Abstract Objectives Due to bone loss, endosseous implants often require addition of a bone graft to support adequate primary fixation, bone regeneration, and osseointegration. The aim of this study was to compare effectiveness of autogeneic and allogeneic bone grafts when used during simultaneous insertion of the implant. Materials and Methods 4mm diameter rabbit diaphyseal bone autografts or allografts (n=16/group) with a 3.2mm pre‐drilled hole in the center were placed into a 4mm defect...
Mon Sep 23, 2019 18:45
Abstract Background Multiple squamous cell carcinoma (SCC) development within the oral cavity is an important consequence of mucosal field cancerization. We have previously profiled contemporaneous demographics and confirmed a rising incidence of oral cancer within the Hong Kong population. In this further study, we sought to characterise the presenting clinico‐pathological features and clinical outcome consequent upon multiple primary tumour (PT) development. Methods Having accessed the...
Sun Sep 22, 2019 21:58
Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01503E, PaperHongzhi Lu, Di Wei, Rongkun Zheng, Shoufang XuWhen molecularly imprinted fluorescence polymers (MIFPs) were prepared by doping method (d-MIFPs), fluorescence nanoparticles were quenched and passivated during the polymerization and elution process, and the detection sensitively would be...The content of this RSS Feed (c) The Royal Society of Chemistry
Mon Sep 23, 2019 02:00
Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01201J, Critical ReviewLars Konermann, Haidy Metwally, Quentin Duez, Insa PetersElectrospray ionization (ESI) is an essential technique for transferring proteins from solution into the gas phase for mass spectrometry and ion mobility spectrometry. The mechanisms whereby [M + zH]z+ protein...The content of this RSS Feed (c) The Royal Society of Chemistry
Mon Sep 23, 2019 02:00
Although several cases of hepatitis B virus reactivation have been described in patients with a history of hepatitis B virus infection while undergoing treatment for hepatitis C virus infection with direct act...
Sun Sep 22, 2019 03:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02207
Mon Sep 23, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02974
Mon Sep 23, 2019 07:00
Summary The prognostic impact of primary excision in the treatment of cutaneous squamous cell carcinoma depends on certain tumor characteristics (risk factors), the surgical approach chosen and the subsequent histological examination. For the development of the AWMF (Association of Scientific Medical Societies in Germany) guidelines for squamous cell carcinoma, the most conclusive guidelines available were evaluated using the DELBI tool (German Instrument for the Methodological Appraisal of Guidelines)....
Mon Sep 23, 2019 17:18
All surgeons and anesthesiologists partner with each other in order to provide high-quality operative care. In Otolaryngology, specifically, the communication between surgeon and anesthesiologist is intimate and can be very complicated. Guest editors Drs Adam Levine, Samuel DeMaria, and Satish Govindaraj have crafted this issue of Otolaryngologic Clinics of North America to address the very particular concerns that are raised when these 2 types of specialists are providing care to a single patient.
Mon Sep 23, 2019 03:00
To clarify the gross anatomy structure of the check ligament of the palpebra superior in relation to congenital blepharoptosis operation.
Mon Sep 23, 2019 03:00
Acoustic parameters are widely used as voice quality therapeutic outcomes in many laryngological diseases. The aim of this study is to explore the impact of changes in the nature and duration of the analyzed time interval and the vowel choice on the significance of the acoustic measurements used as therapeutic outcomes in two different diseases.
Mon Sep 23, 2019 03:00
Laryngeal framework surgery has been a topic of interest since last decades. To succeed with least morbidity, the most important step is mastering the anatomy of larynx. In this study, we aim to show the relation between body height and laryngeal morphometrics that are important during laryngeal framework surgeries.
Mon Sep 23, 2019 03:00
Voices are, by nature, idiosyncratic representations of individuals because they possess anatomical, physiological, and psychological characteristics that are unique to them, which contribute to vocal output, and thus, establish the voice as a salient marker of their individuality. The areas of experimental psychology and cognitive neuroscience have examined the psychological and neurological constructs that form one's sense of self and have employed measures of interoceptive and exteroceptive abilities...
Mon Sep 23, 2019 03:00
Description:The Kidney Disease: Improving Global Outcomes (KDIGO) 2018 clinical practice guideline for the prevention, diagnosis, evaluation, and treatment of hepatitis C virus (HCV) infection in chronic kidney disease (CKD) is an extensive update of KDIGO's 2008 guideline on HCV infection in CKD. This update reflects the major advances since the introduction of direct-acting antivirals (DAAs) in the management of HCV infection in the CKD population.Methods:The KDIGO work group tasked with developing...
