Abstract This study is based on our already published experimental data (Kowalska et al. in Radiat Environ Biophys 58:99–108, 2019) and is devoted to modeling of chromosome aberrations in human lymphocytes induced by 22.1 MeV/u 11B ions, 199 MeV/u 12C ions, 150 MeV and spread-out Bragg peak (SOBP) proton beams as well as by 60Co γ rays. The curvature of the dose–effect curves determined by the linear-quadratic model was considered in the frame of a simple analytical approach taking...
Thu Nov 21, 2019 02:00
Pediatric Allergy, Immunology, and Pulmonology, Ahead of Print.
Thu Nov 21, 2019 19:33
Journal of Investigative Medicine High Impact Case Reports, Volume 7, Issue , January-December 2019. Background. Primary malignant melanoma of the lacrimal sac is rare. A patient with lacrimal sac melanoma was presented, and 14 Japanese patients with lacrimal sac melanoma in the literature were reviewed. Case Presentation. A 78-year-old Japanese man was presented with painless swelling of the lacrimal sac on the left side. Dacryocystectomy revealed diffuse infiltration with large epithelioid cells,...
Thu Nov 21, 2019 08:32
Soft Robotics, Ahead of Print.
Thu Nov 21, 2019 19:04
Publication date: Available online 20 November 2019Source: Behavioural Brain ResearchAuthor(s): Lina Sun, Kai Cui, Fuyan Xing, Xiaoli LiuAbstractPhysical exercise is well-established paradigm for improving adult neurogenesis and brain functions. As considered as an alternative therapeutic strategy, treadmill running could reduce cognitive impairment and psychiatric abnormalities associating post-traumatic stress disorder (PTSD), which might associate with the promote effects to adult neurogenesis....
Thu Nov 21, 2019 18:33
Publication date: Available online 20 November 2019Source: Behavioural Brain ResearchAuthor(s): Xue Zhang, Li-ya Pan, Zhe Zhang, Yuan-yue Zhou, Hai-yin Jiang, Bing RuanAbstractBackgroundAccumulating evidence has focused on elucidating the bacterial component of the gut microbiota in patients with schizophrenia (SC); however, the fungal composition in the gut has not been investigated, although previous studies have suggested that gut mycobiota may be intricately linked to this disorder. The purpose...
Thu Nov 21, 2019 18:33
Abstract Background Physical inactivity is a worldwide pandemic associated with major chronic diseases. Given limited resources, policy makers are in need of physical activity interventions that provide best value for money. Objective To summarize evidence from RCT-based economic evaluations of primary prevention physical activity interventions in adult populations...
Thu Nov 21, 2019 02:00
מה הייתם אומרים לוּ חזרתם אחורה בזמן לשנים 1913–1914 שבהן התרחשה מלחמת השפות? היוזמה היפה של נועה בן חמו, מורה ללשון בבית הספר ויצ"ו ניר העמק שבעפולה, העניקה לתלמידיה חוויה לשונית יוצאת דופן. היא הקימה בעבורם "חדר בריחה" בבית הספר והחזירה אותם אחורה בזמן. פירוט המיזם כפי שמציגה אותו המורה נועה בן חמו: חדר בריחה הוא משחק הרפתקאות פופולרי בקרב בוגרים ובני הנוער בפרט. במהלך המשחק קבוצת אנשים ננעלת בחדר וכדי לצאת ממנו עליה לפתור בהצלחה סדרה של חידות באמצעות שימוש בחפצים הנמצאים בחדר, פיענוח צפנים...
Thu Nov 21, 2019 16:58
המילה כרית משמשת בפי אנשי הטבע לציון אזור החוף שמתכסה ונחשף בגאות ובשפל. יש בעלי חיים שחיים בדיוק באזור הזה, ולכן נחוצה לחוקרים מילה מיוחדת לכך. כך למשל זכו שתי רַכִּיכוֹת לשם הלוואי כְּרִית: צֹהַר כְּרִית, חֲרוּט כְּרִית. יש המשתמשים במילה כְּרִית לציון מחזור הגאות והשפל (tide באנגלית). מניין הגיעה אלינו המילה כְּרִית? במקרא נזכר נחל כְּרִית בסיפור על אליהו לאחר שאמר לאחאב "חַי ה' אֱלֹהֵי יִשְׂרָאֵל אֲשֶׁר עָמַדְתִּי לְפָנָיו אִם יִהְיֶה הַשָּׁנִים הָאֵלֶּה טַל וּמָטָר כִּי אִם לְפִי דְבָרִי",...
