Abstract Systematic reviews and meta‐analysis are booming. Although they were initially thought to be powerful tools to synthetize data of randomized controlled trials (RCTs), they are more and more used in observational studies and retrospective series. Particularly, in advanced endoscopy techniques, the reader often has to stand up to poor meta‐analyses of few studies before well‐designed RCTs are available. This usually leads to systematic reviews with different approaches and conflicting results1.
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Cell Death & Disease, Published online: 23 September 2019; doi:10.1038/s41419-019-1885-6Protein kinase C inhibitors override ZEB1-induced chemoresistance in HCC
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Cell Death & Disease, Published online: 23 September 2019; doi:10.1038/s41419-019-1942-1MicroRNA-29a represses osteoclast formation and protects against osteoporosis by regulating PCAF-mediated RANKL and CXCL12
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Related ArticlesThe relationship between the findings of vestibular evoked myogenic potentials and severity of obstructive sleep apnea syndrome. Eur Arch Otorhinolaryngol. 2019 Sep 21;: Authors: Ulusoy B, Gül O, Elsürer Ç, Bozkurt MK, Tülek B, Körez MK, Ekmekçi H, Çolpan B Abstract PURPOSE: Our study aimed to evaluate the effects of chronic hypoxic state in Obstructive Sleep Apnea Syndrome (OSAS) on brainstem pathways using Vestibular Evoked Myogenic...
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Related ArticlesAssessment of auditory working memory in normal hearing adults with tinnitus. Eur Arch Otorhinolaryngol. 2019 Sep 21;: Authors: Nagaraj MK, Bhaskar A, Prabhu P Abstract PURPOSE: Tinnitus is characterized by the perception of sound without an existing external stimulus. The presence of tinnitus might be intolerable for many and can be sufficiently troublesome in hearing, sleep, thought processing, and other functional abilities, all of...
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Related ArticlesIs the maxillary sinus volume affected by concha bullosa, nasal septal deviation, and impacted teeth? A CBCT study. Eur Arch Otorhinolaryngol. 2019 Sep 21;: Authors: Tassoker M, Magat G, Lale B, Gulec M, Ozcan S, Orhan K Abstract PURPOSE: Various mechanisms play an important role in the growth of maxillary sinus cavities. The purpose of this study was to investigate the correlations of maxillary sinus volume (MSV) with nasal septal deviation...
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Related ArticlesComparative analysis of sublingual immunotherapy medicines for adherence and clinical outcomes. Eur Arch Otorhinolaryngol. 2019 Sep 21;: Authors: Kim JA, Lee YM, Yi KI, Kim SD, Mun SJ, Cho KS Abstract OBJECTIVE: Sublingual immunotherapy (SLIT) has been considered as an effective and safe alternative to the subcutaneous route. However, different modalities and administration methods may lead to significant changes in their adherence and...
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Abstract Persons suffering from opioid use disorder (OUD) experience long‐lasting dysphoric symptoms well into extended periods of withdrawal. This protracted withdrawal syndrome is notably characterized by heightened anxiety and hyperkatifeia. Here we investigated if an exacerbated withdrawal model of acute morphine dependence results in lasting behavioral adaptation 6 weeks into forced abstinence in C57BL/6J mice. We found that our exacerbated morphine withdrawal paradigm produced distinct alterations...
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Related ArticlesA Rare Coexistence of Medullary Thyroid Cancer with Graves Disease: A Case Report and Systematic Review of the Literature. Am J Case Rep. 2019 Sep 22;20:1398-1401 Authors: Sapalidis K, Papanastasiou A, Michalopoulos N, Mantalovas S, Giannakidis D, Koimtzis GD, Florou M, Poulios C, Mantha N, Kesisoglou II Abstract BACKGROUND Graves disease is occasionally associated with thyroid cancer. The most common histological type of thyroid cancer...