02:40
Background:Surveillance of patients with colorectal adenomas has limited long-term evidence to support current practice.Objective:To compare the lifetime benefits and costs of high- versus low-intensity surveillance.Design:Microsimulation model.Data Sources:U.S. cancer registry, cost data, and published literature.Target Population:U.S. patients aged 50, 60, or 70 years with low-risk adenomas (LRAs) (1 to 2 small adenomas) or high-risk adenomas (HRAs) (3 to 10 small adenomas or ≥1 large adenoma)...
02:40
In this issue, Meester and colleagues use microsimulation modeling to assess the cost-effectiveness of high- and low-intensity surveillance colonoscopy in patients with adenomas. The editorialists discuss the findings, unanswered questions about the benefit of surveillance, and the issue of optimal resource use.
02:40
Abstract Objective To characterise the burden of voice disorders in teachers in a UK population, compare it with non‐teachers; and identify groups of teachers who may be particularly at risk of developing a voice problem. Design Questionnaire based survey of primary, secondary teachers and non‐teachers. Questions consisted of general demographics, VHI‐10 and questions relating to voice problems. Methods Distribution of questionnaires to teachers and non‐teachers and statistical analysis...
Sun Sep 22, 2019 21:28
Exp Clin Endocrinol DiabetesDOI: 10.1055/a-1008-9110 Background High-fat-diet induces pancreatic β-cell compensatory proliferation, and impairments in pancreatic β-cell proliferation and function can lead to defects in insulin secretion and diabetes. NFATc3 is important for HFD-induced adipose tissue inflammation. But it is unknown whether NFATc3 is required for β cell compensatory growth in mice fed with HFD. Methods NFATc3 mRNA and protein expression levels were quantified by RT-qPCR and Western...
Mon Sep 23, 2019 02:00
Exp Clin Endocrinol DiabetesDOI: 10.1055/a-1008-9223 Background The single nucleotide polymorphism in TCF7L2 rs7903146 is associated with an increased risk of type 2 diabetes mellitus and gestational diabetes mellitus. Mechanisms by which this mutation acts, and its impact on the clinical course of the diseases remain unclear. Here we investigated the clinical impact of the T risk allele in women with gestational diabetes mellitus. Methods We genotyped the C/T polymorphism in 164 Caucasian women...
Mon Sep 23, 2019 02:00
Clinical and Molecular Characteristics of GNAS Inactivation Disorders Observed in 18 Korean Patients
Exp Clin Endocrinol DiabetesDOI: 10.1055/a-1001-3575 Background The GNAS gene on chromosome 20q13.3 is a complex, imprinted locus regulated in a tissue-specific manner. GNAS inactivation disorders are a heterogeneous group of rare disorders caused by mutations and methylation defects. These are divided into pseudohypoparathyroidism (PHP) types 1A and 1B, pseudo-pseudohypoparathyroidism (PPHP), and progressive osseous heteroplasia (POH), depending on the presence or absence of hormone resistance,...
Mon Sep 23, 2019 02:00
Exp Clin Endocrinol DiabetesDOI: 10.1055/a-1001-2244 Objective Secretagogin, a Ca2+ binding protein, is one of the most abundant proteins in pancreatic β-cells and is critical for maintaining the structural integrity and signaling competence of β-cells. This study seeks to assess the concentrations of plasma secretagogin in participants with prediabetes (pre-DM) and newly diagnosed type 2 diabetes (T2DM) and to explore its relationship to parameters of glucose and lipid metabolism, first-phase insulin...
Mon Sep 23, 2019 02:00
Exp Clin Endocrinol DiabetesDOI: 10.1055/a-0998-8035 Background Subacute thyroiditis (SAT) is a rare inflammatory disease that presents diagnostic challenges. The underlying pathophysiology and prediction of outcomes are elusive. We investigated the long-term follow-up of SAT for up to 30 years and determined predictors for later hypothyroidism. Methods SAT outcome data from 127 patients (age: 47.6 ± 11.0 yrs., BMI: 24.7±4.8 kg/m²) were analyzed retrospectively. Patients with pre-existing and...
Mon Sep 23, 2019 02:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b07926
Mon Sep 23, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b05509
Mon Sep 23, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b08892
Mon Sep 23, 2019 07:00
Lovastatin Enhances Cytotoxicity of Temozolomide via Impairing Autophagic Flux in Glioblastoma Cells
Drug resistance to temozolomide (TMZ) contributes to the majority of tumor recurrence and treatment failure in patients with glioblastoma multiforme (GBM). Autophagy has been reported to play a role in chemoresistance in various types of cancer, including GBM. The anticancer effect of statins is arousing great research interests and has been demonstrated to modulate autophagic function. In this study, we investigated the combinational effects of lovastatin and TMZ on treating U87 and U251 GBM cell...