Thu Nov 21, 2019 13:29
שלשום מעת לעת אנחנו מקבלים הן מילדים הן ממבוגרים את ההצעה החביבה להוסיף לשפה העברית את המילה "אתמוליים". אלא שמונח אחר משמש במשמעות 'היום שלפני אתמול' ומוכר לנו כבר מלשון המקרא – הלוא הוא שלשום. בתנ"ך המילה שלשום מופיעה תמיד בסמיכות ל'אתמול' או 'תמול', כגון "כִּי לֹא הָיְתָה כָּזֹאת אֶתְמוֹל שִׁלְשֹׁם" (שמואל א ד, ז) – ומובן שמדובר בשני ימים רצופים. יש הסוברים כי המילה שלשום היא מיזוג של 'שלוש' ו'יום' – שלשום הוא היום השלישי מהיום, כולל היום, בספירה לאחור. לדעה זו יש תימוכין ממקבילה באכדית (מה...
Thu Nov 21, 2019 13:25
Abstract Background The relationship between oral microbiota and IE (infective endocarditis) is well established. Opportunistic pathogens in normal oral flora enter the bloodstream through daily oral cleaning or invasive dental procedures, leading to the occurrence of infective endocarditis. An in vitro iron-deficient condition leads to a drastic community shift in oral microbiota with increasing proportions of taxa related to infective...
Thu Nov 21, 2019 02:00
Abstract Backgrounds We explored the association between working hours and unmet dental needs among adults who have experienced dental pain, and how this relationship varied by demographic and lifestyle factors. Methods We used the data of 9594 adults who reported dental pain from the Korea National Health and Nutrition Examination Survey (KNHANES)...
Thu Nov 21, 2019 02:00
Abstract Background Although several studies assessed the prevalence of alveolar bone loss, the association with several risk factors has not been fully investigated. The aim of this article is to measure the prevalence of periodontitis by calculating the mean alveolar bone loss/level of posterior teeth using bitewing radiographs among the patients enrolled in the clinics at Harvard School of Dental Medicine and address risk factors...
Thu Nov 21, 2019 02:00
Abstract Background This retrospective clinical study aims to present results of experience with a novel guided surgery system with a sleeveless, open-frame structure, in which the surgical handpiece (not the drills used for preparation) is guided. Methods This study was based on an evaluation of the records of partially edentulous patients...
Thu Nov 21, 2019 02:00
Abstract Background Multimode adhesives incorporate the versatility of adapting to various clinical situations by its capacity to be used in different protocols. This study aimed to evaluate the clinical behavior of composite resin direct restorations (Class I and II) performed with different universal dentin adhesive application protocols comparing adapted FDI and adapted USPHS criteria. ...
Thu Nov 21, 2019 02:00
Publication date: Available online 21 November 2019Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Haider Abo Sharkh, Nicholas MakhoulAbstractPurposeVirtual surgical planning (VSP) and custom fabricated cutting guides for maxillofacial reconstruction have been demonstrated to improve the accuracy of bony reconstruction, overall surgical efficiency, and decrease ischemia time. Our aim is to demonstrate an in-house VSP technique for maxillofacial reconstructive procedures.MethodsWe used...
Thu Nov 21, 2019 17:51
Abstract Aims Adults with type 1 diabetes mellitus (T1D) have decreased bone mineral density (BMD). Our study aimed at determining BMD and the association to metabolic control in children and adolescents with T1D. Methods 244 patients (113 girls) with a median age of 14.3 years and T1D duration of 1–16 years were included. A dual-energy X-ray absorptiometry...
Thu Nov 21, 2019 02:00
Publication date: December 2019Source: Neoplasia, Volume 21, Issue 12Author(s): Casey D. Stefanski, Kaitlyn Keffler, Stephanie McClintock, Lauren Milac, Jenifer R. ProsperiAbstractChemoresistance is one of the leading causes of cancer-related deaths in the United States. Triple negative breast cancer (TNBC), a subtype lacking the known breast cancer receptors used for targeted therapy, is reliant on chemotherapy as the standard of care. The Adenomatous Polyposis Coli (APC) tumor suppressor is mutated...
Thu Nov 21, 2019 17:12
Publication date: December 2019Source: Neoplasia, Volume 21, Issue 12Author(s): Yuli Lin, Bingji Li, Xuguang Yang, Qian Cai, Weiren Liu, Mengxin Tian, Haoyang Luo, Wei Yin, Yan Song, Yinghong Shi, Rui HeAbstractDesmoplasia is a hallmark of intrahepatic cholangiocarcinoma (ICC), which constitutes a barrier to infiltration of lymphocyte, but not myeloid cells. Given that dense desmoplastic stroma has been reported to be a barrier to infiltration of lymphocyte, but not myeloid cells. We here investigated...
