AIMS B-cell acute lymphoblastic leukemia (B-ALL) is amongst the most prevalent cancers of children in Pakistan. Genetic variations in FLT3 are associated with auto-phosphorylation of kinase domain that leads to increased proliferation of blast cells. Paired box family of transcription factor (PAX5) plays a critical role in commitment and differentiation of B-cells. Variations in PAX5 are associated with the risk of B-ALL. We aimed to analyze the association of FLT3 and PAX5 polymorphisms...
03:00
Background Throughout the world, intensive dairy farming has resulted in grasslands almost devoid of arthropods and birds. Meadow birds appear to be especially vulnerable during the chick-rearing period. So far, studies have focused mainly on describing population declines, but solutions to effectively stop these trends on the short-term are lacking. In this study at a single farm, we experimentally manipulated soil moisture through occasional irrigation, to mitigate against early season drainage...
03:00
Background Long non-coding RNAs (lncRNAs) can function as competing endogenous RNAs (ceRNAs) to interact with miRNAs to regulate target genes and promote cancer initiation and progression. The expression of lncRNAs and miRNAs can be epigenetically regulated. The goal of this study was to construct an lncRNA-miRNA-mRNA ceRNA network in laryngeal squamous cell carcinoma (LSCC) and reveal their methylation patterns, which was not investigated previously. ...
03:00
Background Medical institutions worldwide have not reached a consensus on what surgery is the most advisable for pulmonary typical carcinoid (TC) patients at the localized stage. This research focuses on exploring whether wedge resection or segmental resection is the superior option. Methods The demographic and clinical information of 1,887 TC patients diagnosed at the localized stage from 2004 to 2015 was collected...
03:00
Coral reefs are in decline worldwide. In response to this habitat loss, there are efforts to grow, outplant, and restore corals in many regions. The physical oceanographic habitat of corals—such as sea temperature, waves, ocean currents, and available light—is spatially heterogeneous. We therefore hypothesize that outplant location may affect microbiomes, and ultimately, coral health and restoration success. We evaluated the influence of the physical oceanographic habitat on microbes in wild Porites...
03:00
Με αυξημένο κίνδυνο εκδήλωσης διαβήτη τύπου 2 σχετίζεται το χαμηλό ανάστημα σύμφωνα με νέα μελέτη που δημοσιεύεται στο Diabetologia. Αντιθέτως τα ψηλά άτομα φαίνεται να έχουν μειωμένο κίνδυνο, με κάθε 10 εκατοστά διαφορά στο ύψος να σχετίζεται με 41% μειωμένο κίνδυνο διαβήτη στους άνδρες και 33% στις γυναίκες. «Ο αυξημένος κίνδυνος για τους έχοντες χαμηλό ανάστημα μπορεί να οφείλεται στην μεγαλύτερη εναπόθεση λίπους στο σώμα και το λιγότερο ευνοϊκό προφίλ καρδιαμεταβολικών παραγόντων κινδύνου»,...
08:04
Η κατανάλωση κοτόπουλου συσχετίζεται με την πρόκληση καρκίνου σύμφωνα με επιστήμονες του Πανεπιστημίου της Οξφόρδης οι οποίοι υποστηρίζουν ότι οι άνθρωποι που καταναλώνουν πουλερικά διατρέχουν αυξημένο κίνδυνο πρόκλησης αυτής της θανατηφόρου νόσου. Η μελέτη δημοσιεύθηκε στο Journal of Epidemiology and Community Health. Ωστόσο η έρευνα αποκαλύπτει μεν την ύπαρξη ενός συσχετισμού ανάμεσα στην κατανάλωση κοτόπουλου και τον καρκίνο, αλλά δεν εντοπίζει και τα αίτια του συσχετισμού. Να σημειωθεί δε...
