An Ethiopian asylum seeker with advanced breast cancer who was denied treatment for several weeks amid confusion about whether she should be charged by the NHS has died at the age of 39.Kelemua...
10h
The Labour Party has pledged to introduce free personal care in England for the people aged over 65 who need it the most.The policy, which will cost an estimated £6bn (€6.8bn; $7.5bn), was announced...
10h
Chocron and colleagues provide a timely and important review on cannabinoid hyperemesis syndrome.1 One important point to expand on is the use (and pitfalls) of urine drug screens.Most available...
10h
The NHS long term plan is a unique opportunity to reduce variation in cancer care across the country and hold NHS and political leaders to account on their promises, experts have said.At the...
10h
Use of class A drugs among UK adults aged 16 to 24 is at its highest level for 16 years, official figures have shown.1The Home Office, which published the figures on drug misuse on 19 September, said...
10h
Braillon and Bewley emphasise the importance of recognising cannabinoid hyperemesis syndrome; we are pleased that our article might help patients and physicians tackle this condition.12 Our aim was...
13h
An Ethiopian asylum seeker with advanced breast cancer who was denied treatment for several weeks amid confusion about whether she should be charged by the NHS has died at the age of 39.Kelemua...
14h
The Labour Party has pledged to introduce free personal care in England for the people aged over 65 who need it the most.The policy, which will cost an estimated £6bn (€6.8bn; $7.5bn), was announced...
14h
Chocron and colleagues provide a timely and important review on cannabinoid hyperemesis syndrome.1 One important point to expand on is the use (and pitfalls) of urine drug screens.Most available...
14h
The NHS long term plan is a unique opportunity to reduce variation in cancer care across the country and hold NHS and political leaders to account on their promises, experts have said.At the...
14h
Use of class A drugs among UK adults aged 16 to 24 is at its highest level for 16 years, official figures have shown.1The Home Office, which published the figures on drug misuse on 19 September, said...
15h
The Labour Party has said that it will increase the number of GP trainees in England by around 43%—from 3500 to 5000 places—in order to relieve the strain on surgeries and reduce GP burnout, if...
15h
Two proposed bills suggest ways to reduce the high cost of prescription drugs, primarily for the 44 million retired Americans who rely on Medicare health insurance.High drug costs are a concern for...
15h
Chocron and colleagues discuss cannabinoid hyperemesis syndrome.1 We would like to emphasise the importance of cyclic vomiting syndrome (CVS) as a differential diagnosis, especially in patients...
16h
bmj;366/sep23_8/l5616/FAF1faAfter postgraduate training, Leslie Michaels took training positions in clinical pathology, microbiology, and histopathology in Bristol, Manchester, and London. This was...
18h
bmj;366/sep23_7/l5662/FAF1faVarun Kumar Singh was born in Akbarpur, Uttar Pradesh, India, on 26 April 1948. He was the middle child of five of a well known Hindi poet and academic, Shiv Mangal Singh...
18h
bmj;366/sep23_6/l5620/FAF1faKenneth Michael Citron studied medicine at Guy’s Hospital, London, where he won the Golding Bird medal in bacteriology and the Leonard Lubbock prize in clinical pathology....
18h
The article about cannabinoid hyperemesis syndrome as part of the Easily Missed? series is most welcome as “a way to help doctors . . . recognise conditions that are underdiagnosed or serious if not...
18h
On 5 March 2019 the US Food and Drug Administration approved esketamine nasal spray in conjunction with an oral antidepressant for people with treatment resistant depression. Esketamine is a form of...
20h
Combining doctors’ communication skills with cognitive behavioural therapy (CBT) can help clinicians improve patient care and boost their own wellbeing, says Lee David.The GP trainer and CBT...
20h
What you need to knowUnexpected weight loss can be associated with cancer, but also with a range of other conditionsWeight loss codes in primary care typically represent ≥5% loss within a 6 month...
20h
Governments around the world should invest significantly more in primary healthcare, the World Health Organization has said in a new report.1The report coincides with a high level meeting of the...
21h
Key messagesClimate change is threatening to undermine the achievement of universal health care (UHC) through negative health outcomes and healthcare system disruptionsClimate change and UHC agendas...
21h
Key messagesAll countries have failed to achieve universal health coverage for mental disorders, owing to barriers related to budget and stigmaThe architecture of primary healthcare in most countries...
