Related ArticlesSynthesis of Substituted Cinnamido Linked Quinazolinone Congeners as Potential Anticancer Agents via Mitochondrial Dependent Intrinsic Apoptotic Pathway. Anticancer Agents Med Chem. 2019 Sep 06;: Authors: Manasa KL, Saifi MA, Tangella Y, Godugu C, Alvala M Abstract BACKGROUND: The synthesis of novel heterocyclic scaffolds with amide functionality is a key research area due to their plethora of medicinal applications. Present study aims...
Sat Sep 07, 2019 14:47
Related ArticlesTargeted Fluorescence Imaging and Biological Effects of Peptide Conjugated Quantum Dots on Pancreatic Cancer Cells. J Nanosci Nanotechnol. 2020 Mar 01;20(3):1351-1357 Authors: Shi X, Shi C, Ye W, Wang L, Zhan Y, Song F, Liu F, Shi Y Abstract Arginine-glycine-aspartic acid (RGD) peptide sequences exist in a variety of biological extracellular matrices and can specifically bind the cell-surface integrin αvβ3, which is overexpressed in cancer...
Sun Sep 08, 2019 13:02
Related ArticlesAnticancer Action of Psilostachyin-A in 5-Fluorouracil-Resistant Human Liver Carcinoma are Mediated Through Autophagy Induction, G2/M Phase Cell Cycle Arrest and Inhibiting Extracellular-Signal-Regulated Kinase/Mitogen Activated Protein Kinase (ERK/MAPK) Signaling Pathway. Med Sci Monit. 2019 Sep 07;25:6711-6718 Authors: Liu J, Liu Y, Liu Y, Huang L, Wang G, Wang J, Xu X, Shi C, Huang J Abstract BACKGROUND Liver cancer is one of the most...
Sun Sep 08, 2019 13:02
Related ArticlesBiomarker Potential of Plasma MicroRNA-150-5p in Prostate Cancer. Medicina (Kaunas). 2019 Sep 03;55(9): Authors: Paunescu IA, Bardan R, Marcu A, Nitusca D, Dema A, Negru S, Balacescu O, Balacescu L, Cumpanas A, Sirbu IO, Petrut B, Seclaman E, Marian C Abstract Background and Objectives: Over decades, prostate cancer (PCa) has become one of the leading causes of cancer mortality in men. Extensive evidence exists that microRNAs (miRNAs...
Fri Sep 06, 2019 16:28
Related ArticlesTumor-Targeted Drug Conjugates as an Emerging Novel Therapeutic Approach in Small Cell Lung Cancer (SCLC). Cancers (Basel). 2019 Sep 03;11(9): Authors: Deneka AY, Boumber Y, Beck T, Golemis EA Abstract There are few effective therapies for small cell lung cancer (SCLC), a highly aggressive disease representing 15% of total lung cancers. With median survival <2 years, SCLC is one of the most lethal cancers. At present, chemotherapies...
Fri Sep 06, 2019 16:28
Related ArticlesIdentification of Cell-Free Circulating MicroRNAs for the Detection of Early Breast Cancer and Molecular Subtyping. J Oncol. 2019;2019:8393769 Authors: Souza KCB, Evangelista AF, Leal LF, Souza CP, Vieira RA, Causin RL, Neuber AC, Pessoa DP, Passos GAS, Reis RMV, Marques MMC Abstract Early detection is crucial for achieving a reduction in breast cancer mortality. Analysis of circulating cell-free microRNAs present in the serum of cancer...
Fri Sep 06, 2019 16:28
Related ArticlesLow-Dose Irradiation Differentially Impacts Macrophage Phenotype in Dependence of Fibroblast-Like Synoviocytes and Radiation Dose. J Immunol Res. 2019;2019:3161750 Authors: Deloch L, Fuchs J, Rückert M, Fietkau R, Frey B, Gaipl US Abstract Rheumatoid arthritis (RA) is a multifactorial autoimmune disease whose main hallmark is inflammation and destruction of the joints. Two cell types within the synovium that play an important role in...