Mon Sep 09, 2019 13:09
Η Αμερικανίδα Emily Whitehead είναι μια 14χρονη, υγιής, χαρούμενη και δραστήρια έφηβη, που κάνει όνειρα για το μέλλον! Είναι, όμως, ξεχωριστή, καθώς έχει καταγραφεί στα ιατρικά χρονικά ως η πρώτη ασθενής που θεραπεύθηκε από την Οξεία Λεμφοβλαστική Λευχαιμία (ΟΛΛ), χάρη σε μια καινοτόμο θεραπεία με βάση τα T-λεμφοκύτταρα του ίδιου της του οργανισμού. Το ιατρικό αυτό «θαύμα» άνοιξε τον δρόμο για την έγκριση της πρωτοποριακής αγωγής από τις αρμόδιες αμερικανικές και ευρωπαϊκές αρχές για την υποτροπιάζουσα/ανθεκτική...
Mon Sep 09, 2019 12:25
Παρότι οι συχνές μαστογραφίες μπορεί να προλάβουν εγκαίρως τον καρκίνο του μαστού, οι γυναίκες άνω των 75 ετών, που πάσχουν από χρόνιες νόσους, μπορούν να παραλείψουν αυτή την εξέταση, σύμφωνα με νέα έρευνα. Τα αποτελέσματα της συγκεκριμένης μελέτης, που δημοσιεύτηκε στην Journal of the National Cancer Institute, έδειξαν ότι για τις γυναίκες που είναι πάνω από 75 ετών και πάσχουν από χρόνιες νόσους (π.χ. διαβήτη, καρδιαγγειακές νόσοι), το όφελος από τις μαστογραφίες είναι πολύ μικρό επειδή η μεγαλύτερη...
Mon Sep 09, 2019 12:10
Σημαντικό κομμάτι για την ψυχική και σωματική υγεία των ηλικιωμένων αποτελεί η στοματική υγεία σύμφωνα με δύο νέες έρευνες του Πανεπιστημίου Rutgers που δημοσιεύθηκαν στο American Geriatrics Society. Οι ερευνητές εξέτασαν τη σχέση μεταξύ της κακής στοματικής υγείας και της γνωστικής φθοράς καθώς επίσης και του στρες με την ξηρότητα του στόματος. Οι ερευνητές έλαβαν στοιχεία από περισσότερους από 2.700 ανθρώπους 60 ετών και άνω και βρήκαν ότι σχεδόν το 50% των συμμετεχόντων στη μελέτη ανέφεραν ότι...
Mon Sep 09, 2019 09:43
Τη γνωστική εξασθένηση στους ανθρώπους μέσης και μεγαλύτερης ηλικίας φαίνεται πως επιταχύνει η υψηλή αρτηριακή πίεση. Σε αυτό το συμπέρασμα κατέληξαν ερευνητές του Πανεπιστημίου Κολούμπια. «Τα ευρήματα είναι σημαντικά επειδή η υψηλή αρτηριακή πίεση και η γνωστική εξασθένηση είναι δύο από τις πιο κοινές παθήσεις που σχετίζονται με τη γήρανση», δήλωσε ο πρώτος συγγραφέας της μελέτης Δρ. L.H. Lumey. Στην παρατηρητική αυτή μελέτη, οι ερευνητές ανέλυσαν δεδομένα που συλλέχθηκαν από σχεδόν 11.000 ενήλικες...
Mon Sep 09, 2019 09:17
Αμερικανοί επιστήμονες πιστεύουν ότι για πρώτη φορά έκαναν βιολογικά νεότερους τους ανθρώπους χάρη σε ένα πειραματικό «κοκτέιλ» φαρμάκων που αναστρέφει το λεγόμενο «επιγενετικό ρολόι» και τη διαδικασία της γήρανσης. Σε μία μικρή κλινική δοκιμή στις ΗΠΑ, εννέα υγιείς εθελοντές ηλικίας 51 έως 65 ετών έπαιρναν για έναν χρόνο τη συγκεκριμένη θεραπεία και φάνηκε στο τέλος η βιολογική ηλικία τους να είναι έως δυόμισι χρόνια νεότερη από ότι όταν άρχισαν τα φάρμακα, που ήταν μία ορμόνη ανάπτυξης και δύο...