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Related ArticlesDefining atypical croup: A case report and review of the literature. Int J Pediatr Otorhinolaryngol. 2019 Sep 17;127:109686 Authors: Hanna R, Lee F, Drummond D, Yunker WK Abstract BACKGROUND: Croup is a common respiratory illness in children. It presents with a barky cough, stridor and hoarseness occurring secondary to inflammation of the subglottis and larynx. The clinical course of croup is well-described, however atypical presentations...
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Related ArticlesDifferent Vibratory Conditions Elicit Different Structural and Biological Vocal Fold Changes in an In-Vivo Rabbit Model of Phonation. J Voice. 2019 Sep 18;: Authors: Kimball EE, Sayce L, Powell M, Gartling GJ, Brandley J, Rousseau B Abstract OBJECTIVE: Vibration of the vocal folds can disrupt the tissue and induce structural, functional, and molecular changes; the presence or absence of contact between the vocal folds during vibration...
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Nature Reviews Genetics, Published online: 23 September 2019; doi:10.1038/s41576-019-0171-xAneuploidy contributes to tumorigenesis, but the underlying processes are not well understood. This Review explains the context dependency of aneuploidy in cancer and discusses its clinical potential as a prognostic marker and a therapeutic target.
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Nature Reviews Genetics, Published online: 23 September 2019; doi:10.1038/s41576-019-0179-2A study in Science describes the generation of a lineage-resolved single-cell transcriptome atlas for Caenorhabditis elegans embryos. This resource provides insight into the transcriptional changes underlying cell fate decisions.
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Publication date: Available online 23 September 2019Source: Chinese Herbal MedicinesAuthor(s): Pei Li, Shuang-shuang Liu, Qing Liu, Jei Shen, Chun-nian He, Pei-gen XiaoABSTRACTObjectiveDichocarpum auriculatum, an endangered perennial herb, is endemic to China and has been used as folk medicines for the treatment of cough, hepatitis, scrofula, and epilepsy. However, there is no phytochemical report on this herbal so far. For the resource development and protective importance of this endangered medicinal...
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Related ArticlesEfficacy and safety of levoketoconazole in the treatment of endogenous Cushing's syndrome (SONICS): a phase 3, multicentre, open-label, single-arm trial. Lancet Diabetes Endocrinol. 2019 Sep 18;: Authors: Fleseriu M, Pivonello R, Elenkova A, Salvatori R, Auchus RJ, Feelders RA, Geer EB, Greenman Y, Witek P, Cohen F, Biller BMK Abstract BACKGROUND: Levoketoconazole is a ketoconazole stereoisomer in development for treatment of Cushing's...
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Publication date: Available online 23 September 2019Source: Health PolicyAuthor(s): Eline F. de Vries, Hanneke W. Drewes, Jeroen N. Struijs, Richard Heijink, Caroline A. BaanAbstractPopulation health management (PHM) initiatives aim for better population health, quality of care and reduction of expenditure growth by integrating and optimizing services across domains. Theoretically, a precondition for PHM is to shift from traditional fee-for-service towards value-based payment models. We aimed to...
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Publication date: Available online 22 September 2019Source: Atmospheric EnvironmentAuthor(s): Ahmad Taheri, Pourya Aliasghari, Vahid HosseiniAbstractFine particulate matter characterized as PM2.5 is the most important criteria air pollutant in the city of Tehran. Tehran is one of the most polluted cities of the Middle East based on annual mean PM2.5 concentrations. Tehran emission inventory shows the large contribution of mobile sources to the total particles. PM2.5 source apportionment studies show...
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Related ArticlesEpidemiologic features and risk factors of sepsis in ischemic stroke patients admitted to intensive care: A prospective cohort study. J Clin Neurosci. 2019 Sep 18;: Authors: Zaid Y, Rajeh A, Hosseini Teshnizi S, Alqarn A, Tarkesh F, Esmaeilinezhad Z, Nikandish R Abstract BACKGROUND/OBJECTIVE: Stroke is the second leading cause of death globally that predisposed to sepsis. Therefore, this study was aimed to assess the risk factors and...