Fri Sep 06, 2019 16:28
Related ArticlesmiR-548b-3p functions as a tumor suppressor in lung cancer. Lasers Med Sci. 2019 Sep 05;: Authors: Wang Z, Wu X, Hou X, Zhao W, Yang C, Wan W, Chen L Abstract miR-548-3p is one of the members of miR-548 family, a large primate-specific miRNA gene family. The role of miR-548-3p in lung cancer was less studied. In this study, we found the expression of miR-548-3p was lower both in clinical tumor specimens and lung cancer cells compared...
Fri Sep 06, 2019 16:28
Related ArticlesA Review of Recent Decision-Analytic Models Used to Evaluate the Economic Value of Cancer Treatments. Appl Health Econ Health Policy. 2019 Sep 04;: Authors: Bullement A, Cranmer HL, Shields GE Abstract Cost-effectiveness analysis provides information on the potential value of new cancer treatments, which is particularly pertinent for decision makers as demand for treatment grows while healthcare budgets remain fixed. A range of decision-analytic...
Fri Sep 06, 2019 16:28
Related ArticlesLate referral of cancer patients with malnutrition to dietitians: a prospective study of clinical practice. Support Care Cancer. 2019 Sep 04;: Authors: Lorton CM, Griffin O, Higgins K, Roulston F, Stewart G, Gough N, Barnes E, Aktas A, Walsh TD Abstract PURPOSE: Malnutrition (MN) in cancer is common but underdiagnosed. Dietitian referrals may not occur until MN is established. We investigated cancer patient characteristics (demographics,...
Fri Sep 06, 2019 16:28
Related ArticlesMathematical Modeling of Oncolytic Virotherapy. Methods Mol Biol. 2020;2058:307-320 Authors: Heidbuechel JPW, Abate-Daga D, Engeland CE, Enderling H Abstract Mathematical modeling in biology has a long history as it allows the analysis and simulation of complex dynamic biological systems at little cost. A mathematical model trained on experimental or clinical data can be used to generate and evaluate hypotheses, to ask "what if" questions,...
Fri Sep 06, 2019 16:28
Related ArticlesElectronic cigarette use and sleep health in young adults. J Sleep Res. 2019 Sep 04;:e12902 Authors: Brett EI, Miller MB, Leavens ELS, Lopez SV, Wagener TL, Leffingwell TR Abstract Poor sleep health is associated with numerous health concerns, and sleep problems are exacerbated by cigarette smoking. Although rates of traditional tobacco use are declining, rates of electronic cigarette (e-cigarette) use are comparatively high and growing....
Fri Sep 06, 2019 16:28
Related ArticlesFeasibility and acceptability of an animatronic duck intervention for promoting adaptation to the in-patient setting among pediatric patients receiving treatment for cancer. Pediatr Blood Cancer. 2019 Sep 05;:e27984 Authors: Miller TP, Klosky JL, Zamora F, Swift M, Mertens AC Abstract BACKGROUND: During cancer treatment, children undergo potentially stressful hospitalizations and procedures. Animatronic devices are a promising means of...
Fri Sep 06, 2019 16:28
Related ArticlesThe Development and Validation of Updated Palliative and End-of-Life Care Competencies for Medical Undergraduates in Canada. J Palliat Med. 2019 Sep 05;: Authors: Bush SH, Roze des Ordons A, Chary S, Boyle AB Abstract In 2008, a Canadian strategy called the "Educating Future Physicians in Palliative and End-of-Life Care" (EFPPEC) project published national medical undergraduate competencies for palliative and end-of-life care. Since that...
Fri Sep 06, 2019 16:28
Related ArticlesDrug Dose, Drug Choice: Optimizing Medical Therapy for Veterinary Cancer. Vet Comp Oncol. 2019 Sep 05;: Authors: Thamm DH, Gustafson DL Abstract While novel agents hold great promise for the treatment of animal neoplasia, there may be room for significant improvement in the use of currently available agents. These improvements include altered dosing schemes, novel combinations and patient-specific dosing or selection of agents. Previous...