Mon Sep 09, 2019 09:16
Ένας στους οκτώ ηλικιωμένους που κάνει αγωγή με αντιπηκτικούς παράγοντες λαμβάνει και αναστολείς αντλίας πρωτονίων για τη θεραπεία των γαστρικών ελκών ή την πρόληψη της γαστρεντερικής αιμορραγίας. Αλλά για το 36% των ασθενών, γενικά, αυτή η συμπληρωματική φαρμακευτική αγωγή δεν είναι αναγκαία, σύμφωνα με νέα μελέτη που δημοσιεύεται στο Journal of the American Geriatrics Society. Διότι όπως αναφέρουν οι ερευνητές, συνήθως οι ασθενείς παίρνουν τους αναστολείς αντλίας πρωτονίων πολύ μεγαλύτερο χρονικό...
Mon Sep 09, 2019 08:54
Background Malnutrition in cancer is an independent factor associated with negative clinical outcomes. The objective of this study was to evaluate the prevalence of malnutrition across different age groups in patients with cancer in Brazil and to identify associations with nutrition impact symptoms (NIS). Methods In this observational, cross‐sectional, multicenter study, the authors evaluated 4783 patients with cancer aged ≥20 years who were admitted to 45 public hospitals in Brazil. Nutritional...
Mon Sep 09, 2019 13:01
Abstract This study aims to analyze gait variability and stability of individuals with amputation walking on upward (8%), horizontal (0%), and downward (− 8%) inclines, by using linear and nonlinear descriptors. Trunk linear variability and gait spatiotemporal parameters were evaluated. Nonlinear variability (local dynamic stability-LDS), was estimated by the maximum Lyapunov exponent (λ) computed from a trunk marker velocity. The gait descriptors were compared among three distinct...
03:00
Transdisciplinary approaches to the study of adhesion and adhesives in biological systems,compiled and...Transdisciplinary approaches to the study of adhesion and adhesives in biological systems,compiled and edited by Nick Aldred and J. Herbert WaiteVol. 374, No. 1784, (October 2019) The above issue is now available online at:https://royalsocietypublishing.org/toc/rstb/2019/374/1784?ai=aqlc&ui=cbwb&af=HClick the links below to view the abstract for each article, or click the link above to...
10:39
Background. Multiple sclerosis (MS), a chronic inflammatory and degenerative disease of the central nervous system, typically features immune-mediated focal demyelination and secondary axonal degeneration. Cerebral hypoperfusion of the normal-appearing white matter (NAWM) has been reported in MS patients and may be mediated by elevated levels of endothelin-1 (ET-1), a most potent vasoconstrictive peptide released from reactive astrocytes in MS focal lesions. Optic neuritis (ON) is one of the most...
09:05
The Tagliacozzi cross arm flap has been historically described for repair of large nasal defects. The authors report what we believe is the youngest case in modern literature of nasal reconstruction with a Tagliacozzi flap, in a 6-year-old girl. Due to her poor face and scalp skin quality, the more modern reconstructive options of a forehead flap or free tissue transfer were not deemed suitable. Two delay procedures and a complex splint were required to position the medial arm fasciocutaneous flap...
Mon Sep 09, 2019 03:00
No abstract available
Mon Sep 09, 2019 03:00
Background and Objective: The aim of this study was to study the risk factors of intracranial infection after traumatic craniotomy in multiple trauma to provide references for clinical prevention and control of intracranial infection. Methods: A total of 34 multiple trauma patients treated with craniotomy and complicated with intracranial infection from February 2012 to December 2016 in the department of neurosurgery of our hospital were selected as infection group, and 60 multiple trauma...
Mon Sep 09, 2019 03:00
This article examines the clinical presentation of epiphora in Ancient Rome through the historico-medical analysis of the literary evidence provided by the verses by the poet Juvenal in his Satire VI. A gladiator's ophthalmological problem is interpreted as epiphora caused by traumatic injuries to the craniofacial region, compatible with those described in the paleopathological literature. This analysis also focuses on the history of epiphora in antiquity and its treatment. Address correspondence...