21h
The inclusion of universal health coverage as a target in the sustainable development goal for health has boosted the global movement to improve access to healthcare services. To improve health, the...
21h
Key messagesAcute disease outbreaks often shed light on underlying health system failuresHigh rates of distrust health system distrust have been exposed in both recent Ebola epidemics.Health system...
21h
Abstract Hamartoma is the most common benign pulmonary tumor in adults, but is rarely described in the pediatric population. Giant chondromatous and progressive forms are even rarer. We report the novel case of a 13‐month‐old infant hospitalized for giant pulmonary chondromatous hamartoma discovered during a septic episode, rapidly progressive, with severe multifocal lesions, without clear response to several cytotoxic therapies. No predisposition syndrome was identified.
10h
Abstract Autoimmune cytopenias (AIC) following allogeneic hematopoietic stem cell transplantation (HSCT) may cause significant morbidity and mortality and are often challenging to treat. We present a case of a pediatric patient with primary myelofibrosis of infancy caused by VPS45 protein deficiency, who developed severe refractory hemolytic anemia and immune‐mediated thrombocytopenia 3.5 months following HSCT. After the failure of several treatments, he received daratumumab, an anti‐CD38 specific...
10h
Abstract Background Most childhood medulloblastoma (MB) cases are curable using multimodal treatment, including craniospinal irradiation (CSI). However, late effects are a serious problem for survivors. This prospective registry study evaluated Japanese patients to determine whether a reduced radiation dose was feasible. Patients and Methods Patients with MB were classified as an infant group (<3 years old) and a high‐risk (HR) group (≥3 years old with metastasis). The HR group received...
10h
It's the fifth recall by Torrent of losartan-containing medicines due to detection of unacceptable levels of a potential carcinogen. News Alerts
10h
Abstract Purpose Adjuvant FOLFOX therapy is an established standard-of-care for resected colon cancer. Peripheral sensory neuropathy (PSN) is regarded as the major toxicity issue related to FOLFOX therapy. There have been a few reports on the recovery status from PSN thereafter. JOIN trial investigated the tolerability and efficacy of adjuvant modified FOLFOX6 (mFOLFOX6) in Japanese patients with stage II/III colon cancer. ...
10h
Abstract Purpose Veliparib is an oral inhibitor of poly (ADP-ribose) polymerase (PARP)-1 and -2. PARP-1 expression may be increased in cancer, and this increase confers resistance to cytotoxic agents. We aimed to determine the recommended phase 2 dose (RP2D), maximum tolerated dose (MTD), dose-limiting toxicity (DLT), and pharmacokinetics (PK) of veliparib combined with paclitaxel and carboplatin. ...
12h
Abstract Purpose Chemotherapy remains the primary treatment used to improve overall survival and quality of life for patients with gastric cancer (GC); however, multidrug resistance is a major reason underlying failure of chemotherapy. Drug resistance (DR) can arise because of molecular changes inhibiting drug–target interactions; for example, overexpression of drug efflux pumps, such as P-gp, mediated by the activation of AP-1. BATF2...
16h
Abstract Background In this immediate ex vivo study, we aimed to identify the structures of normal and pathological facial skin using optical coherence tomography (OCT) and compared them to the gold standard histopathology. Material and Methods A total of 53 patients, with 57 suspicious facial lesions, participated in this study. A set of variables have been highlighted by the pathologist to represent the minimum unique features that could be used to diagnose a skin pathology have been...
10h
Abstract Background In clinical settings, atypical facial hyperpigmentation such as nevus of Ota, acquired bilateral nevus of Ota‐like macules (ABNOM), melasma, and café‐au‐lait spots are often missed and misdiagnosed. Summarizing in vivo reflectance confocal microscopy (RCM) features of the hyperpigmentation is helpful in the diagnosis of ambiguous lesions. Methods We recruited 196 patients referred for unequivocal facial hyperpigmentation, including 55 patients with nevus of Ota, 45 patients...
10h
Abstract Background The lesion size is a risk factor for keloid recurrence after postoperative radiotherapy. However, it remains unclear whether the major axis diameter is the most appropriate parameter to evaluate lesion size, because keloids are often irregular in shape. Additionally, no previous study has investigated computed tomography (CT) densitometry parameters of keloids as potential predictors for recurrence after postoperative radiotherapy. Materials and Methods The size and...
10h
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