Fri Sep 06, 2019 16:28
Related ArticlesSmall Bowel Adenocarcinoma: Etiology, Presentation, and Molecular Alterations. J Natl Compr Canc Netw. 2019 Sep 01;17(9):1135-1141 Authors: Pedersen KS, Raghav K, Overman MJ Abstract Small bowel adenocarcinoma (SBA) is a rare cancer that has been treated similarly to colorectal cancer (CRC) in the advanced setting. Incidence has been increasing as detection efforts have been improving for these challenging-to-diagnose tumors, but patients...
Fri Sep 06, 2019 16:28
Related ArticlesDisulfiram repurposing combined with nutritional copper supplement as add-on to chemotherapy in recurrent glioblastoma (DIRECT): Study protocol for a randomized controlled trial. F1000Res. 2018;7:1797 Authors: Jakola AS, Werlenius K, Mudaisi M, Hylin S, Kinhult S, Bartek J, Salvesen Ø, Carlsen SM, Strandéus M, Lindskog M, Löfgren D, Rydenhag B, Carstam L, Gulati S, Solheim O, Bartek J, Solheim T Abstract Background: Disulfiram (DSF)...
Sat Sep 07, 2019 13:19
Related ArticlesDe-escalating chemotherapy for stage II colon cancer? Therap Adv Gastroenterol. 2019;12:1756284819867553 Authors: Fu J, Wu L, Ge C, Xu T, Li D, Fu W, Wang L, Du J Abstract Background: Although adjuvant chemotherapy is recommended for patients with stage II colon cancer characterized by poor prognostic features, its pros and cons remain a controversial issue. We aim to evaluate the real effectiveness of chemotherapy on stage II colon cancer...
Sat Sep 07, 2019 13:19
Related ArticlesA review of optimal prostate biopsy: indications and techniques. Ther Adv Urol. 2019 Jan-Dec;11:1756287219870074 Authors: Streicher J, Meyerson BL, Karivedu V, Sidana A Abstract Prostate biopsy is the gold standard diagnostic technique for the detection of prostate cancer. Patient selection for prostate biopsy is complex and is influenced by emerging use of prebiopsy imaging. The introduction of the magnetic resonance imaging (MRI)-transrectal...
Sat Sep 07, 2019 13:19
Related ArticlesKaronudib is a promising anticancer therapy in hepatocellular carcinoma. Ther Adv Med Oncol. 2019;11:1758835919866960 Authors: Hua X, Sanjiv K, Gad H, Pham T, Gokturk C, Rasti A, Zhao Z, He K, Feng M, Zang Y, Zhang J, Xia Q, Helleday T, Warpman Berglund U Abstract Background: Hepatocellular carcinoma (HCC) is the most common form of liver cancer and is generally caused by viral infections or consumption of mutagens, such as alcohol. While...
Sat Sep 07, 2019 13:19
Related ArticlesPerioperative impact of liver venous deprivation compared with portal venous embolization in patients undergoing right hepatectomy: preliminary results from the pioneer center. Hepatobiliary Surg Nutr. 2019 Aug;8(4):329-337 Authors: Panaro F, Giannone F, Riviere B, Sgarbura O, Cusumano C, Deshayes E, Navarro F, Guiu B, Quenet F Abstract Background: Preoperative portal vein embolization (PVE) is currently the standard technique used routinely...
Sat Sep 07, 2019 13:19
Related ArticlesInternational consensus statement on robotic pancreatic surgery. Hepatobiliary Surg Nutr. 2019 Aug;8(4):345-360 Authors: Liu R, Wakabayashi G, Palanivelu C, Tsung A, Yang K, Goh BKP, Chong CC, Kang CM, Peng C, Kakiashvili E, Han HS, Kim HJ, He J, Lee JH, Takaori K, Marino MV, Wang SN, Guo T, Hackert T, Huang TS, Anusak Y, Fong Y, Nagakawa Y, Shyr YM, Wu YM, Zhao Y Abstract The robotic surgical system has been applied to various types...
Sat Sep 07, 2019 13:19
Related ArticlesDecreasing New York esophageal squamous cell carcinoma 1 expression inhibits multiple myeloma growth and osteolytic lesions. J Cell Physiol. 2019 Sep 05;: Authors: Li F, Zhao F, Li M, Pan M, Shi F, Xu H, Zheng D, Wang L, Dou J Abstract New York esophageal squamous cell carcinoma 1 (NY-ESO-1) is aberrantly expressed in multiple myeloma (MM) patients, however, its role remains largely unknown. The present study aimed to investigate the...