Mon Sep 09, 2019 03:00
Background: Bicanalicular lacerations are relatively rare and more of a surgical challenge in clinical practice. The purpose of this study is to evaluate the clinical characteristics and surgical outcomes of bicanalicular lacerations with a new bicanalicular silicone stent at a tertiary eye care center. Methods: All patients who underwent bicanalicular lacerations repair from January 2013 and December 2018 were retrospectively reviewed. Data collected for each patient included patient demographics,...
Mon Sep 09, 2019 03:00
Background: A skull fracture widely occurs in patients with traumatic brain injury, leading to intracranial hematoma, brain contusion, and intracranial infection. It also influences the prognosis and death of patients. This study aimed to discuss cases of patients with comminuted skull fractures. Methods: From October 2015 to December 2018, 38 patients with comminuted skull fractures were admitted to the hospital. All patients underwent three-dimensional reconstruction of computed tomography...
Mon Sep 09, 2019 03:00
Cerebrospinal fluid rhinorrhea is described as cerebrospinal fluid flow through the nose due to the abnormal connection of the subarachnoid space and sinonasal cavity. Spontaneous idiopathic rhinorrhea is a rarely seen disease. Besides the patient's clinical presentation detailed radiological evaluation and other invasive procedures must be carried out to confirm the diagnosis. Its treatment is compelling due to high recurrence rates. In the treatment algorithm when conservative treatment modalities...
Mon Sep 09, 2019 03:00
In this study, the authors present the challenges of replantation and management of 2 patients who have total scalp, partial forehead and ear avulsion. A 39-year-old male farmer was admitted to the emergency room with the total scalp, forehead, partial right eyebrow and upper eyelid amputation after his hair was catched by an agricultural machine. Anastomoses of 2 arteries and 2 veins in the occipital region were done first. Anastomosis of the right and left superficial temporal arteries and veins...
Mon Sep 09, 2019 03:00
Background: Port wine stain (PWS) is a congenital benign vascular malformation. Laser treatment is the main therapy for PWS. But some patients are not sensitive to it, and failed laser treatment will leave scars on face. Hence in this study, the authors used prefabricated flap carried by superficial temporal artery to treat PWS. Methods: Nine patients diagnosed with large-scaled PWS (occupying more than half of the cheek) from January 2008 to December 2017 were selected in the study. One...
Mon Sep 09, 2019 03:00
In the oropharyngeal region examinations, the abeslang (tongue depressor) used to create a wider field of vision and press down the tongue to make the pharynx easier. In order to look under the tongue, the depressor is redesigned so that it can be examined under the tongue and transformed into a retractor by creating an angle in the body of the present invention. This technique is intended to be used in conjunction with new technology surgical procedures. Our invention consists of the stem (1), the...
Mon Sep 09, 2019 03:00
The calcification of the articular disc is an uncommon lesion, usually discovered in hips, elbows, and shoulders, but rarely in temporomandibular joints (TMJ). The TMJ disc calcification may be related to pain and limitation of the mandibular mobility, however, most of the patients were asymptomatic. A 61-year-old female was referred to our hospital after a maxillofacial fist injury, bilateral TMJ disc calcifications were found accidentally by radiological examination. Here the significance of image...
Mon Sep 09, 2019 03:00
The authors innovated a simple device that hooks the bridge of eyeglasses to a snapback cap (EHS) so that the nose-pads of glasses do not rest upon the nose. A snapback cap with 2 eyelets on the front panel is prepared. A fishing line or IV tubing is introduced through 2 eyelets and a loop is made inside of the cap. A paper clip is bent to make a J-shaped hook that holds the bridge of the glasses. A loop of line is connected through the J-hook and the length is adjusted to prevent the nose-pads...
