Tue Nov 19, 2019 02:00
ObjectivesTo examine the relationship between adverse childhood experiences (ACEs), workplace bullying victimisation and bullying behaviours to subordinates among Japanese workers.MethodsWe conducted an internet-based cross-sectional survey among workers who had enacted 0, 1 and ≥2 types of bullying behaviours that had been directed towards subordinates in the past 3 years (n=309 for each group, total N=927). We assessed ACEs with questionnaires about adverse experiences at home and bullying victimisation...
Tue Nov 19, 2019 19:00
Tue Nov 19, 2019 02:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b09643
Tue Nov 19, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b07974
Tue Nov 19, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b08357
Tue Nov 19, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b08415
Tue Nov 19, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b11261
Tue Nov 19, 2019 07:00
Photoresponsive materials that degrade, expand, change shape, or alter their microscopic topology in response to light have been studied for a wide range of applications. Such materials are typically in a metastable state during irradiation and return to their pre‐irradiated state after removal of the light source. Strategies for the synthesis of materials that can reversibly photoswitch between two or more stable states, remaining in each state until a different stimulus is applied, could find applications...
Tue Nov 19, 2019 17:12
Pd‐catalyzed sequences involving oxidative addition, cyclization, and termination through intermolecular nucleophile capture have tremendous utlity. Indeed, they can generate a plethora of different polycyclic structures possessing a diverse range of functionality. However, one area of deficiency for Pd(0)/Pd(II) variants is the ability to conclude them with oxygen‐based species. Inspired by the recent discovery of one such reaction in the course of a total synthesis program, we delineate herein...
Tue Nov 19, 2019 16:30
A base‐catalyzed protocol that enables a stereoselective 1,1‐silaboration of terminal alkynes is described. This method does not only offer a new strategy to functionalize simple and readily accessible alkynes beyond 1,2‐difunctionalization events, but also provides an unconventional atom‐ and step‐economical approach to rapidly and reliably access versatile geminal silylboranes in the absence of transition metals with an exquisite stereoselectivity pattern
Tue Nov 19, 2019 16:29
Thiostrepton is a potent antibiotic against a broad range of Gram‐positive bacteria, but its medical applications have been limited by its poor aqueous solubility. In this work, the first C(sp2)–H amidation of dehydroalanine (Dha) residues was applied to the site selective modification of thiostrepton to prepare a variety of derivatives. Unlike all prior methods for the modification of thiostrepton, the alkene framework of the Dha residue is preserved and with complete selectivity for the Z‐stereoisomer....
Tue Nov 19, 2019 16:25
Studies on passivating oxides on liquid metals are challenging, in part, due to plasticity, entropic, and technological limitations. In alloys, compositional complexity in the passivating oxide(s) and underlying metal interface exacerbates these challenges. This nanoscale complexity, however, offers an opportunity to engineer the surface of the liquid metal under felicitous choice of processing conditions. We inferred that difference in reactivity, coupled with inherent interface ordering, presages...
Tue Nov 19, 2019 16:06
Abstract Purpose Spasticity of the first web space is common in upper limb spasticity. Selective neurectomy is one of the treatments that can reduce spasticity. The purpose of this study was to describe the variations of the deep motor branch of the ulnar nerve for the adductor pollicis (AP) and the first dorsal interosseous muscle (DIO) to assess the feasibility of selective neurectomy and suggest an ideal surgical approach. ...
Tue Nov 19, 2019 02:00
Researchers have discovered striking variation in the underlying genetic machinery that orchestrates sexual differentiation in frogs, demonstrating that evolution of this crucial biological system has moved at a dramatic pace.
Tue Nov 19, 2019 17:54
Publication date: Available online 18 November 2019Source: Behavioural Brain ResearchAuthor(s): Ying Shangguan, Jianghong Han, Haisheng SuAbstractIschemic stroke (IS) caused by cerebral arterial embolism remains the leading cause of disability and death worldwide. Cerebral ischemia / reperfusion (CI / R) injury is one of the common complications of ischemic stroke. Growth arrest specific transcript 5 (GAS5) has been found to be abnormally expressed in various tumors. However, the role and potential...
Tue Nov 19, 2019 17:46
The cancer stem cell model is considered as a putative cause of resistance to chemotherapy and disease recurrence in malignant tumors. In this study, we tested the hypothesis that the response to neoadjuvant/perioperative chemotherapy correlates with the expression of four different putative cancer stem cell markers of gastric cancer (GC), i.e., LGR5, FZD7, TROY, and MIST1. The expression of LGR5, FZD7, TROY, and MIST1 was assessed by immunohistochemistry in 119 perioperatively treated GCs including...
Tue Nov 19, 2019 17:05
Publication date: January 2020Source: Magnetic Resonance Imaging, Volume 65Author(s):
Tue Nov 19, 2019 17:10
Publication date: January 2020Source: Neoplasia, Volume 22, Issue 1Author(s): Lisandra Muñoz-Hidalgo, Teresa San-Miguel, Javier Megías, Daniel Monleón, Lara Navarro, Pedro Roldán, Miguel Cerdá-Nicolás, Concha López-GinésAbstractGlioblastoma (GBM) is the most common malignant primary tumor of the central nervous system. With no effective therapy, the prognosis for patients is terrible poor. It is highly heterogeneous and EGFR amplification is its most frequent molecular alteration.In this light, we...
Tue Nov 19, 2019 16:25
Publication date: January 2020Source: Neoplasia, Volume 22, Issue 1Author(s): Weiqing Shao, Wenwei Zhu, Jing Lin, Mengjun Luo, Zhifei Lin, Lu Lu, Huliang Jia, Lunxiu Qin, Ming Lu, Jinhong ChenAbstractSorafenib is the first approved systemic therapy for advanced hepatocellular carcinoma (HCC) and is the first-line choice in clinic. Sustained activation of receptor tyrosine kinases (RTKs) is associated with low efficacy of sorafenib in HCC. Activation of liver X receptor (LXR) has been reported to...
Tue Nov 19, 2019 16:25
Abstract Objective Typical primary care practices are often not equipped to meet the medical, developmental or social needs of infants discharged from a neonatal intensive care unit (NICU). These needs are exacerbated for infants and caregivers residing in poverty. This article discusses a multidisciplinary, family-centered medical home designed to address the needs of this special population. ...
Tue Nov 19, 2019 02:00
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Tue Nov 19, 2019 02:00
Abstract There has been a move towards a criterion-based return to play in recent years, with 4 single-leg hop tests commonly used to assess functional performance. Despite their widespread integration, research indicates that relationships between ‘passing’ ‘hop test criteria and successful outcomes following rehabilitation are equivocal, and, therefore, require further investigation. This critical review includes key information to examine the evolution of these tests, their...
Tue Nov 19, 2019 02:00
Abstract Rating of perceived effort (RPE) scales are the most frequently used single-item scales in exercise science. They offer an easy and useful way to monitor and prescribe exercise intensity. However, RPE scales suffer from methodological limitations stemming from multiple perceived effort definitions and measurement strategies. In the present review, we attend these issues by covering (1) two popular perceived effort definitions, (2) the terms included within these definitions...
Tue Nov 19, 2019 02:00
In species with sexual reproduction, no two individuals are alike and scientists have long struggled to understand why there is so much genetic variation. A new study shows that a genetic tug-of-war between the sexes acts to maintain variation.
Mon Nov 18, 2019 18:53
New research has found that the genetic diversity of the koloa is high, and conservation efforts on the island of Kauai have been successful.
Mon Nov 18, 2019 14:25
Background. Gastric cancer (GC) has a poor prognosis due to the lack of ideal tumor markers. Circular RNAs (circRNAs) are a novel type of noncoding RNA related to the occurrence of GC. Among our research, we investigated the role of hsa_circ_0005556 in GC. Materials and Methods. The expression of hsa_circ_0005556 of 100 paired GC tissues and adjacent normal tissues was detected using quantitative reverse transcription-polymerase chain reaction (qRT-PCR). A receiver operating characteristic (ROC)...
Tue Nov 19, 2019 14:05
Related ArticlesThe association between oral candidiasis and severity of chemoradiotherapy-induced dysphagia in head and neck cancer patients: A retrospective cohort study. Clin Transl Radiat Oncol. 2020 Jan;20:13-18 Authors: Saito H, Shodo R, Yamazaki K, Katsura K, Ueki Y, Nakano T, Oshikane T, Yamana N, Tanabe S, Utsunomiya S, Ohta A, Abe E, Kaidu M, Sasamoto R, Aoyama H Abstract Background and purpose: Concurrent chemoradiotherapy (CCRT) for head...
Tue Nov 19, 2019 16:05
Related ArticlesComparative study of nasal septal retainer and nasal packing in patients undergoing septoplasty. Eur Arch Otorhinolaryngol. 2019 Aug;276(8):2251-2257 Authors: Fang S, Wei X, Ying L, Zhu L, Cui J, Ma Z, Wang W Abstract PURPOSE: Nasal packing is frequently used after septoplasty and some complications caused by nasal packing are unavoidable. A nasal septal retainer has recently been developed. We evaluated the safety and clinical efficacy...
Tue Nov 19, 2019 14:09
Related ArticlesBayesian Analysis of Three-Parameter Frechet Distribution with Medical Applications. Comput Math Methods Med. 2019;2019:9089856 Authors: Abbas K, Abbasi NY, Ali A, Khan SA, Manzoor S, Khalil A, Khalil U, Khan DM, Hussain Z, Altaf M Abstract The medical data are often filed for each patient in clinical studies in order to inform decision-making. Usually, medical data are generally skewed to the right, and skewed distributions can be...
Tue Nov 19, 2019 14:09
Related ArticlesLateral pharyngotomy. Eur Ann Otorhinolaryngol Head Neck Dis. 2019 Apr;136(2):135-140 Authors: Laccourreye O, Villeneuve A, Rubin F, Holsinger FC Abstract Based on a review of the medical literature, the authors document the key technical points, variants, technical errors to avoid and main functional results of lateral pharyngotomy for resection of cancers originating from the lateral oro and/or hypopharynx.PMID: 30482706 [PubMed -...
Tue Nov 19, 2019 14:09
Related ArticlesA comparison of systemic and local dexamethasone administration: From perilymph/cochlea concentration to cochlear distribution. Hear Res. 2018 12;370:1-10 Authors: Wang Y, Han L, Diao T, Jing Y, Wang L, Zheng H, Ma X, Qi J, Yu L Abstract Different types of inner ear diseases can damage different cochlear subsites by different mechanisms. Steroids administered by different methods are commonly used for treating inner ear diseases. There...
Tue Nov 19, 2019 14:09
Hybrid zones, where phenotypically distinct populations meet and interbreed, give insight into how differences between populations are maintained despite gene flow. Divergence in quantitative traits, controlled by multiple loci, may require stronger barriers to gene flow than traits controlled by few, major effect loci. The butterflies Heliconius erato and Heliconius melpomene are distantly related Mullerian mimics that show parallel divergence in wing colour patterns between geographical races across...
Tue Nov 19, 2019 02:00
Mammals progress through similar physiological stages during life, from early development to puberty, aging, and death. Yet, the extent to which this conserved physiology reflects conserved molecular events is unclear. Here, we map common epigenetic changes experienced by mammalian genomes as they age, focusing on evolutionary comparisons of humans to dogs, an emerging model of aging. Using targeted sequencing, we characterize the methylomes of 104 Labrador retrievers spanning a 16 year age range,...
Tue Nov 19, 2019 02:00
Aims. Early detection of patients at high risk for progressive acute kidney injury (AKI) after cardiac surgery remains a major challenge. We aim to evaluate the utility of urinary matrix metalloproteinase-7 (uMMP-7) and other reported biomarkers for predicting AKI progression during postoperative hospital stay. Methods. We conducted a prospective, multicenter cohort study in 121 adult patients with stage 1 or 2 AKI after cardiac surgery. uMMP-7 and other well-reported biomarkers (uIL-18, uNGAL, and...
Tue Nov 19, 2019 12:05
Background. Geriatric Nutritional Risk Index (GNRI) has been widely used to assess the nutritional status in a variety of human pathological conditions, but the prognostic value of the GNRI in malignancies has not been evinced. Methods. Relevant studies updated on Jul 27, 2019, were retrieved in available databases, including PubMed, Web of Science, Cochrane library, Chinese CNKI, and Chinese Wan-fang. Hazard ratios (HRs) and 95% confidence intervals (CIs) were extracted and pooled by using STATA...
Tue Nov 19, 2019 12:05
Cancer Informatics, Volume 18, Issue , January-December 2019. To fully support their role in translational and personalized medicine, biorepositories and biobanks must continue to advance the annotation of their biospecimens with robust clinical and laboratory data. Translational research and personalized medicine require well-documented and up-to-date information, but the infrastructure used to support biorepositories and biobanks can easily be out of sync with the host institution. To assist researchers...
Tue Nov 19, 2019 08:18
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