Mon Sep 23, 2019 15:05
Microphthalmia-associated transcription factor (MITF) is a key regulator for the development and function of melanocytes in skin, eye, and plumage pigmentations. Thus, the MITF was selected as a candidate gene associated with plumage coloration in ducks. This study analyzed the mRNA expression, promoter methylation, and polymorphisms in the MITF gene in ducks with different plumage colors (Putian Black, Putian White, Liancheng White, and Longsheng Jade-green). No expression of the MITF melanin-specific...
Mon Sep 23, 2019 15:05
Liver fibrosis represents a serious global health-care problem and is the outcome of many chronic liver diseases, cirrhosis, hepatitis, and toxin accumulation. The present study aimed to evaluate the antifibrotic curative effect of Dunaliella salina (D. salina) on thioacetamide- (TAA-) induced liver fibrosis in rats. Liver fibrosis was induced by TAA (200mg/kg; i.p.) twice per week for 6 weeks. D. salina was given orally (100 and 200 mg/kg) and silymarin was given orally (100 mg/kg) daily, for 4 weeks...
03:05
A highly conserved internal stem-loop (ISL) of U6 snRNA is important for the function of the spliceosome. U6 ISL contains a 1x2 nucleotide internal loop that folds and unfold during spliceosomal assembly and activation. This internal loop coordinates magnesium ions needed for catalysis. The 1x2 loop consists of a C67•A79 base pair that forms an additional hydrogen bond upon protonation, C67•A+79, and uracil (U80) that coordinates the catalytically essential magnesium ion(s). We designed a series...
Mon Sep 23, 2019 18:17
Genetic robustness, the preservation of evolved phenotypes against genotypic mutations, is one of the central concepts in evolution. In recent years a large body of work has focused on the origins, mechanisms, and consequences of robustness in a wide range of biological systems. In particular, research on ncRNAs studied the ability of sequences to maintain folded structures against single-point mutations. In these studies, the structure is merely a reference. However, recent work revealed evidence...
Mon Sep 23, 2019 22:24
FDA Approval Summary: Tagraxofusp-erzs For Treatment of Blastic Plasmacytoid Dendritic Cell Neoplasm
Tagraxofusp-erzs (Elzonris, Stemline) is a cytotoxin that targets CD123-expressing cells. On December 21, 2018, FDA approved tagraxofusp-erzs for the treatment of blastic plasmacytoid dendritic cell neoplasms (BPDCN) in adult and pediatric patients 2 years and older. Approval was based on the response rate in a single-arm trial, Study STML-401-0114; the pivotal cohort included 13 patients with treatment-naïve BPDCN who received tagraxofusp-erzs monotherapy. The complete response or clinical complete...
Mon Sep 23, 2019 16:07
Purpose: Acute myeloid leukemia (AML) is a highly aggressive form of leukemia that results in poor survival outcomes. Currently, diagnosis and prognosis are based on invasive single-point bone marrow biopsies (iliac crest). There is currently no AML-specific non-invasive imaging method to detect disease, including in extramedullary organs, representing an unmet clinical need. About 85-90% of human myeloid leukemia cells express CD33 cell surface receptors, highlighting CD33 as an ideal candidate...
Mon Sep 23, 2019 16:07
Background: Patients with 1p/19q co-deleted low grade glioma (LGG) have longer overall survival and better treatment response than patients with 1p/19q intact tumors. Therefore, it is relevant to know the 1p/19q status. To investigate whether the 1p/19q status can be assessed prior to tumor resection, we developed a machine learning algorithm to predict the 1p/19q status of presumed LGG based on preoperative magnetic resonance imaging (MRI). Methods: Preoperative brain MRI scans from 284 patients...
Mon Sep 23, 2019 16:07
Purpose: The outgrowth of antigen negative variants is a significant challenge for adoptive therapy with T cells that target a single specificity. Chimeric antigen receptors (CARs) are typically designed with one or two scFvs that impart antigen specificity fused to activation and costimulation domains of T cell signaling molecules. We designed and evaluated the function of CARs with up to three specificities for overcoming tumor escape using Designed Ankyrin Repeat Proteins (DARPins) rather than...
Mon Sep 23, 2019 16:07
PURPOSE: While patients with advanced-stage non-small cell lung cancers (NSCLCs) harboring MET exon 14 skipping mutations (METex14) often benefit from MET tyrosine kinase inhibitor (TKI) treatment, clinical benefit is limited by primary and acquired drug resistance. The molecular basis for this resistance remains incompletely understood. METHODS: Targeted sequencing analysis was performed on cell-free circulating tumor DNA obtained from 289 patients with advanced-stage METex14-mutated NSCLC. RESULTS:...
Mon Sep 23, 2019 16:07
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