Mon Sep 09, 2019 03:00
Background: The lag time between injury and treatment (LTIT) plays an important role in reduction of complications in mandibular fractures. The aim of this study was to measure the effect of LTIT on recovery of the inferior alveolar nerve (IAN) neurosensory disturbances (NSDs) following surgical management of mandibular body fractures. Methods: This was a prospective cohort study. Patients who had a unilateral mandibular body fracture with paresthesia were studied. Paresthesia was evaluated...
Mon Sep 09, 2019 03:00
Introduction: Distraction osteogenesis is an integral part in management of mandibular defects associated with hemifacial microsomia and post-ankylotic mandibular defects. The most difficult part in distraction osteogenesis is the prediction of distraction vector and risk of injury to vital structures as inferior alveolar. The present study aimed to present 3-dimensionally constructed computer-guided splints in distraction osteogenesis to get an ideal vector and minimal risk of vital structures...
Mon Sep 09, 2019 03:00
Orbital blowout fractures are common. The same goes for its surgical complications when the efficiency of the dissection of entrapped or herniated intraorbital contents into the fracture could not be completely and safely dissected out. The authors describe a modification of the commonly used Howarth periosteal elevator for dissection of intraorbital content displacement or herniation on orbital blowout fracture. The instrument was modified by marking out the instrument from the tip into 10, 20,...
Mon Sep 09, 2019 03:00
Injury to the orbital region represents a significant proportion of emergency department attendances and it is a common injury in patients with multisystem trauma. To date, trauma remains a leading cause of monocular blindness. Traumatic optic neuropathy may be caused by direct trauma to the optic nerve and from compression caused by foreign bodies and bone fragments. Indirect trauma can lead to visual loss from transmitted force to the optic canal by blunt facial trauma without associated fractures....
Mon Sep 09, 2019 03:00
Orbital emphysema is a rare postoperative complication that can cause diplopia and even visual loss. Therefore, immediate diagnosis and treatment are crucial. In this study, a healthy male patient sustained left facial trauma caused by a fall 2 months ago; orbit emphysema occurred when the patient sneezed on the 5th day after surgery. The patient was treated conservatively with oral antibiotics and oral dexamethasone. Sixth-month follow-up showed no residual lesion. Address correspondence and reprint...
Mon Sep 09, 2019 03:00
Purpose: The aim of this study was to measure the cortical bone thickness of the infrazygomatic crest area in individuals with unilateral cleft lip and palate using cone beam computed tomography for placement of miniplates used for bone anchored maxillary protraction. Materials and Methods: CBCT scans were obtained from 31 non-syndromic UCLP children diagnosed with maxillary hypoplasia (17 males, 14 females, mean age: 11.9 years). 5 horizontal and 5 vertical reference planes were drawn at...
Mon Sep 09, 2019 03:00
Pediatric facial fractures are uncommon, especially orbital fractures, which can be unnoticed in 30% of the cases. Any delay regarding either diagnosis or treatment implies the risk of long-term sequels. Limited data exists concerning craniofacial fractures in children, especially the ones compromising the orbital substructures. Distribution varies upon several series; however, there is inexistence of literature regarding specific and isolated fractures of the lacrimal skeletal system. Injuries to...
Mon Sep 09, 2019 03:00
Purpose: The study was conducted to assess the efficacy of orbital chart in detecting postoperative complications of orbital fractures. Materials and Methods: A retrospective study was conducted in the Department of OMFS, SDM College of Dental Sciences, Dharwad from January 2011 to December 2016. It included all the patients with orbital fractures who underwent surgical intervention for reduction of the fracture in the study. We recorded data for the type of fracture, type of intervention,...
Mon Sep 09, 2019 03:00
Null alleles, short allele dominance (SAD), and stuttering increase the perceived relative inbreeding of individuals and subpopulations as measured by Wright's FIS and FST. Ascertainment bias, due to such amplifying problems are usually caused by inaccurate primer design (if developed from a different species or a distant population), poor DNA quality, low DNA concentration, or a combination of some or all these sources of inaccuracy. When combined, these issues can increase the correlation between...
Mon Sep 09, 2019 03:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου