ConclusionMalignancy during pregnancy poses both medical and ethical dilemmas in the management and treatment of cancer. The treatment of late-stage melanoma in pregnancy with a BRAF kinase inhibitor may be an option. (Source: Case Reports in Womens Health)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Thu Oct 31, 2019 11:15
To compare survival measures of women with early-stage endometrial cancer who underwent either hysteroscopy or a non-hysteroscopic procedure as a diagnostic procedure. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Thu Oct 31, 2019 11:14
Pelvic lymph node metastasis carries the highest impact on decreased survival among surgical-pathological risk factors for early-stage cervical cancer. While concurrent administration of chemotherapy during postoperative radiotherapy is the current standard treatment for surgically-treated high-risk early-stage cervical cancer, its effectiveness specific to node-positive disease has not been completely studied. (Source: American Journal of Obstetrics and Gynecology)
Thu Oct 31, 2019 11:14
Women with human immunodeficiency virus (HIV) have higher rates of abnormal cervical and vaginal cytology and, subsequently, of cervical and vaginal cancers. While professional bodies currently advocate for indefinite cytology screening for women living with HIV, these recommendations are based on expert opinion, not evidence-based. In the general population, women who have never had an abnormal cytology result can cease screening at age 65. This is due to the relatively low incidence of dysplasia...
Thu Oct 31, 2019 11:14
Conclusion: MRI staging of RCC is an accurate predictor of the surgical and pathological stage and has the potential to become a useful tool for preoperative identification of patients with RCC who can undergo NSS. (Source: Indian Journal of Radiology and Imaging)
Thu Oct 31, 2019 00:00
We present a case of a 59-year-old woman with a malignant tumor arising within presacral teratoma associated with Currarino syndrome (CS). A characteristic crescent-shaped sacrum was detected on preoperative image examination and the presacral mass was pathologically diagnosed as a malignant tumor associated with CS. To our knowledge, this is the first case report of presacral teratoma associated with CS coexisting with both adenocarcinoma and a neuroendocrine tumor. (Source: Indian Journal of Radiology...
Thu Oct 31, 2019 00:00
(Source: Obesity Surgery)
Thu Oct 31, 2019 00:00
Shouvik Choudhury, Suparna Chatterjee, Sampath B K PulakhandamLung India 2019 36(6):568-569 (Source: Lung India)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Thu Oct 31, 2019 00:00
Jyoti Bajpai, Ayush Jain, Avishek Kar, Surya Kant, Darshan Kumar BajajLung India 2019 36(6):550-552 Massive pleural effusions are commonly caused by malignancy, parapneumonic effusion, and tuberculosis. Parasitic infections are rare causes of massive pleural effusion. Echinococcosis or hydatid disease is a major public health problem in poor hygienic environments. The liver and lungs are the most frequently involved organs. Pulmonary disease appears to be more common in younger individuals. Echinococcus...
Thu Oct 31, 2019 00:00
Unilateral pleural effusions are a common diagnostic challenge for the respiratory physician. In the majority of patients, a diagnosis can be made according to medical history, computed tomography and pleural fluid analysis [1]. A proportion of patients will require a pleural biopsy but, following this, a minority will remain undiagnosed and are defined as having inflammatory pleuritis (IP) [2]. These patients often require extended follow-up to ensure effusion resolution and exclude malignancy....
Thu Oct 31, 2019 00:00
When can a relationship between an exposure and a disease be considered "causal"? Typically, several steps need to be followed to respond to the question, such as identifying, reviewing, evaluating and integrating the scientific evidence for an overall evaluation that includes a thoughtful check of the Bradford Hill criteria [1], as illustrated in the International Agency for Research on Cancer preamble [2] or in the Environmental Protection Agency procedures [3, 4]. (Source: European Respiratory...
Thu Oct 31, 2019 00:00
AbstractTyrosinemia type 1 (TT1) is a rare metabolic disease caused by a defect in tyrosine catabolism. TT1 is clinically characterized by acute liver failure, development of hepatocellular carcinoma, renal and neurological problems, and consequently an extremely poor outcome. This review showed that the introduction of 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione (NTBC) in 1992 has revolutionized the outcome of TT1 patients, especially when started pre-clinically. If started early,...
Thu Oct 31, 2019 00:00
We describe the distinctive MRI features of sABC of long bones from a series of four cases and briefly review the literature. We hope this review will educate all radiologists about this rare entity increasing their diagnostic confidence while formulating differentials for similar appearing lesions. (Source: Indian Journal of Radiology and Imaging)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Thu Oct 31, 2019 00:00
Sepsis survivors face mental and physical sequelae even years after discharge from the intensive care unit (ICU). The aim of this study was to evaluate the long-term courses of sepsis survivors and the effects of a primary care management intervention in sepsis aftercare. 12 months after completion, a primary care management intervention among survivors of sepsis did not improve mental health-related quality of life. Patients in the intervention group showed less posttraumatic stress symptoms. (Source:...
Wed Oct 30, 2019 13:25
At least 25 % of adults admitted to intensive care units (ICU) in the United States have an overweight, obese or morbidly obese body mass index (BMI). The effect of BMI on adjusted mortality in adults requiring ICU treatment for sepsis is unclear. We performed a systematic review of adjusted all-cause mortality for underweight, overweight, obese and morbidly obese BMIs relative to normal BMI for adults admitted to the ICU with sepsis, severe sepsis, and septic shock. This is the first meta-analysis...
Wed Oct 30, 2019 13:20
Nurses play a pivotal role in the early identification and management of sepsis. In recognition of this, four leading international critical care organizations (the European Federation of Critical Care Nursing Associations, EfCCNa, the European Society of Intensive Care Medicine Nursing and Allied Healthcare Professionals Section; the SCCM, and the World Federation of Critical CAre Nurses, WFCCN) collaborated to outline considerations for nursing care based on the revised SSC guidelines. The President...
Wed Oct 30, 2019 13:18
Early recognition of sepsis is challenging, and diagnostic criteria have changed repeatedly. We assessed the robustness of sepsis-3 criteria in intensive care unit (ICU) patients. The sepsis-3 definition lacks robustness as well as discriminatory ability, since nearly all patients presenting to ICU with suspected infection fulfill its criteria. These should therefore be specified in greater detail, and applied more consistently, during future sepsis studies. (Source: Current Awareness Service for...
Wed Oct 30, 2019 12:39
The aim of this study was to investigate the level of resistin in children with and without sepsis hospitalized in the pediatric intensive care unit (PICU) and compare them to levels in healthy subjects in order to determine the trend of resistin levels in children in PICUs and also to identify the cut-off values for positive sepsis. In the present study, resistin level can be used as an indicator of sepsis in children admitted to PICU. However, the cut-off point based upon when a prediction could...
Wed Oct 30, 2019 11:56
Were kindergarteners adequately vaccinated according to school entry requirements during the 2018-19 school year? A new report examines the national trends.Morbidity & Mortality Weekly Report (Source: Medscape Allergy Headlines)
Wed Oct 30, 2019 17:00
Immunotherapy appears to be safe and effective for treating non-small-cell lung cancer (NSCLC) in older people, researchers from Italy report.Reuters Health Information (Source: Medscape Allergy Headlines)
Wed Oct 30, 2019 15:57
Detecting cancer at its early stages remains a major challenge in oncology. Even monitoring the progression of cancer is difficult, but researchers at the University of Michigan have come up with a tiny implantable device that can draw cancer cells toward itself for gene expression analysis. The microscopic device is a biomaterial scaffold that is designed to allow new cells to settle within. Circulating tumor cells, being the most opportunistic at finding fresh nooks to make home, are quickly...
Wed Oct 30, 2019 20:56
To mark the 5th anniversary of its historic partnership with terminally ill Californian Brittany Maynard, Compassion & Choices has produced a new video about the legislative success she inspired to advance medical aid-in-dying laws and enlist diverse new advocates. The new video includes soundbites from Brittany (recorded before her death), her husband Dan Diaz, Compassion & Choices CEO Kim Callinan, and Compassion & Choices volunteer advocates across the demographic spectrum of ethnicity,...
Wed Oct 30, 2019 11:27
Bedside assessment of a new lesion that worried a patient, who believed it represented further spread of his pancreatic cancer, led us to review both the nature of a particular and under-utilized physical sign in the abdominal examination, and to generalize about the enduring power of hands-on bedside evaluation.1 (Source: The American Journal of Medicine)
Thu Oct 31, 2019 10:14
The purpose of this study was to compare the efficacy of intra-articular injections of different agents for temporomandibular osteoarthritis (TMJOA) by network meta-analysis. (Source: Journal of Oral and Maxillofacial Surgery)
Thu Oct 31, 2019 09:38
This study aimed to identify risk factors for DM development and long-term survival. (Source: Journal of Oral and Maxillofacial Surgery)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Thu Oct 31, 2019 09:38
SUJANA S. CHANDRASEKHAR, MD, FACS, FAAOHNS (Source: Otolaryngologic clinics of North America)
Thu Oct 31, 2019 09:38
OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA (Source: Otolaryngologic clinics of North America)
Thu Oct 31, 2019 09:38
Cranial Nerve Stimulation in Otolaryngology (Source: Otolaryngologic clinics of North America)
Thu Oct 31, 2019 09:38
Elsevier (Source: Otolaryngologic clinics of North America)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Thu Oct 31, 2019 09:38
Sujana S. Chandrasekhar (Source: Otolaryngologic clinics of North America)
Thu Oct 31, 2019 09:38
Anesthesiology and Otolaryngology: A Critical and Unique Collaboration of Specialist and Specialties
The fields of anesthesiology and otolaryngology are forever linked due to the physical proximity and the sharing of one of the most critical anatomic structures, the airway. What started as informal discussions and an appreciation of the intimate connection of our mutual specialties among the 3 of us many years ago has evolved into a close professional collaboration and friendship. In 2013, those discussions culminated in creating one of the first textbooks of its kind, Anesthesiology and Otolaryngology,1...
Thu Oct 31, 2019 09:38
Head and neck surgical patients, at times, can represent a challenging population to manage in the intensive care unit postoperatively. Close interaction between the critical care and surgical teams, awareness of potential surgery-specific complications, and utilization of protocol-driven care can reduce risk of morbidity significantly in this population and enhance outcomes. Given the relative complexity of otolaryngologic surgery and the unique risk that head and neck pathologies can pose to patient...
Thu Oct 31, 2019 09:38
ConclusionsImage analysis and volumetric measurements of osteolytic lesions of MRONJ patients is a helpful tool to further understand the clinical appearance and identify compromised anatomic landmarks. Volumetric analysis aids in pre-surgical planning and visualizes the individual extent of the disease for each patient. (Source: Oral and Maxillofacial Surgery)
Thu Oct 31, 2019 00:00
We have explored the relations between clinicopathological features and cervical lymph node metastases (LNM) in patients with cN0 squamous cell carcinoma (SCC) of the tongue, and developed and validated a nomogram for predicting the risk of their development. Clinical data on 230 patients with cN0 SCC of the tongue who had had primary extended excision and lymph node dissection of the neck were collected retrospectively. They were divided into a development cohort and a validation cohort in a 4:1...
Wed Oct 30, 2019 00:00
Infantile myofibromatosis is a rare condition characterized by benign spindle cell tumors most commonly involving the head, neck, and chest. An infant female with a prenatal diagnosis of a large facial mass was delivered via Cesarean at 34 weeks. Sparse prenatal care was received. Following delivery, the neonate was found to have an 8 cm ulcerative mass involving the upper lip and philtrum. Respiratory distress developed, and mask ventilation was difficult secondary to the size of the mass. The...
Wed Oct 30, 2019 00:00
Immune checkpoint inhibitors have some efficacy in treatment of hepatocellular carcinoma (HCC). Programmed cell death 1 ligand 1 (PD-L1), expressed on some cancer cells, binds to the receptor programmed cell death 1 (PDCD1, also called PD1) on T cells to prevent their proliferation and reduce the antigen-tumor immune response. Immune cells that infiltrate some types of HCCs secrete interferon gamma (IFNG). Some HCC cells express myocyte enhancer factor 2D (MEF2D), which has been associated with shorter...
Thu Oct 31, 2019 09:41
(Source: Core Evidence)
Thu Oct 31, 2019 03:00
AbstractThe human respiratory tract, usually considered sterile, is currently being investigated for human-associated microbial communities. According to Dickson's conceptual model, the lung microbiota (LMt) is a dynamic ecosystem, whose composition, in healthy lungs, is likely to reflect microbial migration, reproduction, and elimination. However, which microbial genera constitutes a “healthy microbiome” per se remains hotly debated. It is now widely accepted that a bi-directional gut-lung axis...
Thu Oct 31, 2019 00:00
Report shows decrease in age - adjusted death rates, increase in age - adjusted death rate from overdose (Source: Pulmonary Medicine News - Doctors Lounge)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Wed Oct 30, 2019 18:00
Treatment with umbralisib monotherapy demonstrated improved overall response rates among patients with follicular lymphoma. (Source: CancerNetwork)
Wed Oct 30, 2019 05:00
CONCLUSION: The evidence supporting the efficacy of currently recommended modalities of follow-up care for cancer patients is weak. Until more data from clinical studies become available, the current guidelines should be followed. PMID: 31658935 [PubMed - in process] (Source: Deutsches Arzteblatt International)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Thu Oct 31, 2019 08:35
The treatment landscape of lung cancer is rapidly evolving, with an increasing number of therapeutic options and personalized approaches as never before. In the context of the precision medicine approach, lung cancer management takes into consideration, beyond staging and patients ’ clinical characteristics, also histology and molecular pathology with the identification of oncogenic driver alterations and other predictive factors. Cytotoxic chemotherapy, usually platinum-based, the cornerstone of...
Thu Oct 31, 2019 08:15
Immune checkpoint inhibitors have significantly improved overall survival (OS) of patients with multiple malignancies. Several antibodies against programmed death protein one (PD-1) or its ligand, PD-L1, which are approved by the US Food and Drug Administration for non-small-cell lung cancer (NSCLC) [1,2], are increasingly significant for the management of lung cancer [1 –3]. However, they are not effective in all patients. The response rate to single PD-1/PD-L1 inhibitors ranges from 20% to 40%...
Thu Oct 31, 2019 08:15
(Source: Anti-Cancer Agents in Medicinal Chemistry)
Thu Oct 31, 2019 08:15
(Source: Anti-Cancer Agents in Medicinal Chemistry)
Thu Oct 31, 2019 08:15
(Source: Anti-Cancer Agents in Medicinal Chemistry)
Thu Oct 31, 2019 08:15
(Source: Anti-Cancer Agents in Medicinal Chemistry)
Thu Oct 31, 2019 08:15
(Source: Anti-Cancer Agents in Medicinal Chemistry)
Thu Oct 31, 2019 08:15
(Source: Anti-Cancer Agents in Medicinal Chemistry)
Thu Oct 31, 2019 08:15
(Source: Anti-Cancer Agents in Medicinal Chemistry)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Thu Oct 31, 2019 08:15
(Source: Anti-Cancer Agents in Medicinal Chemistry)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Thu Oct 31, 2019 08:15
(Source: Anti-Cancer Agents in Medicinal Chemistry)
Thu Oct 31, 2019 08:15
(Source: Anti-Cancer Agents in Medicinal Chemistry)
Thu Oct 31, 2019 08:15
(Source: Anti-Cancer Agents in Medicinal Chemistry)
Thu Oct 31, 2019 08:15
(Source: OncoTargets and Therapy)
Thu Oct 31, 2019 04:55
(Source: Cancer Management and Research)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Thu Oct 31, 2019 03:33
(Source: Cancer Management and Research)
Thu Oct 31, 2019 02:45
(Source: Cancer Management and Research)
Thu Oct 31, 2019 01:17
(Source: Cancer Management and Research)
Thu Oct 31, 2019 00:26
(Source: Cancer Management and Research)
Thu Oct 31, 2019 00:07
British Journal of Cancer, Published online: 31 October 2019; doi:10.1038/s41416-019-0616-1Patient-derived organoids as a potential model to predict response to PD-1/PD-L1 checkpoint inhibitors (Source: British Journal of Cancer)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Thu Oct 31, 2019 00:00
In this study, we aimed to identify the relationships between immune cell infiltration levels (ICILs) and IMCIs and identify markers for ICILs.Methods: ICILs were estimated based on single-sample gene set enrichment analysis. The response rates of different ICILs to IMCIs were calculated by combining the ICILs of molecular subtypes in BLCA with the response rates of different molecular subtypes of IMvigor 210 trials to a programmed cell death ligand-1 inhibitor. Weighted gene co-expression network...
Thu Oct 31, 2019 00:00
AbstractAround 1/3 of patients of locally advanced carcinoma thyroid present with tracheal infiltration either alone or along with infiltration of other adjacent structures. Even though trachea is infiltrated, adequate resection is the main modality of treatment in these patients. We retrospectively analysed carcinoma thyroid patients who were operated at our institute, between January 2011 and December 2018, and underwent thyroidectomy with tracheal or laryngeal resection. Seventeen patients underwent...
Thu Oct 31, 2019 00:00
. (Source: Nutrition and Cancer)
Thu Oct 31, 2019 00:00
In this report, we show that clear cell chondrosarcoma may be a rare but canonical VHL manifestation through a cell-autonomous mechanism involving somatic loss-of-heterozygosity of theVHL tumor suppressor gene. We discuss the relevance of this observation with regard to the pathogenesis of clear cell chondrosarcoma in the context of VHL. (Source: Familial Cancer)
Thu Oct 31, 2019 00:00
. (Source: Nutrition and Cancer)
Thu Oct 31, 2019 00:00
ConclusionRABIT is a safe and feasible approach for thyroidectomy. It has several advantages in that it provides similar symmetrical view to conventional open surgery and enables to maintain specimen integrity and use of assistant port permits better handling of the gland. Additionally, the largest operating angles with this technique prevent collision between the robotic arms and provide excellent cosmetic satisfaction due to very small, five separate breast-axillo incisions. (Source: International...
Thu Oct 31, 2019 00:00
This study aims to investigate the effect of BDE-47 on the invasive phenotype of estrogen-dependent EC cells. BDE-47-treated cells, such as Ishikawa-BDE-47 and HEC-1B-BDE-47 cells, exhibited increased cell viability and enhanced metastatic ability. In vivo studies showed larger tumor volumes and more metastasis in mice injected with Ishikawa-BDE-47 cells compared with parental Ishikawa cells. MTT assay showed that BDE-47 exposure could attenuate sensitivity of EC cells to cisplatin or paclitaxel...
Thu Oct 31, 2019 00:00
ConclusionSevoflurane augmented or hampered cell proliferation and Matrigel invasion depending on the cancer cell line examined. Loss of sevoflurane-induced apoptosis occurring in cancer cell lines is likely to be correlated with their enhanced proliferation after sevoflurane exposure. (Source: Journal of Anesthesia)
Thu Oct 31, 2019 00:00
Cancer is one of the most frequent and devastating diseases. Previous reports have shown that radio and chemo-resistant cancer stem cell (CSC) population is primarily responsible for cancer recurrences after radiotherapy and chemotherapy. Other studies demonstrated that Lissencephaly-1 (LIS1) protein, also known as platelet activating factor acetylhydrolase 1b regulatory subunit 1 (PAFAH1B1), a dynein-binding protein involved in neural stem cell division, plays a crucial role in maintaining CSC population...
Thu Oct 31, 2019 00:00
British Journal of Cancer, Published online: 31 October 2019; doi:10.1038/s41416-019-0603-6Circulating biomarkers in patients with glioblastoma (Source: British Journal of Cancer)
Thu Oct 31, 2019 00:00
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