Summary Background It would be useful to have criteria for predicting long-term treatment responses to immune checkpoint inhibitors (ICIs). Maximum depth of response correlates with treatment outcomes among patients receiving programmed death protein 1 axis inhibitors for non-small cell lung cancer (NSCLC). We investigated associations between early depth of response and survival outcomes among patients receiving nivolumab for NSCLC. Methods Using records from prospective observational...
Thu Nov 14, 2019 12:05
Summary Pentagamaboronon-0 (PGB-0), a curcumin analog compound, has been synthesized as a candidate of boron-carrier pharmaceutical (BCP) for boron neutron capture therapy (BNCT); however, this compound is poorly soluble in water. To improve its solubility, aqueous formulations of PGB-0 with a monosaccharide, fructose or sorbitol, were successfully synthesized, namely PGB-0-F and PGB-0-So, respectively. The cytotoxicity study showed that PGB-0-F and PGB-0-So exerted low cytotoxicity...
Thu Nov 14, 2019 12:05
Summary Background Gastric cancer (GC) is the second most common cause of cancer-related death worldwide. Novel anticancer drugs against gastric cancer are urgently needed. Methods Compound 10 was designed and synthesized via a molecular hybridization strategy based on the natural product formononetin. It was evaluated for their antiproliferative activity against three gastric cancer cell lines (SGC7901, MKN45 and MGC803). Results Derivative 10 displayed potently antiproliferative...
Thu Nov 14, 2019 12:05
Publication date: Available online 14 November 2019Source: Behavioural Brain ResearchAuthor(s): Mehdi Moslemi, Fariba Khodagholi, Sareh Asadi, Shahrbanoo Rafiei, Fereshteh MotamediAbstractLearning and memory impairment manifests years before the onset of motor impairments in Huntington’s disease (HD). Oxytocin (OXT), as a neurohypophyseal neuropeptide has a key role in both learning and memory. Hence, we investigated possible protective effect of OXT on instrumental fear conditioning memory impairment...
Thu Nov 14, 2019 12:02
Publication date: Available online 14 November 2019Source: Behavioural Brain ResearchAuthor(s): Carollina Da Ré, Jéssica Maria Souza, Fernanda Fróes, Jéssica Taday, João Paulo dos Santos, Letícia Rodrigues, Patrícia Sesterheim, Carlos Alberto Gonçalves, Marina Concli Leite, Patrícia Sesterheim, Carlos Alberto Gonçalves, Marina Concli LeiteAbstractPeripheral inflammation promotes immune-to-brain communication, mediated by cytokines that affect brain activity. Lipopolysaccharide (LPS) has been widely...
Thu Nov 14, 2019 12:02
Publication date: Available online 13 November 2019Source: Behavioural Brain ResearchAuthor(s): Telma C. Bernardo, Jorge Beleza, David Rizo-Roca, Estela Santos-Alves, Cláudia Leal, Maria João Martins, António Ascensão, José MagalhãesAbstractPhysical exercise has proven to be beneficial to mitigate several deleterious effects associated with neurodegenerative diseases, including Alzheimer’s Disease (AD). Here, we investigated the role of long-term exercise as a preventive and therapeutic tool against...
Thu Nov 14, 2019 12:02
Publication date: Available online 13 November 2019Source: Behavioural Brain ResearchAuthor(s): Taha Kelestemur, Mustafa C. Beker, Ahmet B. Caglayan, Berrak Caglayan, Serdar Altunay, Selim Kutlu, Ertugrul KilicAbstractBackgroundNewborn hypoxia ischemia (HI) is one of the most prevalent cases in the emergency and can result from fetal hypoxia during delivery. In HI, restricted blood supply to the fetal brain may cause epilepsy or mental disorders.MethodsIn the present study, seven-day-old pups were...
Thu Nov 14, 2019 12:02
Publication date: Available online 13 November 2019Source: Behavioural Brain ResearchAuthor(s): Mohammad Hossein Esmaeili, Mohsen Enayati, Farhad Khabbaz Abkenar, Fereshte Ebrahimian, Ali-Akbar SalariAbstractA growing body of evidence suggests that type 2 diabetes (T2D) is a risk factor for cognitive impairment and dementia. Both preclinical and clinical studies have provided evidence that brain insulin resistance is associated with cognitive decline in patients with T2D and sporadic Alzheimer’s...
Thu Nov 14, 2019 12:02
Wed Nov 13, 2019 16:23
Abstract Background Progressive exercise-induced dehydration may impair aerobic exercise performance (AEP). However, no systematic approach has yet been used to determine how pre-exercise hypohydration, which imposes physiological challenges differing from those of a well-hydrated pre-exercise state, affects AEP and related components such as peak oxygen consumption \((\dot{V}{\text{O}}_{{2{\text{peak}}}} )\) and \(\dot{V}{\text{O}}_{2}\)...
Thu Nov 14, 2019 02:00
Journal of Cutaneous Medicine and Surgery, Ahead of Print. BackgroundPenile invasive squamous cell carcinoma (SCC) is a rare disease with several known risk factors. However, few studies have assessed its incidence, mortality, and temporal trends.ObjectiveOur objectives are to analyze the epidemiology of penile SCC in Canada and to examine patient distribution with this cancer across Canada in order to elucidate population risk factors.MethodsThree independent cancer registries were used to retrospectively...
Thu Nov 14, 2019 09:10
Abstract Following a request from the European Commission, the EFSA Panel on Additives and products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of ZM16 10 for all pigs. The additive is a preparation containing viable spores of a strain of Bacillus amyloliquefaciens intended for use in feed at the proposed dose of 5 × 108 CFU/kg complete feedingstuffs and in water for drinking at 1.7 × 108 CFU/L. The additive exists in two forms,...
Wed Nov 13, 2019 15:49
Abstract Following a request from the European Commission, the EFSA Panel on Additives and products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of EB15 10 for all pigs. The additive is a preparation containing viable spores of a strain of Bacillus subtilis intended for use in feed at the proposed dose of 5 × 108 CFU/kg complete feedingstuffs and in water for drinking at 1.7 × 108 CFU/L. The additive exists in two forms, EB15 and...
Wed Nov 13, 2019 15:48
Abstract The killing of poultry for human consumption (slaughtering) can take place in a slaughterhouse or during on‐farm slaughter. The processes of slaughtering that were assessed, from the arrival of birds in containers until their death, were grouped into three main phases: pre‐stunning (including arrival, unloading of containers from the truck, lairage, handling/removing of birds from containers); stunning (including restraint); and bleeding (including bleeding following stunning and bleeding...
Wed Nov 13, 2019 13:36
Abstract Poultry of different ages may have to be killed on‐farm for purposes other than slaughter (in which slaughtering is defined as being for human consumption) either individually or on a large scale (e.g. because unproductive, for disease control, etc.). The processes of on‐farm killing that were assessed are handling and stunning and/or killing methods (including restraint). The latter were grouped into four categories: electrical methods, modified atmosphere, mechanical methods and lethal...
Wed Nov 13, 2019 13:35
Abstract Following a request from the European Commission, the EFSA Panel on Additives and products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of APSA PHYTAFEED® 20,000 GR/L (6‐phytase) as a feed additive for piglets and growing minor porcine species. The additive is a preparation of 6‐phytase produced by a genetically modified strain of Komagataella phaffii and has been previously assessed by the FEEDAP Panel in the context of...
Wed Nov 13, 2019 12:33
Abstract Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the efficacy of ZM16 10 for weaned piglets and minor porcine species. The additive is a preparation containing viable spores of a strain of Bacillus amyloliquefaciens (DSM 25840). This product is available in two forms, ZM16 and ZM16 10, which contain the bacterium in concentrations of 1.25 × 109 CFU/g additive and...
Wed Nov 13, 2019 12:32
Abstract Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the efficacy of EB15 10 for weaned piglets and minor porcine species. The additive is a preparation containing viable spores of a strain of Bacillus subtilis (DSM 25841). This product is available in two forms, EB15 and EB15 10, which contain the bacterium in concentrations of 1.25 × 109 CFU/g additive and 1.25 × 1010...
Wed Nov 13, 2019 12:31
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