CXCL8 (also known as IL-8) can produce different biological effects by binding to its receptors: CXCR1, CXCR2, and the Duffy antigen receptor for chemokines (DARC). CXCL8 and its receptors are associated with the development of various tumor types, especially colorectal cancer and its liver metastases. In addition to promoting angiogenesis, proliferation, invasion, migration, and the survival of colorectal cancer (CRC) cells, CXCL8 and its receptors have also been known to induce the epithelial-mesenchymal...
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Background. Long noncoding RNAs (lncRNAs), which have little or no ability to encode proteins, have attracted special attention due to their potential role in cancer disease. We aimed to establish a lncRNA signature and a nomogram incorporating the genomic and clinicopathologic factors to improve the accuracy of survival prediction for laryngeal squamous cell carcinoma (LSCC). Methods. A LSCC RNA-sequencing (RNA-seq) dataset and the matched clinicopathologic information were downloaded from The Cancer...
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Overexpression of UDP-Glucose 4-Epimerase Is Associated with Differentiation Grade of Gastric Cancer
The UDP-glucose 4-epimerase (GALE) is a glycosyltransferase, which acts on protein and lipid glycosylation in normal and neoplastic cells. This study is aimed at investigating the differential tissue expression of GALE and its possible association with clinical-pathological parameters and the outcome of gastric adenocarcinoma patients. Seventy-one patients were evaluated in relation to GALE expression by immunohistochemistry. Our results showed that 48 (67.6%) patients were GALE positive and 23 (32.4%)...
07:05
Abstract Anticancer drugs are a class of pharmaceutical compounds that have been found in hospital, domestic, and industrial wastewaters and also in surface waters. They have been showing recalcitrance to conventional wastewater treatment technologies and present a potential risk to environment and human health, since they exhibit cytotoxic, teratogenic, and carcinogenic among other effects in higher organisms, even at low concentrations. The presence of these compounds in the...
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Abstract Bacillus licheniformis has been regarded as an outstanding microbial cell factory for the production of biochemicals and enzymes. Due to lack of genetic tools to repress gene expression, metabolic engineering and gene function elucidation are limited in this microbe. In this study, an integrated CRISPR interference (CRISPRi) system was constructed in B. licheniformis. Several endogenous genes, including yvmC, cypX, alsD, pta, ldh, and essential gene rpsC, were severed...
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Environmentally acquired microbial symbionts could contribute to host adaptation to local conditions like vertically transmitted symbionts do. This scenario necessitates symbionts to have different effects in different environments. We investigated this idea in Drosophila melanogaster, a species which communities of bacterial symbionts vary greatly among environments. We isolated four bacterial strains isolated from the feces of a D. melanogaster laboratory strain and tested their effects in two...
Tue Nov 19, 2019 02:00
Nagaraja Mudhigeti, Usha Kalawat, Narendra Hulikal, Meenakshi KanteIndian Journal of Medical Microbiology 2019 37(2):241-247 Background: Many human papillomavirus (HPV) types are associated with cervical cancer (CC). Therefore, HPV genotyping has both clinical and epidemiological importance. HPV 16 and 18 are two principal high-risk types responsible for more than 70% of all CC cases. Although several commercial and non-commercial genotyping assays are available, there is a need for a cost-effective...
Tue Nov 19, 2019 00:00
Tonushyam Sonowal, Malini ShariffIndian Journal of Medical Microbiology 2019 37(2):287-288
Tue Nov 19, 2019 00:00
Rosemol Varghese, Balaji Veeraraghavan, Yuvraj Jeyaraman, Girish Kumar, Narendra Kumar Arora, S BalasubramanianIndian Journal of Medical Microbiology 2019 37(2):141-146 India is one among the four Asian countries with the greatest number of deaths due to pneumococcal infection among children under 5 years. pneumococcal conjugate vaccine (PCV) has been introduced in a phased manner in five major Indian states. Ambiguity remains in choosing the appropriate type of PCV and optimum schedule with...
Tue Nov 19, 2019 00:00
Premalatha Pushpanathan, Gifty Sara Mathew, Sribal Selvarajan, Krishna G Seshadri, Padma SrikanthIndian Journal of Medical Microbiology 2019 37(2):268-277 Gut microbiota are microorganisms that inhabit the gut; they coexist peacefully with the host, thereby contributing to the health and well-being of individuals. Bacteroidetes and Firmicutes largely dominate the gut microbial flora. The intestinal flora promotes intestinal mucosal integrity, provides essential nutrients such as vitamins and...
