Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Issue: Ahead of print
Mon Sep 16, 2019 23:35
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Issue: Ahead of print
Mon Sep 16, 2019 23:35
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Issue: Ahead of print
Mon Sep 16, 2019 23:35
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Issue: Ahead of print
Mon Sep 16, 2019 23:35
Journal Name: Journal of Pediatric Endocrinology and MetabolismIssue: Ahead of print
Mon Sep 16, 2019 23:44
Researchers from University of Massachusetts at Amherst have developed a new smart pajama, dubbed Phyjama, that can track physiological signals during sleep. Their work demonstrates that the technology can reliably measure heart rate, breathing rate, and sleep position during the course of the night. One day, advances like this can be incorporated into regular sleepwear, which can be an additional source of biomedical data and may help track and monitor various health conditions. ...
Mon Sep 16, 2019 16:39
At the ICFO – The Institute of Photonic Sciences, in Catalonia, Spain, researchers have come up with a way to use graphene to make flexible photodetectors to measure heart rate, blood oxygen concentration, and breathing rate. Additionally, the technology can also be used to measure UV levels coming from the Sun and to communicate the measured data from the sensor to a device such as a smartphone. Today’s wearable pulse oximeters and heart rate monitors can be pretty bulky, as is the case with...
Mon Sep 16, 2019 19:03
Engineers at University of California, Los Angeles have come up with a tiny new robot that can be controlled and powered using a beam of light. Called OsciBot, because of its oscillating motion, the robot is made entirely out of a light-responsive hydrogel and doesn’t carry its own power source, relying on an external constant light source to help it push itself along. The technology has significant medical implications, as it allows for very small, soft robots to operate within the body as a drug...
Mon Sep 16, 2019 19:26
Siemens Healthineers unveiled two new CT scanners specifically designed for radiation therapy planning. The SOMATOM go.Sim and SOMATOM go.Open Pro are 64-slice and 128-slice devices, respectively, and feature an 85 cm opening suitable for larger patients. To make patient prep easier and faster, the scanners come with an optional DirectLasers system mounted on top of the gantry that projects laser light beams onto the patients. These help to align each patient accurately and are controlled...
Mon Sep 16, 2019 23:58
Abstract BRAF V600E mutations are common in papillary thyroid carcinoma (PTC) and some de-differentiated thyroid cancers. In this study, we summarize AUS/FLUS diagnosed cases from thyroid fine needle aspirations in our center from 2015 to 2017 to explore the impact of BRAF V600E detection on the cytopathological diagnosis of PTC. BRAF V600E detection could significantly reduce the AUS/FLUS diagnosis rates from 11.59 to 8.42% when all BRAF V600E-mutated AUS/FLUS cases were diagnosed...
Mon Sep 16, 2019 03:00
A sentinel lymph node biopsy is a common surgical procedure for cutaneous melanoma. Our aim was to evaluate risk factors for early postoperatively complications after SLN biopsy, and to examine the impact of complications on healthcare resource utilization.
Mon Sep 16, 2019 03:00
Paradoxical vocal fold motion disorder (PVFMD), or induced laryngeal obstruction (ILO), is a clinical phenomenon characterized by inappropriate adduction of the true vocal folds during inspiration. The resultant episodes of acute respiratory distress marked by exercise-induced cough, inspiratory stridor, throat tightness, and shortness of breath are often misattributed to asthma despite normal pulmonary function testing results. Although the pathogenesis of the disease remains unclear, the etiology...
Mon Sep 16, 2019 03:00
This meeting was the beginning of a long-standing friendship during which I followed her in my personal clinic, without housestaff.
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Candida auris is an emerging, multidrug-resistant yeast that is now known to have caused invasive infections in more than 30 countries spanning every inhabited continent. It is an urgent antimicrobial resistance threat because many strains are resistant to at least 2 of 3 major classes of antifungal drugs and because it causes outbreaks in health care settings to an extent not seen with other Candida species.
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Background:Some reports suggest that body mass index (BMI) is not strongly associated with mortality in Hispanic populations.Objective:To assess the causal relevance of adiposity to mortality in Mexican adults, avoiding reverse causality biases.Design:Prospective study.Setting:2 Mexico City districts.Participants:159 755 adults aged 35 years and older at recruitment, followed for up to 14 years. Participants with a hemoglobin A1c level of 7% or greater, diabetes, or other chronic diseases were excluded.Measurements:BMI,...
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The expanded use of opioids for chronic pain has created a population of patients prescribed long-term opioid therapy at doses that are often above those recommended by the Centers for Disease Control and Prevention. Many patients may benefit from tapering to lower, safer doses. This commentary argues that successful tapering requires implementing and incentivizing tapering protocols, recognizing prescription opioid dependence as a distinct clinical condition necessitating treatment, and expanding...
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On 15 May 2015, the U.S. Food and Drug Administration (FDA) warned that administration of sodium–glucose cotransporter-2 (SGLT2) inhibitors could lead to ketoacidosis in patients with diabetes mellitus. This announcement came more than 2 years after the FDA's first approval of an SGLT2 inhibitor, although the phenomenon had been known for more than 125 years. Luminaries of diabetes research (including Josef von Mering, Frederick Allen, I. Arthur Mirsky, and George Cahill) had described ketosis and...
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A sharp decline in clinical trials has occurred, whether measured as number of trials performed, number of participants enrolled, or number of investigators. This commentary discusses factors contributing to an environment that does not promote clinical trial research and offers suggestions for actions that academic health centers can take to counter these pressures.
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Is it better or worse to know that something remains of our past once dementia robs us of our present?
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In this issue, Leslie and colleagues compiled a disturbing tale of historical amnesia in which the neglect of 19th- and 20th-century information led to preventable adverse events in 21st-century patients. The editorialist discusses what paths we might take in drug development to ensure that we avoid repeated rediscovery of past harms.
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Background:Smaller (<3-mm) infarctions are associated with stroke and stroke mortality, but relationships with cognitive decline are unknown.Objective:To characterize the relationships of smaller, larger, and both smaller and larger infarctions in middle age with 20-year cognitive decline.Design:Longitudinal cohort study.Setting:Two ARIC (Atherosclerosis Risk in Communities) study sites with magnetic resonance imaging data (1993 to 1995) and up to 5 cognitive assessments over 20 years.Participants:Stroke-free...
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Background:Whether health outcomes of menopausal estrogen therapy differ between women with and without bilateral salpingo-oophorectomy (BSO) is unknown.Objective:To examine estrogen therapy outcomes by BSO status, with additional stratification by 10-year age groups.Design:Subgroup analyses of the randomized Women's Health Initiative Estrogen-Alone Trial. (ClinicalTrials.gov: NCT00000611)Setting:40 U.S. clinical centers.Participants:9939 women aged 50 to 79 years with prior hysterectomy and known...
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Description:The American Diabetes Association (ADA) annually updates its Standards of Medical Care in Diabetes to provide clinicians, patients, researchers, payers, and other interested parties with evidence-based recommendations for the diagnosis and management of patients with diabetes.Methods:The ADA Professional Practice Committee comprises physicians, adult and pediatric endocrinologists, diabetes educators, registered dietitians, epidemiologists, pharmacists, and public health experts. To develop...
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