Proteomic research in sarcomas - current status and future opportunities. Semin Cancer Biol. 2019 Nov 10;: Authors: Burns J, Wilding CP, L Jones R, H Huang P Abstract Sarcomas are a rare group of mesenchymal cancers comprising over 70 different histological subtypes. For the majority of these diseases, the molecular understanding of the basis of their initiation and progression remains unclear. As such, limited clinical progress in prognosis or therapeutic...
Thu Nov 14, 2019 16:17
Germ Cell Tumors in Dysgenetic Gonads. Clinics (Sao Paulo). 2019;74:e408 Authors: Piazza MJ, Urbanetz AA Abstract This review describes the germ cell neoplasms that are malignant and most commonly associated with several types of gonadal dysgenesis. The most common neoplasm is gonadoblastoma, while others including dysgerminomas, yolk-sac tumors and teratomas are rare but can occur. The purpose of this review is to evaluate the incidences of these abnormalities...
Thu Nov 14, 2019 16:17
Retrospective analysis of treatment and prognosis for uterine leiomyosarcoma: 10-year experience of a single institute. Asia Pac J Clin Oncol. 2019 Nov 12;: Authors: Kodama K, Sonoda K, Kijima M, Yamaguchi S, Yagi H, Yasunaga M, Ohgami T, Onoyama I, Kaneki E, Okugawa K, Yahata H, Ohishi Y, Oda Y, Kato K Abstract AIM: Uterine leiomyosarcoma (ULMS) is a highly aggressive and lethal disease. This malignancy remains the most common type of uterine sarcoma,...
Thu Nov 14, 2019 16:17
Granular cell tumor of the trachea as a rare cause of dyspnea in a young woman. Respir Med Case Rep. 2019;28:100961 Authors: Rizzo A, Serban ED, Ricci AD, Nannini M, Saponara M, Cancellieri A, Paioli D, Trisolini R, Pantaleo MA Abstract Tracheal granular cell tumors are rare neurogenic neoplasms characterized by an indolent behavior. We report the case of a young woman affected by this tumor with non-specific clinical presentation. We performed a literature...
Thu Nov 14, 2019 16:17
Molecular characterization of a second myeloid neoplasm developing after treatment for acute myeloid leukemia. Leukemia. 2019 Nov 12;: Authors: Hartmann L, Nadarajah N, Meggendorfer M, Höllein A, Vetro C, Kern W, Haferlach T, Haferlach C, Stengel A Abstract Therapy-related myeloid neoplasms (tMN) following successful treatment of acute myeloid leukemia (AML) are rare and poorly characterized. To evaluate the presence of a common ancestral clone, we performed...
Thu Nov 14, 2019 16:17
Penetrance of different cancer types in families with Li-Fraumeni syndrome: a validation study using multi-center cohorts. Cancer Res. 2019 Nov 12;: Authors: Shin SJ, Dodd-Eaton EB, Peng G, Bojadzieva J, Chen J, Amos CI, Frone MN, Khincha P, Mai PL, Savage SA, Ballinger ML, Thomas DM, Yuan Y, Strong LC, Wang W Abstract Li-Fraumeni syndrome (LFS) is a rare hereditary cancer syndrome associated with an autosomal dominant mutation inheritance in the TP53...
Thu Nov 14, 2019 16:17
Penetrance estimates over time to first and second primary cancer diagnosis in families with Li-Fraumeni syndrome: a single institution perspective. Cancer Res. 2019 Nov 12;: Authors: Shin SJ, Dodd-Eaton EB, Gao F, Bojadzieva J, Chen J, Kong X, Amos CI, Ning J, Strong LC, Wang W Abstract Li-Fraumeni syndrome (LFS) is a rare autosomal dominant disorder associated with TP53 germline mutations and an increased lifetime risk of multiple primary cancers (MPC)....
Thu Nov 14, 2019 16:17
Rare entities in head-and-neck cancer: salvage re-irradiation with carbon ions. Radiat Oncol. 2019 Nov 12;14(1):202 Authors: Held T, Windisch P, Akbaba S, Lang K, Farnia B, Liermann J, Bernhardt D, Plinkert P, Freudlsperger C, Rieken S, Herfarth K, Debus J, Adeberg S Abstract BACKGROUND: The objective of this investigation is to evaluate the outcomes and toxicity of carbon-ion re-irradiation (CIR) in patients with rare head and neck cancers (HNC). There...
Thu Nov 14, 2019 16:17
Clinical manifestations and multi-slice computed tomography characteristics of solid pseudopapillary neoplasms of the pancreas between males and females. BMC Med Imaging. 2019 Nov 12;19(1):87 Authors: Shi S, Zhou Y, Hu C Abstract BACKGROUND: Solid-pseudo papillary neoplasms of pancreas (SPNP) are rare in men and are often misdiagnosed. This study aimed to analyze the clinical and multi-slice computer tomography (MSCT) features of patients with SPNP,...
Thu Nov 14, 2019 16:17
Current evidence on thyroid related adverse events in patients treated with protein tyrosine kinase inhibitors. Drug Metab Rev. 2019 Nov 13;:1-8 Authors: Gabora K, Piciu A, Bădulescu IC, Larg MI, Stoian IA, Piciu D Abstract Tyrosine kinase inhibitors (TKI) are gaining more ground in oncology, they are widely used in the treatment of multiple types of cancers; still important side effects limit their efficacy. The aim of this study is to evaluate the...
Thu Nov 14, 2019 16:17
Clinicopathologic Characteristics of HER2-positive Pure Mucinous Carcinoma of the Breast. J Pathol Transl Med. 2019 Nov 13;: Authors: Jang Y, Jung H, Kim HN, Seo Y, Alsharif E, Nam SJ, Kim SW, Lee JE, Park YH, Cho EY, Cho SY Abstract Background: Pure mucinous carcinoma (PMC) is a rare type of breast cancer, estimated to represent 2% of invasive breast cancer. PMC is typically positive for estrogen receptors (ER) and progesterone receptors (PR) and negative...
Thu Nov 14, 2019 16:17
High Clinical Value of Liquid Biopsy to Detect Circulating Tumor Cells and Tumor Exosomes in Pancreatic Ductal Adenocarcinoma Patients Eligible for Up-Front Surgery. Cancers (Basel). 2019 Oct 26;11(11): Authors: Buscail E, Alix-Panabières C, Quincy P, Cauvin T, Chauvet A, Degrandi O, Caumont C, Verdon S, Lamrissi I, Moranvillier I, Buscail C, Marty M, Laurent C, Vendrely V, Moreau-Gaudry F, Bedel A, Dabernat S, Chiche L Abstract PURPOSE: Expediting the...
Thu Nov 14, 2019 16:17
The New Genetic Landscape of Cushing's Disease: Deubiquitinases in the Spotlight. Cancers (Basel). 2019 Nov 08;11(11): Authors: Sbiera S, Kunz M, Weigand I, Deutschbein T, Dandekar T, Fassnacht M Abstract Cushing's disease (CD) is a rare condition caused by adrenocorticotropic hormone (ACTH)-producing adenomas of the pituitary, which lead to hypercortisolism that is associated with high morbidity and mortality. Treatment options in case of persistent...
Thu Nov 14, 2019 16:17
Influencers on Thyroid Cancer Onset: Molecular Genetic Basis. Genes (Basel). 2019 Nov 08;10(11): Authors: Luzón-Toro B, Fernández RM, Villalba-Benito L, Torroglosa A, Antiñolo G, Borrego S Abstract Thyroid cancer, a cancerous tumor or growth located within the thyroid gland, is the most common endocrine cancer. It is one of the few cancers whereby incidence rates have increased in recent years. It occurs in all age groups, from children through to seniors....
Thu Nov 14, 2019 16:17
Related ArticlesThe role of IL22 polymorphisms on liver cirrhosis in patients with hepatitis B virus: A case control study. Medicine (Baltimore). 2019 Nov;98(44):e17867 Authors: Gao YH, Li QQ, Wang CG, Sun J, Wang XM, Li YJ, He XT, Xu HQ, Niu JQ Abstract Glycogen storage disease (GSD) type IX, characterized by liver enlargement and elevated aminotransferase levels, is the most frequent type of GSD. The global incidence of GSD type IXa is only about 1/100,000...
Thu Nov 14, 2019 16:17
Related ArticlesCompressive peroneal neuropathy by an intraneural ganglion cyst combined with L5 radiculopathy: A case report. Medicine (Baltimore). 2019 Nov;98(44):e17865 Authors: Park SH, Do HK, Jo GY Abstract RATIONALE: Most cases of foot drop are known to result from lower motor neuron pathologies, particularly lumbar radiculopathy and peripheral neuropathy, including common peroneal neuropathy. To improve the prognosis of foot drop, it is important...
Thu Nov 14, 2019 16:17
Related ArticlesLaparoscopic simultaneous resection of bilateral giant primary mature retroperitoneal teratoma of the adrenal region: A case report. Medicine (Baltimore). 2019 Nov;98(44):e17836 Authors: Wang J, Zhang J, Xiao C, Fan C Abstract RATIONALE: Giant mature retroperitoneal teratoma of the adrenal region is quite rare in adults. In most cases, open adrenalectomy is required to ensure complete resection. We describe a case of bilateral giant primary...
Thu Nov 14, 2019 16:17
Related ArticlesHyperparathyroidism Due to Concurrent Parathyroid Carcinoma and Parathyroid Adenoma. Clin Nucl Med. 2019 Oct;44(10):844-847 Authors: Yang J, Li Y, Li J, Yang P, Huang L Abstract Parathyroid carcinoma is uncommon, and its coexistence with parathyroid adenoma is extremely rare. A 28-year-old woman with hyperparathyroidism underwent dual-phase Tc-sestamibi SPECT/CT scan for presurgical evaluation. The images showed intense activity inside...
Thu Nov 14, 2019 16:17
Related ArticlesClinical characteristics and treatment of 52 cases of phakomatosis pigmentovascularis. J Dermatol. 2019 Oct;46(10):843-848 Authors: Shin H, Kim YG, Kim YE, Park H Abstract Phakomatosis pigmentovascularis is a rare syndrome characterized by widespread capillary malformation and pigmented nevus. The objective of this study was to evaluate its characteristics and treatment. Fifty-two patients presenting between 2003 and 2017 were retrospectively...
Thu Nov 14, 2019 16:17
Related ArticlesTacrolimus ointment for the treatment of superficial kaposiform hemangioendothelioma and tufted angioma. J Dermatol. 2019 Oct;46(10):898-901 Authors: Zhang X, Yang K, Chen S, Ji Y Abstract Kaposiform hemangioendothelioma (KHE) and tufted angioma (TA) are rare infiltrative vascular tumors. Currently, no standard treatment regimens exist for KHE/TA. The purpose of our study was to evaluate the efficacy and safety of topical application...
Thu Nov 14, 2019 16:17
Related ArticlesLeptomeningeal Metastasis in Carotid Body Paraganglioma: Findings on 68Ga DOTANOC PET-CT. Clin Nucl Med. 2019 Oct;44(10):e583-e585 Authors: Tripathy S, Damle NA, Naranje P, Shamim SA, Tripathi M, Bal C Abstract Carotid body paragangliomas are mostly benign tumors with very rare propensity to metastasize to lymph nodes, bones, liver, and lungs. Leptomeningeal metastasis from a carotid body paraganglioma is a very rare phenomenon. We describe...
Thu Nov 14, 2019 16:17
Related Articles68Ga-Prostate-Specific Membrane Antigen Uptake in a Malignant Pleural Effusion From Metastatic Prostate Cancer After Pleurodesis. Clin Nucl Med. 2019 Oct;44(10):838-839 Authors: Sachpekidis C, Alberts I, Rominger A, Afshar-Oromieh A Abstract A 76-year-old man with metastatic adenocarcinoma of the prostate presented with increasing dyspnea. After being treated initially with drainage and afterwards with pleurodesis, he was referred for...
Thu Nov 14, 2019 16:17
Related ArticlesIsolated Small Bowel Metastasis From Gastric Cancer Detected by 18F-FDG PET/CT. Clin Nucl Med. 2019 Oct;44(10):840-841 Authors: Fan Q, Su M Abstract Small bowel metastasis is rare. Most patients are diagnosed after presenting serious complications. The primary tumors generally arise from breast, lung, and melanoma, but rarely from the stomach. Here we present a case of a gastric cancer patient with asymptomatic small bowel metastasis...
Thu Nov 14, 2019 16:17
Related ArticlesSafety of intralesional injection of lauromacrogol combined with triamcinolone for infantile hemangiomas. J Dermatol. 2019 Sep;46(9):770-776 Authors: Chai Y, Zhou Z, Song J, Lv R, Xu G, Bi J, Li X, Li Z, Huo R Abstract The efficacy of lauromacrogol injection therapy and intralesional triamcinolone for infantile hemangiomas (IH) has been well documented recently, but with an increase in serious or rare adverse reactions. The aim of this...
Thu Nov 14, 2019 16:17
Related ArticlesIncidental Detection of Ovarian Thecoma by 99mTc-MDP Whole-Body Bone Scan: Contribution of Hybrid SPECT/CT. Clin Nucl Med. 2019 Oct;44(10):e577-e578 Authors: Zhang L, He Q, Zhou T, Zhang R Abstract Ovarian thecoma is a benign and rare neoplasm that accounts for 0.5% to 1% of all ovarian tumors. A 55-year-old woman with known breast cancer underwent a metastatic workup before surgery. The Tc-MDP whole-body bone scan revealed intense uptake...
Thu Nov 14, 2019 16:17
Related ArticlesManaging Immuno-Oncology Toxicity: Top 10 Innovative Institutional Solutions. Am Soc Clin Oncol Educ Book. 2019 Jan;39:96-104 Authors: Cole S, Zibelman M, Bertino E, Yucebay F, Reynolds K Abstract Expanded use of immuno-oncology (IO) therapy to treat cancer has led to an increased frequency of novel toxicities known as immune-related adverse events (irAEs). Delayed recognition of IO toxicity can be life-threatening or even fatal. To address...
Thu Nov 14, 2019 16:17
Related ArticlesInternational Collaborations and Regional Challenges in Providing Specialist Multidisciplinary Sarcoma Care. Am Soc Clin Oncol Educ Book. 2019 Jan;39:616-623 Authors: Loong HH, Blay JY, Munhoz RR Abstract Sarcomas represent a highly heterogeneous group of malignancies of mesenchymal original that pose significant therapeutic challenges. Although surgery still represents the cornerstone of therapeutics for those amenable to treatment with...
Thu Nov 14, 2019 16:17
Related ArticlesThe forensic significance of pseudomesotheliomatous adenocarcinoma of the lung. Forensic Sci Med Pathol. 2019 Sep;15(3):458-462 Authors: Kennedy JM Abstract Pseudomesotheliomatous carcinomas (PMC) are rare tumors that clinically, macroscopically, and sometimes histologically resemble malignant pleural mesotheliomas. We report a case of a 91 year woman who was found to have diffuse nodular pleural thickening and a lung mass during a workup...
Thu Nov 14, 2019 16:17
Related ArticlesMelorheostosis with an associated para-articular enhancing soft tissue mass. Clin Imaging. 2019 Jul - Aug;56:9-12 Authors: Manning P, Nguyen TB, Smitaman E Abstract Melorheostosis is a rare non-hereditary sclerosing bone dysplasia which predominantly affects the appendicular skeleton. Although melorheostosis is typically recognized as an osseous lesion, associated soft-tissue components have been reported. Advanced imaging with MRI may...
Thu Nov 14, 2019 16:17
Related ArticlesPenile carcinoma - a rare cause of sudden death. Forensic Sci Med Pathol. 2019 Sep;15(3):506-508 Authors: Dobiáš M, Marecová K, Vránová K, Handlos P Abstract Penile carcinoma is an uncommon but potentially mutilating disease with a heterogeneous etiology. We present a case in which a man died due to severe blood loss from an amputated penis. It was initially regarded as a violent death with an external cause. Autopsy found irregular defects...
Thu Nov 14, 2019 16:17
Related ArticlesRelief of intractable pruritus with romidepsin in patients with cutaneous T-cell lymphoma: A series of four cases. Dermatol Ther. 2019 03;32(2):e12804 Authors: Poligone B, Rubio-Gonzalez B, Querfeld C Abstract Cutaneous T-cell lymphomas (CTCL) are a relatively rare and heterogeneous group of non-Hodgkin lymphomas that typically present in the skin. The majority of patients with CTCL experience pruritus, which can interfere with daily...
Thu Nov 14, 2019 16:17
Related ArticlesVitamin D pathway activation selectively deactivates signal transducer and activator of transcription (STAT) proteins and inflammatory cytokine production in natural killer leukemic large granular lymphocytes. Cytokine. 2018 11;111:551-562 Authors: Olson KC, Kulling Larkin PM, Signorelli R, Hamele CE, Olson TL, Conaway MR, Feith DJ, Loughran TP Abstract Calcitriol, the active form of vitamin D, has been well documented to act directly...
Thu Nov 14, 2019 16:17
Related ArticlesObturator hernia and the elderly. Forensic Sci Med Pathol. 2019 Sep;15(3):491-493 Authors: Gilbert JD, Byard RW Abstract An 84-year-old woman with a history of weight loss, anorexia and episodic vomiting was admitted to hospital where she died soon afterwards. Her diagnosis was acute renal injury due to dehydration and malnutrition. At autopsy the body was cachectic with a small intestinal obstruction due to herniation through a defect...
Thu Nov 14, 2019 16:17
Related ArticlesComplications after proctocolectomy and ileal pouch-anal anastomosis in pediatric patients: A systematic review. J Pediatr Surg. 2019 Jul;54(7):1331-1339 Authors: Drews JD, Onwuka EA, Fisher JG, Huntington JT, Dutkiewicz M, Nogalska A, Nwomeh BC Abstract BACKGROUND/PURPOSE: Colectomy with ileal pouch-anal anastomosis (IPAA) is the standard of care for patients with familial adenomatous polyposis (FAP) and refractory ulcerative colitis...
Thu Nov 14, 2019 16:17
Related ArticlesDysregulation of the endothelin pathway in lymphangioleiomyomatosis with no direct effect on cell proliferation and migration. Sci Rep. 2018 10 02;8(1):14698 Authors: Chebib N, Archer F, Bobet-Erny A, Leroux C, Cottin V Abstract LAM is a rare low-grade metastasizing lung neoplasm. Inhibitors of mTOR improve clinical outcome of LAM patients by preventing loss of lung function. Nevertheless, other cell targets may be of interest for drug...
Thu Nov 14, 2019 16:17
Related ArticlesFDA Supplemental Approval: Blinatumomab for Treatment of Relapsed and Refractory Precursor B-Cell Acute Lymphoblastic Leukemia. Oncologist. 2018 11;23(11):1366-1371 Authors: Pulte ED, Vallejo J, Przepiorka D, Nie L, Farrell AT, Goldberg KB, McKee AE, Pazdur R Abstract On July 11, 2017, the Food and Drug Administration granted approval for blinatumomab for the treatment of relapsed or refractory (R/R) precursor B-cell acute lymphoblastic...
Thu Nov 14, 2019 16:17
Related ArticlesSome findings on zero-inflated and hurdle poisson models for disease mapping. Stat Med. 2018 10 15;37(23):3325-3337 Authors: Corpas-Burgos F, García-Donato G, Martinez-Beneito MA Abstract Zero excess in the study of geographically referenced mortality data sets has been the focus of considerable attention in the literature, with zero-inflation being the most common procedure to handle this lack of fit. Although hurdle models have also...
Thu Nov 14, 2019 16:17
Related ArticlesEmbryonal Tumor with Multilayered Rosettes, C19MC-Altered: Clinical, Pathological, and Neuroimaging Findings. J Neuroimaging. 2018 09;28(5):483-489 Authors: Wang B, Gogia B, Fuller GN, Ketonen LM Abstract BACKGROUND AND PURPOSE: Embryonal tumor with multilayered rosettes (ETMR), C19MC-altered, is a recently described, rare central nervous system tumor. To our knowledge, the imaging findings of this tumor have not been systematically evaluated...
Thu Nov 14, 2019 16:17
Related ArticlesThree-dimensional Photogrammetric Analysis of Facial Soft-to-Hard Tissue Ratios After Bimaxillary Surgery in Facial Asymmetry Patients With and Without Sturge-Weber Syndrome. Ann Plast Surg. 2018 08;81(2):178-185 Authors: Kim SC, Kwon JG, Jeong WS, Lee JY, Kwon SM, Choi JW Abstract Sturge-Weber syndrome (SWS) is a rare neurocutaneous syndrome characterized by facial port-wine stains. Most patients with facial asymmetry due to SWS have...
Thu Nov 14, 2019 16:17
Related ArticlesQuantitative Proteomics Analysis of Sporadic Medullary Thyroid Cancer Reveals FN1 as a Potential Novel Candidate Prognostic Biomarker. Oncologist. 2018 12;23(12):1415-1425 Authors: Zhan S, Li J, Wang T, Ge W Abstract BACKGROUND: Sporadic medullary thyroid cancer (MTC) is a rare neuroendocrine tumor. Currently, although the diagnosis of sporadic MTC is relatively simple, the need to discover novel candidate prognostic biomarkers for sporadic...
Thu Nov 14, 2019 16:17
Related ArticlesLong-Term Survival Rates of Patients with Stage III-IV Hodgkin Lymphoma According to Age, Sex, Race, and Socioeconomic Status, 1984-2013. Oncologist. 2018 11;23(11):1328-1336 Authors: Li Y, Sun H, Yan Y, Sun T, Wang S, Ma H Abstract BACKGROUND: Long-term survival rates for patients with stage III-IV Hodgkin lymphoma, or advanced Hodgkin lymphoma (aHL), have increased substantially since the 1960s. Because large-scale research of aHL is...
Thu Nov 14, 2019 16:17
Related ArticlesA Rare Cause of Progressive Constipation, Abdominal Distension, and Weight Loss. Clin Gastroenterol Hepatol. 2018 12;16(12):e126-e127 Authors: Vijayvargiya P, Anderson B, Nehra V PMID: 29246700 [PubMed - indexed for MEDLINE]
Thu Nov 14, 2019 16:17
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