Tue Nov 19, 2019 00:00
Dhiviya Prabaa Muthuirulandi Sethuvel, Naveen Kumar Devanga Ragupathi, Yamuna Devi Bakthavatchalam, Saranya Vijayakumar, Rosemol Varghese, Chaitra Shankar, Jobin John Jacob, Karthick Vasudevan, Divyaa Elangovan, Veeraraghavan BalajiIndian Journal of Medical Microbiology 2019 37(2):147-162 The prime goal of molecular epidemiology is to identify the origin and evolution of pathogens, which can potentially influence the public health worldwide. Traditional methods provide limited information which...
Tue Nov 19, 2019 00:00
Jobin John Jacob, Balaji Veeraraghavan, Karthick VasudevanIndian Journal of Medical Microbiology 2019 37(2):133-140
Tue Nov 19, 2019 00:00
Chand Wattal, Jaswinder Kaur Oberoi, Neeraj Goel, Sanghamitra Datta, Reena Raveendran, KJ PrasadIndian Journal of Medical Microbiology 2019 37(2):163-172 Introduction: EQAS program at New Delhi under IAMM was started in January 2014 across North and North east regions of India with 217 participants, which grew up to 540 by 2018. Materials and Methods: In 2014, 4 analytes per year were sent for 3 exercises, i.e. smear culture and serology. 2018 onwards PT analytes were increased from 4 to 12 and...
Tue Nov 19, 2019 00:00
Sanjay Singh Negi, Anudita Bhargava, Priyanka Singh, Sarita Aggarwal, Nighat Hussain, Padma DasIndian Journal of Medical Microbiology 2019 37(2):255-262 Background: Identification of 14 high-risk human papillomavirus (HR-HPV) is immensely important in elucidating molecular epidemiology, patient monitoring and evidence-based treatment. There is paucity of such data from Chhattisgarh state of Central India. The present study has evaluated tagging oligonucleotide cleavage and extension-mediated...
Tue Nov 19, 2019 00:00
Devika Subramanian, Jeyakumar NatarajanIndian Journal of Medical Microbiology 2019 37(2):173-185 Context: Vancomycin-intermediate Staphylococcus aureus remains one of the most prevalent multidrug-resistant pathogens causing healthcare infections that are difficult to treat. Aims: This study uses a comprehensive computational analysis to systematically investigate various gene expression profiles of resistant and sensitive S. aureus strains on exposure to antibiotics. Settings and Design: The...
Tue Nov 19, 2019 00:00
Ramya Barani, Vigna Seshan, Yazhini Ravi, Periasamy Soundararajan, Gunasekaran Palani, Padma SrikanthIndian Journal of Medical Microbiology 2019 37(2):281-284 Renal transplantation is a treatment option for end-stage renal disease (ESRD). Cytomegalovirus (CMV) infection was analysed among symptomatic and asymptomatic post-renal-transplant recipients (PRTRs). A total of 30 PRTRs were enrolled. DNA was extracted and quantitative real-time PCR for CMV (CMV R-Gene, France) targeting ppUL83 gene was...
Tue Nov 19, 2019 00:00
Sherin Justin, Beena AntonyIndian Journal of Medical Microbiology 2019 37(2):186-191 Purpose: Prevalence of Clostridium difficile, an anaerobic, Gram-positive, spore-forming bacillus, is very much underestimated in India. The present study was intended to assess the burden of toxigenic C. difficile in hospitalised patients with clinically significant diarrhoea and analysis of their clinical picture. Materials and Methods: This cross-sectional study was conducted in a tertiary care teaching hospital,...
Tue Nov 19, 2019 00:00
Sonu Kumari Agrawal, Prasenjit Das, Shalimar , Gupta Swatantra, Rama ChaudhryIndian Journal of Medical Microbiology 2019 37(2):292-295 To the best of our knowledge, this is the first case of multifocal hepatic abscesses in a young immunocompetent adult from India, which was successfully treated with hepatectomy and short course of oral antibiotic regimen. Publishing further such case reports will provide more clarity regarding the clinical significance of the disease, including associated risk...