Thu Nov 21, 2019 17:12
Publication date: December 2019Source: Neoplasia, Volume 21, Issue 12Author(s): Ken Saito, Hidekazu Iioka, Satoshi Maruyama, I. Wayan Sumardika, Masakiyo Sakaguchi, Eisaku KondoAbstractPancreatic invasive ductal adenocarcinoma (PDAC) is a representative intractable malignancy under the current cancer therapies, and is considered a scirrhous carcinoma because it develops dense stroma. Both PODXL1, a member of CD34 family molecules, and C5aR, a critical cell motility inducer, have gained recent attention,...
Thu Nov 21, 2019 17:12
Publication date: Available online 21 November 2019Source: Journal of the American College of SurgeonsAuthor(s): Charlie J. Nederpelt, Majed El Hechi, Napaporn Kongkaewpaisan, Nikolaos Kokoroskos, April E. Mendoza, Noelle Saillant, Peter J. Fagenholz, David R. King, George C. Velmahos, Haytham MA. KaafaraniABSTRACTObjectiveDespite the presence of highly reliable data, studies on pRBC:FFP ratio suffer from limited sample size and the presence of survivor bias. We sought to study the association between...
Thu Nov 21, 2019 16:52
Publication date: Available online 20 November 2019Source: Journal of the American College of SurgeonsAuthor(s): Yuichiro Nakashima, Hiroshi Saeki, Qingjiang Hu, Yasuo Tsuda, Yoko Zaitsu, Yuichi Hisamatsu, Koji Ando, Yasue Kimura, Eiji Oki, Masaki Mori
Thu Nov 21, 2019 16:52
Related ArticlesA Systematic Review of Rehabilitation for Corticobulbar Symptoms in Adults with Huntington's Disease. J Huntingtons Dis. 2019 Nov 11;: Authors: Burnip E, Wallace E, Gozdzikowska K, Huckabee ML Abstract BACKGROUND: Corticobulbar symptoms have been reported in all stages of Huntington's disease (HD); aspiration pneumonia associated with swallowing impairment has been identified as the most common cause of death. Whilst recent research has...
Thu Nov 21, 2019 16:45
Thu Nov 21, 2019 15:05
Thu Nov 21, 2019 14:05
Aim. To investigate the mRNA expression and clinical significance of structural maintenance of chromosomes protein 4 (SMC4) in breast cancer. Methods. A total of 23 paired samples were sequenced, and data from the Cancer Genome Atlas were analyzed. Results. SMC4 mRNA level was significantly upregulated in breast cancer tissues (). Patients with high mRNA expression of SMC4 had significantly poor survival (). Subgroup analyses show that in nontriple negative breast cancer (non-TNBC) patients, the...
Thu Nov 21, 2019 11:05
Abstract Objectives High definition laryngoscopy (HDL) could lead to better interpretation of the pharyngeal and laryngeal mucosa than regularly used fiberoptic laryngoscopy (FOL). The primary aim of this study is to quantify the diagnostic advantage of HDL over FOL in detecting mucosal anomalies in general, in differentiating malignant from benign lesions and in predicting specific histological entities. The secondary aim is to analyse image quality of both laryngoscopes. Design Retrospective...
Wed Nov 20, 2019 19:10
Abstract Objective To evaluate in children the clinical severity and evolution of otogenic lateral sinus thrombosis (OLST) due to Fusobacterium necrophorum compared to other bacterial otogenic thrombosis and propose a specific management flowchart for Fusobacterium OLST. Design A retrospective multicenter cohort study. Settings Four French ENT pediatric departments. Participants A total of 260 under 18 years old admitted for acute mastoiditis were included. Initial imaging was...
Wed Nov 20, 2019 12:24
Abstract Pediatric neck masses are one of the common conditions presenting to the otorhinolaryngologist. This is retrospective study done on 136 children under the age of ten years presenting with neck masses to a tertiary referral hospital. A complete and adequate clinical assessment should be the basis for every diagnostic and therapeutic decision in children with neck masses Inflammatory neck masses in children were the commonest; followed by congenital masses.
Wed Nov 20, 2019 12:08
Abstract Phenotypic plasticity is a central topic in ecology and evolution. Individuals may differ in the degree of plasticity (individual‐by‐environment interaction (I × E)), which has implications for the capacity of populations to respond to selection. Random regression models (RRMs) are a popular tool to study I × E in behavioural or life‐history traits, yet evidence for I × E is mixed, differing between species, populations, and even between studies on the same population. One important source...
Wed Nov 20, 2019 22:00
Abstract Fig‐pollinating wasps (Agaonidae) only reproduce within fig‐tree inflorescences (figs). Agaonid offspring sex ratios are usually female‐biased and often concur with local mate competition theory (LMC). LMC predicts less female‐bias when several foundresses reproduce in a fig due to reduced relatedness among intra‐sexually competing male offspring. Clutch size, the offspring produced by each foundress, is a strong predictor of agaonid sex ratios and correlates negatively with foundress number....
Wed Nov 20, 2019 15:35
Related ArticlesCheminformatics and virtual screening studies of COMT inhibitors as potential Parkinson's disease therapeutics. Expert Opin Drug Discov. 2019 Nov 20;:1-10 Authors: Moschovou K, Melagraki G, Mavromoustakos T, Zacharia LC, Afantitis A Abstract Introduction: Parkinson's Disease (PD) is a neurodegenerative central nervous system (CNS) disorder characterized by dopaminergic neuron degeneration with consequent reduction in striatal dopamine...
Thu Nov 21, 2019 15:31
Related ArticlesThyroid cancer incidence near nuclear sites in Belgium: an ecological study at small geographical level. Int J Cancer. 2019 Nov 19;: Authors: Demoury C, De Schutter H, Faes C, Carbonnelle S, Fierens S, Molenberghs G, Van Damme N, Van Bladel L, Van Nieuwenhuyse A, Vleminckx C Abstract In Belgium, variations in thyroid cancer incidence were observed around the major nuclear sites. The present ecological study investigates whether there...
Thu Nov 21, 2019 15:01
Related ArticlesOverexpression of EIF5A2 is associated with poor survival and aggressive tumor biology in gallbladder cancer. Histol Histopathol. 2019 Nov 20;:18186 Authors: Zheng X, Gao L, Wang BT, Shen P, Yuan XF, Zhang LQ, Yang L, Zhang DP, Zhang Q, Wang XM Abstract Gallbladder cancer (GBC) is a malignant tumor of the biliary tract. The main problem affecting the treatment of gallbladder cancer is late diagnosis and poor prognosis. EIF5A2 is one of...
Thu Nov 21, 2019 14:57
Related ArticlesExpression of glucose-regulated protein 78 as prognostic biomarkers for triple-negative breast cancer. Histol Histopathol. 2019 Nov 19;:18185 Authors: Yang C, Zhang Z, Zou Y, Gao G, Liu L, Xu H, Liu F Abstract INTRODUCTION: glucose-regulated protein78(GRP78) is a stress - induced endoplasmic reticulum chaperone protein. it is closely related to the occurrence, development, proliferation, differentiation and drug resistance of breast cancer....
Thu Nov 21, 2019 14:57
Related ArticlesAbnormal Presentation of Hypoxic Ischemic Encephalopathy Attributed to Polysubstance Exposure. Am J Case Rep. 2019 Nov 20;20:1715-1718 Authors: Maddox TR, Haas J, Andrews L, Miller B, Davies TH Abstract BACKGROUND With the increasing prevalence of substance use in pregnancy, the rates of neonatal abstinence syndrome (NAS) are dramatically increasing. There is little information on the use of multiple substances in adults, even less so...
Thu Nov 21, 2019 14:53
Related ArticlesHuman Leukocyte Antigen (HLA) Subtype-Dependent Development of Myasthenia Gravis, Type-1 Diabetes Mellitus, and Hashimoto Disease: A Case Report of Autoimmune Polyendocrine Syndrome Type 3. Am J Case Rep. 2019 Nov 20;20:1709-1714 Authors: Gobaru M, Ashida K, Yoshinobu S, Nagayama A, Kabashima M, Iwata S, Hasuzawa N, Tsuruta M, Wada N, Nakayama H, Motomura S, Tajiri Y, Nomura M Abstract BACKGROUND Patients with type 1 diabetes mellitus,...
Thu Nov 21, 2019 14:53
Related ArticlesLaryngeal Electromyography and Botulinum Toxin Injection in Exercise-Induced Laryngeal Obstruction. Mov Disord Clin Pract. 2019 Nov;6(8):708-710 Authors: Rebours C, Brasnu D, Le Garrec S, Ayache D, Mailly M PMID: 31745483 [PubMed]
Thu Nov 21, 2019 14:52
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