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Related ArticlesEndocrine toxicity in cancer patients treated with nivolumab or pembrolizumab: results of a large multicentre study. J Endocrinol Invest. 2019 Sep 21;: Authors: Presotto EM, Rastrelli G, Desideri I, Scotti V, Gunnella S, Pimpinelli N, Vaccher E, Bearz A, Di Costanzo F, Bruggia M, Mini E, Maggi M, Peri A Abstract INTRODUCTION: The immune checkpoint inhibitors (ICPIs) agents anti-T lymphocytes-associated antigen 4 (CTLA-4) and anti-programmed...
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Related ArticlesReview of Factors Contributing to Nodular Goitre and Thyroid Carcinoma. Med Princ Pract. 2019 Sep 23;: Authors: Yildirim Simsir I, Cetinkalp S, Kabalak T Abstract There is an increased incidence of thyroid nodules and cancer. In this article, the reasons of this increase are evaluated and discussed. Factors causing increases in nodules are the same that are causing increases in thyroid cancer. There are publications from all over the...
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Publication date: Available online 22 September 2019Source: Acta BiomaterialiaAuthor(s): Qianli Huang, Zhengxiao Ouyang, Yanni Tan, Hong Wu, Yong LiuAbstractIn the field of orthopaedics, inflammation-modulatory biomaterials are receiving increasing attentions due to their abilities to regulate innate immune response and mediate wound healing. In the current work, a Cu-containing micro/nano-topographical bio-ceramic surface (Cu-Hier-Ti surface) was employed as material model to explore the role played...
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Related ArticlesPolymyalgia Rheumatica: The Great Imitator. Isr Med Assoc J. 2019 Sep;21(9):627-628 Authors: Gazitt T, Kibari A, Nasrallah N, Abu Elhija M, Zisman D PMID: 31542912 [PubMed - in process]
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Related ArticlesLow-risk Non-ST-Elevation Acute Coronary Syndrome and Normal Troponin: Do We Need Further Evaluation? Isr Med Assoc J. 2019 Sep;21(9):603-606 Authors: Marcusohn E, Epstein D, Musallam A, Keidar Z, Roguin A Abstract BACKGROUND: With the recent introduction of high-sensitivity troponin (hsTn), the incremental benefit of stress myocardial perfusion imaging (MPI) in the evaluation of patients who present to the emergency department (ED) with...
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Related ArticlesEpidemiologic Surveillance in Israel of Cryptosporidium, a Unique Waterborne Notifiable Pathogen, and Public Health Policy. Isr Med Assoc J. 2019 Sep;21(9):589-594 Authors: Flugelman AA, Dubnov J, Jacob L, Stein N, Habib S, Rishpon S Abstract BACKGROUND: Cryptosporidium is a major threat to water supplies worldwide. Various biases and obstacles in case identification are recognized. In Israel, Cryptosporidiosis was included among notifiable...
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Related ArticlesThe risk factors and prognosis of delayed perihematomal edema in patients with spontaneous intracerebral hemorrhage. CNS Neurosci Ther. 2019 Sep 22;: Authors: Peng WJ, Li Q, Tang JH, Reis C, Araujo C, Feng R, Yuan MH, Jin LY, Cheng YL, Jia YJ, Luo YT, Zhang J, Yang J Abstract PURPOSE: We hypothesize delayed perihematomal edema (DHE) leads to secondary injury after spontaneous intracerebral hemorrhage (sICH) with a poor prognosis. Hence,...
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Related ArticlesMeasuring horizontal inequity in healthcare utilisation: a review of methodological developments and debates. Eur J Health Econ. 2019 Sep 21;: Authors: Pulok MH, van Gool K, Hajizadeh M, Allin S, Hall J Abstract Equity in healthcare is an overarching goal of many healthcare systems around the world. Empirical studies of equity in healthcare utilisation primarily rely on the horizontal inequity (HI) approach which measures unequal utilisation...