Sat Sep 07, 2019 13:19
Related ArticlesA population-based cohort of young women diagnosed with breast cancer in Geneva, Switzerland. PLoS One. 2019;14(9):e0222136 Authors: Schaffar R, Bouchardy C, Chappuis PO, Bodmer A, Benhamou S, Rapiti E Abstract PURPOSE: Breast cancer is the most frequently diagnosed cancer among women worldwide. Despite the fact that breast cancer is more frequent after fifty years of age, breast cancer among young women has recently drawn particular...
Sat Sep 07, 2019 14:16
Related ArticlesCollecting ducts carcinoma: An orphan disease. Literature overview and future perspectives. Cancer Treat Rev. 2019 Aug 27;79:101891 Authors: Pagani F, Colecchia M, Sepe P, Apollonio G, Claps M, Verzoni E, de Braud F, Procopio G Abstract Collecting ducts carcinoma (CDC) is a rare and aggressive histological subtype of renal cancer accounting for only 1% of renal tumors. Usually patients present in bad clinical conditions due to a symptomatic...
Sat Sep 07, 2019 14:16
Related ArticlesLiquid biopsy for diffuse intrinsic pontine glioma: an update. J Neurosurg Pediatr. 2019 Sep 06;:1-8 Authors: Lu VM, Power EA, Zhang L, Daniels DJ Abstract Diffuse intrinsic pontine glioma (DIPG), otherwise known as diffuse midline glioma with H3K27M mutation, is a devastating brainstem glioma without a cure. Efforts are currently underway to better optimize molecular diagnoses through biological sampling, which today remains largely...
Sat Sep 07, 2019 14:16
Related ArticlesObstructive hydrocephalus and chemical meningitis secondary to a ruptured spinal epidermoid cyst: a case report. World Neurosurg. 2019 Sep 03;: Authors: Fernández-de Thomas RJ, Vicenty-Padilla JC, Sánchez-Jiménez JG, Labat EJ, Carballo-Cuello CM, De Jesús O, Vigo-Prieto JA Abstract BACKGROUND: Epidermoid cysts of the spinal cord may rupture, resulting in keratin dissemination in the subarachnoid space, ventricles and along the central...
Sat Sep 07, 2019 14:44
Related ArticlesIntraoperative resting state functional connectivity and resting state networks in patients with intracerebral lesions: detectability and variations between sessions. World Neurosurg. 2019 Sep 03;: Authors: Metwali H, Raemaekers M, Kniese K, Samii A Abstract OBJECTIVE: Evaluation of the functional connectivity (FC) and resting state networks (RSN) in patients under anesthesia operated for resection of intracerebral lesions. METHODS:...
Sat Sep 07, 2019 14:44
Related ArticlesCervical Range of Motion after Anterior Corpectomy and Fusion versus Laminoplasty for Multilevel Cervical Spondylotic Myelopathy: A Three-Dimensional Comparison Based on Coda Motion System. World Neurosurg. 2019 Sep 03;: Authors: Yang K, Guo S, Xu J, Tao H, Chen H, Feng C, Wang J, Li H Abstract OBJECTIVE: To compare the change of cervical range of motion (CROM) after the two most widely used techniques for multilevel cervical spondylotic...
Sat Sep 07, 2019 14:44
Related ArticlesIntrasphenoidal encephalocele (ISE) with spontaneous CSF rhinorrhea in idiopathic intracranial hypertension: A need for clarity in terminology & imaging delineation. World Neurosurg. 2019 Sep 03;: Authors: Manjubashini D, Kiran M, Akshaya S, Nagarajan K Abstract BACKGROUND: Magnetic Resonance (MR) imaging plays an important role in identification of any underlying structural cause in spontaneous cerebrospinal fluid (CSF) leaks - either...
Sat Sep 07, 2019 14:44
Related ArticlesA rare case of Spinal Mastocytosis presenting as an extradural mass. World Neurosurg. 2019 Sep 03;: Authors: Zafar A, Frygier A, Strickland S, Turney R, Spink G Abstract BACKGROUND: Systemic Mastocytosis is a haematopoetic disorder of mast cells deposits in various systemic tissues which can include skin, spleen, liver and bone marrow. When accumulation occurs within bone it has been reported to cause osteoporosis, osteosclerosis or sometimes...
Sat Sep 07, 2019 14:44
Related ArticlesDecompressive craniectomy for patients with traumatic brain injury: a pooled analysis of randomized controlled trials. World Neurosurg. 2019 Sep 03;: Authors: Lu G, Zhu L, Wang X, Zhang H, Li Y Abstract BACKGROUND: Decompressive hemicraniectomy (DHC) was widely applied for patients with traumatic brain injury (TBI). Although previous studies indicated that DHC could lead to similar or worse outcome compare with the medical treatment (MT)...
Sat Sep 07, 2019 14:44
Related ArticlesLessons learned from the initial experience with pedicled temporoparietal fascial flap for combined revascularization in moyamoya angiopathy: a case series. World Neurosurg. 2019 Sep 03;: Authors: Ravina K, Kim PE, Rennert RC, Wolfswinkel EM, Strickland BA, Carey JN, Russin JJ Abstract BACKGROUND: The pedicled temporoparietal fascial flap (TPFF) with a direct superficial temporal artery-to-middle cerebral artery (STA-MCA) bypass is a...
Sat Sep 07, 2019 14:44
Related ArticlesIntrameningioma metastasis: A wolf in sheep´s clothing? Experience from a series of seven cases. World Neurosurg. 2019 Sep 03;: Authors: Başaran AE, Kiesel B, Frischer JM, Furtner J, Wöhrer A, Dieckmann K, Dorfer C Abstract BACKGROUND: Intrameningioma metastasis is a rare differential diagnosis. The clinical implications of these lesions are poorly understood. METHODS: We screened our database to identify all patients that had...
Sat Sep 07, 2019 14:44
Related ArticlesRecurrent undifferentiated carcinoma of the sella in a patient with Lynch syndrome. World Neurosurg. 2019 Sep 03;: Authors: Ryan VM, Paulo AJ, Bayardo PO, Gelareh Z Abstract BACKGROUND: Lynch syndrome (LS) is a cancer-predisposing condition resulting from germline mutations in DNA mismatch repair (MMR) genes. Patients are at high risk for a multitude of tumors, but no reports of undifferentiated sellar carcinomas have previously been...
Sat Sep 07, 2019 14:44
Related ArticlesA surgical case of complete resection of the focal cortical and subcortical dysplasia in the motor cortex: Case report. World Neurosurg. 2019 Sep 03;: Authors: Sahar F, Houssein D, Wassim N, Joseph S, Ahmad B Abstract Focal cortical dysplasias (FCD) are highly epileptogenic and are frequently associated with medically refractory focal epilepsy. FCD are frequently located in the frontal lobe rendering its complete resection highly challenging...
Sat Sep 07, 2019 14:44
Related ArticlesPipeline Embolization Device For Treatment of Craniocervical Internal Carotid Artery Dissections. World Neurosurg. 2019 Sep 03;: Authors: Shields LBE, Shields CB, Ghiassi M, Dashti SR, Yao TL, Zhang YP, Ghiassi M Abstract BACKGROUND: Dissecting pseudoaneurysms of the craniocervical circulation are uncommon and account for 3% of all cerebral aneurysms. These aneurysms pose a challenge due to their location and anatomic configuration. The...
Sat Sep 07, 2019 14:44
Related Articles"Management of Cushing's disease: Changing trend from microscopic to endoscopic surgery". World Neurosurg. 2019 Sep 03;: Authors: KumarBora S, Suri A, Khadgawat R, Tandon N, Suri V, Chand Sharma M, Satyarthee G, Singh M, Tandon V, Agarwal D, Kumar R, Chandra PS, Gurjar HK, Borkar S, Gupta DK, Singh PK, Kale SS Abstract BACKGROUND: Cushing's disease (CD) is a spectrum of clinical manifestations due to ACTH-secreting pituitary adenoma....
Sat Sep 07, 2019 14:44
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