We explored the performance of three machine learning tools designed to facilitate title and abstract screening in systematic reviews (SRs) when used to (a) eliminate irrelevant records (automated simulation) ...
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Web applications that employ natural language processing technologies to support systematic reviewers during abstract screening have become more common. The goal of our project was to conduct a case study to e...
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Compromised natural killer (NK) cell cytotoxic function is a well-documented and consistent feature of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Other outcomes evaluated in NK cells of ME/CF...
Thu Nov 14, 2019 02:00
Presentation of Case. Dr. Joshua Salvi (Medicine): A 66-year-old man with a history of pancytopenia was transferred to this hospital in the winter for evaluation of pancytopenia and rash. The patient had been well until 1 year before admission, when episodic fevers began to occur. Approximately 3…
Thu Nov 14, 2019 02:00
Abstract Beamformer is one of the most important components in ultrasound imaging system. The delay and sum (DAS) beamforming algorithm has been widely used in recent decades due to its simplicity and robustness. However, it has poor impact on resolution and contrast. A new beamformer named filtered delay multiply and sum (F-DMAS) which was an alternative of delay multiply and sum (DMAS) was proposed to overcome these shortcomings of DAS. Although F-DMAS partially enhances the...
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Abstract Since introducing optical coherence tomography (OCT) technology for 2D eye imaging, it has become one of the most important and widely used imaging modalities for the noninvasive assessment of retinal eye diseases. Age-related macular degeneration (AMD) and diabetic macular edema eye disease are the leading causes of blindness being diagnosed using OCT. Recently, by developing machine learning and deep learning techniques, the classification of eye retina diseases using...
Thu Nov 14, 2019 02:00
Abstract Objective To describe trends in incidence rates of adenoidectomy in children in Denmark from 1998‐2014 and to look for possible explanatory factors such as intranasal steroids and pneumococcal vaccination. Design A nationwide, population‐based, retrospective, interrupted time‐series analysis, using data from Danish registries. Setting Hospitals and private Ear, Nose, and Throat‐clinics. Participants Children who underwent adenoidectomy from 1998‐2014 in Denmark. ...
Thu Nov 14, 2019 22:39
Exposure to diesel exhaust particles (DEPs) has been associated with increased incidence of cardiopulmonary diseases. This study is aimed at examining the proinflammatory effects of DEP on primary human peripheral blood mononuclear cells (PBMC) and the underlying mechanisms using a human mononuclear cell line, THP-1. DEPs were incubated with the PBMC and THP-1 cells for 24 h, respectively. The supernatants were collected and subjected to measurement of proinflammatory mediators including interleukin...
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Abstract Bacteria modulate their physiological behavior by responding to various signal molecules. The signals are received by cognate receptors, which usually mediate transcriptional regulation. Streptomyces employ γ-butyrolactones (GBLs) and cognate GBL receptors (GblRs) to regulate secondary metabolism and morphological development. However, there are additional transcriptional regulators called pseudo GblR regulators, which cannot bind GBLs and are not directly associated with...
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The original version of this article contains error for some of the authors corrections were not included during correction stage
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Abstract Gut microbiome critically contributes to host health status. Thus, investigating the relationship between the gut microbiome and toxic chemicals is a hot topic in toxicology research. Exposure to malachite green (MG) has been linked to various health disorders. Thus, exploring the gut microbiota changes in response to MG would provide a new perspective on the toxicity effects of this chemical substance. MG exposure resulted in the significantly lower alpha diversity (Mann–Whitney...
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Abstract Surfactants not only are widely used in biotechnological processes but also constitute significant contaminants of the modern world. Among many reports, there is a shortage of works which summarize the issue of surfactant sorption to biomass in a way that would elucidate the biological factors for analysts and analytical factors for microbiologists. The main factor, which is not as obvious as one would expect, is associated with the susceptibility of analytical approaches...
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Abstract The most wide-spread “hostile” environmental factor for marine microorganisms is low temperature, which is usually accompanied by high hydrostatic pressure (HHP). Metabolic mechanisms of marine microorganisms adapting to prolonged low temperature under HHP remain to be clarified. To reveal the underlying metabolic mechanisms, we performed NMR-based metabolomic analysis of aqueous extracts derived from a psychrotolerant Microbacterium sediminis YLB-01, which was isolated...
Thu Nov 14, 2019 02:00
Soft Robotics, Ahead of Print.
Thu Nov 14, 2019 10:00
Surgical Infections, Ahead of Print.
Thu Nov 14, 2019 10:00
Abstract Mentorship plays a critical role in the success of academic radiologists. Faculty members with mentors have better career opportunities, publish more papers, receive more research grants, and have greater overall career satisfaction. However, with the increasing focus on clinical productivity, pressure on turn-around times, and the difficult funding climate, effective mentoring in academic radiology can be challenging. The high prevalence of “burnout” among radiologists...
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As developmental biologists in the age of genome editing, we now have access to an ever-increasing array of tools to manipulate endogenous gene expression. The auxin-inducible degradation system allows for spatial and temporal control of protein degradation via a hormone-inducible Arabidopsis F-box protein, transport inhibitor response 1 (TIR1). In the presence of auxin, TIR1 serves as a substrate-recognition component of the E3 ubiquitin ligase complex SKP1-CUL1-F-box (SCF), ubiquitinating auxin-inducible...
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The breeds of domestic dog, Canis lupus familiaris, display a range of coat types with variation in color, texture, length, curl, and growth pattern. One trait of interest is that of partial or full hairlessness, which is found in a small number of breeds. While the standard for some breeds, such as the Xoloitzcuintli, requires sparse hair on their extremities, others are entirely bald, including the American Hairless Terrier. We identified a small, rare family of Scottish Deerhounds in which coated...