Tue Nov 19, 2019 00:00
Paras Mahale, Rajas Warke, Mira Ramaiya, Deepa Balasubramanian, Suvin Shetty, Ranjit Mankeshwar, Abhay ChowdharyIndian Journal of Medical Microbiology 2019 37(2):192-197 Purpose: Sensitive, specific, rapid and cost-effective technique for malaria diagnosis is need of the hour. Microscopy has been the gold standard for malaria diagnosis, but its interpersonnel variability and lack of sensitivity make it subjective test. Conventional polymerase chain reaction (cPCR) has proven to be sensitive technique,...
Tue Nov 19, 2019 00:00
Leimapokpam Shivadutta Singh, Huidrom Lokhendro Singh, Natasha Thokchom, RK Manojkumar SinghIndian Journal of Medical Microbiology 2019 37(2):235-240 Background and Objective: Japanese encephalitis (JE) surveillance is not well established in many countries, and laboratory confirmation is challenging, the true extent and prevalence of the virus and burden of disease are not well understood. It is estimated that 67,900 clinical cases of JE occur annually despite the widespread availability of...
Tue Nov 19, 2019 00:00
Agila Kumari Pragasam, Shalini Anandan, James John, Ayyanraj Neeravi, Vignesh Narasimman, Dhiviya Prabaa Muthuirulandi Sethuvel, Divyaa Elangovan, Balaji VeeraraghavanIndian Journal of Medical Microbiology 2019 37(2):198-202 Background: Non-typhoidal Salmonella (NTS) infection is a serious public health problem globally. Although NTS infections are self-limited, antimicrobial therapy is recommended for severe infections and immunocompromised patients. Antimicrobial resistance (AMR) in these pathogens...
Tue Nov 19, 2019 00:00
Anusha Hindupur, Thangam Menon, Prabu DhandapaniIndian Journal of Medical Microbiology 2019 37(2):248-254 Introduction: Human respiratory syncytial virus (HRSV) an RNA virus belonging to Pneumoviridae family, is an important cause of acute respiratory infections (ARIs) in young children. HRSV circulates as two subgroups A and B, which are further categorised into several genotypes. New genotypes may replace existing ones over successive epidemic seasons and multiple genotypes may cocirculate...
Tue Nov 19, 2019 00:00
Vikas Gautam, Parinitha Kaza, Joseph L Mathew, Varpreet Kaur, Megha Sharma, Pallab RayIndian Journal of Medical Microbiology 2019 37(2):203-209 Background: Cystic fibrosis (CF) is now a recognised entity in India, with prevalence rates between 1/10,000 and 1/50,000. However, no data were available with regard to the profile of respiratory pathogens in the Indian setting. Materials and Methods: The records of respiratory secretion bacterial cultures of children with CF in a tertiary care hospital...
Tue Nov 19, 2019 00:00
Dhanalakshmi Solaimalai, Naveen Kumar Devanga Ragupathi, Kala Ranjini, Hema Paul, Valsan P Verghese, Joy Sarojini Michael, Balaji Veeraraghavan, Ebor Jacob JamesIndian Journal of Medical Microbiology 2019 37(2):263-267 Purpose: Hospital outbreaks are observed increasingly worldwide with various organisms from different sources such as contaminated ultrasound gel, intravenous (IV) fluids and IV medications. Among these, ultrasound gel is one of the most commonly reported sources for Burkholderia...
Tue Nov 19, 2019 00:00
PA Remya, M Shanthi, Uma SekarIndian Journal of Medical Microbiology 2019 37(2):210-218 Purpose: This study was undertaken to characterise the virulence factors in clinical strains of Klebsiella pneumoniae and analyse their association with various infections caused and also to determine the association between virulence factors and antimicrobial resistance profile. Materials and Methods: A total number of 370 clinically significant, non-duplicate isolates of K. pneumoniae isolated from both...
Tue Nov 19, 2019 00:00
Bijayini Behera, Manisha Biswal, Rashmi Ranjan Das, Anupam Dey, Jayanti Jena, Sagarika Dhal, Srujana Mohanty, Baijayantimala Mishra, Ashok Kumar PraharajIndian Journal of Medical Microbiology 2019 37(2):278-280 Acute undifferentiated febrile illness (AUFI) constitutes the predominant cause of healthcare seeking in Odisha. This prospective study was conducted to analyse the clinical, epidemiological and laboratory profile of scrub typhus patients presenting with AUFI from January to December 2017....
Tue Nov 19, 2019 00:00
John Paul Demosthenes, Jaiprasath Sachithanandham, Gnanadurai John Fletcher, Uday George Zachariah, George Mathew Varghese, Hubert Darius John Daniel, Lakshmanan Jeyaseelan, Priya Abraham, Rajesh KannangaiIndian Journal of Medical Microbiology 2019 37(2):219-224 Purpose: Human immunodeficiency virus-1 (HIV-1) and hepatitis B virus (HBV) coinfection has become a major health problem across the globe. The increased life expectancy of HIV-1 patients due to antiretroviral therapy has led to the emergence...
Tue Nov 19, 2019 00:00
Sonu Kumari Agrawal, Jyoti Rawre, Neena Khanna, Benu DhawanIndian Journal of Medical Microbiology 2019 37(2):285-286
Tue Nov 19, 2019 00:00
Shekara Nikitha, Sasidharanpillai Sabeena, Sudandiradas Robin, Dodia Hiren, Varamballi Prasad, Sushama Aswathyraj, Santhosha Devadiga, Jayaram Anup, Govindakarnavar ArunkumarIndian Journal of Medical Microbiology 2019 37(2):225-229 Purpose: The major cause of chronic hepatitis is infections with hepatitis B virus and hepatitis C virus (HCV) globally. However, there exists sparse epidemiological data regarding the prevalence of HCV infection from India. Methodology: We carried out a cross-sectional...
Tue Nov 19, 2019 00:00
Sanchita Mitra, Suryasnata Rath, Sujata Das, Soumyava BasuIndian Journal of Medical Microbiology 2019 37(2):289-291 Accurate identification of infectious pathogens is essential for appropriate management of ocular infections. Routine laboratory protocols typically support bacterial growth at 37°C. We report a case, wherein we serendipitously isolated Pseudomonas fluorescens – an organism that prefers lower temperatures for optimal growth (psychrophilic) in the environment – from eviscerated contents...
Tue Nov 19, 2019 00:00
Arghadip Samaddar, Shripad Taklikar, Pradnya Kale, Chaya A Kumar, Sujata BavejaIndian Journal of Medical Microbiology 2019 37(2):230-234 Context: Acute viral hepatitis (AVH) is predominantly caused by hepatitis A virus (HAV) and hepatitis E virus (HEV), the prevalence of which varies in different geographical regions. Aims: This study aimed to determine the prevalence of HAV and HEV infections in patients with AVH, the rate of HAV-HEV co-infection and the prevalence of HEV infection among pregnant...
Tue Nov 19, 2019 00:00
Chitaranjan Mishra, Usha Kim, Mulasthanam Sai DheeraIndian Journal of Medical Microbiology 2019 37(2):296-297 Phthiriasis palpebrarum (PP) is the infestation of eyelids caused by the ectoparasite Phthirus pubis, frequently misdiagnosed as allergic conjunctivitis, blepharitis or dermatitis. There is no standard treatment of choice although various treatment modalities have been described. A 6-year-old male child with PP was successfully treated with local application of 20% fluorescein solution...
Tue Nov 19, 2019 00:00
Mucosal Immunology, Published online: 19 November 2019; doi:10.1038/s41385-019-0232-7IL-4Rα expression by airway epithelium and smooth muscle accounts for nearly all airway hyperresponsiveness in murine allergic airway disease
Tue Nov 19, 2019 02:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b11968
Tue Nov 19, 2019 07:00
Tue Nov 19, 2019 19:00
Tue Nov 19, 2019 18:58
Tue Nov 19, 2019 18:58
Journal of Cutaneous Medicine and Surgery, Ahead of Print. BackgroundThere is limited data regarding postoperative complications after microtia surgery or tympanoplasty; however, complication rates after pinna reconstruction following tumor resection and comorbidities associated with suboptimal outcomes have not been investigated so far.ObjectiveTo examine the incidence of postoperative complications after auricular reconstruction surgery following tumor resection and determine the association between...
Tue Nov 19, 2019 11:08
Journal of Cutaneous Medicine and Surgery, Ahead of Print. BackgroundMalignant neoplasms of the auricle make up 6% of all skin cancers. Management of cutaneous neoplasms of the conchal bowl presents a unique challenge in visualizing and defining margins that may extend into the external auditory canal (EAC).ObjectivesThe objective of this study was to create a multidisciplinary pathway for cutaneous carcinoma of the conchal bowl extending into the EAC.MethodsWe present a series of patients that were...
Tue Nov 19, 2019 03:48
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