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Related ArticlesCirculating estrogens and postmenopausal ovarian and endometrial cancer risk among current hormone users in the Women's Health Initiative Observational Study. Cancer Causes Control. 2019 Sep 21;: Authors: Trabert B, Coburn SB, Falk RT, Manson JE, Brinton LA, Gass ML, Kuller LH, Rohan TE, Pfeiffer RM, Qi L, Stefanick ML, Wentzensen N, Anderson GL, Xu X Abstract PURPOSE: Menopausal hormone therapy (MHT) use induces alterations in circulating...
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Related ArticlesSkeletal muscle, haematological and splenic volume characteristics of elite breath-hold divers. Eur J Appl Physiol. 2019 Sep 21;: Authors: Elia A, Wilson OJ, Lees M, Parker PJ, Barlow MJ, Cocks M, O'Hara JP Abstract PURPOSE: The aim of the study was to provide an evaluation of the oxygen transport, exchange and storage capacity of elite breath-hold divers (EBHD) compared with non-divers (ND). METHODS: Twenty-one healthy males'...
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Related ArticlesSelf-aligning prosthetic device for older patients with vascular-related amputations: protocol for a randomised feasibility study (the STEPFORWARD study). BMJ Open. 2019 Sep 20;9(9):e032924 Authors: Mitchell N, Coleman E, Watson J, Bell K, McDaid C, Barnett C, Twiste M, Jepson F, Salawu A, Harrison D, Vanicek N Abstract INTRODUCTION: The majority of older patients with a transtibial amputation are prescribed a standard (more rigid, not...
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Related ArticlesClinicopathological risk factors for gastric cancer: a retrospective cohort study in China. BMJ Open. 2019 Sep 20;9(9):e030639 Authors: Hu K, Wang S, Wang Z, Li L, Huang Z, Yu W, Chen Z, Wu QF Abstract OBJECTIVE: To examine the potential clinicopathological factors affecting the prognosis of patients with gastric cancer after surgical treatment in China. METHODS: Between 1 January 2001 and 31 December 2012, a total of 716 patients...
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Related ArticlesEffects of antihypertensives, lipid-modifying drugs, glycaemic control drugs and sodium bicarbonate on the progression of stages 3 and 4 chronic kidney disease in adults: a systematic review and meta-analysis. BMJ Open. 2019 Sep 20;9(9):e030596 Authors: Taylor KS, Mclellan J, Verbakel JY, Aronson JK, Lasserson DS, Pidduck N, Roberts N, Fleming S, O'Callaghan CA, Bankhead CR, Banerjee A, Hobbs FR, Perera R Abstract OBJECTIVE: To evaluate...
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Related ArticlesComparative thromboembolic risk in atrial fibrillation with and without a secondary precipitant-Danish nationwide cohort study. BMJ Open. 2019 Sep 20;9(9):e028468 Authors: Gundlund A, Kümler T, Bonde AN, Butt JH, Gislason GH, Torp-Pedersen C, Køber L, Olesen JB, Fosbøl EL Abstract OBJECTIVES: We compared long-term outcomes in patients with atrial fibrillation (AF) with and without a secondary precipitant. DESIGN AND SETTING:...
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Related ArticlesHelicobacter p ylori eradication treatment for gastric carcinoma prevention in asymptomatic or dyspeptic adults: systematic review and Bayesian meta-analysis of randomised controlled trials. BMJ Open. 2019 Sep 20;9(9):e026002 Authors: Terasawa T, Hamashima C, Kato K, Miyashiro I, Yoshikawa T, Takaku R, Nishida H Abstract OBJECTIVES: Recent meta-analyses of eradication therapy in Helicobacter pylori-infected adults reported significant...
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