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By shaping meiotic recombination, chromosomal inversions can influence genetic exchange between hybridizing species. Despite the recognized importance of inversions in evolutionary processes such as divergence and speciation, teasing apart the effects of inversions over time remains challenging. Many recent studies have examined gene exchange between hybridizing species and observed higher divergence associated with inversion polymorphisms in hybrids. Studies have attributed such patterns either...
Thu Nov 14, 2019 02:00
Plants and their specialized flower visitors provide valuable insights into the evolutionary consequences of species interactions. In particular, antagonistic interactions between insects and plants have often been invoked as a major driver of diversification. Here we use a tropical community of palms and their specialized insect flower visitors to understand whether antagonisms lead to higher population divergence. Interactions between the palms Syagrus coronata and Syagrus botryophora and the weevils...
Thu Nov 14, 2019 02:00
Macroevolutionary and biogeography studies commonly apply multiple models to test state-dependent diversification. These models track the association between states of interest along a phylogeny, but many of them do not consider whether different clades might be evolving under different evolutionary drivers. Yet, they are still commonly applied to empirical studies without careful consideration of possible lineage diversification heterogeneity along the phylogenetic tree. A recent biogeographic study...
Thu Nov 14, 2019 02:00
Male genitalia are thought to ensure transfer of sperm through direct physical contact with female during copulation. Such primary sexual traits were also observed to affect pre-copulatory female mate-choice in some Vertebrates species, but whether this also occurs in insects is unknown. Males of the fruitfly Drosophila pachea have a pair of asymmetric external genital lobes, which are primary sexual structures and stabilize the copulatory complex of female and male genitalia. We tested for a pre-copulatory...
Thu Nov 14, 2019 02:00
Abstract In the present study, we compared estimates of split renal function (SRF) in paediatric patients of various diagnostic subgroups by 99mTc-dimercaptosuccinic acid (DMSA) scintigraphy using either geometric mean (GM) based on planar scans or a volume of interest (VOI)-based analysis on single photon emission tomography combined with low-dose CT (SPECT/ldCT). Two experienced physicians blinded to patient diagnosis retrospectively analysed all paediatric...
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Abstract Objectives Aim of the present analysis is to investigate the biodistribution and pharmacokinetics of the recently clinically introduced radioligand 18F-PSMA-1007 in patients with biochemical recurrence or progression of prostate cancer (PC) by means of multiparametric (dynamic and whole-body) PET/CT. Methods Twenty-five (25) patients with PC biochemical...
Thu Nov 14, 2019 02:00
Abstract Purpose To assess the predictive power of pre-therapy 18F-FDG PET/CT-based radiomic features for epidermal growth factor receptor (EGFR) mutation status in non-small cell lung cancer. Methods Two hundred and forty-eight lung cancer patients underwent pre-therapy diagnostic 18F-FDG PET/CT scans and were tested for genetic mutations. The LIFEx package...
Thu Nov 14, 2019 02:00
Mucosal Immunology, Published online: 14 November 2019; doi:10.1038/s41385-019-0222-9Single-cell TCR sequencing of gut intraepithelial γδ T cells reveals a vast and diverse repertoire in celiac disease
Thu Nov 14, 2019 02:00
Thu Nov 14, 2019 02:00
Facial plast SurgDOI: 10.1055/s-0039-3399577We investigated the sonoelastographic features of the lower lateral nasal cartilage lateral crus (LLNC-LC), auricular conchal cartilage (ACC), and costal cartilage (CC). In this prospective study, group 1 consisted of 60 participants (30 males and 30 females) between 18 and 35 years of age. Group 2 consisted of 60 participants (30 males and 30 females) between 35 and 50 years of age. Strain elastography (SE) and shear wave elastography (SWE) were performed....
Thu Nov 14, 2019 01:00
Purpose: The aim of this study was to examine the endoscopic anatomy of the valve of Rosenmüller in real-time and its potential functional implications. Methods: High-definition endoscopic documentation of the valve of Rosenmüller (VOR) during 50 powered endoscopic dacryocystorhinostomy over a period of 2 years were reviewed. The presence or absence of the valves were assessed and when present, each of the valves were studied for their anatomical configuration, shape, precise location, and...
Wed Nov 06, 2019 02:00
Journal Name: Journal of Pediatric Endocrinology and MetabolismIssue: Ahead of print
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Journal Name: Journal of Pediatric Endocrinology and MetabolismIssue: Ahead of print
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Journal Name: Journal of Pediatric Endocrinology and MetabolismIssue: Ahead of print
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Natural genetic engineering allowed plants to move from water to land, according to a new study.
Thu Nov 14, 2019 18:59
Researchers have cultivated lifelike chemical reactions while pioneering a new strategy for studying the origin of life.
Thu Nov 14, 2019 19:40
An international team of scientists working with Heliconius butterflies in Panama was faced with a mystery: how do pairs of unrelated butterflies from Peru to Costa Rica evolve nearly the same wing-color patterns over and over again? The answer forever changes the way evolution is understood.
Thu Nov 14, 2019 18:59
Scientists have unraveled the genetic mechanisms behind tiny waterfleas' ability to adapt to increased levels of phosphorus pollution in lakes.
Thu Nov 14, 2019 03:13
Intra-individual stable but inter-individually variable behaviours, i.e. personalities, are commonly reported across diverse animal groups, yet the reasons for their maintenance remain controversial. Therefore...
Thu Nov 14, 2019 02:00
Journal Name: Biological ChemistryIssue: Ahead of print
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Journal Name: Biological ChemistryIssue: Ahead of print
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